Scamp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scamp2
Entrez Gene ID	65168
Full Name	secretory carrier membrane protein 2
General protein information	Preferred Names secretory carrier membrane protein 2 Names secretory carrier-associated membrane protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24
Summary	may be involved in membrane trafficking and endocytosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_023955.1	NP_076445.1	secretory carrier-associated membrane protein 2
XM_017595894.1	XP_017451383.1	secretory carrier-associated membrane protein 2 isoform X1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	SCAMP2	XP_001233172.2
Arabidopsis thaliana (thale cress)	AT2G20840	NP_179680.1
Pan troglodytes (chimpanzee)	SCAMP2	XP_001135846.2
Arabidopsis thaliana (thale cress)	AT1G03550	NP_563686.1
Oryza sativa (rice)	Os01g0780500	NP_001044437.1
Mus musculus (house mouse)	Scamp2	NP_073724.1
Rattus norvegicus (Norway rat)	Scamp2	NP_076445.1
Oryza sativa (rice)	Os07g0564600	NP_001060004.1
Homo sapiens (human)	SCAMP2	NP_005688.2
Canis lupus familiaris (dog)	SCAMP2	XP_544777.2
Bos taurus (cattle)	SCAMP2	NP_001095640.1
Danio rerio (zebrafish)	scamp2l	NP_957488.1
Arabidopsis thaliana (thale cress)	AT1G11180	NP_001184960.1
	SCAMP2	XP_001098273.2
Danio rerio (zebrafish)	scamp2	NP_998543.1
Arabidopsis thaliana (thale cress)	SC3	NP_176320.1
Oryza sativa (rice)	Os05g0503000	NP_001055977.1
Xenopus tropicalis (tropical clawed frog)	scamp2	NP_001001223.1

Gene Ontology
Bibliography

Related articles in PubMed

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis.
Liao H, Zhang J, Shestopal S, Szabo G, Castle A, Castle D
American journal of physiology. Cell physiology294(3)C797-809(2008 Mar)

Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2.
M?ller HK, Wiborg O, Haase J
The Journal of biological chemistry281(39)28901-9(2006 Sep)

SCAMP2 interacts with Arf6 and phospholipase D1 and links their function to exocytotic fusion pore formation in PC12 cells.
Liu L, Liao H, Castle A, Zhang J, Casanova J, Szabo G, Castle D
Molecular biology of the cell16(10)4463-72(2005 Oct)

Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7.
Lin PJ, Williams WP, Luu Y, Molday RS, Orlowski J, Numata M
Journal of cell science118(Pt 9)1885-97(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SCAMP isoforms regulate membrane fusion and dense core vesicle exocytosis in neurons.
Title: Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis.

SCAMP2 plays an important role in the regulation of the subcellular distribution of SERT
Title: Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2.

SCAMP2 couples Arf6-stimulated PLD activity to exocytosis and links this process to formation of fusion pores.
Title: SCAMP2 interacts with Arf6 and phospholipase D1 and links their function to exocytotic fusion pore formation in PC12 cells.

SCAMP2 not only colocalizes with fusion sites but also appears to have an essential function in granule exocytosis through actions mediated by its E peptide-containing domain
Title: Role of secretory carrier membrane protein SCAMP2 in granule exocytosis.

role in perturbation of a very late step of regulated exocytosis
Title: Perturbation of a very late step of regulated exocytosis by a secretory carrier membrane protein (SCAMP2)-derived peptide.

The following Scamp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scamp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06631	NM_023955.1 Latest version!	Rattus norvegicus secretory carrier membrane protein 2 (Scamp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa62541	XM_017595894.1 Latest version!	Rattus norvegicus secretory carrier membrane protein 2 (Scamp2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scamp2 ( NM_023955.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_076445.1 Rattus norvegicus secretory carrier membrane protein 2 (Scamp2), mRNA.

Price & Availability↑

CloneID	ORa06631
Clone ID Related Accession (Same CDS sequence)	NM_023955.1
Accession Version	NM_023955.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-26
Organism	Rattus norvegicus(Norway rat)
Product	secretory carrier-associated membrane protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085862.1. On Nov 22, 2004 this sequence version replaced XM_343399.1. ##Evidence-Data-START## Transcript exon combination :: BC085862.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGCCT TCGACACTAA CCCCTTCGCG GACCCAGTGG ATGTAAACCC CTTCCAGGAT 
CCTTCTGTGA CCCAGCTGAC CAGTGCTCCT CAGAGTGGCC TGGCTGAGTT CAATCCCTTC 
TCAGAGACAA ATGCAGCGAC AACAGTTCCT GTCACACAAC TTCCTGGGCC CTCCCAGCCA 
GCAGTTCTCC AGCCCTCAGT GGAGCCAGCA CAGCCATCGC CCCAGGCTGT TGCGGCTGCA 
GCCCAGGCAG GCCTGCTTCG GCAGCAGGAA GAGTTAGACA GGAAAGCTGC TGAGCTGGAA 
CGCAAGGAGC GAGAGTTGCA GAACACTGCG GCGAATTTGC ATGTAAGAGA AAACAACTGG 
CCGCCACTCC CCTCATGGTG CCCTGTGAAA CCCTGCTTCT ATCAGGACTT CTCCACGGAG 
ATCCCTGCCG ACTACCAGCG GATATGCAAG ATGCTTTACT ATCTGTGGAT GTTGCATTCA 
GTGACTCTGT TTCTAAACCT GCTTGCATGC CTGGCCTGGT TCACAAGTGA CGCAGCTAAT 
GGAACAGCCT TTGGCCTCTC CATCCTTTGG TTTCTGATTT TCACGCCCTG TGCCTTCCTT 
TGTTGGTACC GACCCATCTA CAAGGCTTTC AGGTCTGACA ACTCTTTCAG CTTCTTCGTG 
TTCTTTTTTG TATTTTTTTG TCAAATAGGA ATCTACTTCA TCCAGTTGAT TGGCTTGCCT 
AACTTGGGGA CCAGTGGTTG GCTCGCAGCC CTCTCTACAG TGAATAAGGG GCCCTTAGCT 
GTGACCATCA TCATGATGGT AGTGGCTGGC TTCTTTACCC TCTGTGCTGG GCTCTCACTC 
TTCCTCCTGC AGCGGGTCCA TGCCTTCTAC CGCCGAACAG GAGCCAGCTT CCAGCAGGCT 
CAGGAAGAAT TCTCCCAGGG CATCTTCAGC AGCAGAACCT TCCGCACTGC TGCCTCGTCT 
GCTGCCCGAG GAACCTTCCA GGGGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076445.1
CDS	97..1086
Translation	MSAFDTNPFADPVDVNPFQDPSVTQLTSAPQSGLAEFNPFSETNAATTVPVTQLPGPSQPAVLQPSVEPAQPSPQAVAAAAQAGLLRQQEELDRKAAELERKERELQNTAANLHVRENNWPPLPSWCPVKPCFYQDFSTEIPADYQRICKMLYYLWMLHSVTLFLNLLACLAWFTSDAANGTAFGLSILWFLIFTPCAFLCWYRPIYKAFRSDNSFSFFVFFFVFFCQIGIYFIQLIGLPNLGTSGWLAALSTVNKGPLAVTIIMMVVAGFFTLCAGLSLFLLQRVHAFYRRTGASFQQAQEEFSQGIFSSRTFRTAASSAARGTFQGN

Target ORF information:

RefSeq Version	NM_023955.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus secretory carrier membrane protein 2 (Scamp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023955.1

ORF Insert Sequence:

ATGTCGGCCT TCGACACTAA CCCCTTCGCG GACCCAGTGG ATGTAAACCC CTTCCAGGAT 
CCTTCTGTGA CCCAGCTGAC CAGTGCTCCT CAGAGTGGCC TGGCTGAGTT CAATCCCTTC 
TCAGAGACAA ATGCAGCGAC AACAGTTCCT GTCACACAAC TTCCTGGGCC CTCCCAGCCA 
GCAGTTCTCC AGCCCTCAGT GGAGCCAGCA CAGCCATCGC CCCAGGCTGT TGCGGCTGCA 
GCCCAGGCAG GCCTGCTTCG GCAGCAGGAA GAGTTAGACA GGAAAGCTGC TGAGCTGGAA 
CGCAAGGAGC GAGAGTTGCA GAACACTGCG GCGAATTTGC ATGTAAGAGA AAACAACTGG 
CCGCCACTCC CCTCATGGTG CCCTGTGAAA CCCTGCTTCT ATCAGGACTT CTCCACGGAG 
ATCCCTGCCG ACTACCAGCG GATATGCAAG ATGCTTTACT ATCTGTGGAT GTTGCATTCA 
GTGACTCTGT TTCTAAACCT GCTTGCATGC CTGGCCTGGT TCACAAGTGA CGCAGCTAAT 
GGAACAGCCT TTGGCCTCTC CATCCTTTGG TTTCTGATTT TCACGCCCTG TGCCTTCCTT 
TGTTGGTACC GACCCATCTA CAAGGCTTTC AGGTCTGACA ACTCTTTCAG CTTCTTCGTG 
TTCTTTTTTG TATTTTTTTG TCAAATAGGA ATCTACTTCA TCCAGTTGAT TGGCTTGCCT 
AACTTGGGGA CCAGTGGTTG GCTCGCAGCC CTCTCTACAG TGAATAAGGG GCCCTTAGCT 
GTGACCATCA TCATGATGGT AGTGGCTGGC TTCTTTACCC TCTGTGCTGG GCTCTCACTC 
TTCCTCCTGC AGCGGGTCCA TGCCTTCTAC CGCCGAACAG GAGCCAGCTT CCAGCAGGCT 
CAGGAAGAAT TCTCCCAGGG CATCTTCAGC AGCAGAACCT TCCGCACTGC TGCCTCGTCT 
GCTGCCCGAG GAACCTTCCA GGGGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scamp2 ( XM_017595894.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017451383.1 Rattus norvegicus secretory carrier membrane protein 2 (Scamp2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa62541
Clone ID Related Accession (Same CDS sequence)	XM_017595894.1
Accession Version	XM_017595894.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	secretory carrier-associated membrane protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGCCT TCGACACTAA CCCCTTCGCG GACCCAGTGG ATGTAAACCC CTTCCAGGAT 
CCTTCTGTGA CCCAGCTGAC CAGTGCTCCT CAGAGTGGCC TGGCTGAGTT CAATCCCTTC 
TCAGAGACAA ATGCAGCGAC AACAGTTCCT GTCACACAAC TTCCTGGGCC CTCCCAGCCA 
GCAGTTCTCC AGCCCTCAGT GGAGCCAGCA CAGCCATCGC CCCAGCTCCT GCTTAGACAG 
GCCAGCAAGT TTCTGCCTGC CCGATTCCTG GCAGCGGGTG AGCCCTCAGA GAGGCAGATG 
CTACTAGGAG GAGATAGTAG TCCCAGGGAC AGCTACATGT GCAAGCTTCC GAAGGCTGTT 
GCGGCTGCAG CCCAGGCAGG CCTGCTTCGG CAGCAGGAAG AGTTAGACAG GAAAGCTGCT 
GAGCTGGAAC GCAAGGAGCG AGAGTTGCAG AACACTGCGG CGAATTTGCA TGTAAGAGAA 
AACAACTGGC CGCCACTCCC CTCATGGTGC CCTGTGAAAC CCTGCTTCTA TCAGGACTTC 
TCCACGGAGA TCCCTGCCGA CTACCAGCGG ATATGCAAGA TGCTTTACTA TCTGTGGATG 
TTGCATTCAG TGACTCTGTT TCTAAACCTG CTTGCATGCC TGGCCTGGTT CACAAGTGAC 
GCAGCTAATG GAACAGCCTT TGGCCTCTCC ATCCTTTGGT TTCTGATTTT CACGCCCTGT 
GCCTTCCTTT GTTGGTACCG ACCCATCTAC AAGGCTTTCA GGTCTGACAA CTCTTTCAGC 
TTCTTCGTGT TCTTTTTTGT ATTTTTTTGT CAAATAGGAA TCTACTTCAT CCAGTTGATT 
GGCTTGCCTA ACTTGGGGAC CAGTGGTTGG CTCGCAGCCC TCTCTACAGT GAATAAGGGG 
CCCTTAGCTG TGACCATCAT CATGATGGTA GTGGCTGGCT TCTTTACCCT CTGTGCTGGG 
CTCTCACTCT TCCTCCTGCA GCGGGTCCAT GCCTTCTACC GCCGAACAGG AGCCAGCTTC 
CAGCAGGCTC AGGAAGAATT CTCCCAGGGC ATCTTCAGCA GCAGAACCTT CCGCACTGCT 
GCCTCGTCTG CTGCCCGAGG AACCTTCCAG GGGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017451383.1
CDS	126..1244
Translation	MSAFDTNPFADPVDVNPFQDPSVTQLTSAPQSGLAEFNPFSETNAATTVPVTQLPGPSQPAVLQPSVEPAQPSPQLLLRQASKFLPARFLAAGEPSERQMLLGGDSSPRDSYMCKLPKAVAAAAQAGLLRQQEELDRKAAELERKERELQNTAANLHVRENNWPPLPSWCPVKPCFYQDFSTEIPADYQRICKMLYYLWMLHSVTLFLNLLACLAWFTSDAANGTAFGLSILWFLIFTPCAFLCWYRPIYKAFRSDNSFSFFVFFFVFFCQIGIYFIQLIGLPNLGTSGWLAALSTVNKGPLAVTIIMMVVAGFFTLCAGLSLFLLQRVHAFYRRTGASFQQAQEEFSQGIFSSRTFRTAASSAARGTFQGN

Target ORF information:

RefSeq Version	XM_017595894.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus secretory carrier membrane protein 2 (Scamp2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017595894.1

ORF Insert Sequence:

ATGTCGGCCT TCGACACTAA CCCCTTCGCG GACCCAGTGG ATGTAAACCC CTTCCAGGAT 
CCTTCTGTGA CCCAGCTGAC CAGTGCTCCT CAGAGTGGCC TGGCTGAGTT CAATCCCTTC 
TCAGAGACAA ATGCAGCGAC AACAGTTCCT GTCACACAAC TTCCTGGGCC CTCCCAGCCA 
GCAGTTCTCC AGCCCTCAGT GGAGCCAGCA CAGCCATCGC CCCAGCTCCT GCTTAGACAG 
GCCAGCAAGT TTCTGCCTGC CCGATTCCTG GCAGCGGGTG AGCCCTCAGA GAGGCAGATG 
CTACTAGGAG GAGATAGTAG TCCCAGGGAC AGCTACATGT GCAAGCTTCC GAAGGCTGTT 
GCGGCTGCAG CCCAGGCAGG CCTGCTTCGG CAGCAGGAAG AGTTAGACAG GAAAGCTGCT 
GAGCTGGAAC GCAAGGAGCG AGAGTTGCAG AACACTGCGG CGAATTTGCA TGTAAGAGAA 
AACAACTGGC CGCCACTCCC CTCATGGTGC CCTGTGAAAC CCTGCTTCTA TCAGGACTTC 
TCCACGGAGA TCCCTGCCGA CTACCAGCGG ATATGCAAGA TGCTTTACTA TCTGTGGATG 
TTGCATTCAG TGACTCTGTT TCTAAACCTG CTTGCATGCC TGGCCTGGTT CACAAGTGAC 
GCAGCTAATG GAACAGCCTT TGGCCTCTCC ATCCTTTGGT TTCTGATTTT CACGCCCTGT 
GCCTTCCTTT GTTGGTACCG ACCCATCTAC AAGGCTTTCA GGTCTGACAA CTCTTTCAGC 
TTCTTCGTGT TCTTTTTTGT ATTTTTTTGT CAAATAGGAA TCTACTTCAT CCAGTTGATT 
GGCTTGCCTA ACTTGGGGAC CAGTGGTTGG CTCGCAGCCC TCTCTACAGT GAATAAGGGG 
CCCTTAGCTG TGACCATCAT CATGATGGTA GTGGCTGGCT TCTTTACCCT CTGTGCTGGG 
CTCTCACTCT TCCTCCTGCA GCGGGTCCAT GCCTTCTACC GCCGAACAGG AGCCAGCTTC 
CAGCAGGCTC AGGAAGAATT CTCCCAGGGC ATCTTCAGCA GCAGAACCTT CCGCACTGCT 
GCCTCGTCTG CTGCCCGAGG AACCTTCCAG GGGAATTAG