P2ry12 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	P2ry12
Entrez Gene ID	64803
Full Name	purinergic receptor P2Y12
Synonyms	P2y12
General protein information	Preferred Names purinergic receptor P2Y12 Names P2Y purinoceptor 12 P2Y12 platelet ADP receptor purinergic receptor P2Y, G-protein coupled, 12
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q26
Summary	receptor activated by platelet ADP release; mediates adenylate cyclase inhibition and is a target of antithrombotic drugs [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006232406.3	XP_006232468.1	P2Y purinoceptor 12 isoform X1
XM_006232407.3	XP_006232469.1	P2Y purinoceptor 12 isoform X1
XM_006232408.3	XP_006232470.1	P2Y purinoceptor 12 isoform X1
NM_022800.1	NP_073637.1	P2Y purinoceptor 12

Pathways from BioSystems

Homologies

	P2RY12	XP_001107465.1
Danio rerio (zebrafish)	LOC100149618	XP_001921964.1
Xenopus tropicalis (tropical clawed frog)	p2ry12	XP_002941149.1
Canis lupus familiaris (dog)	P2RY12	NP_001003365.1
Mus musculus (house mouse)	P2ry12	NP_081847.3
Rattus norvegicus (Norway rat)	P2ry12	NP_073637.1
Homo sapiens (human)	P2RY12	NP_795345.1
Pan troglodytes (chimpanzee)	P2RY12	XP_001145406.1
Bos taurus (cattle)	P2RY12	NP_001001174.2

Gene Ontology
Bibliography

Related articles in PubMed

P2Y
Yi Z, Xie L, Zhou C, Yuan H, Ouyang S, Fang Z, Zhao S, Jia T, Zou L, Wang S, Xue Y, Wu B, Gao Y, Li G, Liu S, Xu H, Xu C, Zhang C, Liang S
Purinergic signalling(2017 Nov)

Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.
Gremmel T, Yanachkov IB, Yanachkova MI, Wright GE, Wider J, Undyala VV, Michelson AD, Frelinger AL 3rd, Przyklenk K
Arteriosclerosis, thrombosis, and vascular biology36(3)501-9(2016 Mar)

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex.
Sipe GO, Lowery RL, Tremblay M?, Kelly EA, Lamantia CE, Majewska AK
Nature communications710905(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Synergistic inhibition of both P2Y1 and P2Y12 adenosine diphosphate receptors by GLS-409 immediately attenuates platelet-mediated thrombosis and effectively blocks agonist-stimulated platelet aggregation irrespective of concomitant aspirin therapy.
Title: Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.

study reports robust involvement of P2Y12R in inflammatory pain: anti-hyperalgesic effect of P2Y12R antagonism could be mediated by the inhibition of both central and peripheral cytokine production and involves alpha7-receptor mediated efferent pathways
Title: Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents.

Establish a reliable antiplatelet profile of SAR216471, and support its potential use in clinical practice as an alternative to currently available P2Y12 receptor antagonists.
Title: SAR216471, an alternative to the use of currently available P2Y?? receptor inhibitors?

Platelet ADP and AA receptor inhibition is a prominent early feature of coagulopathy in traumatic brain injury in humans and rats and is linked to the severity of brain injury in patients with isolated head trauma.
Title: Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats.

Notoginsenoside Ft1, a saponin isolated from Panax notoginseng, enhanced platelet aggregation by activating a signalling network mediated through P2Y12 receptors.
Title: Platelet P2Y?? receptors are involved in the haemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng.

The following P2ry12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the P2ry12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa06340	NM_022800.1 Latest version!	Rattus norvegicus purinergic receptor P2Y12 (P2ry12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa24717	XM_006232406.3 Latest version!	Rattus norvegicus purinergic receptor P2Y12 (P2ry12), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa24717	XM_006232407.3 Latest version!	Rattus norvegicus purinergic receptor P2Y12 (P2ry12), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa24717	XM_006232408.3 Latest version!	Rattus norvegicus purinergic receptor P2Y12 (P2ry12), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

P2ry12 ( NM_022800.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_073637.1 Rattus norvegicus purinergic receptor P2Y12 (P2ry12), mRNA.

Price & Availability↑

CloneID	ORa06340
Clone ID Related Accession (Same CDS sequence)	NM_022800.1
Accession Version	NM_022800.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	P2Y purinoceptor 12
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF313450.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF313450.1, H31419.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGTGC CTGGTGCCAA CGCCACCTCA GCCAACACCA CCTCCATTCC TGGGACCAGC 
ACCCTGTGCA GCAGAGACTA CAAGATCACC CAGGTTCTCT TCCCATTGCT CTACACTGTC 
CTGTTTTTTG CTGGGCTCAT CACGAACAGC TTGGCGATGA GGATTTTCTT CCAGATCCGC 
AGTAAATCGA ACTTCATCAT TTTTCTTAAG AACACGGTCA TCTCTGATCT TCTTATGATC 
CTAACTTTTC CTTTCAAAAT TCTCAGTGAT GCCAAACTGG GAGCTGGGCA CCTGAGAACC 
CTGGTGTGCC AAGTCACTTC AGTCACGTTT TACTTCACAA TGTACATCAG TATCTCGTTC 
CTCGGATTGA TAACCATTGA CCGATACCTG AAGACCACCA GACCATTTAA AACTTCCAGC 
CCCAGCAATC TTTTGGGTGC GAAGATTCTT TCTGTTGCCA TCTGGGCCTT CATGTTCCTG 
CTGTCACTGC CTAACATGAT TCTCACCAAC AGGAGGCCAA AAGATAAGGA CATAACGAAA 
TGTTCTTTCT TGAAGTCGGA GTTTGGTCTG GTCTGGCACG AGATAGTCAA TTACATCTGC 
CAAGTCATTT TCTGGATTAA TTTTTTAATT GTTATTGTTT GTTACAGCCT CATTACAAAA 
GAGCTCTATA GGTCCTACGT CAGAACGAGG GGTTCAGCCA AAGCTCCCAA GAAAAGGGTG 
AACATCAAGG TTTTCATCAT CATTGCTGTG TTCTTCATTT GCTTCGTTCC CTTCCACTTT 
GCACGGATTC CCTACACCCT GAGCCAGACA CGGGCCGTCT TTGACTGCAA TGCCGAGAAC 
ACTCTGTTCT ACGTGAAGGA GAGCACCCTG TGGCTGACGT CCTTGAACGC CTGCCTTGAT 
CCATTCATCT ATTTCTTTCT TTGCAAGTCT TTCAGAAATT CCTTGATGAG CATGCTGAGG 
TGCTCAACAT CCGGGGCAAA TAAGAAGAAA GGACAGGAAG GTGGGGACCC AAGCGAGGAG 
ACCCCAATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073637.1
CDS	124..1155
Translation	MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM

Target ORF information:

RefSeq Version	NM_022800.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus purinergic receptor P2Y12 (P2ry12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022800.1

ORF Insert Sequence:

ATGGAGGTGC CTGGTGCCAA CGCCACCTCA GCCAACACCA CCTCCATTCC TGGGACCAGC 
ACCCTGTGCA GCAGAGACTA CAAGATCACC CAGGTTCTCT TCCCATTGCT CTACACTGTC 
CTGTTTTTTG CTGGGCTCAT CACGAACAGC TTGGCGATGA GGATTTTCTT CCAGATCCGC 
AGTAAATCGA ACTTCATCAT TTTTCTTAAG AACACGGTCA TCTCTGATCT TCTTATGATC 
CTAACTTTTC CTTTCAAAAT TCTCAGTGAT GCCAAACTGG GAGCTGGGCA CCTGAGAACC 
CTGGTGTGCC AAGTCACTTC AGTCACGTTT TACTTCACAA TGTACATCAG TATCTCGTTC 
CTCGGATTGA TAACCATTGA CCGATACCTG AAGACCACCA GACCATTTAA AACTTCCAGC 
CCCAGCAATC TTTTGGGTGC GAAGATTCTT TCTGTTGCCA TCTGGGCCTT CATGTTCCTG 
CTGTCACTGC CTAACATGAT TCTCACCAAC AGGAGGCCAA AAGATAAGGA CATAACGAAA 
TGTTCTTTCT TGAAGTCGGA GTTTGGTCTG GTCTGGCACG AGATAGTCAA TTACATCTGC 
CAAGTCATTT TCTGGATTAA TTTTTTAATT GTTATTGTTT GTTACAGCCT CATTACAAAA 
GAGCTCTATA GGTCCTACGT CAGAACGAGG GGTTCAGCCA AAGCTCCCAA GAAAAGGGTG 
AACATCAAGG TTTTCATCAT CATTGCTGTG TTCTTCATTT GCTTCGTTCC CTTCCACTTT 
GCACGGATTC CCTACACCCT GAGCCAGACA CGGGCCGTCT TTGACTGCAA TGCCGAGAAC 
ACTCTGTTCT ACGTGAAGGA GAGCACCCTG TGGCTGACGT CCTTGAACGC CTGCCTTGAT 
CCATTCATCT ATTTCTTTCT TTGCAAGTCT TTCAGAAATT CCTTGATGAG CATGCTGAGG 
TGCTCAACAT CCGGGGCAAA TAAGAAGAAA GGACAGGAAG GTGGGGACCC AAGCGAGGAG 
ACCCCAATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

P2ry12 ( XM_006232406.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006232468.1 Rattus norvegicus purinergic receptor P2Y12 (P2ry12), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa24717
Clone ID Related Accession (Same CDS sequence)	XM_006232406.3 , XM_006232407.3 , XM_006232408.3
Accession Version	XM_006232406.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	P2Y purinoceptor 12 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006232406.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGTGC CTGGTGCCAA CGCCACCTCA GCCAACACCA CCTCCATTCC TGGGACCAGC 
ACCCTGTGCA GCAGAGACTA CAAGATCACC CAGGTTCTCT TCCCATTGCT CTACACTGTC 
CTGTTTTTTG CTGGGCTCAT CACGAACAGC TTGGCGATGA GGATTTTCTT CCAGATCCGC 
AGTAAATCCA ACTTCATCAT TTTTCTTAAG AACACGGTCA TCTCTGATCT TCTTATGATC 
CTAACTTTTC CTTTCAAAAT TCTCAGTGAT GCCAAACTGG GAGCTGGGCA CCTGAGAACC 
CTGGTGTGCC AAGTCACTTC AGTCACGTTT TACTTCACAA TGTACATCAG TATCTCGTTC 
CTCGGATTGA TAACCATTGA CCGATACCTG AAGACCACCA GACCATTTAA AACTTCCAGC 
CCCAGCAATC TCTTGGGTGC GAAGATTCTT TCTGTTGCCA TCTGGGCCTT CATGTTCCTG 
CTGTCACTGC CTAACATGAT TCTCACCAAC AGGAGGCCAA AAGATAAGGA CATAACGAAA 
TGTTCTTTCT TGAAGTCGGA GTTTGGTCTG GTCTGGCACG AGATAGTCAA TTACATCTGC 
CAAGTCATTT TCTGGATTAA TTTTTTAATT GTTATTGTTT GTTACAGCCT CATTACAAAA 
GAGCTCTATA GGTCCTACGT CAGAACGAGG GGTTCAGCCA AAGCTCCCAA GAAAAGGGTG 
AACATCAAGG TTTTCATCAT CATTGCTGTG TTCTTCATTT GCTTCGTTCC CTTCCACTTT 
GCACGGATTC CCTACACCCT GAGCCAGACA CGGGCCGTCT TTGACTGCAA TGCCGAGAAC 
ACTCTGTTCT ACGTGAAGGA GAGCACCCTG TGGCTGACGT CCTTGAACGC CTGCCTTGAT 
CCATTCATCT ATTTCTTTCT TTGCAAGTCT TTCAGAAATT CCTTGATGAG CATGCTGAGG 
TGCTCAACAT CCGGGGCAAA TAAGAAGAAA GGACAGGAAG GTGGGGACCC AAGCGAGGAG 
ACCCCAATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006232468.1
CDS	501..1532
Translation	MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM

Target ORF information:

RefSeq Version	XM_006232406.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus purinergic receptor P2Y12 (P2ry12), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006232406.3

ORF Insert Sequence:

ATGGAGGTGC CTGGTGCCAA CGCCACCTCA GCCAACACCA CCTCCATTCC TGGGACCAGC 
ACCCTGTGCA GCAGAGACTA CAAGATCACC CAGGTTCTCT TCCCATTGCT CTACACTGTC 
CTGTTTTTTG CTGGGCTCAT CACGAACAGC TTGGCGATGA GGATTTTCTT CCAGATCCGC 
AGTAAATCCA ACTTCATCAT TTTTCTTAAG AACACGGTCA TCTCTGATCT TCTTATGATC 
CTAACTTTTC CTTTCAAAAT TCTCAGTGAT GCCAAACTGG GAGCTGGGCA CCTGAGAACC 
CTGGTGTGCC AAGTCACTTC AGTCACGTTT TACTTCACAA TGTACATCAG TATCTCGTTC 
CTCGGATTGA TAACCATTGA CCGATACCTG AAGACCACCA GACCATTTAA AACTTCCAGC 
CCCAGCAATC TCTTGGGTGC GAAGATTCTT TCTGTTGCCA TCTGGGCCTT CATGTTCCTG 
CTGTCACTGC CTAACATGAT TCTCACCAAC AGGAGGCCAA AAGATAAGGA CATAACGAAA 
TGTTCTTTCT TGAAGTCGGA GTTTGGTCTG GTCTGGCACG AGATAGTCAA TTACATCTGC 
CAAGTCATTT TCTGGATTAA TTTTTTAATT GTTATTGTTT GTTACAGCCT CATTACAAAA 
GAGCTCTATA GGTCCTACGT CAGAACGAGG GGTTCAGCCA AAGCTCCCAA GAAAAGGGTG 
AACATCAAGG TTTTCATCAT CATTGCTGTG TTCTTCATTT GCTTCGTTCC CTTCCACTTT 
GCACGGATTC CCTACACCCT GAGCCAGACA CGGGCCGTCT TTGACTGCAA TGCCGAGAAC 
ACTCTGTTCT ACGTGAAGGA GAGCACCCTG TGGCTGACGT CCTTGAACGC CTGCCTTGAT 
CCATTCATCT ATTTCTTTCT TTGCAAGTCT TTCAGAAATT CCTTGATGAG CATGCTGAGG 
TGCTCAACAT CCGGGGCAAA TAAGAAGAAA GGACAGGAAG GTGGGGACCC AAGCGAGGAG 
ACCCCAATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

P2ry12 ( XM_006232407.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006232469.1 Rattus norvegicus purinergic receptor P2Y12 (P2ry12), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa24717
Clone ID Related Accession (Same CDS sequence)	XM_006232406.3 , XM_006232407.3 , XM_006232408.3
Accession Version	XM_006232407.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	P2Y purinoceptor 12 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006232407.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGTGC CTGGTGCCAA CGCCACCTCA GCCAACACCA CCTCCATTCC TGGGACCAGC 
ACCCTGTGCA GCAGAGACTA CAAGATCACC CAGGTTCTCT TCCCATTGCT CTACACTGTC 
CTGTTTTTTG CTGGGCTCAT CACGAACAGC TTGGCGATGA GGATTTTCTT CCAGATCCGC 
AGTAAATCCA ACTTCATCAT TTTTCTTAAG AACACGGTCA TCTCTGATCT TCTTATGATC 
CTAACTTTTC CTTTCAAAAT TCTCAGTGAT GCCAAACTGG GAGCTGGGCA CCTGAGAACC 
CTGGTGTGCC AAGTCACTTC AGTCACGTTT TACTTCACAA TGTACATCAG TATCTCGTTC 
CTCGGATTGA TAACCATTGA CCGATACCTG AAGACCACCA GACCATTTAA AACTTCCAGC 
CCCAGCAATC TCTTGGGTGC GAAGATTCTT TCTGTTGCCA TCTGGGCCTT CATGTTCCTG 
CTGTCACTGC CTAACATGAT TCTCACCAAC AGGAGGCCAA AAGATAAGGA CATAACGAAA 
TGTTCTTTCT TGAAGTCGGA GTTTGGTCTG GTCTGGCACG AGATAGTCAA TTACATCTGC 
CAAGTCATTT TCTGGATTAA TTTTTTAATT GTTATTGTTT GTTACAGCCT CATTACAAAA 
GAGCTCTATA GGTCCTACGT CAGAACGAGG GGTTCAGCCA AAGCTCCCAA GAAAAGGGTG 
AACATCAAGG TTTTCATCAT CATTGCTGTG TTCTTCATTT GCTTCGTTCC CTTCCACTTT 
GCACGGATTC CCTACACCCT GAGCCAGACA CGGGCCGTCT TTGACTGCAA TGCCGAGAAC 
ACTCTGTTCT ACGTGAAGGA GAGCACCCTG TGGCTGACGT CCTTGAACGC CTGCCTTGAT 
CCATTCATCT ATTTCTTTCT TTGCAAGTCT TTCAGAAATT CCTTGATGAG CATGCTGAGG 
TGCTCAACAT CCGGGGCAAA TAAGAAGAAA GGACAGGAAG GTGGGGACCC AAGCGAGGAG 
ACCCCAATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006232469.1
CDS	495..1526
Translation	MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM

Target ORF information:

RefSeq Version	XM_006232407.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus purinergic receptor P2Y12 (P2ry12), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006232407.3

ORF Insert Sequence:

ATGGAGGTGC CTGGTGCCAA CGCCACCTCA GCCAACACCA CCTCCATTCC TGGGACCAGC 
ACCCTGTGCA GCAGAGACTA CAAGATCACC CAGGTTCTCT TCCCATTGCT CTACACTGTC 
CTGTTTTTTG CTGGGCTCAT CACGAACAGC TTGGCGATGA GGATTTTCTT CCAGATCCGC 
AGTAAATCCA ACTTCATCAT TTTTCTTAAG AACACGGTCA TCTCTGATCT TCTTATGATC 
CTAACTTTTC CTTTCAAAAT TCTCAGTGAT GCCAAACTGG GAGCTGGGCA CCTGAGAACC 
CTGGTGTGCC AAGTCACTTC AGTCACGTTT TACTTCACAA TGTACATCAG TATCTCGTTC 
CTCGGATTGA TAACCATTGA CCGATACCTG AAGACCACCA GACCATTTAA AACTTCCAGC 
CCCAGCAATC TCTTGGGTGC GAAGATTCTT TCTGTTGCCA TCTGGGCCTT CATGTTCCTG 
CTGTCACTGC CTAACATGAT TCTCACCAAC AGGAGGCCAA AAGATAAGGA CATAACGAAA 
TGTTCTTTCT TGAAGTCGGA GTTTGGTCTG GTCTGGCACG AGATAGTCAA TTACATCTGC 
CAAGTCATTT TCTGGATTAA TTTTTTAATT GTTATTGTTT GTTACAGCCT CATTACAAAA 
GAGCTCTATA GGTCCTACGT CAGAACGAGG GGTTCAGCCA AAGCTCCCAA GAAAAGGGTG 
AACATCAAGG TTTTCATCAT CATTGCTGTG TTCTTCATTT GCTTCGTTCC CTTCCACTTT 
GCACGGATTC CCTACACCCT GAGCCAGACA CGGGCCGTCT TTGACTGCAA TGCCGAGAAC 
ACTCTGTTCT ACGTGAAGGA GAGCACCCTG TGGCTGACGT CCTTGAACGC CTGCCTTGAT 
CCATTCATCT ATTTCTTTCT TTGCAAGTCT TTCAGAAATT CCTTGATGAG CATGCTGAGG 
TGCTCAACAT CCGGGGCAAA TAAGAAGAAA GGACAGGAAG GTGGGGACCC AAGCGAGGAG 
ACCCCAATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

P2ry12 ( XM_006232408.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006232470.1 Rattus norvegicus purinergic receptor P2Y12 (P2ry12), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa24717
Clone ID Related Accession (Same CDS sequence)	XM_006232406.3 , XM_006232407.3 , XM_006232408.3
Accession Version	XM_006232408.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	P2Y purinoceptor 12 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006232408.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGTGC CTGGTGCCAA CGCCACCTCA GCCAACACCA CCTCCATTCC TGGGACCAGC 
ACCCTGTGCA GCAGAGACTA CAAGATCACC CAGGTTCTCT TCCCATTGCT CTACACTGTC 
CTGTTTTTTG CTGGGCTCAT CACGAACAGC TTGGCGATGA GGATTTTCTT CCAGATCCGC 
AGTAAATCCA ACTTCATCAT TTTTCTTAAG AACACGGTCA TCTCTGATCT TCTTATGATC 
CTAACTTTTC CTTTCAAAAT TCTCAGTGAT GCCAAACTGG GAGCTGGGCA CCTGAGAACC 
CTGGTGTGCC AAGTCACTTC AGTCACGTTT TACTTCACAA TGTACATCAG TATCTCGTTC 
CTCGGATTGA TAACCATTGA CCGATACCTG AAGACCACCA GACCATTTAA AACTTCCAGC 
CCCAGCAATC TCTTGGGTGC GAAGATTCTT TCTGTTGCCA TCTGGGCCTT CATGTTCCTG 
CTGTCACTGC CTAACATGAT TCTCACCAAC AGGAGGCCAA AAGATAAGGA CATAACGAAA 
TGTTCTTTCT TGAAGTCGGA GTTTGGTCTG GTCTGGCACG AGATAGTCAA TTACATCTGC 
CAAGTCATTT TCTGGATTAA TTTTTTAATT GTTATTGTTT GTTACAGCCT CATTACAAAA 
GAGCTCTATA GGTCCTACGT CAGAACGAGG GGTTCAGCCA AAGCTCCCAA GAAAAGGGTG 
AACATCAAGG TTTTCATCAT CATTGCTGTG TTCTTCATTT GCTTCGTTCC CTTCCACTTT 
GCACGGATTC CCTACACCCT GAGCCAGACA CGGGCCGTCT TTGACTGCAA TGCCGAGAAC 
ACTCTGTTCT ACGTGAAGGA GAGCACCCTG TGGCTGACGT CCTTGAACGC CTGCCTTGAT 
CCATTCATCT ATTTCTTTCT TTGCAAGTCT TTCAGAAATT CCTTGATGAG CATGCTGAGG 
TGCTCAACAT CCGGGGCAAA TAAGAAGAAA GGACAGGAAG GTGGGGACCC AAGCGAGGAG 
ACCCCAATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006232470.1
CDS	1652..2683
Translation	MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM

Target ORF information:

RefSeq Version	XM_006232408.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus purinergic receptor P2Y12 (P2ry12), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006232408.3

ORF Insert Sequence:

ATGGAGGTGC CTGGTGCCAA CGCCACCTCA GCCAACACCA CCTCCATTCC TGGGACCAGC 
ACCCTGTGCA GCAGAGACTA CAAGATCACC CAGGTTCTCT TCCCATTGCT CTACACTGTC 
CTGTTTTTTG CTGGGCTCAT CACGAACAGC TTGGCGATGA GGATTTTCTT CCAGATCCGC 
AGTAAATCCA ACTTCATCAT TTTTCTTAAG AACACGGTCA TCTCTGATCT TCTTATGATC 
CTAACTTTTC CTTTCAAAAT TCTCAGTGAT GCCAAACTGG GAGCTGGGCA CCTGAGAACC 
CTGGTGTGCC AAGTCACTTC AGTCACGTTT TACTTCACAA TGTACATCAG TATCTCGTTC 
CTCGGATTGA TAACCATTGA CCGATACCTG AAGACCACCA GACCATTTAA AACTTCCAGC 
CCCAGCAATC TCTTGGGTGC GAAGATTCTT TCTGTTGCCA TCTGGGCCTT CATGTTCCTG 
CTGTCACTGC CTAACATGAT TCTCACCAAC AGGAGGCCAA AAGATAAGGA CATAACGAAA 
TGTTCTTTCT TGAAGTCGGA GTTTGGTCTG GTCTGGCACG AGATAGTCAA TTACATCTGC 
CAAGTCATTT TCTGGATTAA TTTTTTAATT GTTATTGTTT GTTACAGCCT CATTACAAAA 
GAGCTCTATA GGTCCTACGT CAGAACGAGG GGTTCAGCCA AAGCTCCCAA GAAAAGGGTG 
AACATCAAGG TTTTCATCAT CATTGCTGTG TTCTTCATTT GCTTCGTTCC CTTCCACTTT 
GCACGGATTC CCTACACCCT GAGCCAGACA CGGGCCGTCT TTGACTGCAA TGCCGAGAAC 
ACTCTGTTCT ACGTGAAGGA GAGCACCCTG TGGCTGACGT CCTTGAACGC CTGCCTTGAT 
CCATTCATCT ATTTCTTTCT TTGCAAGTCT TTCAGAAATT CCTTGATGAG CATGCTGAGG 
TGCTCAACAT CCGGGGCAAA TAAGAAGAAA GGACAGGAAG GTGGGGACCC AAGCGAGGAG 
ACCCCAATGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

P2Y
Purinergic signalling(2017 Nov)
Yi Z,Xie L,Zhou C,Yuan H,Ouyang S,Fang Z,Zhao S,Jia T,Zou L,Wang S,Xue Y,Wu B,Gao Y,Li G,Liu S,Xu H,Xu C,Zhang C,Liang S

Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.
Arteriosclerosis, thrombosis, and vascular biology36(3)501-9(2016 Mar)
Gremmel T,Yanachkov IB,Yanachkova MI,Wright GE,Wider J,Undyala VV,Michelson AD,Frelinger AL 3rd,Przyklenk K

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex.
Nature communications710905(2016 Mar)
Sipe GO,Lowery RL,Tremblay M?,Kelly EA,Lamantia CE,Majewska AK

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P2ry12 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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