Ntsr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ntsr2
Entrez Gene ID	64636
Full Name	neurotensin receptor 2
General protein information	Preferred Names neurotensin receptor 2 Names neurotensin receptor type 2 NT-R-2 NTR2 receptor high-affinity levocabastine-sensitive neurotensin receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q16
Summary	high affinity G-protein coupled receptor for neurotensin [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006239918.3	XP_006239980.1	neurotensin receptor type 2 isoform X2
NM_022695.2	NP_073186.1	neurotensin receptor type 2
XM_017594348.1	XP_017449837.1	neurotensin receptor type 2 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	NTSR2	XP_002691525.1
Mus musculus (house mouse)	Ntsr2	NP_032773.2
Pan troglodytes (chimpanzee)	NTSR2	XP_003949804.1
Rattus norvegicus (Norway rat)	Ntsr2	NP_073186.1
Homo sapiens (human)	NTSR2	NP_036476.1
Canis lupus familiaris (dog)	NTSR2	XP_540085.2
	NTSR2	XP_002799189.1

Gene Ontology
Bibliography

Related articles in PubMed

Neurotensin NTS
Steele FF 3rd, Whitehouse SC, Aday JS, Prus AJ
Brain research165831-35(2017 03)

Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.
Thomas JB, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP
Journal of medicinal chemistry57(17)7472-7(2014 Sep)

Neurotensin-produced antinociception in the rostral ventromedial medulla is partially mediated by spinal cord norepinephrine.
Buhler AV, Proudfit HK, Gebhart GF
Pain135(3)280-90(2008 Apr)

NTS2 modulates the intracellular distribution and trafficking of NTS1 via heterodimerization.
Perron A, Sharif N, Sarret P, Stroh T, Beaudet A
Biochemical and biophysical research communications353(3)582-90(2007 Feb)

Sustained neurotensin exposure promotes cell surface recruitment of NTS2 receptors.
Perron A, Sharif N, Gendron L, Lavall?e M, Stroh T, Mazella J, Beaudet A
Biochemical and biophysical research communications343(3)799-808(2006 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study suggests that NTS1 and NTS2 neurotensin receptor mechanisms appear involved in fear conditioning processes and that agonists for neurotensin receptors may be pursued as novel anxiolytic drugs.
Title: Neurotensin NTS

Data indicate that the NTRC-824 (title compound) is selective for neurotensin receptors NTS2 versus NTS1 and behaves like the endogenous ligand neurotensin in the functional assay.
Title: Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.

These results also provide evidence that activation of NTR1 in the RVM produces antinociception through spinal release of norepinephrine (NE) and serotonin, and that activation of NTR2 in the RVM produces antinociception mediated by spinal release of NE.
Title: Neurotensin-produced antinociception in the rostral ventromedial medulla is partially mediated by spinal cord norepinephrine.

NTS1/NTS2 heterodimerization affects the intracellular distribution and trafficking of NTS1 by making it more similar to that of NTS2 as witnessed in cells expressing NTS2 alone.
Title: NTS2 modulates the intracellular distribution and trafficking of NTS1 via heterodimerization.

NTS2 receptors play a role in the regulation of spinal nociceptive inputs and selective NTS2 agonists may offer new avenues for the treatment of acute pain.
Title: Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors.

The following Ntsr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ntsr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa06273	NM_022695.2 Latest version!	Rattus norvegicus neurotensin receptor 2 (Ntsr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa29225	XM_006239918.3 Latest version!	Rattus norvegicus neurotensin receptor 2 (Ntsr2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa61744	XM_017594348.1 Latest version!	Rattus norvegicus neurotensin receptor 2 (Ntsr2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ntsr2 ( NM_022695.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_073186.1 Rattus norvegicus neurotensin receptor 2 (Ntsr2), mRNA.

Price & Availability↑

CloneID	ORa06273
Clone ID Related Accession (Same CDS sequence)	NM_022695.2
Accession Version	NM_022695.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	neurotensin receptor type 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X97121.1. On Aug 31, 2012 this sequence version replaced NM_022695.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X97121.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGACCA GCAGTCCGTG GCCTCCGAGG CCCAGCCCCA GCGCAGGGCT GAGCCTGGAG 
GCGCGGCTGG GCGTGGACAC TCGCCTCTGG GCCAAGGTGC TGTTCACCGC GCTCTACTCG 
CTCATCTTCG CATTTGGCAC AGCGGGCAAT GCGCTGTCCG TGCACGTGGT GCTGAAGGCG 
CGGGCCGGTC GCCCCGGGCG CCTGCGCTAC CACGTGCTCA GCCTGGCGCT CTCAGCCCTG 
CTGCTACTGC TGGTCAGCAT GCCCATGGAG CTCTACAACT TCGTGTGGTC CCACTACCCA 
TGGGTCTTCG GCGATCTGGG CTGCCGTGGC TATTACTTCG TGCGCGAGCT GTGCGCCTAC 
GCCACAGTGC TGAGCGTTGC CAGCCTAAGC GCAGAGCGCT GCCTGGCCGT GTGCCAGCCG 
CTGCGCGCCC GCCGCCTTCT CACCCCGCGC CGCACCCGCC GCCTGCTGTC ACTGGTCTGG 
GTCGCCTCTC TGGGCCTTGC CCTGCCCATG GCGGTTATCA TGGGACAGAA GCACGAAGTG 
GAAAGCGCGG ACGGGGAGCC TGAGCCTGCC TCGCGTGTGT GCACGGTGCT GGTGAGCCGC 
GCCACACTTC AGGTCTTCAT CCAGGTGAAT GTGCTGGTGT CCTTCGCTCT CCCCTTGGCA 
CTCACTGCTT TCCTGAATGG CATCACTGTC AACCACCTGA TGGCCCTCTA CTCCCAGGTA 
CCATCAGCTT CTGCCCAAGT CAGCTCCATC CCCAGCCGCC TGGAGCTCCT GAGTGAGGAA 
GGCCTCCTGG GCTTCATCAC GTGGAGAAAG ACTCTCTCCC TGGGGGTCCA AGCCAGCCTG 
GTGAGACACA AGGATGCCAG CCAGATCCGC AGCCTCCAGC ACAGCGCCCA GGTTCTCAGA 
GCCATCGTGG CTGTGTATGT CATCTGCTGG CTGCCGTACC ATGCCCGCCG ACTCATGTAC 
TGCTACATCC CCGATGATGG ATGGACTAAT GAGCTCTATG ATTTCTATCA CTATTTCTAC 
ATGGTGACCA ACACGCTCTT CTATGTCAGC TCAGCAGTGA CCCCAATCCT CTACAACGCC 
GTGTCTTCCT CCTTCAGAAA GCTCTTCCTG GAATCCCTCG GCTCCCTGTG TGGTGAACAG 
CACTCCTTGG TGCCCTTACC CCAAGAAGCC CCAGAGTCAA CCACTAGTAC GTACAGTTTC 
CGGCTTTGGG GATCCCCAAG AAACCCCAGC CTGGGAGAAA TACAAGTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073186.1
CDS	39..1289
Translation	METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEVESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQVPSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTNELYDFYHYFYMVTNTLFYVSSAVTPILYNAVSSSFRKLFLESLGSLCGEQHSLVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV

Target ORF information:

RefSeq Version	NM_022695.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neurotensin receptor 2 (Ntsr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022695.2

ORF Insert Sequence:

ATGGAGACCA GCAGTCCGTG GCCTCCGAGG CCCAGCCCCA GCGCAGGGCT GAGCCTGGAG 
GCGCGGCTGG GCGTGGACAC TCGCCTCTGG GCCAAGGTGC TGTTCACCGC GCTCTACTCG 
CTCATCTTCG CATTTGGCAC AGCGGGCAAT GCGCTGTCCG TGCACGTGGT GCTGAAGGCG 
CGGGCCGGTC GCCCCGGGCG CCTGCGCTAC CACGTGCTCA GCCTGGCGCT CTCAGCCCTG 
CTGCTACTGC TGGTCAGCAT GCCCATGGAG CTCTACAACT TCGTGTGGTC CCACTACCCA 
TGGGTCTTCG GCGATCTGGG CTGCCGTGGC TATTACTTCG TGCGCGAGCT GTGCGCCTAC 
GCCACAGTGC TGAGCGTTGC CAGCCTAAGC GCAGAGCGCT GCCTGGCCGT GTGCCAGCCG 
CTGCGCGCCC GCCGCCTTCT CACCCCGCGC CGCACCCGCC GCCTGCTGTC ACTGGTCTGG 
GTCGCCTCTC TGGGCCTTGC CCTGCCCATG GCGGTTATCA TGGGACAGAA GCACGAAGTG 
GAAAGCGCGG ACGGGGAGCC TGAGCCTGCC TCGCGTGTGT GCACGGTGCT GGTGAGCCGC 
GCCACACTTC AGGTCTTCAT CCAGGTGAAT GTGCTGGTGT CCTTCGCTCT CCCCTTGGCA 
CTCACTGCTT TCCTGAATGG CATCACTGTC AACCACCTGA TGGCCCTCTA CTCCCAGGTA 
CCATCAGCTT CTGCCCAAGT CAGCTCCATC CCCAGCCGCC TGGAGCTCCT GAGTGAGGAA 
GGCCTCCTGG GCTTCATCAC GTGGAGAAAG ACTCTCTCCC TGGGGGTCCA AGCCAGCCTG 
GTGAGACACA AGGATGCCAG CCAGATCCGC AGCCTCCAGC ACAGCGCCCA GGTTCTCAGA 
GCCATCGTGG CTGTGTATGT CATCTGCTGG CTGCCGTACC ATGCCCGCCG ACTCATGTAC 
TGCTACATCC CCGATGATGG ATGGACTAAT GAGCTCTATG ATTTCTATCA CTATTTCTAC 
ATGGTGACCA ACACGCTCTT CTATGTCAGC TCAGCAGTGA CCCCAATCCT CTACAACGCC 
GTGTCTTCCT CCTTCAGAAA GCTCTTCCTG GAATCCCTCG GCTCCCTGTG TGGTGAACAG 
CACTCCTTGG TGCCCTTACC CCAAGAAGCC CCAGAGTCAA CCACTAGTAC GTACAGTTTC 
CGGCTTTGGG GATCCCCAAG AAACCCCAGC CTGGGAGAAA TACAAGTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ntsr2 ( XM_006239918.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006239980.1 Rattus norvegicus neurotensin receptor 2 (Ntsr2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa29225
Clone ID Related Accession (Same CDS sequence)	XM_006239918.3
Accession Version	XM_006239918.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	neurotensin receptor type 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006239918.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGACCA GCAGTCCTTG GCCTCCGAGG CCCAGCCCCA GCGCAGGGCT GAGCCTGGAG 
GCGCGGCTGG GCGTGGACAC TCGCCTCTGG GCCAAGGTGC TGTTCACCGC GCTCTACTCG 
CTCATCTTCG CATTTGGCAC AGCGGGCAAT GCGCTGTCCG TGCACGTGGT GCTGAAGGCG 
CGGGCCGGTC GCCCCGGGCG CCTGCGCTAC CACGTGCTCA GCCTGGCGCT CTCAGCCCTG 
CTGCTACTGC TGGTCAGCGT GCCCATGGAG CTCTACAACT TCGTGTGGTC CCACTACCCA 
TGGGTCTTCG GCGATCTGGG CTGCCGTGGC TATTACTTCG TGCGCGAGCT GTGCGCCTAC 
GCCACAGTGC TGAGCGTTGC CAGCCTAAGC GCAGAGCGCT GCCTGGCCGT GTGCCAGCCG 
CTGCGCGCCC GCCGCCTTCT CACCCCGCGC CGCACCCGCC GCCTGCTGTC ACTGGTCTGG 
GTCGCCTCTC TGGGCCTTGC CCTGCCCATG GCGGTTATCA TGGGACAGAA GCACGAAGTG 
GAAAGCGCGG ACGGGGAGCC TGAGCCTGCC TCGCGTGTGT GCACGGTGCT GGTGAGCCGC 
GCCACACTTC AGGTCTTCAT CCAGGTGAAT GTGCTGGTGT CCTTCGCTCT CCCCTTGGCA 
CTCACTGCTT TCCTGAATGG CATCACTGTC AACCACCTGA TGGCCCTCTA CTCCCAGGAG 
CCATCGTGGC TGTGTATGTC ATCTGCTGGC TGCCGTACCA TGCCCGCCGA CTCATGTACT 
GCTACATCCC CGATGATGGA TGGACTAATG AGCTCTATGA TTTCTATCAC TATTTCTACA 
TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006239980.1
CDS	68..913
Translation	METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLVSVPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEVESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQEPSWLCMSSAGCRTMPADSCTATSPMMDGLMSSMISITISTW

Target ORF information:

RefSeq Version	XM_006239918.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neurotensin receptor 2 (Ntsr2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006239918.3

ORF Insert Sequence:

ATGGAGACCA GCAGTCCTTG GCCTCCGAGG CCCAGCCCCA GCGCAGGGCT GAGCCTGGAG 
GCGCGGCTGG GCGTGGACAC TCGCCTCTGG GCCAAGGTGC TGTTCACCGC GCTCTACTCG 
CTCATCTTCG CATTTGGCAC AGCGGGCAAT GCGCTGTCCG TGCACGTGGT GCTGAAGGCG 
CGGGCCGGTC GCCCCGGGCG CCTGCGCTAC CACGTGCTCA GCCTGGCGCT CTCAGCCCTG 
CTGCTACTGC TGGTCAGCGT GCCCATGGAG CTCTACAACT TCGTGTGGTC CCACTACCCA 
TGGGTCTTCG GCGATCTGGG CTGCCGTGGC TATTACTTCG TGCGCGAGCT GTGCGCCTAC 
GCCACAGTGC TGAGCGTTGC CAGCCTAAGC GCAGAGCGCT GCCTGGCCGT GTGCCAGCCG 
CTGCGCGCCC GCCGCCTTCT CACCCCGCGC CGCACCCGCC GCCTGCTGTC ACTGGTCTGG 
GTCGCCTCTC TGGGCCTTGC CCTGCCCATG GCGGTTATCA TGGGACAGAA GCACGAAGTG 
GAAAGCGCGG ACGGGGAGCC TGAGCCTGCC TCGCGTGTGT GCACGGTGCT GGTGAGCCGC 
GCCACACTTC AGGTCTTCAT CCAGGTGAAT GTGCTGGTGT CCTTCGCTCT CCCCTTGGCA 
CTCACTGCTT TCCTGAATGG CATCACTGTC AACCACCTGA TGGCCCTCTA CTCCCAGGAG 
CCATCGTGGC TGTGTATGTC ATCTGCTGGC TGCCGTACCA TGCCCGCCGA CTCATGTACT 
GCTACATCCC CGATGATGGA TGGACTAATG AGCTCTATGA TTTCTATCAC TATTTCTACA 
TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ntsr2 ( XM_017594348.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017449837.1 Rattus norvegicus neurotensin receptor 2 (Ntsr2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa61744
Clone ID Related Accession (Same CDS sequence)	XM_017594348.1
Accession Version	XM_017594348.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	neurotensin receptor type 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGACCA GCAGTCCTTG GCCTCCGAGG CCCAGCCCCA GCGCAGGGCT GAGCCTGGAG 
GCGCGGCTGG GCGTGGACAC TCGCCTCTGG GCCAAGGTGC TGTTCACCGC GCTCTACTCG 
CTCATCTTCG CATTTGGCAC AGCGGGCAAT GCGCTGTCCG TGCACGTGGT GCTGAAGGCG 
CGGGCCGGTC GCCCCGGGCG CCTGCGCTAC CACGTGCTCA GCCTGGCGCT CTCAGCCCTG 
CTGCTACTGC TGGTCAGCGT GCCCATGGAG CTCTACAACT TCGTGTGGTC CCACTACCCA 
TGGGTCTTCG GCGATCTGGG CTGCCGTGGC TATTACTTCG TGCGCGAGCT GTGCGCCTAC 
GCCACAGTGC TGAGCGTTGC CAGCCTAAGC GCAGAGCGCT GCCTGGCCGT GTGCCAGCCG 
CTGCGCGCCC GCCGCCTTCT CACCCCGCGC CGCACCCGCC GCCTGCTGTC ACTGGTCTGG 
GTCGCCTCTC TGGGCCTTGC CCTGCCCATG GCGGTTATCA TGGGACAGAA GCACGAAGTG 
GAAAGCGCGG ACGGGGAGCC TGAGCCTGCC TCGCGTGTGT GCACGGTGCT GGTGAGCCGC 
GCCACACTTC AGGTCTTCAT CCAGGTGAAT GTGCTGGTGT CCTTCGCTCT CCCCTTGGCA 
CTCACTGCTT TCCTGAATGG CATCACTGTC AACCACCTGA TGGCCCTCTA CTCCCAGGTA 
CCATCAGCTT CTGCCCAAGT CAGCTCCATC CCCAGCCGCC TGGAGCTCCT GAGTGAGGAA 
GGCCTCCTGG GCTTCATCAC GTGGAGAAAG ACTCTCTCCC TGGGGGTCCA AGCCAGCCTG 
GTGAGACACA AGGATGCCAG CCAGATCCGC AGCCTCCAGC ACAGCGCCCA GGAGCCATCG 
TGGCTGTGTA TGTCATCTGC TGGCTGCCGT ACCATGCCCG CCGACTCATG TACTGCTACA 
TCCCCGATGA TGGATGGACT AATGAGCTCT ATGATTTCTA TCACTATTTC TACATGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017449837.1
CDS	68..1087
Translation	METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLVSVPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEVESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQVPSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQEPSWLCMSSAGCRTMPADSCTATSPMMDGLMSSMISITISTW

Target ORF information:

RefSeq Version	XM_017594348.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neurotensin receptor 2 (Ntsr2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017594348.1

ORF Insert Sequence:

ATGGAGACCA GCAGTCCTTG GCCTCCGAGG CCCAGCCCCA GCGCAGGGCT GAGCCTGGAG 
GCGCGGCTGG GCGTGGACAC TCGCCTCTGG GCCAAGGTGC TGTTCACCGC GCTCTACTCG 
CTCATCTTCG CATTTGGCAC AGCGGGCAAT GCGCTGTCCG TGCACGTGGT GCTGAAGGCG 
CGGGCCGGTC GCCCCGGGCG CCTGCGCTAC CACGTGCTCA GCCTGGCGCT CTCAGCCCTG 
CTGCTACTGC TGGTCAGCGT GCCCATGGAG CTCTACAACT TCGTGTGGTC CCACTACCCA 
TGGGTCTTCG GCGATCTGGG CTGCCGTGGC TATTACTTCG TGCGCGAGCT GTGCGCCTAC 
GCCACAGTGC TGAGCGTTGC CAGCCTAAGC GCAGAGCGCT GCCTGGCCGT GTGCCAGCCG 
CTGCGCGCCC GCCGCCTTCT CACCCCGCGC CGCACCCGCC GCCTGCTGTC ACTGGTCTGG 
GTCGCCTCTC TGGGCCTTGC CCTGCCCATG GCGGTTATCA TGGGACAGAA GCACGAAGTG 
GAAAGCGCGG ACGGGGAGCC TGAGCCTGCC TCGCGTGTGT GCACGGTGCT GGTGAGCCGC 
GCCACACTTC AGGTCTTCAT CCAGGTGAAT GTGCTGGTGT CCTTCGCTCT CCCCTTGGCA 
CTCACTGCTT TCCTGAATGG CATCACTGTC AACCACCTGA TGGCCCTCTA CTCCCAGGTA 
CCATCAGCTT CTGCCCAAGT CAGCTCCATC CCCAGCCGCC TGGAGCTCCT GAGTGAGGAA 
GGCCTCCTGG GCTTCATCAC GTGGAGAAAG ACTCTCTCCC TGGGGGTCCA AGCCAGCCTG 
GTGAGACACA AGGATGCCAG CCAGATCCGC AGCCTCCAGC ACAGCGCCCA GGAGCCATCG 
TGGCTGTGTA TGTCATCTGC TGGCTGCCGT ACCATGCCCG CCGACTCATG TACTGCTACA 
TCCCCGATGA TGGATGGACT AATGAGCTCT ATGATTTCTA TCACTATTTC TACATGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neurotensin NTS
Brain research165831-35(2017 03)
Steele FF 3rd,Whitehouse SC,Aday JS,Prus AJ

Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.
Journal of medicinal chemistry57(17)7472-7(2014 Sep)
Thomas JB,Giddings AM,Wiethe RW,Olepu S,Warner KR,Sarret P,Gendron L,Longpre JM,Zhang Y,Runyon SP,Gilmour BP

Neurotensin-produced antinociception in the rostral ventromedial medulla is partially mediated by spinal cord norepinephrine.
Pain135(3)280-90(2008 Apr)
Buhler AV,Proudfit HK,Gebhart GF

NTS2 modulates the intracellular distribution and trafficking of NTS1 via heterodimerization.
Biochemical and biophysical research communications353(3)582-90(2007 Feb)
Perron A,Sharif N,Sarret P,Stroh T,Beaudet A

Sustained neurotensin exposure promotes cell surface recruitment of NTS2 receptors.
Biochemical and biophysical research communications343(3)799-808(2006 May)
Perron A,Sharif N,Gendron L,Lavall?e M,Stroh T,Mazella J,Beaudet A

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Ntsr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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