Ykt6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ykt6
Entrez Gene ID	64351
Full Name	YKT6 v-SNARE homolog
General protein information	Preferred Names YKT6 v-SNARE homolog Names synaptobrevin homolog YKT6 YKT6 homolog prenylated SNARE protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q21
Summary	may play a role in vesicle mediated transport [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017599369.1	XP_017454858.1	synaptobrevin homolog YKT6 isoform X1
NM_031692.2	NP_113880.2	synaptobrevin homolog YKT6

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Ykt6	NP_572423.1
Oryza sativa (rice)	Os01g0866300	NP_001044905.1
Canis lupus familiaris (dog)	YKT6	XP_532720.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000392	XP_310711.2
Schizosaccharomyces pombe (fission yeast)	ykt6	NP_596561.1
Xenopus tropicalis (tropical clawed frog)	ykt6	NP_989023.1
Mus musculus (house mouse)	Ykt6	NP_062635.2
Danio rerio (zebrafish)	ykt6	NP_957386.1
Saccharomyces cerevisiae (baker's yeast)	YKT6	NP_012725.1
Eremothecium gossypii	AGOS_AER109W	NP_984969.1
Homo sapiens (human)	YKT6	NP_006546.1
	YKT6	XP_001092567.1
Rattus norvegicus (Norway rat)	Ykt6	NP_113880.2
Caenorhabditis elegans (roundworm)	ykt-6	NP_498605.1
Pan troglodytes (chimpanzee)	YKT6	XP_001144106.1
Bos taurus (cattle)	YKT6	NP_001030219.1
Gallus gallus (chicken)	YKT6	NP_001107216.1
Kluyveromyces lactis	KLLA0D02684g	XP_453187.1
Magnaporthe oryzae (rice blast fungus)	MGG_06125	XP_003711992.1
Neurospora crassa	NCU08973	XP_959001.2

Gene Ontology
Bibliography

Related articles in PubMed

Lipid Regulated Intramolecular Conformational Dynamics of SNARE-Protein Ykt6.
Dai Y, Seeger M, Weng J, Song S, Wang W, Tan YW
Scientific reports630282(2016 Aug)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed.
Thayanidhi N, Liang Y, Hasegawa H, Nycz DC, Oorschot V, Klumperman J, Hay JC
Biology of the cell104(7)397-417(2012 Jul)

Lipid-Induced conformational switch controls fusion activity of longin domain SNARE Ykt6.
Wen W, Yu J, Pan L, Wei Z, Weng J, Wang W, Ong YS, Tran TH, Hong W, Zhang M
Molecular cell37(3)383-95(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The ykt6 particles/aggregates may represent ykt6 engaged in a non-SNARE function(s) or else nonfunctional, stored and/or excess ykt6.
Title: R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed.

A posttranslationally attached farnesyl group can actively regulate Ykt6 fusion activity in addition to its anticipated membrane-anchoring role.
Title: Lipid-Induced conformational switch controls fusion activity of longin domain SNARE Ykt6.

The Ykt6 intramolecular interactions would be predicted to create a compact, closed conformation of the SNARE that prevents promiscuous targeting interactions and premature insertion into membranes.
Title: Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6.

ykt6 is a neuronal SNARE targeted to a specialized compartment by its profilin-like amino terminal domain
Title: Mammalian ykt6 is a neuronal SNARE targeted to a specialized compartment by its profilin-like amino terminal domain.

Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport.
Title: GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.

The following Ykt6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ykt6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08492	NM_031692.2 Latest version!	Rattus norvegicus YKT6 v-SNARE homolog (Ykt6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa58420	XM_017599369.1 Latest version!	Rattus norvegicus YKT6 v-SNARE homolog (S. cerevisiae) (Ykt6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ykt6 ( NM_031692.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113880.2 Rattus norvegicus YKT6 v-SNARE homolog (Ykt6), mRNA.

Price & Availability↑

CloneID	ORa08492
Clone ID Related Accession (Same CDS sequence)	NM_031692.2
Accession Version	NM_031692.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	synaptobrevin homolog YKT6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY881621.1. On Dec 8, 2007 this sequence version replaced NM_031692.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF033027.1, AY881621.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCTGT ACAGCCTTAG TGTCTTTTAC AAAGGCGAAC CAAAAGCGGT GCTTCTCAAA 
GCCGCGTACG ATGTGTCTTC CTTCAGTTTC TTCCAGAGGT CCAGTGTTCA GGAATTCATG 
ACCTTTACAA GTCAACTGAT TGTGGAACGA TCGGCGAAAG GCAGCAGAGC TTCTGTTAAA 
GAACAAGAGT ACCTTTGCCA TGTCTACGTC CGGAGTGACA GTCTGGCAGG TGTGGTCATT 
GCTGACAGCG AATACCCTTC CAGAGTGGCC TTTACCTTGC TGGAGAAGGT ACTAGATGAA 
TTCTCCAAGC AGGTCGATAG AATAGACTGG CCAGTAGGAT CCCCTGCTAC AATCCATTAC 
ACAGCCCTAG ATGGCCACCT TAGTAGATAC CAGAACCCCC GGGAGGCTGA TCCCATGAGT 
AAAGTGCAGG CCGAACTGGA TGAGACCAAA ATCATTCTGC ACAACACCAT GGAGTCTTTG 
TTAGAGCGAG GCGAGAAGCT TGATGACTTG GTATCCAAAT CAGAAGTCCT GGGAACACAG 
TCGAAAGCCT TCTATAAAAC TGCCCGGAAA CAAAACTCAT GCTGTGCAAT CATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113880.2
CDS	1..597
Translation	MKLYSLSVFYKGEPKAVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSAKGSRASVKEQEYLCHVYVRSDSLAGVVIADSEYPSRVAFTLLEKVLDEFSKQVDRIDWPVGSPATIHYTALDGHLSRYQNPREADPMSKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM

Target ORF information:

RefSeq Version	NM_031692.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus YKT6 v-SNARE homolog (Ykt6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031692.2

ORF Insert Sequence:

ATGAAGCTGT ACAGCCTTAG TGTCTTTTAC AAAGGCGAAC CAAAAGCGGT GCTTCTCAAA 
GCCGCGTACG ATGTGTCTTC CTTCAGTTTC TTCCAGAGGT CCAGTGTTCA GGAATTCATG 
ACCTTTACAA GTCAACTGAT TGTGGAACGA TCGGCGAAAG GCAGCAGAGC TTCTGTTAAA 
GAACAAGAGT ACCTTTGCCA TGTCTACGTC CGGAGTGACA GTCTGGCAGG TGTGGTCATT 
GCTGACAGCG AATACCCTTC CAGAGTGGCC TTTACCTTGC TGGAGAAGGT ACTAGATGAA 
TTCTCCAAGC AGGTCGATAG AATAGACTGG CCAGTAGGAT CCCCTGCTAC AATCCATTAC 
ACAGCCCTAG ATGGCCACCT TAGTAGATAC CAGAACCCCC GGGAGGCTGA TCCCATGAGT 
AAAGTGCAGG CCGAACTGGA TGAGACCAAA ATCATTCTGC ACAACACCAT GGAGTCTTTG 
TTAGAGCGAG GCGAGAAGCT TGATGACTTG GTATCCAAAT CAGAAGTCCT GGGAACACAG 
TCGAAAGCCT TCTATAAAAC TGCCCGGAAA CAAAACTCAT GCTGTGCAAT CATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ykt6 ( XM_017599369.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017454858.1 Rattus norvegicus YKT6 v-SNARE homolog (S. cerevisiae) (Ykt6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa58420
Clone ID Related Accession (Same CDS sequence)	XM_017599369.1
Accession Version	XM_017599369.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	synaptobrevin homolog YKT6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCTTTA CAAGTCAACT GATTGTGGAA CGATCGGCGA AAGGCAGCAG AGCTTCTGTT 
AAAGAACAAG AGTACCTTTG CCATGTCTAC GTCCGGAGTG ACAGTCTGGC AGGTGTGGTC 
ATTGCTGACA GCGAATACCC TTCCAGAGTG GCCTTTACCT TGCTGGAGAA GGTACTAGAT 
GAATTCTCCA AGCAGGTCGA TAGAATAGAC TGGCCAGTAG GATCCCCTGC TACAATCCAT 
TACACAGCCC TAGATGGCCA CCTTAGTAGA TACCAGAACC CCCGGGAGGC TGATCCCATG 
AGTAAAGTGC AGGCCGAACT GGATGAGACC AAAATCATTC TGCACAACAC CATGGAGTCT 
TTGTTAGAGC GAGGCGAGAA GCTTGATGAC TTGGTATCCA AATCAGAAGT CCTGGGAACA 
CAGTCGAAAG CCTTCTATAA AACTGCCCGG AAACAAAACT CATGCTGTGC AATCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017454858.1
CDS	1150..1629
Translation	MTFTSQLIVERSAKGSRASVKEQEYLCHVYVRSDSLAGVVIADSEYPSRVAFTLLEKVLDEFSKQVDRIDWPVGSPATIHYTALDGHLSRYQNPREADPMSKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM

Target ORF information:

RefSeq Version	XM_017599369.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus YKT6 v-SNARE homolog (S. cerevisiae) (Ykt6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599369.1

ORF Insert Sequence:

ATGACCTTTA CAAGTCAACT GATTGTGGAA CGATCGGCGA AAGGCAGCAG AGCTTCTGTT 
AAAGAACAAG AGTACCTTTG CCATGTCTAC GTCCGGAGTG ACAGTCTGGC AGGTGTGGTC 
ATTGCTGACA GCGAATACCC TTCCAGAGTG GCCTTTACCT TGCTGGAGAA GGTACTAGAT 
GAATTCTCCA AGCAGGTCGA TAGAATAGAC TGGCCAGTAG GATCCCCTGC TACAATCCAT 
TACACAGCCC TAGATGGCCA CCTTAGTAGA TACCAGAACC CCCGGGAGGC TGATCCCATG 
AGTAAAGTGC AGGCCGAACT GGATGAGACC AAAATCATTC TGCACAACAC CATGGAGTCT 
TTGTTAGAGC GAGGCGAGAA GCTTGATGAC TTGGTATCCA AATCAGAAGT CCTGGGAACA 
CAGTCGAAAG CCTTCTATAA AACTGCCCGG AAACAAAACT CATGCTGTGC AATCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lipid Regulated Intramolecular Conformational Dynamics of SNARE-Protein Ykt6.
Scientific reports630282(2016 Aug)
Dai Y,Seeger M,Weng J,Song S,Wang W,Tan YW

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed.
Biology of the cell104(7)397-417(2012 Jul)
Thayanidhi N,Liang Y,Hasegawa H,Nycz DC,Oorschot V,Klumperman J,Hay JC

Lipid-Induced conformational switch controls fusion activity of longin domain SNARE Ykt6.
Molecular cell37(3)383-95(2010 Feb)
Wen W,Yu J,Pan L,Wei Z,Weng J,Wang W,Ong YS,Tran TH,Hong W,Zhang M

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Ykt6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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