Fxyd6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fxyd6
Entrez Gene ID	63847
Full Name	FXYD domain-containing ion transport regulator 6
Synonyms	Php
General protein information	Preferred Names FXYD domain-containing ion transport regulator 6 Names FXYD domain-containing ion transport regulator 6 VESP6 phosphohippolin vascular endothelial cell-specific protein 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q22
Summary	This reference sequence was derived from multiple replicate ESTs and a deposited cDNA, and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD6, is novel and has not been characterized as a protein. The name 'phosphohippolin' has been used in GenBank, but there is no evidence yet of protein phosphorylation. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008766171.2	XP_008764393.1	FXYD domain-containing ion transport regulator 6 isoform X1
NM_022005.2	NP_071288.1	FXYD domain-containing ion transport regulator 6 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FXYD6	NP_001239265.1
Mus musculus (house mouse)	Fxyd6	NP_071287.1
Danio rerio (zebrafish)	fxyd6	NP_956141.1
Xenopus tropicalis (tropical clawed frog)	fxyd6	NP_001096515.1
Pan troglodytes (chimpanzee)	FXYD6	NP_001230843.1
	FXYD6	XP_001095861.1
Bos taurus (cattle)	FXYD6	NP_001029571.1
Gallus gallus (chicken)	FXYD6	NP_001074348.1
Rattus norvegicus (Norway rat)	Fxyd6	NP_071288.1
Homo sapiens (human)	FXYD6	NP_071286.1

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
Biesemann C, Gr?nborg M, Luquet E, Wichert SP, Bernard V, Bungers SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, Jahn O, Brose N, Herzog E
The EMBO journal33(2)157-70(2014 Jan)

A serial analysis of gene expression profile of the Alzheimer's disease Tg2576 mouse model.
George AJ, Gordon L, Beissbarth T, Koukoulas I, Holsinger RM, Perreau V, Cappai R, Tan SS, Masters CL, Scott HS, Li QX
Neurotoxicity research17(4)360-79(2010 May)

Dynamic expression of FXYD6 in the inner ear suggests a role of the protein in endolymph homeostasis and neuronal activity.
Delprat B, Puel JL, Geering K
Developmental dynamics : an official publication of the American Association of Anatomists236(9)2534-40(2007 Sep)

Phosphohippolin expression in the rat central nervous system.
Kadowaki K, Sugimoto K, Yamaguchi F, Song T, Watanabe Y, Singh K, Tokuda M
Brain research. Molecular brain research125(1-2)105-12(2004 Jun)

Molecular cloning and characterization of a novel phospholemman-like protein from rat hippocampus.
Yamaguchi F, Yamaguchi K, Tai Y, Sugimoto K, Tokuda M
Brain research. Molecular brain research86(1-2)189-92(2001 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FXYD6 is expressed in the inner ear and may have a role in endolymph homeostasis and neuronal activity
Title: Dynamic expression of FXYD6 in the inner ear suggests a role of the protein in endolymph homeostasis and neuronal activity.

findings suggest that Php may play an important role in the excitability of neurons in the central nervous system during postnatal development, as well as those in the adult brain
Title: Phosphohippolin expression in the rat central nervous system.

The following Fxyd6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fxyd6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05351	NM_022005.2 Latest version!	Rattus norvegicus FXYD domain-containing ion transport regulator 6 (Fxyd6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa43539	XM_008766171.2 Latest version!	Rattus norvegicus FXYD domain-containing ion transport regulator 6 (Fxyd6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fxyd6 ( NM_022005.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071288.1 Rattus norvegicus FXYD domain-containing ion transport regulator 6 (Fxyd6), mRNA.

Price & Availability↑

CloneID	ORa05351
Clone ID Related Accession (Same CDS sequence)	NM_022005.2
Accession Version	NM_022005.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 285bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	FXYD domain-containing ion transport regulator 6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Kathleen Sweadner. The reference sequence was derived from CB741544.1, AB030908.1, BM385427.1, AF142439.1 and AI072935.1. On Jan 29, 2011 this sequence version replaced NM_022005.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGACGG TGCTGATCCT CTGCAGCTTG CTGGCCCCTG TGGTCCTGGC TAGTGCAGCT 
GAGAAGGAGA AAGAAAAGGA TCCTTTCTAT TATGACTACC AGACCCTGAG GATTGGGGGA 
TTGGTGTTTG CTGTGGTCCT CTTCTCTGTT GGGATACTTC TCATCCTAAG TCGCAGGTGC 
AAGTGCAGTT TCAATCAGAA ACCCAGGGCT CCAGGTGATG AAGAGGCCCA GGTGGAGAAC 
CTTATCACCA CAAATGCTGC GGAGCCCCAG AAGGCAGAGA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071288.1
CDS	225..509
Translation	METVLILCSLLAPVVLASAAEKEKEKDPFYYDYQTLRIGGLVFAVVLFSVGILLILSRRCKCSFNQKPRAPGDEEAQVENLITTNAAEPQKAEN

Target ORF information:

RefSeq Version	NM_022005.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FXYD domain-containing ion transport regulator 6 (Fxyd6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022005.2

ORF Insert Sequence:

ATGGAGACGG TGCTGATCCT CTGCAGCTTG CTGGCCCCTG TGGTCCTGGC TAGTGCAGCT 
GAGAAGGAGA AAGAAAAGGA TCCTTTCTAT TATGACTACC AGACCCTGAG GATTGGGGGA 
TTGGTGTTTG CTGTGGTCCT CTTCTCTGTT GGGATACTTC TCATCCTAAG TCGCAGGTGC 
AAGTGCAGTT TCAATCAGAA ACCCAGGGCT CCAGGTGATG AAGAGGCCCA GGTGGAGAAC 
CTTATCACCA CAAATGCTGC GGAGCCCCAG AAGGCAGAGA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fxyd6 ( XM_008766171.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008764393.1 Rattus norvegicus FXYD domain-containing ion transport regulator 6 (Fxyd6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa43539
Clone ID Related Accession (Same CDS sequence)	XM_008766171.2
Accession Version	XM_008766171.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	FXYD domain-containing ion transport regulator 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008766171.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGACGG TGCTGATCCT CTGCAGCTTG CTGGCCCCTG TGGTCCTGGC TAGTGCTGAG 
AAGGAGAAAG AAAAGGATCC TTTCTATTAT GACTACCAGA CCCTGAGGAT TGGGGGATTG 
GTGTTTGCTG TGGTCCTCTT CTCTGTTGGG ATACTTCTCA TCCTAAGTCG CAGGTGCAAG 
TGCAGTTTCA ATCAGAAACC CAGGGCTCCA GGTGATGAAG AGGCCCAGGT GGAGAACCTT 
ATCACCACAA ATGCTGCGGA GCCCCAGAAG GCAGAGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008764393.1
CDS	245..526
Translation	METVLILCSLLAPVVLASAEKEKEKDPFYYDYQTLRIGGLVFAVVLFSVGILLILSRRCKCSFNQKPRAPGDEEAQVENLITTNAAEPQKAEN

Target ORF information:

RefSeq Version	XM_008766171.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FXYD domain-containing ion transport regulator 6 (Fxyd6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008766171.2

ORF Insert Sequence:

ATGGAGACGG TGCTGATCCT CTGCAGCTTG CTGGCCCCTG TGGTCCTGGC TAGTGCTGAG 
AAGGAGAAAG AAAAGGATCC TTTCTATTAT GACTACCAGA CCCTGAGGAT TGGGGGATTG 
GTGTTTGCTG TGGTCCTCTT CTCTGTTGGG ATACTTCTCA TCCTAAGTCG CAGGTGCAAG 
TGCAGTTTCA ATCAGAAACC CAGGGCTCCA GGTGATGAAG AGGCCCAGGT GGAGAACCTT 
ATCACCACAA ATGCTGCGGA GCCCCAGAAG GCAGAGAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
The EMBO journal33(2)157-70(2014 Jan)
Biesemann C,Gr?nborg M,Luquet E,Wichert SP,Bernard V,Bungers SR,Cooper B,Varoqueaux F,Li L,Byrne JA,Urlaub H,Jahn O,Brose N,Herzog E

A serial analysis of gene expression profile of the Alzheimer's disease Tg2576 mouse model.
Neurotoxicity research17(4)360-79(2010 May)
George AJ,Gordon L,Beissbarth T,Koukoulas I,Holsinger RM,Perreau V,Cappai R,Tan SS,Masters CL,Scott HS,Li QX

Dynamic expression of FXYD6 in the inner ear suggests a role of the protein in endolymph homeostasis and neuronal activity.
Developmental dynamics : an official publication of the American Association of Anatomists236(9)2534-40(2007 Sep)
Delprat B,Puel JL,Geering K

Phosphohippolin expression in the rat central nervous system.
Brain research. Molecular brain research125(1-2)105-12(2004 Jun)
Kadowaki K,Sugimoto K,Yamaguchi F,Song T,Watanabe Y,Singh K,Tokuda M

Molecular cloning and characterization of a novel phospholemman-like protein from rat hippocampus.
Brain research. Molecular brain research86(1-2)189-92(2001 Jan)
Yamaguchi F,Yamaguchi K,Tai Y,Sugimoto K,Tokuda M

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Fxyd6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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