Sh2b3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sh2b3
Entrez Gene ID	58838
Full Name	SH2B adaptor protein 3
Synonyms	Lnk
General protein information	Preferred Names SH2B adaptor protein 3 Names SH2B adapter protein 3 linker of T-cell receptor pathways lymphocyte adapter protein lymphocyte-specific adapter protein Lnk signal transduction protein Lnk
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q16
Summary	transmits activated T-cell receptor signal to phosphatidylinositol 3-kinase, phospholipase C gamma 1 and Ras signaling pathways [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031621.1	NP_113809.1	SH2B adapter protein 3

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis.
Wang W, Tang Y, Wang Y, Tascau L, Balcerek J, Tong W, Levine RL, Welch C, Tall AR, Wang N
Circulation research119(6)e91-e103(2016 Sep)

Exacerbating Pressure Overload-Induced Cardiac Hypertrophy: Novel Role of Adaptor Molecule Src Homology 2-B3.
Zhu X, Fang J, Jiang DS, Zhang P, Zhao GN, Zhu X, Yang L, Wei X, Li H
Hypertension (Dallas, Tex. : 1979)66(3)571-81(2015 Sep)

Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.
Rudemiller NP, Lund H, Priestley JR, Endres BT, Prokop JW, Jacob HJ, Geurts AM, Cohen EP, Mattson DL
Hypertension (Dallas, Tex. : 1979)65(5)1111-7(2015 May)

SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.
Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ
Circulation. Cardiovascular genetics8(2)294-304(2015 Apr)

Creation and preliminary characterization of a leptin knockout rat.
Vaira S, Yang C, McCoy A, Keys K, Xue S, Weinstein EJ, Novack DV, Cui X
Endocrinology153(11)5622-8(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SH2B3 functions as a novel and effective modulator of cardiac remodeling and failure.
Title: Exacerbating Pressure Overload-Induced Cardiac Hypertrophy: Novel Role of Adaptor Molecule Src Homology 2-B3.

The resulting mutation was a 6-bp, in-frame deletion within a highly conserved region of the Src homology 2 (SH2) domain of SH2B3. This mutation significantly attenuated Dahl SS hypertension and renal disease.
Title: Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.

These data demonstrate for the first time that SH2B3 is a crucial mediator of post-MI inflammation and fibrosis.
Title: SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.

SH2B3 inhibits neuronal differentiation of PC12 cells and primary cortical neurons
Title: The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons.

The following Sh2b3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sh2b3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08287	NM_031621.1 Latest version!	Rattus norvegicus SH2B adaptor protein 3 (Sh2b3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sh2b3 ( NM_031621.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113809.1 Rattus norvegicus SH2B adaptor protein 3 (Sh2b3), mRNA.

Price & Availability↑

CloneID	ORa08287
Clone ID Related Accession (Same CDS sequence)	NM_031621.1
Accession Version	NM_031621.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	SH2B adapter protein 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U24655.1. On Dec 17, 2003 this sequence version replaced XM_346434.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U24655.1, CB759518.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGGCA GAACTCAGGG CAAGCACAGG CCTAGGGTGA GGACCTGCCC ATCCCTGGTT 
CCCTTTGATA ACCCCTGCTG GCCCCCTTCT CACCAGCCTC TTCCCCTACA GGTTGGAGCA 
CCTGGACACA GAGTTACCTC TTTCCTTAGT GGCAGAGCCT GGCCCAGCTA TATCCCCAAG 
GGGAAGCACG GACTCCCTGG ACCAAGGTAT GTGCCAGATC CTTGGTCTCT GGGTGTCCTT 
GGACATGTGG CCCCTCTGCG GGTCACCACC ACCATCTTTC TGCCAGGTGC TTCACCTGGG 
GTGATGTTGG ACCCAGCCTG CCAGAAAACA GATCACTTCC TGTCCTGCTA CCCCTGGTTC 
CACGGCCCCA TCTCCAGGGT GAGGGCTGCA CAGCTGGTTC AGCTGCAGGG CCCTGATGCC 
CACGGTGTGT TCCTGGTGCG GCAGAGTGAG TCCCGGAGAG GGGAATATGT ACTCACATTC 
AACTTACAGG GGAGAGCCAA GCACCTCCGC CTGGTGCTCA CAGAGCGTGG ACAGTGCCGG 
GTGCAACACC TGCACTTCCC CTCGGTGGTG GATATGCTCC GCCACTTCCA GCGCTCCCCC 
ATCCCACTTG AATGTGGAGC AGCCTGTGAT GTCCGACTCT CTGGCTATGT GGTAGTCGTC 
TCTCAGGCAC CAGGTAGGAA GCCCAAAGTT GTGTCAAGGG GTGGTGTCAC AGCAAGTACA 
GCACGTACAA AACTTCCTTC CTGGTTACGC CTTCTTCATG GAGTCATCCA TGTTATCTCT 
CCAGGTTCCT CCAACACCGT TCTCTTCCCC TTTTCCCTTC CTCACTGGGA CTCAGAGCTG 
GGCCATCCCC ACCTCAGCTC TGCTGGCTGT CCCCCTGGCC ATGGTGCAGA GGCTCTCCGT 
GGCCAAGTGA CACCTCCTGA GCAGATCTTC CACCTGGTGC CTTCTCCTGA GGAACTGGCC 
AACAGTCTGC GGCAGCTGGA GCTTGAGTCT GTGAGCAGTG CCCGGGACTC AGACTATGAA 
ATGGACTCCT CCTCACGGAG CCACCTTCGG GCCATTGACA ACCAGTACAC CCCTCTCTCA 
CAGCTGTGCA GAGAGGCAAA CTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113809.1
CDS	243..1349
Translation	MAGRTQGKHRPRVRTCPSLVPFDNPCWPPSHQPLPLQVGAPGHRVTSFLSGRAWPSYIPKGKHGLPGPRYVPDPWSLGVLGHVAPLRVTTTIFLPGASPGVMLDPACQKTDHFLSCYPWFHGPISRVRAAQLVQLQGPDAHGVFLVRQSESRRGEYVLTFNLQGRAKHLRLVLTERGQCRVQHLHFPSVVDMLRHFQRSPIPLECGAACDVRLSGYVVVVSQAPGRKPKVVSRGGVTASTARTKLPSWLRLLHGVIHVISPGSSNTVLFPFSLPHWDSELGHPHLSSAGCPPGHGAEALRGQVTPPEQIFHLVPSPEELANSLRQLELESVSSARDSDYEMDSSSRSHLRAIDNQYTPLSQLCREANL

Target ORF information:

RefSeq Version	NM_031621.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SH2B adaptor protein 3 (Sh2b3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031621.1

ORF Insert Sequence:

ATGGCTGGCA GAACTCAGGG CAAGCACAGG CCTAGGGTGA GGACCTGCCC ATCCCTGGTT 
CCCTTTGATA ACCCCTGCTG GCCCCCTTCT CACCAGCCTC TTCCCCTACA GGTTGGAGCA 
CCTGGACACA GAGTTACCTC TTTCCTTAGT GGCAGAGCCT GGCCCAGCTA TATCCCCAAG 
GGGAAGCACG GACTCCCTGG ACCAAGGTAT GTGCCAGATC CTTGGTCTCT GGGTGTCCTT 
GGACATGTGG CCCCTCTGCG GGTCACCACC ACCATCTTTC TGCCAGGTGC TTCACCTGGG 
GTGATGTTGG ACCCAGCCTG CCAGAAAACA GATCACTTCC TGTCCTGCTA CCCCTGGTTC 
CACGGCCCCA TCTCCAGGGT GAGGGCTGCA CAGCTGGTTC AGCTGCAGGG CCCTGATGCC 
CACGGTGTGT TCCTGGTGCG GCAGAGTGAG TCCCGGAGAG GGGAATATGT ACTCACATTC 
AACTTACAGG GGAGAGCCAA GCACCTCCGC CTGGTGCTCA CAGAGCGTGG ACAGTGCCGG 
GTGCAACACC TGCACTTCCC CTCGGTGGTG GATATGCTCC GCCACTTCCA GCGCTCCCCC 
ATCCCACTTG AATGTGGAGC AGCCTGTGAT GTCCGACTCT CTGGCTATGT GGTAGTCGTC 
TCTCAGGCAC CAGGTAGGAA GCCCAAAGTT GTGTCAAGGG GTGGTGTCAC AGCAAGTACA 
GCACGTACAA AACTTCCTTC CTGGTTACGC CTTCTTCATG GAGTCATCCA TGTTATCTCT 
CCAGGTTCCT CCAACACCGT TCTCTTCCCC TTTTCCCTTC CTCACTGGGA CTCAGAGCTG 
GGCCATCCCC ACCTCAGCTC TGCTGGCTGT CCCCCTGGCC ATGGTGCAGA GGCTCTCCGT 
GGCCAAGTGA CACCTCCTGA GCAGATCTTC CACCTGGTGC CTTCTCCTGA GGAACTGGCC 
AACAGTCTGC GGCAGCTGGA GCTTGAGTCT GTGAGCAGTG CCCGGGACTC AGACTATGAA 
ATGGACTCCT CCTCACGGAG CCACCTTCGG GCCATTGACA ACCAGTACAC CCCTCTCTCA 
CAGCTGTGCA GAGAGGCAAA CTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis.
Circulation research119(6)e91-e103(2016 Sep)
Wang W,Tang Y,Wang Y,Tascau L,Balcerek J,Tong W,Levine RL,Welch C,Tall AR,Wang N

Exacerbating Pressure Overload-Induced Cardiac Hypertrophy: Novel Role of Adaptor Molecule Src Homology 2-B3.
Hypertension (Dallas, Tex. : 1979)66(3)571-81(2015 Sep)
Zhu X,Fang J,Jiang DS,Zhang P,Zhao GN,Zhu X,Yang L,Wei X,Li H

Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.
Hypertension (Dallas, Tex. : 1979)65(5)1111-7(2015 May)
Rudemiller NP,Lund H,Priestley JR,Endres BT,Prokop JW,Jacob HJ,Geurts AM,Cohen EP,Mattson DL

SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.
Circulation. Cardiovascular genetics8(2)294-304(2015 Apr)
Flister MJ,Hoffman MJ,Lemke A,Prisco SZ,Rudemiller N,O'Meara CC,Tsaih SW,Moreno C,Geurts AM,Lazar J,Adhikari N,Hall JL,Jacob HJ

Creation and preliminary characterization of a leptin knockout rat.
Endocrinology153(11)5622-8(2012 Nov)
Vaira S,Yang C,McCoy A,Keys K,Xue S,Weinstein EJ,Novack DV,Cui X

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Sh2b3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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