Anxa2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Anxa2
Entrez Gene ID	56611
Full Name	annexin A2
Synonyms	ANX2
General protein information	Preferred Names annexin A2 Names annexin A2 PAP-IV annexin-2 calpactin I heavy chain calpactin-1 heavy chain chromobindin-8 lipocortin II p36 placental anticoagulant protein IV protein I
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24
Summary	a plasminogen receptor; may be involved in cellular transformation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019905.1	NP_063970.1	annexin A2

Pathways from BioSystems

Homologies

Homo sapiens (human)	ANXA2	NP_004030.1
Pan troglodytes (chimpanzee)	ANXA2	XP_001155637.2
Danio rerio (zebrafish)	anxa2a	NP_861426.1
Danio rerio (zebrafish)	anxa2b	NP_001099070.1
Bos taurus (cattle)	ANXA2	NP_777141.1
Gallus gallus (chicken)	ANXA2	NP_990682.1
Xenopus tropicalis (tropical clawed frog)	anxa2	NP_988921.1
Canis lupus familiaris (dog)	ANXA2	NP_001002961.1
Mus musculus (house mouse)	Anxa2	NP_031611.1
	ANXA2	XP_002804841.1
Rattus norvegicus (Norway rat)	Anxa2	NP_063970.1

Gene Ontology
Bibliography

Related articles in PubMed

Annexin A2-modulated proliferation of pulmonary arterial smooth muscle cells depends on caveolae and caveolin-1 in hepatopulmonary syndrome.
Liao L, Zheng B, Yi B, Liu C, Chen L, Zeng Z, Gao J
Experimental cell research359(1)266-274(2017 10)

Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats.
Sun L, Min L, Zhou H, Li M, Shao F, Wang W
Behavioural brain research333258-266(2017 Aug)

A CO-releasing molecule prevents annexin A2 down-regulation and associated disorders in LPS-administered rat lung.
Unuma K, Aki T, Noritake K, Funakoshi T, Uemura K
Biochemical and biophysical research communications487(3)748-754(2017 Jun)

Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis.
Chojnacka K, Bilinska B, Mruk DD
Biochimica et biophysica acta1864(3)527-545(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cav-1 participates upstream of ANXA2 in the activation of ERK1/2 and NF-kappaB.
Title: Annexin A2-modulated proliferation of pulmonary arterial smooth muscle cells depends on caveolae and caveolin-1 in hepatopulmonary syndrome.

Concordant with the levels of AnxA2, the levels of both LC3 and collagen VI (COL VI) were decreased in the LPS group but not in the LPS + CORM group. Given the established roles of AnxA2 in fibrinolysis as well as intracellular vesicle trafficking, AnxA2 down-regulation should play an important role in the pathogenesis of septic lung injuries.
Title: A CO-releasing molecule prevents annexin A2 down-regulation and associated disorders in LPS-administered rat lung.

The results indicate that ANXA2 is critical for the integrity of the blood-testis barrier and the timely release of spermatids.
Title: Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis.

Our data suggested that ANXA2 might play important roles in CNS pathophysiology after spinal cord injury.
Title: The upregulation of annexin A2 after spinal cord injury in rats may have implication for astrocyte proliferation.

Oxidative stress causes the incorporation of pTyr23AnxA2 into extracellular vesicles.
Title: Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2.

The following Anxa2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Anxa2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13448	NM_019905.1 Latest version!	Rattus norvegicus annexin A2 (Anxa2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Anxa2 ( NM_019905.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_063970.1 Rattus norvegicus annexin A2 (Anxa2), mRNA.

Price & Availability↑

CloneID	ORa13448
Clone ID Related Accession (Same CDS sequence)	NM_019905.1
Accession Version	NM_019905.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	annexin A2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X66871.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X66871.1, BC059136.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCTACTG TCCACGAAAT CCTGTGCAAG CTCAGCTTGG AGGGTGATCA TTCTACACCC 
CCAAGTGCCT ATGGGTCGGT CAAACCCTAC ACCAACTTCG ACGCTGAGAG GGATGCTTTG 
AACATTGAAA CAGCAATCAA GACCAAAGGC GTGGACGAGG TCACCATTGT CAACATTCTG 
ACTAACCGCA GCAATGCACA GAGGCAGGAC ATTGCCTTCG CCTACCAGAG GAGGACCAAA 
AAGGAACTGC CATCGGCGAT GAAGTCGGCC TTGTCTGGTC ACCTGGAGAC CGTGATGTTA 
GGCCTGTTGA AGACACCTGC TCAGTACGAT GCCTCTGAGC TCAAAGCCTC CATGAAGGGC 
CTGGGGACTG ATGAGGACTC CCTCATCGAG ATCATCTGCT CAAGAACCAA CCAGGAGCTG 
CAGGAGATTA ACCGAGTGTA TAAGGAAATG TACAAGACCG ATCTGGAGAA GGACATCATC 
TCTGACACAT CTGGAGAATT CCGAAAGCTG TTGGTCGCCC TTGCAAAGGG TAAACGGGCA 
GAGGATGGTT CTGTTATTGA CTACGAGCTG ATTGACCAGG ATGCCCGGGA GCTCTATGAT 
GCTGGGGTGA AGAGGAAAGG AACCGATGTC CCCAAGTGGA TCAGCATCAT GACTGAGCGC 
AGTGTGTGCC ACCTCCAGAA AGTGTTCGAA AGGTACAAGA GCTACAGTCC TTATGACATG 
CTGGAGAGCA TCAGGAAAGA GGTCAAAGGA GACCTGGAGA ACGCCTTCCT GAACCTGGTT 
CAGTGCATTC AGAACAAGCC CCTGTACTTT GCTGACCGGC TGTATGACTC CATGAAGGGC 
AAGGGGACTC GAGACAAGGT CCTGATTAGA ATCATGGTCT CTCGCAGTGA AGTGGACATG 
TTGAAAATCA GATCTGAATT CAAGAGGAAA TATGGCAAAT CCCTGTACTA CTTCATCCAG 
CAAGACACTA AGGGTGACTA CCAGAAGGCG CTGCTGTACC TGTGTGGTGG GGACGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_063970.1
CDS	43..1062
Translation	MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELPSAMKSALSGHLETVMLGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGEFRKLLVALAKGKRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYFIQQDTKGDYQKALLYLCGGDD

Target ORF information:

RefSeq Version	NM_019905.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus annexin A2 (Anxa2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019905.1

ORF Insert Sequence:

ATGTCTACTG TCCACGAAAT CCTGTGCAAG CTCAGCTTGG AGGGTGATCA TTCTACACCC 
CCAAGTGCCT ATGGGTCGGT CAAACCCTAC ACCAACTTCG ACGCTGAGAG GGATGCTTTG 
AACATTGAAA CAGCAATCAA GACCAAAGGC GTGGACGAGG TCACCATTGT CAACATTCTG 
ACTAACCGCA GCAATGCACA GAGGCAGGAC ATTGCCTTCG CCTACCAGAG GAGGACCAAA 
AAGGAACTGC CATCGGCGAT GAAGTCGGCC TTGTCTGGTC ACCTGGAGAC CGTGATGTTA 
GGCCTGTTGA AGACACCTGC TCAGTACGAT GCCTCTGAGC TCAAAGCCTC CATGAAGGGC 
CTGGGGACTG ATGAGGACTC CCTCATCGAG ATCATCTGCT CAAGAACCAA CCAGGAGCTG 
CAGGAGATTA ACCGAGTGTA TAAGGAAATG TACAAGACCG ATCTGGAGAA GGACATCATC 
TCTGACACAT CTGGAGAATT CCGAAAGCTG TTGGTCGCCC TTGCAAAGGG TAAACGGGCA 
GAGGATGGTT CTGTTATTGA CTACGAGCTG ATTGACCAGG ATGCCCGGGA GCTCTATGAT 
GCTGGGGTGA AGAGGAAAGG AACCGATGTC CCCAAGTGGA TCAGCATCAT GACTGAGCGC 
AGTGTGTGCC ACCTCCAGAA AGTGTTCGAA AGGTACAAGA GCTACAGTCC TTATGACATG 
CTGGAGAGCA TCAGGAAAGA GGTCAAAGGA GACCTGGAGA ACGCCTTCCT GAACCTGGTT 
CAGTGCATTC AGAACAAGCC CCTGTACTTT GCTGACCGGC TGTATGACTC CATGAAGGGC 
AAGGGGACTC GAGACAAGGT CCTGATTAGA ATCATGGTCT CTCGCAGTGA AGTGGACATG 
TTGAAAATCA GATCTGAATT CAAGAGGAAA TATGGCAAAT CCCTGTACTA CTTCATCCAG 
CAAGACACTA AGGGTGACTA CCAGAAGGCG CTGCTGTACC TGTGTGGTGG GGACGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Annexin A2-modulated proliferation of pulmonary arterial smooth muscle cells depends on caveolae and caveolin-1 in hepatopulmonary syndrome.
Experimental cell research359(1)266-274(2017 10)
Liao L,Zheng B,Yi B,Liu C,Chen L,Zeng Z,Gao J

Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats.
Behavioural brain research333258-266(2017 Aug)
Sun L,Min L,Zhou H,Li M,Shao F,Wang W

A CO-releasing molecule prevents annexin A2 down-regulation and associated disorders in LPS-administered rat lung.
Biochemical and biophysical research communications487(3)748-754(2017 Jun)
Unuma K,Aki T,Noritake K,Funakoshi T,Uemura K

Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis.
Biochimica et biophysica acta1864(3)527-545(2017 03)
Chojnacka K,Bilinska B,Mruk DD

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Anxa2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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