Ucp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ucp2
Entrez Gene ID	54315
Full Name	uncoupling protein 2
General protein information	Preferred Names uncoupling protein 2 Names mitochondrial uncoupling protein 2 UCP 2 Uncoupling protein 2, mitochondrial solute carrier family 25 member 8 uncoupling protein 2 (mitochondrial, proton carrier)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q32
Summary	catalyzes a proton leak across the inner mitochondrial membrane to uncouple oxidative phosphorylation; may reduce the concentration of reactive ozygen species in mitochondria [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019354.3	NP_062227.2	mitochondrial uncoupling protein 2

Pathways from BioSystems

Homologies

	UCP2	XP_001115559.1
Bos taurus (cattle)	UCP2	NP_001028783.1
Danio rerio (zebrafish)	ucp2	NP_571251.1
Arabidopsis thaliana (thale cress)	PUMP1	NP_190979.1
Pan troglodytes (chimpanzee)	UCP2	XP_508635.1
Rattus norvegicus (Norway rat)	Ucp2	NP_062227.2
Mus musculus (house mouse)	Ucp2	NP_035801.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011676	XP_552584.3
Oryza sativa (rice)	Os11g0707800	NP_001068559.2
Homo sapiens (human)	UCP2	NP_003346.2
Canis lupus familiaris (dog)	UCP2	NP_001003048.1
Xenopus tropicalis (tropical clawed frog)	ucp2	NP_989179.1

Gene Ontology
Bibliography

Related articles in PubMed

Uncoupling Protein 2 Inhibits Myointimal Hyperplasia in Preclinical Animal Models of Vascular Injury.
Zhang Y, Zhang Y, Li W, Wang P, Gu R, Feng Y, Wei S, Peng K, Zhang Y, Su L, Wang Q, Li, Yang D, Wong WT, Yang Y, Ma S
Journal of the American Heart Association6(10)(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

UCP2 has an apoptotic effect in beta cells via regulation of the intrinsic pathway of apoptosis in brain dead organ donors.
Title: UCP2 Expression Is Increased in Pancreas From Brain-Dead Donors and Involved in Cytokine-Induced ? Cells Apoptosis.

These observations suggest that downregulation of UCP2 expression in the hypothermic preserved rat heart in part initiated the protective mechanism via the SIRT1 pathway.
Title: Mechanism of uncoupling protein?2?mediated myocardial injury in hypothermic preserved rat hearts.

GLP-1 likewise increased the synthesis of GR and favored the translocation of the nuclear transcription factor erythroid 2p45-related factor (Nrf2)..Glucose-stimulated insulin secretion was also preserved in beta-cells challenged with tert-BOOH but pre-treated with GLP-1, probably through the down-regulation of the mitochondrial uncoupling-protein2 (UCP2).
Title: Glucagon-like peptide-1 improves beta-cell antioxidant capacity via extracellular regulated kinases pathway and Nrf2 translocation.

The expression level of UCP2 is closely correlated with mitochondrial injury in sepsis rat model.
Title: [Correlation between uncoupling protein 2 expression and myocardial mitochondrial injury in rats with sepsis induced by lipopolysaccharide].

In the lungs and the spleen of rats with a chronic alcohol diet cytochrome c release from mitochondria was significantly increased. Both organs did not show any altered gene and protein expression of UCP-2.
Title: Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2.

The following Ucp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ucp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13519	NM_019354.3 Latest version!	Rattus norvegicus uncoupling protein 2 (Ucp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ucp2 ( NM_019354.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062227.2 Rattus norvegicus uncoupling protein 2 (Ucp2), mRNA.

Price & Availability↑

CloneID	ORa13519
Clone ID Related Accession (Same CDS sequence)	NM_019354.3
Accession Version	NM_019354.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	mitochondrial uncoupling protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FQ227097.1 and AB006613.1. On or before Aug 22, 2014 this sequence version replaced XM_006229784.2, NM_019354.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ227097.1, AB010743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology regulatory uORF :: PMID: 16845607 ##RefSeq-Attributes-END##

ATGGTTGGTT TCAAGGCCAC CGATGTGCCC CCCACAGCCA CCGTGAAGTT CCTGGGGGCT 
GGGACAGCAG CCTGTATTGC AGATCTCATC ACTTTCCCTC TAGACACCGC CAAAGTCCGG 
CTGCAGATCC AAGGAGAGAG TCAAGGGCTA GCGCGCACCG CCGCCAGCGC CCAGTACCGC 
GGCGTGCTGG GCACCATCCT AACCATGGTG CGCACTGAGG GTCCGCGCAG CCTCTACAAT 
GGGCTGGTCG CCGGCCTACA GCGCCAGATG AGCTTTGCCT CCGTCCGCAT TGGCCTCTAC 
GACTCTGTAA AGCAGTTCTA CACCAAGGGC TCAGAGCATG CAGGCATCGG GAGCCGCCTC 
CTGGCAGGTA GCACCACAGG TGCCCTGGCT GTGGCTGTGG CCCAACCTAC AGATGTGGTA 
AAGGTCCGCT TCCAGGCCCA GGCCCGGGCT GGCGGTGGTC GGAGATACCA GAGCACTGTC 
GAAGCCTACA AGACCATTGC ACGAGAGGAA GGGATCCGGG GCCTCTGGAA AGGGACCTCT 
CCCAATGTTG CCCGAAATGC CATTGTCAAC TGTACTGAGC TGGTGACCTA TGACCTCATC 
AAAGATACTC TCCTGAAAGC CAACCTCATG ACAGACGACC TCCCTTGCCA CTTCACTTCT 
GCCTTCGGGG CGGGCTTCTG CACCACCGTC ATTGCCTCCC CCGTTGATGT GGTCAAGACG 
AGATATATGA ACTCTGCCTT GGGCCAGTAC CACAGCGCCG GCCACTGTGC CCTGACCATG 
CTCCGGAAGG AGGGGCCCCG AGCCTTCTAC AAGGGGTTCA TGCCTTCCTT CCTCCGCTTG 
GGATCCTGGA ACGTAGTAAT GTTTGTCACC TATGAGCAGC TCAAAAGGGC CCTGATGGCT 
GCCTATGAAT CCCGGGAGGC ACCCTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062227.2
CDS	374..1303
Translation	MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGLARTAASAQYRGVLGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAGIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVEAYKTIAREEGIRGLWKGTSPNVARNAIVNCTELVTYDLIKDTLLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYHSAGHCALTMLRKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMAAYESREAPF

Target ORF information:

RefSeq Version	NM_019354.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus uncoupling protein 2 (Ucp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019354.3

ORF Insert Sequence:

ATGGTTGGTT TCAAGGCCAC CGATGTGCCC CCCACAGCCA CCGTGAAGTT CCTGGGGGCT 
GGGACAGCAG CCTGTATTGC AGATCTCATC ACTTTCCCTC TAGACACCGC CAAAGTCCGG 
CTGCAGATCC AAGGAGAGAG TCAAGGGCTA GCGCGCACCG CCGCCAGCGC CCAGTACCGC 
GGCGTGCTGG GCACCATCCT AACCATGGTG CGCACTGAGG GTCCGCGCAG CCTCTACAAT 
GGGCTGGTCG CCGGCCTACA GCGCCAGATG AGCTTTGCCT CCGTCCGCAT TGGCCTCTAC 
GACTCTGTAA AGCAGTTCTA CACCAAGGGC TCAGAGCATG CAGGCATCGG GAGCCGCCTC 
CTGGCAGGTA GCACCACAGG TGCCCTGGCT GTGGCTGTGG CCCAACCTAC AGATGTGGTA 
AAGGTCCGCT TCCAGGCCCA GGCCCGGGCT GGCGGTGGTC GGAGATACCA GAGCACTGTC 
GAAGCCTACA AGACCATTGC ACGAGAGGAA GGGATCCGGG GCCTCTGGAA AGGGACCTCT 
CCCAATGTTG CCCGAAATGC CATTGTCAAC TGTACTGAGC TGGTGACCTA TGACCTCATC 
AAAGATACTC TCCTGAAAGC CAACCTCATG ACAGACGACC TCCCTTGCCA CTTCACTTCT 
GCCTTCGGGG CGGGCTTCTG CACCACCGTC ATTGCCTCCC CCGTTGATGT GGTCAAGACG 
AGATATATGA ACTCTGCCTT GGGCCAGTAC CACAGCGCCG GCCACTGTGC CCTGACCATG 
CTCCGGAAGG AGGGGCCCCG AGCCTTCTAC AAGGGGTTCA TGCCTTCCTT CCTCCGCTTG 
GGATCCTGGA ACGTAGTAAT GTTTGTCACC TATGAGCAGC TCAAAAGGGC CCTGATGGCT 
GCCTATGAAT CCCGGGAGGC ACCCTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Uncoupling Protein 2 Inhibits Myointimal Hyperplasia in Preclinical Animal Models of Vascular Injury.
Journal of the American Heart Association6(10)(2017 Oct)
Zhang Y,Zhang Y,Li W,Wang P,Gu R,Feng Y,Wei S,Peng K,Zhang Y,Su L,Wang Q,Li,Yang D,Wong WT,Yang Y,Ma S

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Ucp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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