Rgs8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rgs8
Entrez Gene ID	54297
Full Name	regulator of G-protein signaling 8
General protein information	Preferred Names regulator of G-protein signaling 8 Names regulator of G-protein signaling 8
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q21
Summary	activates GTPase; inhibits G-protein coupled receptor signaling; modulates activity of G-protein-coupled inwardly rectifying K+ channels [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006250015.3	XP_006250077.1	regulator of G-protein signaling 8 isoform X1
XM_006250016.3	XP_006250078.1	regulator of G-protein signaling 8 isoform X2
NM_019344.2	NP_062217.1	regulator of G-protein signaling 8

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	RGS8	XP_424195.3
Danio rerio (zebrafish)	rgs8	NP_001002531.1
Pan troglodytes (chimpanzee)	RGS8	XP_003308676.1
Canis lupus familiaris (dog)	RGS8	XP_849550.1
Homo sapiens (human)	RGS8	NP_203131.1
Mus musculus (house mouse)	Rgs8	NP_080656.2
Xenopus tropicalis (tropical clawed frog)	rgs8	XP_002937412.1
Bos taurus (cattle)	RGS8	XP_003587148.1
Rattus norvegicus (Norway rat)	Rgs8	NP_062217.1

Gene Ontology
Bibliography

Related articles in PubMed

The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.
Sun H, Calipari ES, Beveridge TJ, Jones SR, Chen R
Neuroscience307253-61(2015 Oct)

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstr?m M, Doyle DA, Siderovski DP
Proceedings of the National Academy of Sciences of the United States of America105(17)6457-62(2008 Apr)

RGS8 expression in developing cerebellar Purkinje cells.
Saitoh O, Odagiri M
Biochemical and biophysical research communications309(4)836-42(2003 Oct)

Distribution of regulator of G protein signaling 8 (RGS8) protein in the cerebellum.
Saitoh O, Masuho I, Itoh M, Abe H, Komori K, Odagiri M
Cerebellum (London, England)2(2)154-60(2003)

Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures.
Gold SJ, Heifets BD, Pudiak CM, Potts BW, Nestler EJ
Journal of neurochemistry82(4)828-38(2002 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

examination of expression of mRNA in developing cerebellum by in situ hybridization
Title: RGS8 expression in developing cerebellar Purkinje cells.

Alternative splicing determines inhibitory function of receptor type-specific Gq signaling.
Title: Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling.

RGS8 protein is distributed in dendrites and cell body but not the nucleus nor axons of cerebellar Purkinje cells, suggesting protein distribution is controlled.
Title: RGS8 protein is distributed in dendrites and cell body of cerebellar Purkinje cell.

The following Rgs8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rgs8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa04496	NM_019344.2 Latest version!	Rattus norvegicus regulator of G-protein signaling 8 (Rgs8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa04496	XM_006250016.3 Latest version!	Rattus norvegicus regulator of G-protein signaling 8 (Rgs8), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa35459	XM_006250015.3 Latest version!	Rattus norvegicus regulator of G-protein signaling 8 (Rgs8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rgs8 ( NM_019344.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062217.1 Rattus norvegicus regulator of G-protein signaling 8 (Rgs8), mRNA.

Price & Availability↑

CloneID	ORa04496
Clone ID Related Accession (Same CDS sequence)	XM_006250016.3 , NM_019344.2
Accession Version	NM_019344.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	regulator of G-protein signaling 8
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC089064.1. On Jan 23, 2005 this sequence version replaced NM_019344.1. ##Evidence-Data-START## Transcript exon combination :: BC089064.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCCT TACTGATGCC ACGCAGGAAC AAAGGCATGA GGACTCGACT GGGATGCCTG 
TCGCACAAAT CAGACTCCTG TAGTGACTTC ACAGCCATCC TTCCTGACAA ACCCAACCGC 
GCTCTCAAGA GACTCTCCAC AGAAGAAGCG ACGAGGTGGG CAGATTCCTT TGATGTGCTT 
CTCTCTCACA AGTATGGGGT GGCAGCCTTC CGTGCCTTCC TGAAGACAGA GTTCAGCGAG 
GAGAACCTGG AGTTCTGGCT GGCCTGTGAG GAGTTCAAGA AGACCAGGTC GACTGCAAAG 
CTAGTCACCA AGGCCCACAG GATCTTTGAG GAGTTTGTGG ATGTGCAGGC TCCACGGGAG 
GTGAATATCG ATTTCCAGAC CCGAGAGGCC ACGAGGAAGA ACATGCAGGA GCCGTCCCTG 
ACTTGTTTTG ATCAAGCCCA GGGAAAAGTC CACAGCCTCA TGGAGAAAGA CTCTTATCCT 
AGGTTCCTGA GGTCCAAAAT GTACTTAGAT CTGCTGTCCC AAAGCCAGAG GAGGCTCAGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062217.1
CDS	406..948
Translation	MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS

Target ORF information:

RefSeq Version	NM_019344.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus regulator of G-protein signaling 8 (Rgs8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019344.2

ORF Insert Sequence:

ATGGCTGCCT TACTGATGCC ACGCAGGAAC AAAGGCATGA GGACTCGACT GGGATGCCTG 
TCGCACAAAT CAGACTCCTG TAGTGACTTC ACAGCCATCC TTCCTGACAA ACCCAACCGC 
GCTCTCAAGA GACTCTCCAC AGAAGAAGCG ACGAGGTGGG CAGATTCCTT TGATGTGCTT 
CTCTCTCACA AGTATGGGGT GGCAGCCTTC CGTGCCTTCC TGAAGACAGA GTTCAGCGAG 
GAGAACCTGG AGTTCTGGCT GGCCTGTGAG GAGTTCAAGA AGACCAGGTC GACTGCAAAG 
CTAGTCACCA AGGCCCACAG GATCTTTGAG GAGTTTGTGG ATGTGCAGGC TCCACGGGAG 
GTGAATATCG ATTTCCAGAC CCGAGAGGCC ACGAGGAAGA ACATGCAGGA GCCGTCCCTG 
ACTTGTTTTG ATCAAGCCCA GGGAAAAGTC CACAGCCTCA TGGAGAAAGA CTCTTATCCT 
AGGTTCCTGA GGTCCAAAAT GTACTTAGAT CTGCTGTCCC AAAGCCAGAG GAGGCTCAGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rgs8 ( XM_006250016.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006250078.1 Rattus norvegicus regulator of G-protein signaling 8 (Rgs8), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa04496
Clone ID Related Accession (Same CDS sequence)	XM_006250016.3 , NM_019344.2
Accession Version	XM_006250016.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	regulator of G-protein signaling 8 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006250016.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCCT TACTGATGCC ACGCAGGAAC AAAGGCATGA GGACTCGACT GGGATGCCTG 
TCGCACAAAT CAGACTCCTG TAGTGACTTC ACAGCCATCC TTCCTGACAA ACCCAACCGC 
GCTCTCAAGA GACTCTCCAC AGAAGAAGCG ACGAGGTGGG CAGATTCCTT TGATGTGCTT 
CTCTCTCACA AGTATGGGGT GGCAGCCTTC CGTGCCTTCC TGAAGACAGA GTTCAGCGAG 
GAGAACCTGG AGTTCTGGCT GGCCTGTGAG GAGTTCAAGA AGACCAGGTC GACTGCAAAG 
CTAGTCACCA AGGCCCACAG GATCTTTGAG GAGTTTGTGG ATGTGCAGGC TCCACGGGAG 
GTGAATATCG ATTTCCAGAC CCGAGAGGCC ACGAGGAAGA ACATGCAGGA GCCGTCCCTG 
ACTTGTTTTG ATCAAGCCCA GGGAAAAGTC CACAGCCTCA TGGAGAAAGA CTCTTATCCT 
AGGTTCCTGA GGTCCAAAAT GTACTTAGAT CTGCTGTCCC AAAGCCAGAG GAGGCTCAGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006250078.1
CDS	339..881
Translation	MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS

Target ORF information:

RefSeq Version	XM_006250016.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus regulator of G-protein signaling 8 (Rgs8), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006250016.3

ORF Insert Sequence:

ATGGCTGCCT TACTGATGCC ACGCAGGAAC AAAGGCATGA GGACTCGACT GGGATGCCTG 
TCGCACAAAT CAGACTCCTG TAGTGACTTC ACAGCCATCC TTCCTGACAA ACCCAACCGC 
GCTCTCAAGA GACTCTCCAC AGAAGAAGCG ACGAGGTGGG CAGATTCCTT TGATGTGCTT 
CTCTCTCACA AGTATGGGGT GGCAGCCTTC CGTGCCTTCC TGAAGACAGA GTTCAGCGAG 
GAGAACCTGG AGTTCTGGCT GGCCTGTGAG GAGTTCAAGA AGACCAGGTC GACTGCAAAG 
CTAGTCACCA AGGCCCACAG GATCTTTGAG GAGTTTGTGG ATGTGCAGGC TCCACGGGAG 
GTGAATATCG ATTTCCAGAC CCGAGAGGCC ACGAGGAAGA ACATGCAGGA GCCGTCCCTG 
ACTTGTTTTG ATCAAGCCCA GGGAAAAGTC CACAGCCTCA TGGAGAAAGA CTCTTATCCT 
AGGTTCCTGA GGTCCAAAAT GTACTTAGAT CTGCTGTCCC AAAGCCAGAG GAGGCTCAGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rgs8 ( XM_006250015.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006250077.1 Rattus norvegicus regulator of G-protein signaling 8 (Rgs8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa35459
Clone ID Related Accession (Same CDS sequence)	XM_006250015.3
Accession Version	XM_006250015.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	regulator of G-protein signaling 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006250015.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTACCAGG AGAGGGCTGA CTCTGTCACT CAGGGCTTCA CCGAGCCATG CACAGCGGTT 
GTCGACACCA GCCACATCTT TCCAGCTGCG CTGCCCACCA CCAGACAGAG CTCCTTAACC 
AGAAGCATCT CTGACCATCC ACTTGGCAAA AACCTGCAGG CCATGAGGAC CGGCCAACAA 
CAGAACAAAG GCATGAGGAC TCGACTGGGA TGCCTGTCGC ACAAATCAGA CTCCTGTAGT 
GACTTCACAG CCATCCTTCC TGACAAACCC AACCGCGCTC TCAAGAGACT CTCCACAGAA 
GAAGCGACGA GGTGGGCAGA TTCCTTTGAT GTGCTTCTCT CTCACAAGTA TGGGGTGGCA 
GCCTTCCGTG CCTTCCTGAA GACAGAGTTC AGCGAGGAGA ACCTGGAGTT CTGGCTGGCC 
TGTGAGGAGT TCAAGAAGAC CAGGTCGACT GCAAAGCTAG TCACCAAGGC CCACAGGATC 
TTTGAGGAGT TTGTGGATGT GCAGGCTCCA CGGGAGGTGA ATATCGATTT CCAGACCCGA 
GAGGCCACGA GGAAGAACAT GCAGGAGCCG TCCCTGACTT GTTTTGATCA AGCCCAGGGA 
AAAGTCCACA GCCTCATGGA GAAAGACTCT TATCCTAGGT TCCTGAGGTC CAAAATGTAC 
TTAGATCTGC TGTCCCAAAG CCAGAGGAGG CTCAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006250077.1
CDS	178..876
Translation	MYQERADSVTQGFTEPCTAVVDTSHIFPAALPTTRQSSLTRSISDHPLGKNLQAMRTGQQQNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS

Target ORF information:

RefSeq Version	XM_006250015.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus regulator of G-protein signaling 8 (Rgs8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006250015.3

ORF Insert Sequence:

ATGTACCAGG AGAGGGCTGA CTCTGTCACT CAGGGCTTCA CCGAGCCATG CACAGCGGTT 
GTCGACACCA GCCACATCTT TCCAGCTGCG CTGCCCACCA CCAGACAGAG CTCCTTAACC 
AGAAGCATCT CTGACCATCC ACTTGGCAAA AACCTGCAGG CCATGAGGAC CGGCCAACAA 
CAGAACAAAG GCATGAGGAC TCGACTGGGA TGCCTGTCGC ACAAATCAGA CTCCTGTAGT 
GACTTCACAG CCATCCTTCC TGACAAACCC AACCGCGCTC TCAAGAGACT CTCCACAGAA 
GAAGCGACGA GGTGGGCAGA TTCCTTTGAT GTGCTTCTCT CTCACAAGTA TGGGGTGGCA 
GCCTTCCGTG CCTTCCTGAA GACAGAGTTC AGCGAGGAGA ACCTGGAGTT CTGGCTGGCC 
TGTGAGGAGT TCAAGAAGAC CAGGTCGACT GCAAAGCTAG TCACCAAGGC CCACAGGATC 
TTTGAGGAGT TTGTGGATGT GCAGGCTCCA CGGGAGGTGA ATATCGATTT CCAGACCCGA 
GAGGCCACGA GGAAGAACAT GCAGGAGCCG TCCCTGACTT GTTTTGATCA AGCCCAGGGA 
AAAGTCCACA GCCTCATGGA GAAAGACTCT TATCCTAGGT TCCTGAGGTC CAAAATGTAC 
TTAGATCTGC TGTCCCAAAG CCAGAGGAGG CTCAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.
Neuroscience307253-61(2015 Oct)
Sun H,Calipari ES,Beveridge TJ,Jones SR,Chen R

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proceedings of the National Academy of Sciences of the United States of America105(17)6457-62(2008 Apr)
Soundararajan M,Willard FS,Kimple AJ,Turnbull AP,Ball LJ,Schoch GA,Gileadi C,Fedorov OY,Dowler EF,Higman VA,Hutsell SQ,Sundstr?m M,Doyle DA,Siderovski DP

RGS8 expression in developing cerebellar Purkinje cells.
Biochemical and biophysical research communications309(4)836-42(2003 Oct)
Saitoh O,Odagiri M

Distribution of regulator of G protein signaling 8 (RGS8) protein in the cerebellum.
Cerebellum (London, England)2(2)154-60(2003)
Saitoh O,Masuho I,Itoh M,Abe H,Komori K,Odagiri M

Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures.
Journal of neurochemistry82(4)828-38(2002 Aug)
Gold SJ,Heifets BD,Pudiak CM,Potts BW,Nestler EJ

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Rgs8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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