Rgs5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rgs5
Entrez Gene ID	54294
Full Name	regulator of G-protein signaling 5
General protein information	Preferred Names regulator of G-protein signaling 5 Names regulator of G-protein signaling 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q24
Summary	inhibits G-protein coupled receptor signaling by activating Galpha subunit GTP hydrolysis; inhibits angiotensin AT1a receptor signaling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019341.1	NP_062214.1	regulator of G-protein signaling 5

Pathways from BioSystems

Homologies

Homo sapiens (human)	RGS5	NP_003608.1
Xenopus tropicalis (tropical clawed frog)	rgs5	NP_001072762.1
Pan troglodytes (chimpanzee)	RGS5	XP_001174440.1
	RGS5	XP_001082591.1
Danio rerio (zebrafish)	rgs5a	NP_956256.1
Bos taurus (cattle)	RGS5	NP_001029879.1
Rattus norvegicus (Norway rat)	Rgs5	NP_062214.1
Canis lupus familiaris (dog)	RGS5	XP_545784.2
Mus musculus (house mouse)	Rgs5	NP_033089.2
Gallus gallus (chicken)	RGS5	XP_001233314.1

Gene Ontology
Bibliography

Related articles in PubMed

Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries: Impaired Trafficking of RGS5 in Hypertension.
Hong K, Li M, Nourian Z, Meininger GA, Hill MA
Hypertension (Dallas, Tex. : 1979)70(6)1264-1272(2017 12)

Regulation of RGS5 GAP activity by GPSM3.
Zhao P, Chidiac P
Molecular and cellular biochemistry405(1-2)33-40(2015 Jul)

Dlx1 and Rgs5 in the ductus arteriosus: vessel-specific genes identified by transcriptional profiling of laser-capture microdissected endothelial and smooth muscle cells.
B?kenkamp R, van Brempt R, van Munsteren JC, van den Wijngaert I, de Hoogt R, Finos L, Goeman J, Groot AC, Poelmann RE, Blom NA, DeRuiter MC
PloS one9(1)e86892(2014)

Antihypertensive effects of peroxisome proliferator-activated receptor-? activation in spontaneously hypertensive rats.
Zarzuelo MJ, Jim?nez R, Galindo P, S?nchez M, Nieto A, Romero M, Quintela AM, L?pez-Sep?lveda R, G?mez-Guzm?n M, Bail?n E, Rodr?guez-G?mez I, Zarzuelo A, G?lvez J, Tamargo J, P?rez-Vizca?no F, Duarte J
Hypertension (Dallas, Tex. : 1979)58(4)733-43(2011 Oct)

PDGF-dependent regulation of regulator of G protein signaling-5 expression and vascular smooth muscle cell functionality.
Gunaje JJ, Bahrami AJ, Schwartz SM, Daum G, Mahoney WM Jr
American journal of physiology. Cell physiology301(2)C478-89(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AT1R activation results in translocation of RGS5 toward the plasma membrane, limiting AT1R-mediated vasoconstriction through its role in Gq/11 protein-dependent signaling.
Title: Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries: Impaired Trafficking of RGS5 in Hypertension.

The enhancement of RGS5 activity by GPSM3 is maintained under these conditions.
Title: Regulation of RGS5 GAP activity by GPSM3.

Rgs5 and Dlx1 represent novel molecular targets for the regulation of ductus arteriosus maturation and closure.
Title: Dlx1 and Rgs5 in the ductus arteriosus: vessel-specific genes identified by transcriptional profiling of laser-capture microdissected endothelial and smooth muscle cells.

Results demonstrate that RGS5 expression is a critical mediator of both vascular smooth muscle contraction and potentially, arterial remodeling.
Title: PDGF-dependent regulation of regulator of G protein signaling-5 expression and vascular smooth muscle cell functionality.

RGS5 and VEGF coexpressed in the area of choroidal neovascularization, and RGS5 expressed later than VEGF.
Title: [Role and possible mechanism of regulators of G-protein signaling 5 in development of experimental choroidal neovascularization].

The following Rgs5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rgs5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04483	NM_019341.1 Latest version!	Rattus norvegicus regulator of G-protein signaling 5 (Rgs5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rgs5 ( NM_019341.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062214.1 Rattus norvegicus regulator of G-protein signaling 5 (Rgs5), mRNA.

Price & Availability↑

CloneID	ORa04483
Clone ID Related Accession (Same CDS sequence)	NM_019341.1
Accession Version	NM_019341.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	regulator of G-protein signaling 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF241259.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF241259.1, EF568934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTGTAAGG GACTGGCAGC TCTGCCACAC TCATGCCTGG AAAGGGCCAA AGAGATCAAG 
ATCAAATTGG GTATTCTTCT CCAGAAGCCA GACTCTGCTG TTGACCTTGT CATTCCATAT 
AATGAGAAGC CAGAGAAGCC TGCCAAGGCG CACAAGCCCT CGCTGGAGGA GGTCCTGCAA 
TGGCGCCAAT CCCTGGACAA ACTTCTCCAG AGCAACTACG GATTTGCCAG CTTCAAAAGT 
TTCCTGAAGT CTGAATTCAG TGAGGAAAAC CTTGAGTTCT GGGTTGCCTG TGAGAATTAC 
AAGAAGATCA AGTCCCCCAT CAAAATGGCA GAGAAGGCAA AGCAAATCTA TGAAGAATTC 
ATCCAGACAG AGGCCCCTAA AGAGGTGAAC ATTGACCACT TCACTAAAGA CATCACCATG 
AAGAACCTGG TGGAACCTTC CCCTCACAGC TTTGACCTGG CCCAGAAAAG GATCTACGCC 
CTGATGGAGA AGGATTCTCT GCCCCGCTTC GTGCGCTCTG AGTTTTATAA GGAGTTAATC 
AACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062214.1
CDS	1..546
Translation	MCKGLAALPHSCLERAKEIKIKLGILLQKPDSAVDLVIPYNEKPEKPAKAHKPSLEEVLQWRQSLDKLLQSNYGFASFKSFLKSEFSEENLEFWVACENYKKIKSPIKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSPHSFDLAQKRIYALMEKDSLPRFVRSEFYKELIN

Target ORF information:

RefSeq Version	NM_019341.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus regulator of G-protein signaling 5 (Rgs5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019341.1

ORF Insert Sequence:

ATGTGTAAGG GACTGGCAGC TCTGCCACAC TCATGCCTGG AAAGGGCCAA AGAGATCAAG 
ATCAAATTGG GTATTCTTCT CCAGAAGCCA GACTCTGCTG TTGACCTTGT CATTCCATAT 
AATGAGAAGC CAGAGAAGCC TGCCAAGGCG CACAAGCCCT CGCTGGAGGA GGTCCTGCAA 
TGGCGCCAAT CCCTGGACAA ACTTCTCCAG AGCAACTACG GATTTGCCAG CTTCAAAAGT 
TTCCTGAAGT CTGAATTCAG TGAGGAAAAC CTTGAGTTCT GGGTTGCCTG TGAGAATTAC 
AAGAAGATCA AGTCCCCCAT CAAAATGGCA GAGAAGGCAA AGCAAATCTA TGAAGAATTC 
ATCCAGACAG AGGCCCCTAA AGAGGTGAAC ATTGACCACT TCACTAAAGA CATCACCATG 
AAGAACCTGG TGGAACCTTC CCCTCACAGC TTTGACCTGG CCCAGAAAAG GATCTACGCC 
CTGATGGAGA AGGATTCTCT GCCCCGCTTC GTGCGCTCTG AGTTTTATAA GGAGTTAATC 
AACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries: Impaired Trafficking of RGS5 in Hypertension.
Hypertension (Dallas, Tex. : 1979)70(6)1264-1272(2017 12)
Hong K,Li M,Nourian Z,Meininger GA,Hill MA

Regulation of RGS5 GAP activity by GPSM3.
Molecular and cellular biochemistry405(1-2)33-40(2015 Jul)
Zhao P,Chidiac P

Dlx1 and Rgs5 in the ductus arteriosus: vessel-specific genes identified by transcriptional profiling of laser-capture microdissected endothelial and smooth muscle cells.
PloS one9(1)e86892(2014)
B?kenkamp R,van Brempt R,van Munsteren JC,van den Wijngaert I,de Hoogt R,Finos L,Goeman J,Groot AC,Poelmann RE,Blom NA,DeRuiter MC

Antihypertensive effects of peroxisome proliferator-activated receptor-? activation in spontaneously hypertensive rats.
Hypertension (Dallas, Tex. : 1979)58(4)733-43(2011 Oct)
Zarzuelo MJ,Jim?nez R,Galindo P,S?nchez M,Nieto A,Romero M,Quintela AM,L?pez-Sep?lveda R,G?mez-Guzm?n M,Bail?n E,Rodr?guez-G?mez I,Zarzuelo A,G?lvez J,Tamargo J,P?rez-Vizca?no F,Duarte J

PDGF-dependent regulation of regulator of G protein signaling-5 expression and vascular smooth muscle cell functionality.
American journal of physiology. Cell physiology301(2)C478-89(2011 Aug)
Gunaje JJ,Bahrami AJ,Schwartz SM,Daum G,Mahoney WM Jr

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Rgs5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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