Cr1l cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cr1l
Entrez Gene ID	54243
Full Name	complement C3b/C4b receptor 1 like
Synonyms	Cr1,Crry
General protein information	Preferred Names complement C3b/C4b receptor 1 like Names complement component receptor 1-like protein 5I2 antigen Complement receptor related protein antigen 5I2 complement component (3b/4b) receptor 1-like complement receptor type 1 complement regulatory protein Crry complement regulatory protein Crry-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q27
Summary	This gene encodes a membrane-bound inhibitor of complement activation, which contains several tandemly arranged short consensus repeats (SCRs) of approximately 60 amino acids. The encoded protein may play a role in tumor immune surveillance, which is unrelated to complement inhibition. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019301.2	NP_062174.1	complement component receptor 1-like protein isoform 2 precursor
NM_001005330.1	NP_001005330.1	complement component receptor 1-like protein isoform 1 precursor
NM_001005265.1	NP_001005265.1	complement component receptor 1-like protein isoform 3 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CR1L	NP_783641.1
Mus musculus (house mouse)	Cr1l	NP_038527.2
Rattus norvegicus (Norway rat)	Cr1l	NP_001005330.1
Pan troglodytes (chimpanzee)	CR1L	XP_003308767.1

Gene Ontology
Bibliography

Related articles in PubMed

Circulating AIM prevents hepatocellular carcinoma through complement activation.
Maehara N, Arai S, Mori M, Iwamura Y, Kurokawa J, Kai T, Kusunoki S, Taniguchi K, Ikeda K, Ohara O, Yamamura K, Miyazaki T
Cell reports9(1)61-74(2014 Oct)

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li SS, Teasdale RD, Collins BM
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)

Structures of the rat complement regulator CrrY.
Roversi P, Johnson S, Caesar JJ, McLean F, Leath KJ, Tsiftsoglou SA, Morgan BP, Harris CL, Sim RB, Lea SM
Acta crystallographica. Section F, Structural biology and crystallization communications67(Pt 7)739-43(2011 Jul)

Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury.
Ruseva MM, Hughes TR, Donev RM, Sivasankar B, Pickering MC, Wu X, Harris CL, Morgan BP
Molecular immunology46(5)803-11(2009 Feb)

The role of rat Crry, a complement regulatory protein, in proliferation of thymocytes.
Antic Stankovic J, Vucevic D, Majstorovic I, Vasilijic S, Colic M
Life sciences75(25)3053-62(2004 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

structure of rat CrrY domains 1-4 has been determined in two distinct crystal forms and reveals a 70 degrees bend between domains 3 and 4
Title: Structures of the rat complement regulator CrrY.

Crry is involved in the LFA-1 dependent proliferation of thymocytes, a phenomenon that has not been recognized so far.
Title: The role of rat Crry, a complement regulatory protein, in proliferation of thymocytes.

X-ray and neutron scattering was performed on recombinant rat Crry containing the first five SCR domains (rCrry) and mouse Crry with five SCR domains conjugated to the Fc fragment of mouse IgG1 (mCrry-Ig)
Title: The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.

Rat Crry on the surface of human tumor cell lines inhibited rat NK-cell-mediated ADCC. Anti-Crry enhanced NK-mediated ADCC in the absence of complement, suggesting a novel function for rat Crry in immune surveillance unrelated to complement inhibition.
Title: Expression of rat complement control protein Crry on tumor cells inhibits rat natural killer cell-mediated cytotoxicity.

The following Cr1l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cr1l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa10410	NM_001005265.1 Latest version!	Rattus norvegicus complement C3b/C4b receptor 1 like (Cr1l), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa04335	NM_019301.2 Latest version!	Rattus norvegicus complement C3b/C4b receptor 1 like (Cr1l), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
ORa10411	NM_001005330.1 Latest version!	Rattus norvegicus complement C3b/C4b receptor 1 like (Cr1l), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cr1l ( NM_001005265.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001005265.1 Rattus norvegicus complement C3b/C4b receptor 1 like (Cr1l), transcript variant 3, mRNA.

Price & Availability↑

CloneID	ORa10410
Clone ID Related Accession (Same CDS sequence)	NM_001005265.1
Accession Version	NM_001005265.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1494bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	complement component receptor 1-like protein isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB775511.1, CB707374.1 and D42114.1. On Jun 25, 2006 this sequence version replaced XM_001070455.1. Transcript Variant: This variant (3) lacks an in-frame segment including two identical exons, as compared to variant 1. The encoded isoform 3 thus lacks an internal segment, which includes two short consensus repeats, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D42114.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCTT CTTCGCCTCT GGACCCCGTG GGGCGCCTTG TAGCCTTCTG CCGCGGAGGA 
GTGCATCTGG CCGTCCTGCT GCTGTTCTTG TCGCCATCTA CTTTGGGCCA GTGCCCAGCC 
CCACCACTGT TTCCTTATGC CAAACCTATA AATCCAACTG ATGAATCCAC GTTTCCCGTT 
GGAACATCTT TGAAGTATGA ATGTCGTCCA GGATATATCA AGAGGCAGTT CTCTATCACC 
TGCGAAGTAA ACTCAGTGTG GACAAGTCCT CAAGACGTGT GTATACGTAA ACAATGTGAA 
ACTCCTTTAG ATCCTCAGAA TGGCATAGTA CATGTAAACA CAGACATCCG GTTTGGATCC 
TCTATCACTT ATACCTGTAA TGAAGGATAC CGCCTCATTG GTTCCTCCTC TGCTATGTGC 
ATAATCTCTG ATCAGAGCGT TGCCTGGGAT GCCGAGGCAC CTATTTGTGA ATCAATTCCT 
TGTGAGATAC CCCCAAGCAT TCCCAATGGA GATTTCTTCA GTCCTAACAG AGAAGATTTT 
CATTATGGAA TGGTAGTTAC CTACCAGTGC AACACTGATG CGAGAGGGAA GAAGCTCTTT 
AACCTGGTGG GTGAGCCCTC CATACACTGT ACCAGCATCG ATGGTCAAGT TGGAGTCTGG 
AGTGGCCCTC CTCCTCAGTG CATTGAACTC AACAAATGTA CTCCTCCCCA TGTTGAAAAT 
GCAGTCATAG TGTCTAAAAA CAAAAGCTTG TTTTCCTTAA GGGATATGGT GGAGTTTAGA 
TGTCAGGATG GCTTTATGAT GAAAGGAGAC AGCAGTGTGT ATTGTCGATC CCTAAACAGA 
TGGGAGCCTC AGTTACCAAG CTGCTTCAAG GTGAAATCCT GTGGTGCTTT CCTGGGTGAG 
CTTCCTAATG GGCATGTATT CGTTCCACAA AATCTTCAAC TCGGGGCCAA AGTGACCTTT 
GTTTGTAATA CAGGGTATCA ATTAAAAGGC AATTCTTCTA GTCATTGTGT TCTTGATGGA 
GTGGAAAGCA TTTGGAATAG CAGCGTTCCT GTGTGTGAAC AAGTGATATG TAAACTCCCT 
CAGGATATGA GTGGATTCCA GAAAGGGTTG CAAATGAAAA AAGATTATTA CTATGGAGAT 
AATGTAGCCT TGGAATGTGA GGATGGGTAT ACTCTAGAAG GCAGTTCTCA GAGCCAGTGC 
CAGTCCGATG CCAGCTGGGA TCCTCCTCTG CCCAAATGTG TCTCTCGCTC AAACAGTGGT 
CTAATAGCTG GAATTTTCAT TGGGATAATC GTCCTTATTT TATTCATCAT TTTTTCCTAC 
TGGATGATTA TGAAGTTTAA AAAACGCAAT TCCACCAATG AAAAGTGTAA AGAAGTGGGT 
ATCTATTTAA ATTCTAAAGA AGACAGCTGT GTTCAGCCTC AGTCTCTGCT CACAAGTCAG 
GAGAACAACA GTACCAGTAG CCCAGCACGG AATTCACTCA CTCAAGAAGT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005265.1
CDS	256..1749
Translation	MEASSPLDPVGRLVAFCRGGVHLAVLLLFLSPSTLGQCPAPPLFPYAKPINPTDESTFPVGTSLKYECRPGYIKRQFSITCEVNSVWTSPQDVCIRKQCETPLDPQNGIVHVNTDIRFGSSITYTCNEGYRLIGSSSAMCIISDQSVAWDAEAPICESIPCEIPPSIPNGDFFSPNREDFHYGMVVTYQCNTDARGKKLFNLVGEPSIHCTSIDGQVGVWSGPPPQCIELNKCTPPHVENAVIVSKNKSLFSLRDMVEFRCQDGFMMKGDSSVYCRSLNRWEPQLPSCFKVKSCGAFLGELPNGHVFVPQNLQLGAKVTFVCNTGYQLKGNSSSHCVLDGVESIWNSSVPVCEQVICKLPQDMSGFQKGLQMKKDYYYGDNVALECEDGYTLEGSSQSQCQSDASWDPPLPKCVSRSNSGLIAGIFIGIIVLILFIIFSYWMIMKFKKRNSTNEKCKEVGIYLNSKEDSCVQPQSLLTSQENNSTSSPARNSLTQEV

Target ORF information:

RefSeq Version	NM_001005265.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus complement C3b/C4b receptor 1 like (Cr1l), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005265.1

ORF Insert Sequence:

ATGGAGGCTT CTTCGCCTCT GGACCCCGTG GGGCGCCTTG TAGCCTTCTG CCGCGGAGGA 
GTGCATCTGG CCGTCCTGCT GCTGTTCTTG TCGCCATCTA CTTTGGGCCA GTGCCCAGCC 
CCACCACTGT TTCCTTATGC CAAACCTATA AATCCAACTG ATGAATCCAC GTTTCCCGTT 
GGAACATCTT TGAAGTATGA ATGTCGTCCA GGATATATCA AGAGGCAGTT CTCTATCACC 
TGCGAAGTAA ACTCAGTGTG GACAAGTCCT CAAGACGTGT GTATACGTAA ACAATGTGAA 
ACTCCTTTAG ATCCTCAGAA TGGCATAGTA CATGTAAACA CAGACATCCG GTTTGGATCC 
TCTATCACTT ATACCTGTAA TGAAGGATAC CGCCTCATTG GTTCCTCCTC TGCTATGTGC 
ATAATCTCTG ATCAGAGCGT TGCCTGGGAT GCCGAGGCAC CTATTTGTGA ATCAATTCCT 
TGTGAGATAC CCCCAAGCAT TCCCAATGGA GATTTCTTCA GTCCTAACAG AGAAGATTTT 
CATTATGGAA TGGTAGTTAC CTACCAGTGC AACACTGATG CGAGAGGGAA GAAGCTCTTT 
AACCTGGTGG GTGAGCCCTC CATACACTGT ACCAGCATCG ATGGTCAAGT TGGAGTCTGG 
AGTGGCCCTC CTCCTCAGTG CATTGAACTC AACAAATGTA CTCCTCCCCA TGTTGAAAAT 
GCAGTCATAG TGTCTAAAAA CAAAAGCTTG TTTTCCTTAA GGGATATGGT GGAGTTTAGA 
TGTCAGGATG GCTTTATGAT GAAAGGAGAC AGCAGTGTGT ATTGTCGATC CCTAAACAGA 
TGGGAGCCTC AGTTACCAAG CTGCTTCAAG GTGAAATCCT GTGGTGCTTT CCTGGGTGAG 
CTTCCTAATG GGCATGTATT CGTTCCACAA AATCTTCAAC TCGGGGCCAA AGTGACCTTT 
GTTTGTAATA CAGGGTATCA ATTAAAAGGC AATTCTTCTA GTCATTGTGT TCTTGATGGA 
GTGGAAAGCA TTTGGAATAG CAGCGTTCCT GTGTGTGAAC AAGTGATATG TAAACTCCCT 
CAGGATATGA GTGGATTCCA GAAAGGGTTG CAAATGAAAA AAGATTATTA CTATGGAGAT 
AATGTAGCCT TGGAATGTGA GGATGGGTAT ACTCTAGAAG GCAGTTCTCA GAGCCAGTGC 
CAGTCCGATG CCAGCTGGGA TCCTCCTCTG CCCAAATGTG TCTCTCGCTC AAACAGTGGT 
CTAATAGCTG GAATTTTCAT TGGGATAATC GTCCTTATTT TATTCATCAT TTTTTCCTAC 
TGGATGATTA TGAAGTTTAA AAAACGCAAT TCCACCAATG AAAAGTGTAA AGAAGTGGGT 
ATCTATTTAA ATTCTAAAGA AGACAGCTGT GTTCAGCCTC AGTCTCTGCT CACAAGTCAG 
GAGAACAACA GTACCAGTAG CCCAGCACGG AATTCACTCA CTCAAGAAGT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cr1l ( NM_019301.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062174.1 Rattus norvegicus complement C3b/C4b receptor 1 like (Cr1l), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa04335
Clone ID Related Accession (Same CDS sequence)	NM_019301.2
Accession Version	NM_019301.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1680bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	complement component receptor 1-like protein isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB775511.1, CB707374.1, L36532.1 and D42114.1. On Oct 4, 2004 this sequence version replaced NM_019301.1. Transcript Variant: This variant (2) lacks an in-frame exon, which is one of the three identical exons, as compared to variant 1. The encoded isoform 2 thus lacks an internal segment, or a short consensus repeat, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061736.1, L36532.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCTT CTTCGCCTCT GGACCCCGTG GGGCGCCTTG TAGCCTTCTG CCGCGGAGGA 
GTGCATCTGG CCGTCCTGCT GCTGTTCTTG TCGCCATCTA CTTTGGGCCA GTGCCCAGCC 
CCACCACTGT TTCCTTATGC CAAACCTATA AATCCAACTG ATGAATCCAC GTTTCCCGTT 
GGAACATCTT TGAAGTATGA ATGTCGTCCA GGATATATCA AGAGGCAGTT CTCTATCACC 
TGCGAAGTAA ACTCAGTGTG GACAAGTCCT CAAGACGTGT GTATACGTAA ACAATGTGAA 
ACTCCTTTAG ATCCTCAGAA TGGCATAGTA CATGTAAACA CAGACATCCG GTTTGGATCC 
TCTATCACTT ATACCTGTAA TGAAGGATAC CGCCTCATTG GTTCCTCCTC TGCTATGTGC 
ATAATCTCTG ATCAGAGCGT TGCCTGGGAT GCCGAGGCAC CTATTTGTGA ATCAATTCCT 
TGTGAGATAC CCCCAAGCAT TCCCAATGGA GATTTCTTCA GTCCTAACAG AGAAGATTTT 
CATTATGGAA TGGTAGTTAC CTACCAGTGC AACACTGATG CGAGAGGGAA GAAGCTCTTT 
AACCTGGTGG GTGAGCCCTC CATACACTGT ACCAGCATCG ATGGTCAAGT TGGAGTCTGG 
AGTGGCCCTC CTCCTCAGTG CATTGAACTC AACAAATGTA CTCCTCCCCA TGTTGAAAAT 
GCAGTCATAG TGTCTAAAAA CAAAAGCTTG TTTTCCTTAA GGGATATGGT GGAGTTTAGA 
TGTCAGGATG GCTTTATGAT GAAAGGAGAC AGCAGTGTGT ATTGTCGATC CCTAAACAGA 
TGGGAGCCTC AGTTACCAAG CTGCTTCAAG GTGAAATCCT GTGGTGCTTT CCTGGGTGAG 
CTTCCTAATG GGCATGTATT CGTTCCACAA AATCTTCAAC TCGGGGCCAA AGTGACCTTT 
GTTTGTAATA CAGGGTATCA ATTAAAAGGC AATTCTTCTA GTCATTGTGT TCTTGATGGA 
GTGGAAAGCA TTTGGAATAG CAGCGTTCCT GTGTGTGAAC AAGTGATATG TAAACTCCCT 
CAGGATATGA GTGGATTCCA GAAAGGGTTG CAAATGAAAA AAGATTATTA CTATGGAGAT 
AATGTAGCCT TGGAATGTGA GGATGGGTAT ACTCTAGAAG GCAGTTCTCA GAGCCAGTGC 
CAGTCCGATG CCAGCTGGGA TCCTCCTCTG CCCAAATGTG TCTCTCAAGT GATATGTAAA 
CTCCCTCAGG ATATGAGTGG ATTCCAGAAA GGGTTGCAAA TGAAAAAAGA TTATTACTAT 
GGAGATAATG TAGCCTTGGA ATGTGAGGAT GGGTATACTC TAGAAGGCAG TTCTCAGAGC 
CAGTGCCAGT CCGATGCCAG CTGGGATCCT CCTCTGCCCA AATGTGTCTC TCGCTCAAAC 
AGTGGTCTAA TAGCTGGAAT TTTCATTGGG ATAATCGTCC TTATTTTATT CATCATTTTT 
TCCTACTGGA TGATTATGAA GTTTAAAAAA CGCAATTCCA CCAATGAAAA GTGTAAAGAA 
GTGGGTATCT ATTTAAATTC TAAAGAAGAC AGCTGTGTTC AGCCTCAGTC TCTGCTCACA 
AGTCAGGAGA ACAACAGTAC CAGTAGCCCA GCACGGAATT CACTCACTCA AGAAGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062174.1
CDS	256..1935
Translation	MEASSPLDPVGRLVAFCRGGVHLAVLLLFLSPSTLGQCPAPPLFPYAKPINPTDESTFPVGTSLKYECRPGYIKRQFSITCEVNSVWTSPQDVCIRKQCETPLDPQNGIVHVNTDIRFGSSITYTCNEGYRLIGSSSAMCIISDQSVAWDAEAPICESIPCEIPPSIPNGDFFSPNREDFHYGMVVTYQCNTDARGKKLFNLVGEPSIHCTSIDGQVGVWSGPPPQCIELNKCTPPHVENAVIVSKNKSLFSLRDMVEFRCQDGFMMKGDSSVYCRSLNRWEPQLPSCFKVKSCGAFLGELPNGHVFVPQNLQLGAKVTFVCNTGYQLKGNSSSHCVLDGVESIWNSSVPVCEQVICKLPQDMSGFQKGLQMKKDYYYGDNVALECEDGYTLEGSSQSQCQSDASWDPPLPKCVSQVICKLPQDMSGFQKGLQMKKDYYYGDNVALECEDGYTLEGSSQSQCQSDASWDPPLPKCVSRSNSGLIAGIFIGIIVLILFIIFSYWMIMKFKKRNSTNEKCKEVGIYLNSKEDSCVQPQSLLTSQENNSTSSPARNSLTQEV

Target ORF information:

RefSeq Version	NM_019301.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus complement C3b/C4b receptor 1 like (Cr1l), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019301.2

ORF Insert Sequence:

ATGGAGGCTT CTTCGCCTCT GGACCCCGTG GGGCGCCTTG TAGCCTTCTG CCGCGGAGGA 
GTGCATCTGG CCGTCCTGCT GCTGTTCTTG TCGCCATCTA CTTTGGGCCA GTGCCCAGCC 
CCACCACTGT TTCCTTATGC CAAACCTATA AATCCAACTG ATGAATCCAC GTTTCCCGTT 
GGAACATCTT TGAAGTATGA ATGTCGTCCA GGATATATCA AGAGGCAGTT CTCTATCACC 
TGCGAAGTAA ACTCAGTGTG GACAAGTCCT CAAGACGTGT GTATACGTAA ACAATGTGAA 
ACTCCTTTAG ATCCTCAGAA TGGCATAGTA CATGTAAACA CAGACATCCG GTTTGGATCC 
TCTATCACTT ATACCTGTAA TGAAGGATAC CGCCTCATTG GTTCCTCCTC TGCTATGTGC 
ATAATCTCTG ATCAGAGCGT TGCCTGGGAT GCCGAGGCAC CTATTTGTGA ATCAATTCCT 
TGTGAGATAC CCCCAAGCAT TCCCAATGGA GATTTCTTCA GTCCTAACAG AGAAGATTTT 
CATTATGGAA TGGTAGTTAC CTACCAGTGC AACACTGATG CGAGAGGGAA GAAGCTCTTT 
AACCTGGTGG GTGAGCCCTC CATACACTGT ACCAGCATCG ATGGTCAAGT TGGAGTCTGG 
AGTGGCCCTC CTCCTCAGTG CATTGAACTC AACAAATGTA CTCCTCCCCA TGTTGAAAAT 
GCAGTCATAG TGTCTAAAAA CAAAAGCTTG TTTTCCTTAA GGGATATGGT GGAGTTTAGA 
TGTCAGGATG GCTTTATGAT GAAAGGAGAC AGCAGTGTGT ATTGTCGATC CCTAAACAGA 
TGGGAGCCTC AGTTACCAAG CTGCTTCAAG GTGAAATCCT GTGGTGCTTT CCTGGGTGAG 
CTTCCTAATG GGCATGTATT CGTTCCACAA AATCTTCAAC TCGGGGCCAA AGTGACCTTT 
GTTTGTAATA CAGGGTATCA ATTAAAAGGC AATTCTTCTA GTCATTGTGT TCTTGATGGA 
GTGGAAAGCA TTTGGAATAG CAGCGTTCCT GTGTGTGAAC AAGTGATATG TAAACTCCCT 
CAGGATATGA GTGGATTCCA GAAAGGGTTG CAAATGAAAA AAGATTATTA CTATGGAGAT 
AATGTAGCCT TGGAATGTGA GGATGGGTAT ACTCTAGAAG GCAGTTCTCA GAGCCAGTGC 
CAGTCCGATG CCAGCTGGGA TCCTCCTCTG CCCAAATGTG TCTCTCAAGT GATATGTAAA 
CTCCCTCAGG ATATGAGTGG ATTCCAGAAA GGGTTGCAAA TGAAAAAAGA TTATTACTAT 
GGAGATAATG TAGCCTTGGA ATGTGAGGAT GGGTATACTC TAGAAGGCAG TTCTCAGAGC 
CAGTGCCAGT CCGATGCCAG CTGGGATCCT CCTCTGCCCA AATGTGTCTC TCGCTCAAAC 
AGTGGTCTAA TAGCTGGAAT TTTCATTGGG ATAATCGTCC TTATTTTATT CATCATTTTT 
TCCTACTGGA TGATTATGAA GTTTAAAAAA CGCAATTCCA CCAATGAAAA GTGTAAAGAA 
GTGGGTATCT ATTTAAATTC TAAAGAAGAC AGCTGTGTTC AGCCTCAGTC TCTGCTCACA 
AGTCAGGAGA ACAACAGTAC CAGTAGCCCA GCACGGAATT CACTCACTCA AGAAGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cr1l ( NM_001005330.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001005330.1 Rattus norvegicus complement C3b/C4b receptor 1 like (Cr1l), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa10411
Clone ID Related Accession (Same CDS sequence)	NM_001005330.1
Accession Version	NM_001005330.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1866bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	complement component receptor 1-like protein isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB775511.1, CB707374.1, L36532.1, D42116.1 and D42114.1. Transcript Variant: This variant (1) represents the longest transcript and contains three identical exons in the coding region. It encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN01906348 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCTT CTTCGCCTCT GGACCCCGTG GGGCGCCTTG TAGCCTTCTG CCGCGGAGGA 
GTGCATCTGG CCGTCCTGCT GCTGTTCTTG TCGCCATCTA CTTTGGGCCA GTGCCCAGCC 
CCACCACTGT TTCCTTATGC CAAACCTATA AATCCAACTG ATGAATCCAC GTTTCCCGTT 
GGAACATCTT TGAAGTATGA ATGTCGTCCA GGATATATCA AGAGGCAGTT CTCTATCACC 
TGCGAAGTAA ACTCAGTGTG GACAAGTCCT CAAGACGTGT GTATACGTAA ACAATGTGAA 
ACTCCTTTAG ATCCTCAGAA TGGCATAGTA CATGTAAACA CAGACATCCG GTTTGGATCC 
TCTATCACTT ATACCTGTAA TGAAGGATAC CGCCTCATTG GTTCCTCCTC TGCTATGTGC 
ATAATCTCTG ATCAGAGCGT TGCCTGGGAT GCCGAGGCAC CTATTTGTGA ATCAATTCCT 
TGTGAGATAC CCCCAAGCAT TCCCAATGGA GATTTCTTCA GTCCTAACAG AGAAGATTTT 
CATTATGGAA TGGTAGTTAC CTACCAGTGC AACACTGATG CGAGAGGGAA GAAGCTCTTT 
AACCTGGTGG GTGAGCCCTC CATACACTGT ACCAGCATCG ATGGTCAAGT TGGAGTCTGG 
AGTGGCCCTC CTCCTCAGTG CATTGAACTC AACAAATGTA CTCCTCCCCA TGTTGAAAAT 
GCAGTCATAG TGTCTAAAAA CAAAAGCTTG TTTTCCTTAA GGGATATGGT GGAGTTTAGA 
TGTCAGGATG GCTTTATGAT GAAAGGAGAC AGCAGTGTGT ATTGTCGATC CCTAAACAGA 
TGGGAGCCTC AGTTACCAAG CTGCTTCAAG GTGAAATCCT GTGGTGCTTT CCTGGGTGAG 
CTTCCTAATG GGCATGTATT CGTTCCACAA AATCTTCAAC TCGGGGCCAA AGTGACCTTT 
GTTTGTAATA CAGGGTATCA ATTAAAAGGC AATTCTTCTA GTCATTGTGT TCTTGATGGA 
GTGGAAAGCA TTTGGAATAG CAGCGTTCCT GTGTGTGAAC AAGTGATATG TAAACTCCCT 
CAGGATATGA GTGGATTCCA GAAAGGGTTG CAAATGAAAA AAGATTATTA CTATGGAGAT 
AATGTAGCCT TGGAATGTGA GGATGGGTAT ACTCTAGAAG GCAGTTCTCA GAGCCAGTGC 
CAGTCCGATG CCAGCTGGGA TCCTCCTCTG CCCAAATGTG TCTCTCAAGT GATATGTAAA 
CTCCCTCAGG ATATGAGTGG ATTCCAGAAA GGGTTGCAAA TGAAAAAAGA TTATTACTAT 
GGAGATAATG TAGCCTTGGA ATGTGAGGAT GGGTATACTC TAGAAGGCAG TTCTCAGAGC 
CAGTGCCAGT CCGATGCCAG CTGGGATCCT CCTCTGCCCA AATGTGTCTC TCAAGTGATA 
TGTAAACTCC CTCAGGATAT GAGTGGATTC CAGAAAGGGT TGCAAATGAA AAAAGATTAT 
TACTATGGAG ATAATGTAGC CTTGGAATGT GAGGATGGGT ATACTCTAGA AGGCAGTTCT 
CAGAGCCAGT GCCAGTCCGA TGCCAGCTGG GATCCTCCTC TGCCCAAATG TGTCTCTCGC 
TCAAACAGTG GTCTAATAGC TGGAATTTTC ATTGGGATAA TCGTCCTTAT TTTATTCATC 
ATTTTTTCCT ACTGGATGAT TATGAAGTTT AAAAAACGCA ATTCCACCAA TGAAAAGTGT 
AAAGAAGTGG GTATCTATTT AAATTCTAAA GAAGACAGCT GTGTTCAGCC TCAGTCTCTG 
CTCACAAGTC AGGAGAACAA CAGTACCAGT AGCCCAGCAC GGAATTCACT CACTCAAGAA 
GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005330.1
CDS	256..2121
Translation	MEASSPLDPVGRLVAFCRGGVHLAVLLLFLSPSTLGQCPAPPLFPYAKPINPTDESTFPVGTSLKYECRPGYIKRQFSITCEVNSVWTSPQDVCIRKQCETPLDPQNGIVHVNTDIRFGSSITYTCNEGYRLIGSSSAMCIISDQSVAWDAEAPICESIPCEIPPSIPNGDFFSPNREDFHYGMVVTYQCNTDARGKKLFNLVGEPSIHCTSIDGQVGVWSGPPPQCIELNKCTPPHVENAVIVSKNKSLFSLRDMVEFRCQDGFMMKGDSSVYCRSLNRWEPQLPSCFKVKSCGAFLGELPNGHVFVPQNLQLGAKVTFVCNTGYQLKGNSSSHCVLDGVESIWNSSVPVCEQVICKLPQDMSGFQKGLQMKKDYYYGDNVALECEDGYTLEGSSQSQCQSDASWDPPLPKCVSQVICKLPQDMSGFQKGLQMKKDYYYGDNVALECEDGYTLEGSSQSQCQSDASWDPPLPKCVSQVICKLPQDMSGFQKGLQMKKDYYYGDNVALECEDGYTLEGSSQSQCQSDASWDPPLPKCVSRSNSGLIAGIFIGIIVLILFIIFSYWMIMKFKKRNSTNEKCKEVGIYLNSKEDSCVQPQSLLTSQENNSTSSPARNSLTQEV

Target ORF information:

RefSeq Version	NM_001005330.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus complement C3b/C4b receptor 1 like (Cr1l), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005330.1

ORF Insert Sequence:

ATGGAGGCTT CTTCGCCTCT GGACCCCGTG GGGCGCCTTG TAGCCTTCTG CCGCGGAGGA 
GTGCATCTGG CCGTCCTGCT GCTGTTCTTG TCGCCATCTA CTTTGGGCCA GTGCCCAGCC 
CCACCACTGT TTCCTTATGC CAAACCTATA AATCCAACTG ATGAATCCAC GTTTCCCGTT 
GGAACATCTT TGAAGTATGA ATGTCGTCCA GGATATATCA AGAGGCAGTT CTCTATCACC 
TGCGAAGTAA ACTCAGTGTG GACAAGTCCT CAAGACGTGT GTATACGTAA ACAATGTGAA 
ACTCCTTTAG ATCCTCAGAA TGGCATAGTA CATGTAAACA CAGACATCCG GTTTGGATCC 
TCTATCACTT ATACCTGTAA TGAAGGATAC CGCCTCATTG GTTCCTCCTC TGCTATGTGC 
ATAATCTCTG ATCAGAGCGT TGCCTGGGAT GCCGAGGCAC CTATTTGTGA ATCAATTCCT 
TGTGAGATAC CCCCAAGCAT TCCCAATGGA GATTTCTTCA GTCCTAACAG AGAAGATTTT 
CATTATGGAA TGGTAGTTAC CTACCAGTGC AACACTGATG CGAGAGGGAA GAAGCTCTTT 
AACCTGGTGG GTGAGCCCTC CATACACTGT ACCAGCATCG ATGGTCAAGT TGGAGTCTGG 
AGTGGCCCTC CTCCTCAGTG CATTGAACTC AACAAATGTA CTCCTCCCCA TGTTGAAAAT 
GCAGTCATAG TGTCTAAAAA CAAAAGCTTG TTTTCCTTAA GGGATATGGT GGAGTTTAGA 
TGTCAGGATG GCTTTATGAT GAAAGGAGAC AGCAGTGTGT ATTGTCGATC CCTAAACAGA 
TGGGAGCCTC AGTTACCAAG CTGCTTCAAG GTGAAATCCT GTGGTGCTTT CCTGGGTGAG 
CTTCCTAATG GGCATGTATT CGTTCCACAA AATCTTCAAC TCGGGGCCAA AGTGACCTTT 
GTTTGTAATA CAGGGTATCA ATTAAAAGGC AATTCTTCTA GTCATTGTGT TCTTGATGGA 
GTGGAAAGCA TTTGGAATAG CAGCGTTCCT GTGTGTGAAC AAGTGATATG TAAACTCCCT 
CAGGATATGA GTGGATTCCA GAAAGGGTTG CAAATGAAAA AAGATTATTA CTATGGAGAT 
AATGTAGCCT TGGAATGTGA GGATGGGTAT ACTCTAGAAG GCAGTTCTCA GAGCCAGTGC 
CAGTCCGATG CCAGCTGGGA TCCTCCTCTG CCCAAATGTG TCTCTCAAGT GATATGTAAA 
CTCCCTCAGG ATATGAGTGG ATTCCAGAAA GGGTTGCAAA TGAAAAAAGA TTATTACTAT 
GGAGATAATG TAGCCTTGGA ATGTGAGGAT GGGTATACTC TAGAAGGCAG TTCTCAGAGC 
CAGTGCCAGT CCGATGCCAG CTGGGATCCT CCTCTGCCCA AATGTGTCTC TCAAGTGATA 
TGTAAACTCC CTCAGGATAT GAGTGGATTC CAGAAAGGGT TGCAAATGAA AAAAGATTAT 
TACTATGGAG ATAATGTAGC CTTGGAATGT GAGGATGGGT ATACTCTAGA AGGCAGTTCT 
CAGAGCCAGT GCCAGTCCGA TGCCAGCTGG GATCCTCCTC TGCCCAAATG TGTCTCTCGC 
TCAAACAGTG GTCTAATAGC TGGAATTTTC ATTGGGATAA TCGTCCTTAT TTTATTCATC 
ATTTTTTCCT ACTGGATGAT TATGAAGTTT AAAAAACGCA ATTCCACCAA TGAAAAGTGT 
AAAGAAGTGG GTATCTATTT AAATTCTAAA GAAGACAGCT GTGTTCAGCC TCAGTCTCTG 
CTCACAAGTC AGGAGAACAA CAGTACCAGT AGCCCAGCAC GGAATTCACT CACTCAAGAA 
GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Circulating AIM prevents hepatocellular carcinoma through complement activation.
Cell reports9(1)61-74(2014 Oct)
Maehara N,Arai S,Mori M,Iwamura Y,Kurokawa J,Kai T,Kusunoki S,Taniguchi K,Ikeda K,Ohara O,Yamamura K,Miyazaki T

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)
Ghai R,Bugarcic A,Liu H,Norwood SJ,Skeldal S,Coulson EJ,Li SS,Teasdale RD,Collins BM

Structures of the rat complement regulator CrrY.
Acta crystallographica. Section F, Structural biology and crystallization communications67(Pt 7)739-43(2011 Jul)
Roversi P,Johnson S,Caesar JJ,McLean F,Leath KJ,Tsiftsoglou SA,Morgan BP,Harris CL,Sim RB,Lea SM

Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury.
Molecular immunology46(5)803-11(2009 Feb)
Ruseva MM,Hughes TR,Donev RM,Sivasankar B,Pickering MC,Wu X,Harris CL,Morgan BP

The role of rat Crry, a complement regulatory protein, in proliferation of thymocytes.
Life sciences75(25)3053-62(2004 Nov)
Antic Stankovic J,Vucevic D,Majstorovic I,Vasilijic S,Colic M

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Cr1l cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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