Ubc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ubc
Entrez Gene ID	50522
Full Name	ubiquitin C
General protein information	Preferred Names ubiquitin C Names polyubiquitin-C
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q15
Summary	may play a role in muscle protein catabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017314.1	NP_059010.1	polyubiquitin-C precursor

Pathways from BioSystems

Homologies

	LOC712934	XP_002798876.1
Homo sapiens (human)	UBC	NP_066289.2
Bos taurus (cattle)	UBC	NP_001193236.1
Drosophila melanogaster (fruit fly)	Ubi-p63E	NP_001261383.1
Arabidopsis thaliana (thale cress)	UBQ8	NP_566357.1
Pan troglodytes (chimpanzee)	UBC	NP_001129078.1
Mus musculus (house mouse)	Ubc	NP_062613.3
Rattus norvegicus (Norway rat)	Ubc	NP_059010.1
Canis lupus familiaris (dog)	UBC	XP_853060.1
Xenopus tropicalis (tropical clawed frog)	ubb	XP_004911738.1

Gene Ontology
Bibliography

Related articles in PubMed

Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases.
Beeken M, Lindenmeyer MT, Blattner SM, Rad?n V, Oh J, Meyer TN, Hildebrand D, Schl?ter H, Reinicke AT, Knop JH, Vivekanandan-Giri A, M?nster S, Sachs M, Wiech T, Pennathur S, Cohen CD, Kretzler M, Stahl RA, Meyer-Schwesinger C
Journal of the American Society of Nephrology : JASN25(11)2511-25(2014 Nov)

Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury.
Joshi SK, Kim HT, Feeley BT, Liu X
Journal of orthopaedic research : official publication of the Orthopaedic Research Society32(1)138-44(2014 Jan)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

Ubiquitin is a novel substrate for human insulin-degrading enzyme.
Ralat LA, Kalas V, Zheng Z, Goldman RD, Sosnick TR, Tang WJ
Journal of molecular biology406(3)454-66(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study identifies altered proteolysis as a feature of persistent podocyte injury. In the future, specific UPS proteins may serve as new biomarkers or therapeutic targets in persistent nephrotic syndrome.
Title: Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases.

While the ubiquitin-proteasome pathway was a major contributor to the atrophy seen following suprascapular nerve denervation, autophagy was a major contributor following tendon transection.
Title: Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury.

The following Ubc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ubc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03622	NM_017314.1 Latest version!	Rattus norvegicus ubiquitin C (Ubc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ubc ( NM_017314.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_059010.1 Rattus norvegicus ubiquitin C (Ubc), mRNA.

Price & Availability↑

CloneID	ORa03622
Clone ID Related Accession (Same CDS sequence)	NM_017314.1
Accession Version	NM_017314.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2433bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	polyubiquitin-C precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D17296.1. On Aug 30, 2004 this sequence version replaced XM_346436.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D17296.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCAGATCT TTGTGAAAAC CTTAACTGGT AAGACCATCA CCCTGGAGGT CGAGCCCAGT 
GACACCATTG AAAATGTCAA GGCAAAGATC CAGGACAAGG AGGGCATCCC CCCTGACCAG 
CAGAGGCTGA TCTTTGCAGG CAAGCAGCTG GAAGATGGCC GCACCCTGTC AGACTACAAC 
ATCCAGAAGG AGTCCACCCT GCACCTGGTC CTGCGCCTCA GAGGGGGCAT GCAGATCTTT 
GTGAAGACCC TGACAGGCAA GACCATCACC CTGGAGGTCG AGCCCAGTGA CACCATTGAA 
AATGTCAAGG CAAAGATCCA GGACAAGGAG GGCATCCCCC CTGACCAGCA GAGGCTGATC 
TTTGCAGGCA AGCAGCTGGA AGATGGCCGC ACCCTGTCAG ACTACAACAT CCAGAAGGAG 
TCCACCTTGC ACCTGGTCCT TCGCCTCAGA GGGGGCATGC AGATCTTTGT GAAGACCCTG 
ACAGGCAAGA CCATCACCCT GGAGGTCGAG CCCAGTGACA CCATTGAAAA TGTCAAGGCA 
AAGATCCAGG ACAAGGAGGG CATCCCCCCT GACCAGCAGA GGCTGATCTT TGCAGGCAAG 
CAGCTGGAAG ATGGCCGCAC CCTGTCAGAC TACAACATCC AGAAGGAGTC CACCCTGCAC 
CTGGTCCTTC GCCTCAGAGG GGGCATGCAG ATCTTTGTGA AGACCCTGAC AGGCAAGACC 
ATCACCCTGG AGGTCGAGCC CAGTGACACC ATTGAAAATG TCAAGGCAAA GATCCAGGAC 
AAGGAGGGCA TCCCCCCTGA CCAGCAGAGG CTGATCTTTG CAGGCAAGCA GCTGGAAGAT 
GGCCGCACCC TGTCAGACTA CAACATCCAG AAGGAGTCCA CCCTGCACCT GGTCCTGCGC 
CTCAGAGGGG GCATGCAGAT CTTTGTGAAG ACCCTGACAG GCAAGACCAT CACCCTGGAG 
GTCGAGCCCA GTGACACCAT TGAAAATGTC AAGGCAAAGA TCCAGGACAA GGAGGGCATC 
CCCCCTGACC AGCAGAGGCT GATCTTTGCA GGCAAGCAGC TGGAAGATGG CCGCACCCTG 
TCAGACTACA ACATCCAGAA GGAGTCCACC CTGCACCTGG TCCTTCGCCT CAGAGGGGGC 
ATGCAGATCT TTGTGAAGAC CCTGACAGGC AAGACCATCA CCCTGGAGGT CGAGCCCAGT 
GACACCATTG AAAATGTCAA GGCAAAGATC CAGGACAAGG AGGGCATCCC CCCTGACCAG 
CAGAGGCTGA TCTTTGCAGG CAAGCAGCTG GAAGATGGCC GCACCCTGTC AGACTACAAC 
ATCCAGAAGG AGTCCACCCT GCACCTGGTC CTTCGCCTCA GAGGGGGCAT GCAGATCTTT 
GTGAAGACCC TGACAGGCAA GACCATCACC CTGGAGGTCG AGCCCAGTGA CACCATTGAA 
AATGTCAAGG CAAAGATCCA GGACAAGGAG GGCATCCCCC CTGACCAGCA GAGGCTGATC 
TTTGCAGGCA AGCAGCTGGA AGATGGCCGC ACCCTGTCAG ACTACAACAT CCAGAAGGAG 
TCCACCCTGC ACCTGGTCCT TCGCCTCAGA GGGGGCATGC AGATCTTTGT GAAGACCCTG 
ACAGGCAAGA CCATCACCCT GGAGGTCGAG CCCAGTGACA CCATTGAAAA TGTCAAGGCA 
AAGATCCAGG ACAAGGAGGG CATCCCCCCT GACCAGCAGA GGCTGATCTT TGCAGGCAAG 
CAGCTGGAAG ATGGCCGCAC CCTGTCAGAC TACAACATCC AGAAGGAGTC CACCCTGCAC 
CTGGTCCTGC GCCTCAGAGG GGGCATGCAG ATCTTTGTGA AGACCCTGAC AGGCAAGACC 
ATCACCCTGG AGGTCGAGCC CAGTGACACC ATTGAAAATG TCAAGGCAAA GATCCAGGAC 
AAGGAGGGCA TCCCCCCTGA CCAGCAGAGG CTGATCTTTG CAGGCAAGCA GCTGGAAGAT 
GGCCGCACCC TGTCAGACTA CAACATCCAG AAGGAGTCCA CCCTGCACCT GGTCCTGCGC 
CTCAGAGGGG GCATGCAGAT CTTTGTGAAG ACCCTGACAG GCAAGACCAT CACCCTGGAG 
GTCGAGCCCA GTGACACCAT TGAAAATGTC AAGGCAAAGA TCCAGGACAA GGAGGGCATC 
CCCCCTGACC AGCAGAGGCT GATCTTTGCA GGCAAGCAGC TGGAAGATGG CCGCACCCTG 
TCAGACTACA ACATCCAGAA GGAGTCCACC CTGCACCTGG TCCTGCGCCT CAGAGGGGGC 
ATGCAGATCT TTGTGAAGAC CCTGACAGGC AAGACCATCA CTCTGGAGGT CGAGCCCAGT 
GTTAACACCA AGAAGGTCAA ACAGGAAGAT ACTCGTACCT TTCTCACCAC AGTATCTAGA 
AAGAGCCCTT CTTGTGCTTG TTCTTGGGTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059010.1
CDS	34..2466
Translation	MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSVNTKKVKQEDTRTFLTTVSRKSPSCACSWV

Target ORF information:

RefSeq Version	NM_017314.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ubiquitin C (Ubc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017314.1

ORF Insert Sequence:

ATGCAGATCT TTGTGAAAAC CTTAACTGGT AAGACCATCA CCCTGGAGGT CGAGCCCAGT 
GACACCATTG AAAATGTCAA GGCAAAGATC CAGGACAAGG AGGGCATCCC CCCTGACCAG 
CAGAGGCTGA TCTTTGCAGG CAAGCAGCTG GAAGATGGCC GCACCCTGTC AGACTACAAC 
ATCCAGAAGG AGTCCACCCT GCACCTGGTC CTGCGCCTCA GAGGGGGCAT GCAGATCTTT 
GTGAAGACCC TGACAGGCAA GACCATCACC CTGGAGGTCG AGCCCAGTGA CACCATTGAA 
AATGTCAAGG CAAAGATCCA GGACAAGGAG GGCATCCCCC CTGACCAGCA GAGGCTGATC 
TTTGCAGGCA AGCAGCTGGA AGATGGCCGC ACCCTGTCAG ACTACAACAT CCAGAAGGAG 
TCCACCTTGC ACCTGGTCCT TCGCCTCAGA GGGGGCATGC AGATCTTTGT GAAGACCCTG 
ACAGGCAAGA CCATCACCCT GGAGGTCGAG CCCAGTGACA CCATTGAAAA TGTCAAGGCA 
AAGATCCAGG ACAAGGAGGG CATCCCCCCT GACCAGCAGA GGCTGATCTT TGCAGGCAAG 
CAGCTGGAAG ATGGCCGCAC CCTGTCAGAC TACAACATCC AGAAGGAGTC CACCCTGCAC 
CTGGTCCTTC GCCTCAGAGG GGGCATGCAG ATCTTTGTGA AGACCCTGAC AGGCAAGACC 
ATCACCCTGG AGGTCGAGCC CAGTGACACC ATTGAAAATG TCAAGGCAAA GATCCAGGAC 
AAGGAGGGCA TCCCCCCTGA CCAGCAGAGG CTGATCTTTG CAGGCAAGCA GCTGGAAGAT 
GGCCGCACCC TGTCAGACTA CAACATCCAG AAGGAGTCCA CCCTGCACCT GGTCCTGCGC 
CTCAGAGGGG GCATGCAGAT CTTTGTGAAG ACCCTGACAG GCAAGACCAT CACCCTGGAG 
GTCGAGCCCA GTGACACCAT TGAAAATGTC AAGGCAAAGA TCCAGGACAA GGAGGGCATC 
CCCCCTGACC AGCAGAGGCT GATCTTTGCA GGCAAGCAGC TGGAAGATGG CCGCACCCTG 
TCAGACTACA ACATCCAGAA GGAGTCCACC CTGCACCTGG TCCTTCGCCT CAGAGGGGGC 
ATGCAGATCT TTGTGAAGAC CCTGACAGGC AAGACCATCA CCCTGGAGGT CGAGCCCAGT 
GACACCATTG AAAATGTCAA GGCAAAGATC CAGGACAAGG AGGGCATCCC CCCTGACCAG 
CAGAGGCTGA TCTTTGCAGG CAAGCAGCTG GAAGATGGCC GCACCCTGTC AGACTACAAC 
ATCCAGAAGG AGTCCACCCT GCACCTGGTC CTTCGCCTCA GAGGGGGCAT GCAGATCTTT 
GTGAAGACCC TGACAGGCAA GACCATCACC CTGGAGGTCG AGCCCAGTGA CACCATTGAA 
AATGTCAAGG CAAAGATCCA GGACAAGGAG GGCATCCCCC CTGACCAGCA GAGGCTGATC 
TTTGCAGGCA AGCAGCTGGA AGATGGCCGC ACCCTGTCAG ACTACAACAT CCAGAAGGAG 
TCCACCCTGC ACCTGGTCCT TCGCCTCAGA GGGGGCATGC AGATCTTTGT GAAGACCCTG 
ACAGGCAAGA CCATCACCCT GGAGGTCGAG CCCAGTGACA CCATTGAAAA TGTCAAGGCA 
AAGATCCAGG ACAAGGAGGG CATCCCCCCT GACCAGCAGA GGCTGATCTT TGCAGGCAAG 
CAGCTGGAAG ATGGCCGCAC CCTGTCAGAC TACAACATCC AGAAGGAGTC CACCCTGCAC 
CTGGTCCTGC GCCTCAGAGG GGGCATGCAG ATCTTTGTGA AGACCCTGAC AGGCAAGACC 
ATCACCCTGG AGGTCGAGCC CAGTGACACC ATTGAAAATG TCAAGGCAAA GATCCAGGAC 
AAGGAGGGCA TCCCCCCTGA CCAGCAGAGG CTGATCTTTG CAGGCAAGCA GCTGGAAGAT 
GGCCGCACCC TGTCAGACTA CAACATCCAG AAGGAGTCCA CCCTGCACCT GGTCCTGCGC 
CTCAGAGGGG GCATGCAGAT CTTTGTGAAG ACCCTGACAG GCAAGACCAT CACCCTGGAG 
GTCGAGCCCA GTGACACCAT TGAAAATGTC AAGGCAAAGA TCCAGGACAA GGAGGGCATC 
CCCCCTGACC AGCAGAGGCT GATCTTTGCA GGCAAGCAGC TGGAAGATGG CCGCACCCTG 
TCAGACTACA ACATCCAGAA GGAGTCCACC CTGCACCTGG TCCTGCGCCT CAGAGGGGGC 
ATGCAGATCT TTGTGAAGAC CCTGACAGGC AAGACCATCA CTCTGGAGGT CGAGCCCAGT 
GTTAACACCA AGAAGGTCAA ACAGGAAGAT ACTCGTACCT TTCTCACCAC AGTATCTAGA 
AAGAGCCCTT CTTGTGCTTG TTCTTGGGTT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases.
Journal of the American Society of Nephrology : JASN25(11)2511-25(2014 Nov)
Beeken M,Lindenmeyer MT,Blattner SM,Rad?n V,Oh J,Meyer TN,Hildebrand D,Schl?ter H,Reinicke AT,Knop JH,Vivekanandan-Giri A,M?nster S,Sachs M,Wiech T,Pennathur S,Cohen CD,Kretzler M,Stahl RA,Meyer-Schwesinger C

Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society32(1)138-44(2014 Jan)
Joshi SK,Kim HT,Feeley BT,Liu X

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

Ubiquitin is a novel substrate for human insulin-degrading enzyme.
Journal of molecular biology406(3)454-66(2011 Feb)
Ralat LA,Kalas V,Zheng Z,Goldman RD,Sosnick TR,Tang WJ

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Ubc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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