Atoh1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atoh1
Entrez Gene ID	500156
Full Name	atonal bHLH transcription factor 1
Synonyms	RGD1565171
General protein information	Preferred Names atonal bHLH transcription factor 1 Names protein atonal homolog 1 atonal homolog 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q31

mRNA and Protein(s)

mRNA	Protein	Name
NM_001109238.1	NP_001102708.1	protein atonal homolog 1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	atoh1a	NP_571166.1
	ATOH1	XP_001102247.1
Bos taurus (cattle)	ATOH1	NP_001091568.1
Rattus norvegicus (Norway rat)	Atoh1	NP_001102708.1
Gallus gallus (chicken)	ATOH1	XP_004941187.1
Xenopus tropicalis (tropical clawed frog)	atoh1	XP_004911142.1
Homo sapiens (human)	ATOH1	NP_005163.1
Pan troglodytes (chimpanzee)	ATOH1	NP_001012434.1
Canis lupus familiaris (dog)	ATOH1	XP_544986.2
Mus musculus (house mouse)	Atoh1	NP_031526.1

Gene Ontology
Bibliography

Related articles in PubMed

Afferent synaptogenesis between ectopic hair-cell-like cells and neurites of spiral ganglion induced by Atoh1 in mammals in vitro.
Luo WW, Ma R, Cheng X, Yang XY, Han Z, Ren DD, Chen P, Chi FL, Yang JM
Neuroscience357185-196(2017 Aug)

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.
Li W, Wu J, Yang J, Sun S, Chai R, Chen ZY, Li H
Proceedings of the National Academy of Sciences of the United States of America112(1)166-71(2015 Jan)

Ectopic hair cell-like cell induction by Math1 mainly involves direct transdifferentiation in neonatal mammalian cochlea.
Yang J, Cong N, Han Z, Huang Y, Chi F
Neuroscience letters5497-11(2013 Aug)

Functional features of trans-differentiated hair cells mediated by Atoh1 reveals a primordial mechanism.
Yang J, Bouvron S, Lv P, Chi F, Yamoah EN
The Journal of neuroscience : the official journal of the Society for Neuroscience32(11)3712-25(2012 Mar)

Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.
Pan N, Jahan I, Kersigo J, Kopecky B, Santi P, Johnson S, Schmitz H, Fritzsch B
Hearing research275(1-2)66-80(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Math1 induced hair cell-like cells from lateral epithelial ridge cells mainly underwent direct trans-differentiation instead of mitosis of LER cells or newly hair cell-like cells.
Title: Ectopic hair cell-like cell induction by Math1 mainly involves direct transdifferentiation in neonatal mammalian cochlea.

Atoh1 mediates trans-differentiation of morphological and functional "ancestral" hair cells that are likely to undergo diversification in an endorgan-specific manner.
Title: Functional features of trans-differentiated hair cells mediated by Atoh1 reveals a primordial mechanism.

The following Atoh1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atoh1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12272	NM_001109238.1 Latest version!	Rattus norvegicus atonal bHLH transcription factor 1 (Atoh1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atoh1 ( NM_001109238.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102708.1 Rattus norvegicus atonal bHLH transcription factor 1 (Atoh1), mRNA.

Price & Availability↑

CloneID	ORa12272
Clone ID Related Accession (Same CDS sequence)	NM_001109238.1
Accession Version	NM_001109238.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-29
Organism	Rattus norvegicus(Norway rat)
Product	protein atonal homolog 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474042.2. On or before Oct 4, 2007 this sequence version replaced XM_001066177.1, XM_575508.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGTCCCGCC TGCTGCATGC AGAAGAGTGG GCTGAGGTAA AAGAGTTGGG GGACCACCAT 
CGCCATCCCC AGCCGCACCA CATCCCTCAG CTGACGCCAC AGCCACCTGC TACCCTACAG 
GCGAGAGACC ATCCGGTCTA CCCGGCAGAA CTGTCCCTCC TGGATAGCAC CGACCCACGC 
GCCTGGCTGA CTCCCACTTT GCAGGGCCTC TGCACGGCAC GCGCCGCCCA GTATCTGCTG 
CATTCTCCCG AGCTGGGTGC CTCCGAGGCC GCGGCGCCCG GGGACGAGGC TGACGGCCAG 
GGTGAGCTGG TAAGGAGAAG CGGCTGCGGC GGCCTCAGCA AGAGCCCCGG GCCGGTGAAA 
GTGCGGGAAC AACTGTGCAA GCTGAAGGGC GGGGTTGTAG TAGACGAGCT GGGCTGCAGC 
CGCCAGCGAG CCCCTTCCAG CAAACAGGTG AATGGGGTAC AGAAGCAAAG GCGACTGGCA 
GCAAACGCAA GGGAGCGGCG CAGGATGCAC GGGCTGAACC ACGCCTTCGA CCAGCTGCGC 
AACGTTATCC CGTCCTTCAA CAACGACAAG AAGCTGTCCA AATATGAGAC CCTGCAGATG 
GCCCAGATCT ACATCAACGC CCTGTCGGAG TTGCTGCAGA CTCCCAGTGT CGGAGAGCAG 
CCACCGCCGC CAGCAGCCTC CTGCAAAAAT GACCACCATC ACCTTCGCGC AGCCGCCTCT 
TATGAAGGAG GAGCAGGCGC CTCTGCGGTA GCTGGGGCTC AGCCAGCCCC GGGAGGGGGC 
CCGAGACCCA CCCCGCCTGG AGCTTGCCGG ACTCGCTTCT CCACCCCAGC TTCCTCCGGG 
GGTTATTCAG TGCAGCTGGA CGCTTTGCAC TTTCCAGCTT TCGAGGACCG GGCCCTAACA 
GCGATGATGG CACAGAAGGA CCTGTCGCCT TCGCTGCCCG GGGGCATCCT GCAGCCAGTA 
CCGGAGGACA GCAGCAAAAC ATCTCCCAGG TCCCACAGAA GTGACGGAGA GTTTTCCCCC 
CACTCTCATT ACAGTGACTC TGACGAGGCC AGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102708.1
CDS	197..1252
Translation	MSRLLHAEEWAEVKELGDHHRHPQPHHIPQLTPQPPATLQARDHPVYPAELSLLDSTDPRAWLTPTLQGLCTARAAQYLLHSPELGASEAAAPGDEADGQGELVRRSGCGGLSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSVGEQPPPPAASCKNDHHHLRAAASYEGGAGASAVAGAQPAPGGGPRPTPPGACRTRFSTPASSGGYSVQLDALHFPAFEDRALTAMMAQKDLSPSLPGGILQPVPEDSSKTSPRSHRSDGEFSPHSHYSDSDEAS

Target ORF information:

RefSeq Version	NM_001109238.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus atonal bHLH transcription factor 1 (Atoh1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109238.1

ORF Insert Sequence:

ATGTCCCGCC TGCTGCATGC AGAAGAGTGG GCTGAGGTAA AAGAGTTGGG GGACCACCAT 
CGCCATCCCC AGCCGCACCA CATCCCTCAG CTGACGCCAC AGCCACCTGC TACCCTACAG 
GCGAGAGACC ATCCGGTCTA CCCGGCAGAA CTGTCCCTCC TGGATAGCAC CGACCCACGC 
GCCTGGCTGA CTCCCACTTT GCAGGGCCTC TGCACGGCAC GCGCCGCCCA GTATCTGCTG 
CATTCTCCCG AGCTGGGTGC CTCCGAGGCC GCGGCGCCCG GGGACGAGGC TGACGGCCAG 
GGTGAGCTGG TAAGGAGAAG CGGCTGCGGC GGCCTCAGCA AGAGCCCCGG GCCGGTGAAA 
GTGCGGGAAC AACTGTGCAA GCTGAAGGGC GGGGTTGTAG TAGACGAGCT GGGCTGCAGC 
CGCCAGCGAG CCCCTTCCAG CAAACAGGTG AATGGGGTAC AGAAGCAAAG GCGACTGGCA 
GCAAACGCAA GGGAGCGGCG CAGGATGCAC GGGCTGAACC ACGCCTTCGA CCAGCTGCGC 
AACGTTATCC CGTCCTTCAA CAACGACAAG AAGCTGTCCA AATATGAGAC CCTGCAGATG 
GCCCAGATCT ACATCAACGC CCTGTCGGAG TTGCTGCAGA CTCCCAGTGT CGGAGAGCAG 
CCACCGCCGC CAGCAGCCTC CTGCAAAAAT GACCACCATC ACCTTCGCGC AGCCGCCTCT 
TATGAAGGAG GAGCAGGCGC CTCTGCGGTA GCTGGGGCTC AGCCAGCCCC GGGAGGGGGC 
CCGAGACCCA CCCCGCCTGG AGCTTGCCGG ACTCGCTTCT CCACCCCAGC TTCCTCCGGG 
GGTTATTCAG TGCAGCTGGA CGCTTTGCAC TTTCCAGCTT TCGAGGACCG GGCCCTAACA 
GCGATGATGG CACAGAAGGA CCTGTCGCCT TCGCTGCCCG GGGGCATCCT GCAGCCAGTA 
CCGGAGGACA GCAGCAAAAC ATCTCCCAGG TCCCACAGAA GTGACGGAGA GTTTTCCCCC 
CACTCTCATT ACAGTGACTC TGACGAGGCC AGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Afferent synaptogenesis between ectopic hair-cell-like cells and neurites of spiral ganglion induced by Atoh1 in mammals in vitro.
Neuroscience357185-196(2017 Aug)
Luo WW,Ma R,Cheng X,Yang XY,Han Z,Ren DD,Chen P,Chi FL,Yang JM

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.
Proceedings of the National Academy of Sciences of the United States of America112(1)166-71(2015 Jan)
Li W,Wu J,Yang J,Sun S,Chai R,Chen ZY,Li H

Ectopic hair cell-like cell induction by Math1 mainly involves direct transdifferentiation in neonatal mammalian cochlea.
Neuroscience letters5497-11(2013 Aug)
Yang J,Cong N,Han Z,Huang Y,Chi F

Functional features of trans-differentiated hair cells mediated by Atoh1 reveals a primordial mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience32(11)3712-25(2012 Mar)
Yang J,Bouvron S,Lv P,Chi F,Yamoah EN

Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.
Hearing research275(1-2)66-80(2011 May)
Pan N,Jahan I,Kersigo J,Kopecky B,Santi P,Johnson S,Schmitz H,Fritzsch B

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Atoh1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

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