Phlpp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Phlpp2
Entrez Gene ID	498949
Full Name	PH domain and leucine rich repeat protein phosphatase 2
Synonyms	Phlppl,RGD1562857
General protein information	Preferred Names PH domain and leucine rich repeat protein phosphatase 2 Names PH domain leucine-rich repeat-containing protein phosphatase 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001109131.1	NP_001102601.1	PH domain leucine-rich repeat-containing protein phosphatase 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PHLPP2	XP_546844.4
Rattus norvegicus (Norway rat)	Phlpp2	NP_001102601.1
Gallus gallus (chicken)	PHLPP2	XP_414238.3
Homo sapiens (human)	PHLPP2	NP_055835.2
	PHLPP2	XP_001105985.1
Bos taurus (cattle)	PHLPP2	NP_001193122.1
Mus musculus (house mouse)	Phlpp2	NP_001116066.2
Caenorhabditis elegans (roundworm)	F43C1.1	NP_497845.2
Pan troglodytes (chimpanzee)	PHLPP2	XP_003315243.1
Danio rerio (zebrafish)	LOC100332895	XP_002664145.2

Gene Ontology
Bibliography

Related articles in PubMed

Signaling specificity in the Akt pathway in biology and disease.
Toker A, Marmiroli S
Advances in biological regulation5528-38(2014 May)

Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3?/Fyn kinase axis during oxidative hepatocellular toxicity.
Rizvi F, Shukla S, Kakkar P
Cell death & disease5e1153(2014 Mar)

PHLPP1 splice variants differentially regulate AKT and PKC? signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus.
Jackson TC, Verrier JD, Semple-Rowland S, Kumar A, Foster TC
Journal of neurochemistry115(4)941-55(2010 Nov)

Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL.
Kanan Y, Matsumoto H, Song H, Sokolov M, Anderson RE, Rajala RV
Journal of neurochemistry113(2)477-88(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cellular PHLPP2 levels may aggravate oxidative toxicity by suppressing Nrf2/ARE transcriptional regulation via Akt(Se473)/GSK3beta/Fyn kinase axis.
Title: Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3?/Fyn kinase axis during oxidative hepatocellular toxicity.

increased Akt activity was associated with inhibition of PHLPP2 activity by adenylyl cyclase type 6.
Title: Activation of PH-domain leucine-rich protein phosphatase 2 (PHLPP2) by agonist stimulation in cardiac myocytes expressing adenylyl cyclase type 6.

The following Phlpp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Phlpp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09068	NM_001109131.1 Latest version!	Rattus norvegicus PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$1000.30 $1429.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Phlpp2 ( NM_001109131.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102601.1 Rattus norvegicus PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2), mRNA.

Price & Availability↑

CloneID	ORa09068
Clone ID Related Accession (Same CDS sequence)	NM_001109131.1
Accession Version	NM_001109131.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Rattus norvegicus(Norway rat)
Product	PH domain leucine-rich repeat-containing protein phosphatase 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473972.1. On or before Oct 4, 2007 this sequence version replaced XM_574238.1, XM_001077164.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGGGAGG TGGAGCCCGT GCCCGCGGGC TCGCTGGAGC CCCCGGAGCC ACCTGAAGCG 
GCGGCGCCTC GCCGGCCCGG AGGTATTCGG GTCCTAAAGA GGAATATGAA ACACAATGGG 
AGCAGAAATT GTTTGAATAG AAGAAGTAGG TTTGGCTCTC GAGAAAGAGA CTGGCTAAGA 
GAAGATGTGA AGAGAGGCTG TGTTTACCTT TATGGAGCGG ACACGACCAC TGCCACTACA 
ACCACCACCT CCTCCTCCTC CTCCTCCTCC TCCTCCTCCT CCTCTGATTT ACATCTTGTC 
CTTTGCACAG TGGAGACACC AGCGTCAGAA ATATGTGCTG GAGAGGGAAG AGAAAGTCTC 
TATCTACAGC TTCATGGAGA TCTGGTCAGG AGACTGGAGC CCACTGAACG GCCTCTCCAG 
ATTGTTTACG ACTACTTATC CAGGCTGGGG TTTGAAGATC CCGTGCGCAT ACAGGAGGAG 
GCTACGAACC CTGATCTCAG CTGTATGATT CGATTTTATG GTGAAAAGCC ATGCCAGATG 
GATCATCTGG ACCGAATCCT GCTGTCTGGC ATCTATAACG TCCGCAAAGG GAAGACCCAG 
CTGCACAAAT GGGCTGAGCG CCTCGTTGTT CTCTGTGGCA CCTGCCTTAT TGTCTCCTCA 
GTGAAGGATT GCCAAACTGG AAAGATGCAC ATCTTGCCAC TGGTTGGGGG AAAGATAGAA 
GAAGTGAAGC GCCGGCAACA CTCCCTTGCT TTCAGCTCAG CTGGAGCCCA AGCTCAGACC 
TATCATGTCA GCTTCGAGAC TTTGGCTGAG TACCAGAGAT GGCAGCGGCA GGCGTCTAAG 
GTGGTGTCCC AGAGGATCAG CACCGTGGAC CTCTCGTGTT ACAGCCTTGA GGAGGTTCCT 
GAGCATCTCT TCTACAGTCA AGACATCACC TACCTCAACC TGCGACACAA CTTCATGCAG 
TTAGAAAGAC CAGGGGGCCT TGACACACTC TACAAATTTT CTCAACTGAA GGGCCTGAAC 
TTGTCCCATA ATAAGCTTGG ACTGTTTCCT GTGTTGCTGT GTGAGATTTC TACCCTGACT 
GAACTCAACC TTTCTTGTAA TGGATTTCAT GACTTGCCAA GTCAGATTGG TAATCTGTTA 
AATCTTCAGA CCCTCTGCCT TGATGGCAAT GTTCTCACAG CTCTACCAGA TGAATTGGGA 
AACCTGCAGC AGCTTACTTC TCTGGGAATT TCCTTCAACA ATTTTAGTCA AATTCCTGAA 
GTTTTGGAGA AACTCACCAT GTTAGATAAA GTGGTTATGG CAGGAAACCG TTTGGAAATC 
CTGAACCTAG GGGTGCTGAC CAGGATGAAC CATGTTAAGC ATGTGGATCT AAGGATGAAC 
CACTTGAAAA CGGTGATTAT TGAAAATCTG GAGGGAAATA AACACATCAC TCACATGGAT 
TTGCGGGACA ATCAGTTGAC TGATTTGGAC CTTAGCTCCT TATGTAGCTT GGAGCAGCTG 
CATTGTGAGC GGAACCAGTT GAGAGAGCTG ACACTCAGTG GCTTCTCCCT TCGAAACCTC 
TACGCCAATT GGAACAAGCT GACAGCAGTG AATGTCTATC CAGTACCAAG CCTGCTCACT 
TCTTTGGAAC TCTCCCGAAA CTTGCTAGAA TGTATCCCTG ACTGGGCCTG TGAAGCAAAA 
AAGCTAGAAA TACTAGATAT AAGCTACAAT CTGCTTACAG AGGTTCCCAT GAGAATTCTG 
AGTAGTCTGA GTCTTCGGAA ACTGATGGTA GGACACAACC ACATCCATGT CCTTCCGGCA 
CTGGTGGAGC ACATTCCCCT CGAGGTACTG GATGTCCAGC ATAACACTCT GTCCAGGCTG 
CCGGACACAC TGTTCTCCAA GGCCTTAAAT CTCAGGTACT TGAATGCATC CGCAAATAGT 
CTGGAGTCTT TGCCTTCTGC GTGTGCTGGA GAGGAGAGTC TGAGTGTGCT GCAGCTGCTG 
TACCTGACCA ACAACCTTCT GACAGACCAG TGCATACCTG TTTTGGTCGG GCACCCACAC 
CTGCGTGTTC TGCACCTTGC AAACAACCAG CTACAGACCT TTCCTGCAAG CAAACTAAAC 
AAATTGGAGC AACTGGAAGA ACTGAATCTA AGTGGGAACA AGCTTAAAGC TATTCCCACA 
ACCATAGCAA ACTGCAAAAG ACTGCACACC CTTGTCGCAC ATGCCAACAA CATCAGCATT 
TTCCCAGAGA TCCTGCAGCT GCCTCAGATT CAGTTTGTTG ACCTGAGTTG CAATGATTTG 
ACAGAAATAC TAATTCCAGA GACTCTGCCT GCCACTTTAC AAGACCTTGA TCTTACAGGA 
AATACAAATC TGGTTCTGGA ACACAAGACT TTGGACATGT TTAGCCATAT CACAACACTG 
AAAATTGATC AGAAACCTTT ACCGACCACA GATTCTACAG TTACATCAAC CTTCTGGAGC 
CATGGACTGG CCGAGATGGC TGGGCAGAGG AATAAACTCT GTGTGTCTGC TCTGGCTATG 
GATAACTTTG CAGAGGGCGT GGGGGCTGTG TACGGCATGT TTGATGGGGA CAGGAATGAG 
GAACTCCCCC GTCTGCTGCA GTGTACAATG GCAGACGTGC TTTTGGAAGA GGTACAGCAC 
TCAACAAGTG ACACCGTTTT CATGGCCAAT ACCTTCCTGG TGTCTCACAG GAAATTAGGA 
ATGGCTGGCC AGAAGCTAGG TTCCTCTGCT CTCCTGTGCT ATATTCGACC TGACACTGCC 
GACCCAACAA GTAGTTTTAG CTTGACTGTA GCCAATGTTG GCACGTGCCA AGCTGTCCTG 
TGCCGAGGTG GAAAGCCAGT ACCTCTTTCT AAAGTCTTCA GCTTGGAGCA TGACCCAGAG 
GAGGCACAGA GGGTGAAGGA CCAGAAAGCT ATCATAACAG AGGACAACAA GGTGAATGGG 
GTTACCTGCT GCACCCGGAT GCTGGGATGT ACATACCTCT ACCCCTGGAT CCTCCCCAAG 
CCTCACATAT CCTCCACTCC GCTTACCATT CAAGATGAAT TGCTGATTTT GGGAAACAAA 
GCACTGTGGG AACACTTGTC CTATCTAGAA GCTGTCAGTG CAGTCCGTCA TGTGCAAGAC 
CCATTAGCTG CTGCTAAGAA GCTGTGCACA TTAGCACAGA GCTATGGTTG TCAGGACAAT 
GTGGGGGCAA TGGTGGTTTA TTTGAACATT GGTGAAGAAG GCTGTACCTG TGAAATGCAT 
GGGCTTGCCC TTCCAGGCCC TGTGGGATTT GCTTCAACAG CAACCATCAA GGATGCCCCC 
AAGCCAACCA CTCCCTCCTC TAGCAGTGGG ATTGCCTCAG AGCTGAGCAG TGAGGTGTCG 
ACCTCAGAGG TGAGCAGTGA GGTGGGTTCC ACAGCGTCTG ACGAACACAA CACTGTGGGC 
CTGGAGACGA GCTTGCTTCC CAGGCCTGAG AGGCGCTGTA GTCTGCACCC TGTGCCCTCT 
GCAGGCACTT TCCAGCGCCA GCCTTCTTGT GCTACCTTTT CCAGCAATCA GTCTGACAAT 
GGACTGGACA GTGACGATGA CCAGCCTGTT GAAGGCGTCA TAACCAATGG CAGCAGGGTT 
GAGGTAGAGG TAGACATTCA TTGCTGCCGA GGCAGAGAGT CTGAGAACTC CCCTACTCTC 
CCGAAGAATT CTTCCTACCC CTGTTCAGAG GAACATGCTA GGGGGTTGGG TTTTGGGATC 
CGAAGACAGA ACAGTGTGAA TAGTGGTATA CTTCTGCCAG TGAACAAAGA CAAGATGGAG 
TTACAGAAGT CTCCCTCCAC TTCTTGTTTG TATGGAAAGA AACTCTCCAA TGGCTCCATT 
GTGCCCCTAG AAGACAGCCT GAACCTCATT GAGGTGGCCA CAGAAGCACC CAAGAGGAAA 
ACTGGCTATT TTGCTGCCCC CACTCAGCTG GAACCAGAGG ATCAATTTGT TGTCCCCCGT 
GACCTGGAAG ACGAAGTGAA GGAGCAAATG AAGCAGCACC AGGAGAGCAG GCCTGAGCCT 
GAACCCAGGG AAGAGGACCG GACAGAGCCC CTGCAGGAGT TTGATACAGC ACTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102601.1
CDS	72..4148
Translation	MGEVEPVPAGSLEPPEPPEAAAPRRPGGIRVLKRNMKHNGSRNCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTTSSSSSSSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFEDPVRIQEEATNPDLSCMIRFYGEKPCQMDHLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPVLLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNVLTALPDELGNLQQLTSLGISFNNFSQIPEVLEKLTMLDKVVMAGNRLEILNLGVLTRMNHVKHVDLRMNHLKTVIIENLEGNKHITHMDLRDNQLTDLDLSSLCSLEQLHCERNQLRELTLSGFSLRNLYANWNKLTAVNVYPVPSLLTSLELSRNLLECIPDWACEAKKLEILDISYNLLTEVPMRILSSLSLRKLMVGHNHIHVLPALVEHIPLEVLDVQHNTLSRLPDTLFSKALNLRYLNASANSLESLPSACAGEESLSVLQLLYLTNNLLTDQCIPVLVGHPHLRVLHLANNQLQTFPASKLNKLEQLEELNLSGNKLKAIPTTIANCKRLHTLVAHANNISIFPEILQLPQIQFVDLSCNDLTEILIPETLPATLQDLDLTGNTNLVLEHKTLDMFSHITTLKIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKLCVSALAMDNFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQHSTSDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPTSSFSLTVANVGTCQAVLCRGGKPVPLSKVFSLEHDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYLEAVSAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMHGLALPGPVGFASTATIKDAPKPTTPSSSSGIASELSSEVSTSEVSSEVGSTASDEHNTVGLETSLLPRPERRCSLHPVPSAGTFQRQPSCATFSSNQSDNGLDSDDDQPVEGVITNGSRVEVEVDIHCCRGRESENSPTLPKNSSYPCSEEHARGLGFGIRRQNSVNSGILLPVNKDKMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEAPKRKTGYFAAPTQLEPEDQFVVPRDLEDEVKEQMKQHQESRPEPEPREEDRTEPLQEFDTAL

Target ORF information:

RefSeq Version	NM_001109131.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109131.1

ORF Insert Sequence:

ATGGGGGAGG TGGAGCCCGT GCCCGCGGGC TCGCTGGAGC CCCCGGAGCC ACCTGAAGCG 
GCGGCGCCTC GCCGGCCCGG AGGTATTCGG GTCCTAAAGA GGAATATGAA ACACAATGGG 
AGCAGAAATT GTTTGAATAG AAGAAGTAGG TTTGGCTCTC GAGAAAGAGA CTGGCTAAGA 
GAAGATGTGA AGAGAGGCTG TGTTTACCTT TATGGAGCGG ACACGACCAC TGCCACTACA 
ACCACCACCT CCTCCTCCTC CTCCTCCTCC TCCTCCTCCT CCTCTGATTT ACATCTTGTC 
CTTTGCACAG TGGAGACACC AGCGTCAGAA ATATGTGCTG GAGAGGGAAG AGAAAGTCTC 
TATCTACAGC TTCATGGAGA TCTGGTCAGG AGACTGGAGC CCACTGAACG GCCTCTCCAG 
ATTGTTTACG ACTACTTATC CAGGCTGGGG TTTGAAGATC CCGTGCGCAT ACAGGAGGAG 
GCTACGAACC CTGATCTCAG CTGTATGATT CGATTTTATG GTGAAAAGCC ATGCCAGATG 
GATCATCTGG ACCGAATCCT GCTGTCTGGC ATCTATAACG TCCGCAAAGG GAAGACCCAG 
CTGCACAAAT GGGCTGAGCG CCTCGTTGTT CTCTGTGGCA CCTGCCTTAT TGTCTCCTCA 
GTGAAGGATT GCCAAACTGG AAAGATGCAC ATCTTGCCAC TGGTTGGGGG AAAGATAGAA 
GAAGTGAAGC GCCGGCAACA CTCCCTTGCT TTCAGCTCAG CTGGAGCCCA AGCTCAGACC 
TATCATGTCA GCTTCGAGAC TTTGGCTGAG TACCAGAGAT GGCAGCGGCA GGCGTCTAAG 
GTGGTGTCCC AGAGGATCAG CACCGTGGAC CTCTCGTGTT ACAGCCTTGA GGAGGTTCCT 
GAGCATCTCT TCTACAGTCA AGACATCACC TACCTCAACC TGCGACACAA CTTCATGCAG 
TTAGAAAGAC CAGGGGGCCT TGACACACTC TACAAATTTT CTCAACTGAA GGGCCTGAAC 
TTGTCCCATA ATAAGCTTGG ACTGTTTCCT GTGTTGCTGT GTGAGATTTC TACCCTGACT 
GAACTCAACC TTTCTTGTAA TGGATTTCAT GACTTGCCAA GTCAGATTGG TAATCTGTTA 
AATCTTCAGA CCCTCTGCCT TGATGGCAAT GTTCTCACAG CTCTACCAGA TGAATTGGGA 
AACCTGCAGC AGCTTACTTC TCTGGGAATT TCCTTCAACA ATTTTAGTCA AATTCCTGAA 
GTTTTGGAGA AACTCACCAT GTTAGATAAA GTGGTTATGG CAGGAAACCG TTTGGAAATC 
CTGAACCTAG GGGTGCTGAC CAGGATGAAC CATGTTAAGC ATGTGGATCT AAGGATGAAC 
CACTTGAAAA CGGTGATTAT TGAAAATCTG GAGGGAAATA AACACATCAC TCACATGGAT 
TTGCGGGACA ATCAGTTGAC TGATTTGGAC CTTAGCTCCT TATGTAGCTT GGAGCAGCTG 
CATTGTGAGC GGAACCAGTT GAGAGAGCTG ACACTCAGTG GCTTCTCCCT TCGAAACCTC 
TACGCCAATT GGAACAAGCT GACAGCAGTG AATGTCTATC CAGTACCAAG CCTGCTCACT 
TCTTTGGAAC TCTCCCGAAA CTTGCTAGAA TGTATCCCTG ACTGGGCCTG TGAAGCAAAA 
AAGCTAGAAA TACTAGATAT AAGCTACAAT CTGCTTACAG AGGTTCCCAT GAGAATTCTG 
AGTAGTCTGA GTCTTCGGAA ACTGATGGTA GGACACAACC ACATCCATGT CCTTCCGGCA 
CTGGTGGAGC ACATTCCCCT CGAGGTACTG GATGTCCAGC ATAACACTCT GTCCAGGCTG 
CCGGACACAC TGTTCTCCAA GGCCTTAAAT CTCAGGTACT TGAATGCATC CGCAAATAGT 
CTGGAGTCTT TGCCTTCTGC GTGTGCTGGA GAGGAGAGTC TGAGTGTGCT GCAGCTGCTG 
TACCTGACCA ACAACCTTCT GACAGACCAG TGCATACCTG TTTTGGTCGG GCACCCACAC 
CTGCGTGTTC TGCACCTTGC AAACAACCAG CTACAGACCT TTCCTGCAAG CAAACTAAAC 
AAATTGGAGC AACTGGAAGA ACTGAATCTA AGTGGGAACA AGCTTAAAGC TATTCCCACA 
ACCATAGCAA ACTGCAAAAG ACTGCACACC CTTGTCGCAC ATGCCAACAA CATCAGCATT 
TTCCCAGAGA TCCTGCAGCT GCCTCAGATT CAGTTTGTTG ACCTGAGTTG CAATGATTTG 
ACAGAAATAC TAATTCCAGA GACTCTGCCT GCCACTTTAC AAGACCTTGA TCTTACAGGA 
AATACAAATC TGGTTCTGGA ACACAAGACT TTGGACATGT TTAGCCATAT CACAACACTG 
AAAATTGATC AGAAACCTTT ACCGACCACA GATTCTACAG TTACATCAAC CTTCTGGAGC 
CATGGACTGG CCGAGATGGC TGGGCAGAGG AATAAACTCT GTGTGTCTGC TCTGGCTATG 
GATAACTTTG CAGAGGGCGT GGGGGCTGTG TACGGCATGT TTGATGGGGA CAGGAATGAG 
GAACTCCCCC GTCTGCTGCA GTGTACAATG GCAGACGTGC TTTTGGAAGA GGTACAGCAC 
TCAACAAGTG ACACCGTTTT CATGGCCAAT ACCTTCCTGG TGTCTCACAG GAAATTAGGA 
ATGGCTGGCC AGAAGCTAGG TTCCTCTGCT CTCCTGTGCT ATATTCGACC TGACACTGCC 
GACCCAACAA GTAGTTTTAG CTTGACTGTA GCCAATGTTG GCACGTGCCA AGCTGTCCTG 
TGCCGAGGTG GAAAGCCAGT ACCTCTTTCT AAAGTCTTCA GCTTGGAGCA TGACCCAGAG 
GAGGCACAGA GGGTGAAGGA CCAGAAAGCT ATCATAACAG AGGACAACAA GGTGAATGGG 
GTTACCTGCT GCACCCGGAT GCTGGGATGT ACATACCTCT ACCCCTGGAT CCTCCCCAAG 
CCTCACATAT CCTCCACTCC GCTTACCATT CAAGATGAAT TGCTGATTTT GGGAAACAAA 
GCACTGTGGG AACACTTGTC CTATCTAGAA GCTGTCAGTG CAGTCCGTCA TGTGCAAGAC 
CCATTAGCTG CTGCTAAGAA GCTGTGCACA TTAGCACAGA GCTATGGTTG TCAGGACAAT 
GTGGGGGCAA TGGTGGTTTA TTTGAACATT GGTGAAGAAG GCTGTACCTG TGAAATGCAT 
GGGCTTGCCC TTCCAGGCCC TGTGGGATTT GCTTCAACAG CAACCATCAA GGATGCCCCC 
AAGCCAACCA CTCCCTCCTC TAGCAGTGGG ATTGCCTCAG AGCTGAGCAG TGAGGTGTCG 
ACCTCAGAGG TGAGCAGTGA GGTGGGTTCC ACAGCGTCTG ACGAACACAA CACTGTGGGC 
CTGGAGACGA GCTTGCTTCC CAGGCCTGAG AGGCGCTGTA GTCTGCACCC TGTGCCCTCT 
GCAGGCACTT TCCAGCGCCA GCCTTCTTGT GCTACCTTTT CCAGCAATCA GTCTGACAAT 
GGACTGGACA GTGACGATGA CCAGCCTGTT GAAGGCGTCA TAACCAATGG CAGCAGGGTT 
GAGGTAGAGG TAGACATTCA TTGCTGCCGA GGCAGAGAGT CTGAGAACTC CCCTACTCTC 
CCGAAGAATT CTTCCTACCC CTGTTCAGAG GAACATGCTA GGGGGTTGGG TTTTGGGATC 
CGAAGACAGA ACAGTGTGAA TAGTGGTATA CTTCTGCCAG TGAACAAAGA CAAGATGGAG 
TTACAGAAGT CTCCCTCCAC TTCTTGTTTG TATGGAAAGA AACTCTCCAA TGGCTCCATT 
GTGCCCCTAG AAGACAGCCT GAACCTCATT GAGGTGGCCA CAGAAGCACC CAAGAGGAAA 
ACTGGCTATT TTGCTGCCCC CACTCAGCTG GAACCAGAGG ATCAATTTGT TGTCCCCCGT 
GACCTGGAAG ACGAAGTGAA GGAGCAAATG AAGCAGCACC AGGAGAGCAG GCCTGAGCCT 
GAACCCAGGG AAGAGGACCG GACAGAGCCC CTGCAGGAGT TTGATACAGC ACTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Signaling specificity in the Akt pathway in biology and disease.
Advances in biological regulation5528-38(2014 May)
Toker A,Marmiroli S

Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3?/Fyn kinase axis during oxidative hepatocellular toxicity.
Cell death & disease5e1153(2014 Mar)
Rizvi F,Shukla S,Kakkar P

PHLPP1 splice variants differentially regulate AKT and PKC? signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus.
Journal of neurochemistry115(4)941-55(2010 Nov)
Jackson TC,Verrier JD,Semple-Rowland S,Kumar A,Foster TC

Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL.
Journal of neurochemistry113(2)477-88(2010 Apr)
Kanan Y,Matsumoto H,Song H,Sokolov M,Anderson RE,Rajala RV

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Phlpp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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