Lpar2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lpar2
Entrez Gene ID	498609
Full Name	lysophosphatidic acid receptor 2
Synonyms	Edg4,RGD1561336
General protein information	Preferred Names lysophosphatidic acid receptor 2 Names lysophosphatidic acid receptor 2 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4 pre-B-cell leukemia transcription factor 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p14

mRNA and Protein(s)

mRNA	Protein	Name
NM_001109109.1	NP_001102579.1	lysophosphatidic acid receptor 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Lpar2	NP_001102579.1
Bos taurus (cattle)	LPAR2	NP_001179164.1
Danio rerio (zebrafish)	lpar2b	NP_001032783.1
Xenopus tropicalis (tropical clawed frog)	lpar2	NP_001007475.1
Mus musculus (house mouse)	Lpar2	NP_064412.2
Homo sapiens (human)	LPAR2	NP_004711.2
Pan troglodytes (chimpanzee)	LPAR2	XP_001143951.2
	LPAR2	XP_002801189.1
Canis lupus familiaris (dog)	LPAR2	XP_541918.2
Gallus gallus (chicken)	LPAR2	NP_001108553.1

Gene Ontology
Bibliography

Related articles in PubMed

The autotaxin-LPA2 GPCR axis is modulated by ?-irradiation and facilitates DNA damage repair.
Balogh A, Shimizu Y, Lee SC, Norman DD, Gangwar R, Bavaria M, Moon C, Shukla P, Rao R, Ray R, Naren AP, Banerjee S, Banerje S, Miller DD, Balazs L, Pelus L, Tigyi G
Cellular signalling27(9)1751-62(2015 Sep)

Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3.
Alc?ntara-Hern?ndez R, Hern?ndez-M?ndez A, Campos-Mart?nez GA, Meizoso-Huesca A, Garc?a-S?inz JA
PloS one10(10)e0140583(2015)

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Br?uer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R
Cell138(6)1222-35(2009 Sep)

Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK.
Aziziyeh AI, Li TT, Pape C, Pampillo M, Chidiac P, Possmayer F, Babwah AV, Bhattacharya M
Cellular signalling21(7)1207-17(2009 Jul)

Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs).
Yamada T, Ohoka Y, Kogo M, Inagaki S
The Journal of biological chemistry280(19)19358-63(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings identify ATX and LPA2 as radiation-regulated genes that appear to play a physiological role in DNA repair.
Title: The autotaxin-LPA2 GPCR axis is modulated by ?-irradiation and facilitates DNA damage repair.

Data showed that lysophosphatidic acid receptors LPA1-3, are phosphoproteins whose phosphorylation state is modulated by the natural agonist, LPA.
Title: Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3.

The following Lpar2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lpar2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41566	NM_001109109.1 Latest version!	Rattus norvegicus lysophosphatidic acid receptor 2 (Lpar2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lpar2 ( NM_001109109.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102579.1 Rattus norvegicus lysophosphatidic acid receptor 2 (Lpar2), mRNA.

Price & Availability↑

CloneID	ORa41566
Clone ID Related Accession (Same CDS sequence)	NM_001109109.1
Accession Version	NM_001109109.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	lysophosphatidic acid receptor 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474031.2. On or before Oct 4, 2007 this sequence version replaced XR_008774.1, XM_573887.2.

ATGGGCCAGT GCTACTACAA TGAGACCATC GGCTTTTTCT ATAATAACAG CGGCAAGGAG 
CTCAGCCTTC ACTGGCGCCC CAAAGATGTG GTGGTGGTGG CCCTGGGGCT GACAGTCAGT 
GTGCTGGTAT TGCTGACCAA CCTGCTGGTT ATTGCAGCCA TTGCCTCCAA CCGACGCTTC 
CACCAGCCCA TATACTACCT GCTTGGCAAC TTGGCTGCAG CTGACCTCTT CGCTGGCATG 
GCCTACCTCT TCCTCATGTT CCATACTGGC CCCCGCACCG CCAGGCTCTC CATCAAAGGC 
TGGTTCCTGC GACAGGGCCT GCTGGACACC AGCCTCACGG CATCGGTGGC CACGTTGCTG 
GCCATTGCTG TGGAACGGCA CCGCAGTGTG ATGGCTGTGC AGCTGCACAG CCGCTTGCCC 
CGGGGTCGTG TGGTCACACT CATCGTGGGA GTGTGGGTGG CTGCGCTGGG TCTGGGGTTG 
CTGCCTGCAC ACTTCTGGCA CTGCCTCTGT GACTTGGACA GCTGCTCACG AATGGTGCCC 
CTGTTCAGCC GCTCCTACCT GGCTGTGTGG GCCCTATCCA GCCTGCTTGT CTTCCTACTC 
ATGGTAGCCG TCTACACACG AATTTTCTTC TTTGTGCGCA GACGGGTTGA ACGCATGGCA 
GAGCACGTCA GCTGCCATCC CCGCTACCGA GAGACAACGC TCAGCCTAGT CAAGACAGTT 
GTCATCATTC TGGGGGCATT TGTGGTGTGC TGGACACCGG GGCCAGGTGG TGCTGCTCTT 
GGACGGTCTG GACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102579.1
CDS	108..905
Translation	MGQCYYNETIGFFYNNSGKELSLHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGMAYLFLMFHTGPRTARLSIKGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVTLIVGVWVAALGLGLLPAHFWHCLCDLDSCSRMVPLFSRSYLAVWALSSLLVFLLMVAVYTRIFFFVRRRVERMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGPGGAALGRSGL

Target ORF information:

RefSeq Version	NM_001109109.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysophosphatidic acid receptor 2 (Lpar2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109109.1

ORF Insert Sequence:

ATGGGCCAGT GCTACTACAA TGAGACCATC GGCTTTTTCT ATAATAACAG CGGCAAGGAG 
CTCAGCCTTC ACTGGCGCCC CAAAGATGTG GTGGTGGTGG CCCTGGGGCT GACAGTCAGT 
GTGCTGGTAT TGCTGACCAA CCTGCTGGTT ATTGCAGCCA TTGCCTCCAA CCGACGCTTC 
CACCAGCCCA TATACTACCT GCTTGGCAAC TTGGCTGCAG CTGACCTCTT CGCTGGCATG 
GCCTACCTCT TCCTCATGTT CCATACTGGC CCCCGCACCG CCAGGCTCTC CATCAAAGGC 
TGGTTCCTGC GACAGGGCCT GCTGGACACC AGCCTCACGG CATCGGTGGC CACGTTGCTG 
GCCATTGCTG TGGAACGGCA CCGCAGTGTG ATGGCTGTGC AGCTGCACAG CCGCTTGCCC 
CGGGGTCGTG TGGTCACACT CATCGTGGGA GTGTGGGTGG CTGCGCTGGG TCTGGGGTTG 
CTGCCTGCAC ACTTCTGGCA CTGCCTCTGT GACTTGGACA GCTGCTCACG AATGGTGCCC 
CTGTTCAGCC GCTCCTACCT GGCTGTGTGG GCCCTATCCA GCCTGCTTGT CTTCCTACTC 
ATGGTAGCCG TCTACACACG AATTTTCTTC TTTGTGCGCA GACGGGTTGA ACGCATGGCA 
GAGCACGTCA GCTGCCATCC CCGCTACCGA GAGACAACGC TCAGCCTAGT CAAGACAGTT 
GTCATCATTC TGGGGGCATT TGTGGTGTGC TGGACACCGG GGCCAGGTGG TGCTGCTCTT 
GGACGGTCTG GACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The autotaxin-LPA2 GPCR axis is modulated by ?-irradiation and facilitates DNA damage repair.
Cellular signalling27(9)1751-62(2015 Sep)
Balogh A,Shimizu Y,Lee SC,Norman DD,Gangwar R,Bavaria M,Moon C,Shukla P,Rao R,Ray R,Naren AP,Banerjee S,Banerje S,Miller DD,Balazs L,Pelus L,Tigyi G

Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3.
PloS one10(10)e0140583(2015)
Alc?ntara-Hern?ndez R,Hern?ndez-M?ndez A,Campos-Mart?nez GA,Meizoso-Huesca A,Garc?a-S?inz JA

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Cell138(6)1222-35(2009 Sep)
Trimbuch T,Beed P,Vogt J,Schuchmann S,Maier N,Kintscher M,Breustedt J,Schuelke M,Streu N,Kieselmann O,Brunk I,Laube G,Strauss U,Battefeld A,Wende H,Birchmeier C,Wiese S,Sendtner M,Kawabe H,Kishimoto-Suga M,Brose N,Baumgart J,Geist B,Aoki J,Savaskan NE,Br?uer AU,Chun J,Ninnemann O,Schmitz D,Nitsch R

Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK.
Cellular signalling21(7)1207-17(2009 Jul)
Aziziyeh AI,Li TT,Pape C,Pampillo M,Chidiac P,Possmayer F,Babwah AV,Bhattacharya M

Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs).
The Journal of biological chemistry280(19)19358-63(2005 May)
Yamada T,Ohoka Y,Kogo M,Inagaki S