Coq2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Coq2
Entrez Gene ID	498332
Full Name	coenzyme Q2, polyprenyltransferase
Synonyms	PHB:PPT,RGD1306722
General protein information	Preferred Names coenzyme Q2, polyprenyltransferase Names 4-hydroxybenzoate polyprenyltransferase, mitochondrial 4-HB polyprenyltransferase PHB:polyprenyltransferase coenzyme Q2 4-hydroxybenzoate polyprenyltransferase coenzyme Q2 homolog, prenyltransferase para-hydroxybenzoate--polyprenyltransferase, mitochondrial
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p22

mRNA and Protein(s)

mRNA	Protein	Name
XM_006250675.3	XP_006250737.1	4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X1
NM_001044255.1	NP_001037720.1	4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor

Pathways from BioSystems

Homologies

	LOC707681	XP_002808454.1
Rattus norvegicus (Norway rat)	Coq2	NP_001037720.1
Gallus gallus (chicken)	COQ2	XP_420564.3
Danio rerio (zebrafish)	coq2	NP_001082955.1
Drosophila melanogaster (fruit fly)	Coq2	NP_649789.1
Saccharomyces cerevisiae (baker's yeast)	COQ2	NP_014439.3
Eremothecium gossypii	AGOS_AGL231W	NP_986436.1
Schizosaccharomyces pombe (fission yeast)	ppt1	NP_593219.2
Neurospora crassa	NCU01553	XP_956256.1
Pan troglodytes (chimpanzee)	COQ2	XP_526592.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004513	XP_003436832.1
Caenorhabditis elegans (roundworm)	coq-2	NP_871684.1
Arabidopsis thaliana (thale cress)	PPT1	NP_001190815.1
Homo sapiens (human)	COQ2	NP_056512.5
Bos taurus (cattle)	COQ2	NP_001039358.1
Mus musculus (house mouse)	Coq2	NP_082254.2
Kluyveromyces lactis	KLLA0F10307g	XP_455549.1
Canis lupus familiaris (dog)	COQ2	XP_535634.2
Magnaporthe oryzae (rice blast fungus)	MGG_01067	XP_003717872.1
Oryza sativa (rice)	Os08g0322600	NP_001061539.1
Xenopus tropicalis (tropical clawed frog)	LOC100486844	XP_002936501.1

Gene Ontology
Bibliography

Related articles in PubMed

The COQ2 genotype predicts the severity of coenzyme Q10 deficiency.
Desbats MA, Morbidoni V, Silic-Benussi M, Doimo M, Ciminale V, Cassina M, Sacconi S, Hirano M, Basso G, Pierrel F, Navas P, Salviati L, Trevisson E
Human molecular genetics25(19)4256-4265(2016 10)

New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats.
Sasaki D, Kotoh J, Watadani R, Matsumoto K
Mammalian genome : official journal of the International Mammalian Genome Society26(11-12)619-29(2015 Dec)

Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis.
L?pez-Mart?n JM, Salviati L, Trevisson E, Montini G, DiMauro S, Quinzii C, Hirano M, Rodriguez-Hernandez A, Cordero MD, S?nchez-Alc?zar JA, Santos-Oca?a C, Navas P
Human molecular genetics16(9)1091-7(2007 May)

A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency.
Quinzii C, Naini A, Salviati L, Trevisson E, Navas P, Dimauro S, Hirano M
American journal of human genetics78(2)345-9(2006 Feb)

Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ.
Forsgren M, Attersand A, Lake S, Gr?nler J, Swiezewska E, Dallner G, Climent I
The Biochemical journal382(Pt 2)519-26(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are differentially expressed in obese rats, suggesting that these two genes are candidates for the onset of type 2 diabetes associated with obesity in rats.
Title: New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats.

The following Coq2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Coq2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12849	NM_001044255.1 Latest version!	Rattus norvegicus coenzyme Q2, polyprenyltransferase (Coq2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
ORa35861	XM_006250675.3 Latest version!	Rattus norvegicus coenzyme Q2, polyprenyltransferase (Coq2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Coq2 ( NM_001044255.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001037720.1 Rattus norvegicus coenzyme Q2, polyprenyltransferase (Coq2), mRNA.

Price & Availability↑

CloneID	ORa12849
Clone ID Related Accession (Same CDS sequence)	NM_001044255.1
Accession Version	NM_001044255.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC099827.1. On or before Aug 24, 2006 this sequence version replaced XM_573556.2, XM_001061021.1. ##Evidence-Data-START## Transcript exon combination :: BC099827.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGCTGCGCT TGGGAGGCGC GGGGCTAGTG CGGGGCCTGC GGGTGGTGTC GCCCGCATGG 
CTGCGAGGTC CGGGTGGACT CCCGCTGGCC CTGGCGCGCA CCACAGGGAC GTCGGGAGCG 
CGGGACCGGC GAGCGCCGGC CTCCGGGACG CAGCGCGGGC GCGCACTCAG CCTGTCCGCC 
GCAGCCGTAG TGAACTCGGC GCCCCGCCCG CTGCAGCCCT ACCTGCGGCT CATGCGCCTG 
GACAAGCCCA TCGGAACCTG GCTGCTGTAT TTGCCATGCA CTTGGAGCAT TGGTCTGGCC 
GCTGACCCGG GTTGTTTTCC TGACTGGTAT ATGTTATCAC TCTTTGGCAC TGGAGCTATT 
CTCATGCGTG GAGCAGGCTG TACTATTAAT GACATGTGGG ACCGTGACTT CGATAAAAAG 
GTCGAGAGGA CAGCAAACCG CCCAATCGCC GCGGGAGACA TTTCAGCCTT CCAGTCCTTC 
GTCTTCCTTG GGGCACAGCT GACCTTGGCA CTGGGCGTTC TCCTGCATCT GAACTACTAC 
AGTATAGCAA TGGGAGCAGC ATCCTTACTT CTTGTCGTCA CCTACCCCCT CATGAAAAGA 
GTCACGTTCT GGCCTCAGTT AGCCTTGGGC TTGACTTTTA ATTGGGGTGC GTTACTCGGA 
TGGTCTGCTG TCAAGGGCTC CTGTGATCCA GCTGTGTGCC TGCCTCTTTA TTTTTCTGGA 
GTTATGTGGA CACTGATATA TGATACTATT TATGCCCACC AGGACAAGAA AGATGATGCT 
CTGATTGGCC TGAAGTCCAC AGCTCTGCTC TTCAGGGAGA ACACCAAGCA GTGGCTCAGT 
GGCTTTGGGG TCGCCATGGT GGGAGCGCTG AGCCTGGTGG GAGCCAGCAG TGGTCAGACC 
CTCCCTTACT ACGCTGCCGT GGCTGCAGTG GGAGCCCACC TGGCTCACCA GATTTACACC 
GTGGACATCC ACAGAGCCGA GGACTGCTGG GAAAAGTTTA CCTCCAACCG CACAGTAGGC 
CTACTCCTGT TCTTAGGGAT TGTGCTTGGG AATTTGTACA AAGACAAGCC GGACGAGACG 
AAGGGAGTGG ACGCTGTTGG AGAGGAAAGT GAGCGGACAA GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001037720.1
CDS	5..1129
Translation	MLRLGGAGLVRGLRVVSPAWLRGPGGLPLALARTTGTSGARDRRAPASGTQRGRALSLSAAAVVNSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGSCDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAVAAVGAHLAHQIYTVDIHRAEDCWEKFTSNRTVGLLLFLGIVLGNLYKDKPDETKGVDAVGEESERTS

Target ORF information:

RefSeq Version	NM_001044255.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus coenzyme Q2, polyprenyltransferase (Coq2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001044255.1

ORF Insert Sequence:

ATGCTGCGCT TGGGAGGCGC GGGGCTAGTG CGGGGCCTGC GGGTGGTGTC GCCCGCATGG 
CTGCGAGGTC CGGGTGGACT CCCGCTGGCC CTGGCGCGCA CCACAGGGAC GTCGGGAGCG 
CGGGACCGGC GAGCGCCGGC CTCCGGGACG CAGCGCGGGC GCGCACTCAG CCTGTCCGCC 
GCAGCCGTAG TGAACTCGGC GCCCCGCCCG CTGCAGCCCT ACCTGCGGCT CATGCGCCTG 
GACAAGCCCA TCGGAACCTG GCTGCTGTAT TTGCCATGCA CTTGGAGCAT TGGTCTGGCC 
GCTGACCCGG GTTGTTTTCC TGACTGGTAT ATGTTATCAC TCTTTGGCAC TGGAGCTATT 
CTCATGCGTG GAGCAGGCTG TACTATTAAT GACATGTGGG ACCGTGACTT CGATAAAAAG 
GTCGAGAGGA CAGCAAACCG CCCAATCGCC GCGGGAGACA TTTCAGCCTT CCAGTCCTTC 
GTCTTCCTTG GGGCACAGCT GACCTTGGCA CTGGGCGTTC TCCTGCATCT GAACTACTAC 
AGTATAGCAA TGGGAGCAGC ATCCTTACTT CTTGTCGTCA CCTACCCCCT CATGAAAAGA 
GTCACGTTCT GGCCTCAGTT AGCCTTGGGC TTGACTTTTA ATTGGGGTGC GTTACTCGGA 
TGGTCTGCTG TCAAGGGCTC CTGTGATCCA GCTGTGTGCC TGCCTCTTTA TTTTTCTGGA 
GTTATGTGGA CACTGATATA TGATACTATT TATGCCCACC AGGACAAGAA AGATGATGCT 
CTGATTGGCC TGAAGTCCAC AGCTCTGCTC TTCAGGGAGA ACACCAAGCA GTGGCTCAGT 
GGCTTTGGGG TCGCCATGGT GGGAGCGCTG AGCCTGGTGG GAGCCAGCAG TGGTCAGACC 
CTCCCTTACT ACGCTGCCGT GGCTGCAGTG GGAGCCCACC TGGCTCACCA GATTTACACC 
GTGGACATCC ACAGAGCCGA GGACTGCTGG GAAAAGTTTA CCTCCAACCG CACAGTAGGC 
CTACTCCTGT TCTTAGGGAT TGTGCTTGGG AATTTGTACA AAGACAAGCC GGACGAGACG 
AAGGGAGTGG ACGCTGTTGG AGAGGAAAGT GAGCGGACAA GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Coq2 ( XM_006250675.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006250737.1 Rattus norvegicus coenzyme Q2, polyprenyltransferase (Coq2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa35861
Clone ID Related Accession (Same CDS sequence)	XM_006250675.3
Accession Version	XM_006250675.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006250675.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCGCT TGGGAGGCGC GGGGCTAGTG CGGGACCTGC GGGTGGTGTG GCCCGCATGG 
CTGCGAGGTC CGGGTGGACT CCCGCTGGCC CTGGCGCGCA CCACAGGGAC GTCGGGAGCG 
CGGGACCGGC GAGCGCCGGC CTCCGGGACG CAGCGCGGGC GCGCACTCAG CCTGTCCGCC 
GCAGCCGTAG TGAACTCGGC GCCCCGCCCG CTGCAGCCCT ACCTGCGGCT CATGCGCCTG 
GACAAGCCCA TCGGAACCTG GCTGCTGTAT TTGCCATGCA CTTGGAGCAT TGGTCTGGCC 
GCTGACCCGG GTTGTTTTCC TGACTGGTAT ATGTTATCAC TCTTTGGCAC TGGAGCTATT 
CTCATGCGTG GAGCAGGCTG TACTATTAAT GACATGTGGG ACCGTGACTT CGATAAAAAG 
GTCGAGAGGA CAGCAAACCG CCCAATCGCC GCGGGAGACA TTTCAGCCTT CCAGTCCTTC 
GTCTTCCTTG GGGCACAGCT GACCTTGGCA CTGGGCGTTC TCCTGCATCT GAACTACTAC 
AGTATAGCAA TGGGAGCAGC ATCCTTACTT CTTGTCGTCA CCTACCCCCT CATGAAAAGA 
GTCACGTTCT GGCCTCAGTT AGCCTTGGGC TTGACTTTTA ATTGGGGTGC GTTACTCGGA 
TGGTCTGCTG TCAAGGGCTC CTGTGATCCA GCTGTGTGCC TGCCTCTTTA TTTTTCTGGA 
GTTATGTGGA CACTGATATA TGATACTATT TATGCCCACC AGATTTACAC CGTGGACATC 
CACAGAGCCG AGGACTGCTG GGAAAAGTTT ACCTCCAACC GCACAGTAGG CCTACTCCTG 
TTCTTAGGGA TTGTGCTTGG GAATTTGTAC AAAGACAAGC CGGACGAGAC GAAGGGAGTG 
GACGCTGTTG GAGAGGAAAG TGAGCGGACA AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006250737.1
CDS	39..974
Translation	MLRLGGAGLVRDLRVVWPAWLRGPGGLPLALARTTGTSGARDRRAPASGTQRGRALSLSAAAVVNSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGSCDPAVCLPLYFSGVMWTLIYDTIYAHQIYTVDIHRAEDCWEKFTSNRTVGLLLFLGIVLGNLYKDKPDETKGVDAVGEESERTS

Target ORF information:

RefSeq Version	XM_006250675.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus coenzyme Q2, polyprenyltransferase (Coq2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006250675.3

ORF Insert Sequence:

ATGCTGCGCT TGGGAGGCGC GGGGCTAGTG CGGGACCTGC GGGTGGTGTG GCCCGCATGG 
CTGCGAGGTC CGGGTGGACT CCCGCTGGCC CTGGCGCGCA CCACAGGGAC GTCGGGAGCG 
CGGGACCGGC GAGCGCCGGC CTCCGGGACG CAGCGCGGGC GCGCACTCAG CCTGTCCGCC 
GCAGCCGTAG TGAACTCGGC GCCCCGCCCG CTGCAGCCCT ACCTGCGGCT CATGCGCCTG 
GACAAGCCCA TCGGAACCTG GCTGCTGTAT TTGCCATGCA CTTGGAGCAT TGGTCTGGCC 
GCTGACCCGG GTTGTTTTCC TGACTGGTAT ATGTTATCAC TCTTTGGCAC TGGAGCTATT 
CTCATGCGTG GAGCAGGCTG TACTATTAAT GACATGTGGG ACCGTGACTT CGATAAAAAG 
GTCGAGAGGA CAGCAAACCG CCCAATCGCC GCGGGAGACA TTTCAGCCTT CCAGTCCTTC 
GTCTTCCTTG GGGCACAGCT GACCTTGGCA CTGGGCGTTC TCCTGCATCT GAACTACTAC 
AGTATAGCAA TGGGAGCAGC ATCCTTACTT CTTGTCGTCA CCTACCCCCT CATGAAAAGA 
GTCACGTTCT GGCCTCAGTT AGCCTTGGGC TTGACTTTTA ATTGGGGTGC GTTACTCGGA 
TGGTCTGCTG TCAAGGGCTC CTGTGATCCA GCTGTGTGCC TGCCTCTTTA TTTTTCTGGA 
GTTATGTGGA CACTGATATA TGATACTATT TATGCCCACC AGATTTACAC CGTGGACATC 
CACAGAGCCG AGGACTGCTG GGAAAAGTTT ACCTCCAACC GCACAGTAGG CCTACTCCTG 
TTCTTAGGGA TTGTGCTTGG GAATTTGTAC AAAGACAAGC CGGACGAGAC GAAGGGAGTG 
GACGCTGTTG GAGAGGAAAG TGAGCGGACA AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The COQ2 genotype predicts the severity of coenzyme Q10 deficiency.
Human molecular genetics25(19)4256-4265(2016 10)
Desbats MA,Morbidoni V,Silic-Benussi M,Doimo M,Ciminale V,Cassina M,Sacconi S,Hirano M,Basso G,Pierrel F,Navas P,Salviati L,Trevisson E

New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats.
Mammalian genome : official journal of the International Mammalian Genome Society26(11-12)619-29(2015 Dec)
Sasaki D,Kotoh J,Watadani R,Matsumoto K

Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis.
Human molecular genetics16(9)1091-7(2007 May)
L?pez-Mart?n JM,Salviati L,Trevisson E,Montini G,DiMauro S,Quinzii C,Hirano M,Rodriguez-Hernandez A,Cordero MD,S?nchez-Alc?zar JA,Santos-Oca?a C,Navas P

A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency.
American journal of human genetics78(2)345-9(2006 Feb)
Quinzii C,Naini A,Salviati L,Trevisson E,Navas P,Dimauro S,Hirano M

Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ.
The Biochemical journal382(Pt 2)519-26(2004 Sep)
Forsgren M,Attersand A,Lake S,Gr?nler J,Swiezewska E,Dallner G,Climent I

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Coq2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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