Crppa cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Crppa
Entrez Gene ID	493574
Full Name	isoprenoid synthase domain containing
Synonyms	Nip
General protein information	Preferred Names isoprenoid synthase domain containing Names D-ribitol-5-phosphate cytidylyltransferase isoprenoid synthase domain-containing protein 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein notch1-induced protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q16-q21

mRNA and Protein(s)

mRNA	Protein	Name
XM_008764603.2	XP_008762825.1	isoprenoid synthase domain-containing protein isoform X1
NM_001008386.1	NP_001008387.1	D-ribitol-5-phosphate cytidylyltransferase

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ISPD	XP_002686725.1
	ISPD	XP_001105001.2
Mus musculus (house mouse)	Ispd	NP_848744.2
Gallus gallus (chicken)	ISPD	XP_004939388.1
Danio rerio (zebrafish)	ispd	NP_001071270.1
Homo sapiens (human)	ISPD	NP_001094896.1
Pan troglodytes (chimpanzee)	ISPD	XP_003318374.1
Canis lupus familiaris (dog)	ISPD	XP_003431914.1
Rattus norvegicus (Norway rat)	Ispd	NP_001008387.1
Xenopus tropicalis (tropical clawed frog)	ispd	NP_001016240.1

Gene Ontology
Bibliography

Related articles in PubMed

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.
Riemersma M, Froese DS, van Tol W, Engelke UF, Kopec J, van Scherpenzeel M, Ashikov A, Krojer T, von Delft F, Tessari M, Buczkowska A, Swiezewska E, Jae LT, Brummelkamp TR, Manya H, Endo T, van Bokhoven H, Yue WW, Lefeber DJ
Chemistry & biology22(12)1643-52(2015 Dec)

Dystroglycan organizes axon guidance cue localization and axonal pathfinding.
Wright KM, Lyon KA, Leung H, Leahy DJ, Ma L, Ginty DD
Neuron76(5)931-44(2012 Dec)

Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of ?-dystroglycan.
Roscioli T, Kamsteeg EJ, Buysse K, Maystadt I, van Reeuwijk J, van den Elzen C, van Beusekom E, Riemersma M, Pfundt R, Vissers LE, Schraders M, Altunoglu U, Buckley MF, Brunner HG, Grisart B, Zhou H, Veltman JA, Gilissen C, Mancini GM, Delr?e P, Willemsen MA, Ramad?a DP, Chitayat D, Bennett C, Sheridan E, Peeters EA, Tan-Sindhunata GM, de Die-Smulders CE, Devriendt K, Kayserili H, El-Hashash OA, Stemple DL, Lefeber DJ, Lin YY, van Bokhoven H
Nature genetics44(5)581-5(2012 May)

ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome.
Willer T, Lee H, Lommel M, Yoshida-Moriguchi T, de Bernabe DB, Venzke D, Cirak S, Schachter H, Vajsar J, Voit T, Muntoni F, Loder AS, Dobyns WB, Winder TL, Strahl S, Mathews KD, Nelson SF, Moore SA, Campbell KP
Nature genetics44(5)575-80(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Crppa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crppa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00155	NM_001008386.1 Latest version!	Rattus norvegicus CDP-L-ribitol pyrophosphorylase A (Crppa), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
ORa48975	XM_008764603.2 Latest version!	Rattus norvegicus isoprenoid synthase domain containing (Ispd), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Crppa ( NM_001008386.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001008387.1 Rattus norvegicus CDP-L-ribitol pyrophosphorylase A (Crppa), mRNA.

Price & Availability↑

CloneID	ORa00155
Clone ID Related Accession (Same CDS sequence)	NM_001008386.1
Accession Version	NM_001008386.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	D-ribitol-5-phosphate cytidylyltransferase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY769992.1. ##Evidence-Data-START## Transcript exon combination :: AY769992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGTCCG GGCCGTGCAG CAGGCCCGCT GAGCCTCGGC ATTGCGTGAG CGGCCGGGCG 
GGCGCGGGTT TAGCGTTCCC GGCGTTCCCA TTGTCCGCTG CCGGGGCGGA GCCCGGGAGC 
CGCATTGGAA CTGTAGCCGC TGTGCTGCCG GCTGGGGGCT GCGGAGAAAG GATGGGCGTC 
CGCACCCCGA AGCAGTTCTG CCGGGTCCTG GAGAGGCCGC TCATCAGCTA CACACTGCAG 
GCTATGGAGA GAGTATGCTG GATAAAGGAC ATTGTTGTGA CAGTGACAGG GGAGAACATG 
GAAGCGATGA GAAGCATCAT TCAGAGGTAT GGGCATAAGC GCATCTCACT AGCTGAGGCC 
GGAGCCACGC GCCACAGATC AATTTTCAAT GGACTGAAAG CCCTGGCAGA AGATCAGCCA 
GGCTGTGAAC TCACTAGACC AGAAGTTGTG ATTATCCACG ATGCCGTGAG ACCTTTTGTT 
GAGGAAGATA TCCTCCTGAG AGTTGTCCTA GCAGCTAAGG AGCATGGGGC AGCAGGAGCA 
ATTCGACCTC TGGTGTCCAC TGTCGTCAGT CCGTCTGCTG ATGGTCACTT AGACCACTCA 
CTGGACCGTG CCAAGCACAG GGCAAGCGAA ATGCCCCAGG CTTTTCACTT TGATGTGATC 
TATGAAGCGT ATCAGAAGTG TAGTGATTTT GACTTGGAAT TTGGAACAGA GTGCTTGCAG 
TTGGCCCTAA AATACTGTCA CAGGAAAGCA AAACTTGTAG AAGGGACCCC TGACCTCTGG 
AAGGTGACCT ACAAACAAGA CCTGTGTGCA GCTGAAGCCA TGATTAAGGA AAAAATTTCA 
CAAGAGATTT GTGTGGTCGT GAACACAAAA GATGAAGAAT CTGTAGGACA TCTTCTTGAG 
GAAGTGCTAA GAAATGAACT AAATTGTATT AAAGTCACAT CCACAGTTTT GGATCGCACC 
AGTGGAGACA TTGAGAACTT CATAGACCAA TGCTACAGTT TCATCTGTGT GAATGTTGTG 
TCCTCTGAGA GTCGAGAAAC CAGGAAGTTA CTGAGTATCC TCGAAGAGAG CAGCCTTCCT 
CTTCTGTATC CCGTCGTTGT CGTTTTGGTG CATTGCTTTG ATTTCACGGT AGTGCCGCTC 
GCTCAGAAGA TGGAGAACCT GGTGTGGATC AGGGAATTAG CAAAGGAAGC AAAAGGAAGG 
AATGTTCTAT TAAGTGGAGT CCTCCTAAAT CACTCACAGG ATGAGCAGAA GCTACAAGAG 
AGTTTAGTAC AAAGTGCAGC CATCATAGCT GCCTTGGTTA AGGAAAGAAA TTCTGCACTC 
GTCGGGCAGC TCCTGGTGGC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008387.1
CDS	93..1436
Translation	MESGPCSRPAEPRHCVSGRAGAGLAFPAFPLSAAGAEPGSRIGTVAAVLPAGGCGERMGVRTPKQFCRVLERPLISYTLQAMERVCWIKDIVVTVTGENMEAMRSIIQRYGHKRISLAEAGATRHRSIFNGLKALAEDQPGCELTRPEVVIIHDAVRPFVEEDILLRVVLAAKEHGAAGAIRPLVSTVVSPSADGHLDHSLDRAKHRASEMPQAFHFDVIYEAYQKCSDFDLEFGTECLQLALKYCHRKAKLVEGTPDLWKVTYKQDLCAAEAMIKEKISQEICVVVNTKDEESVGHLLEEVLRNELNCIKVTSTVLDRTSGDIENFIDQCYSFICVNVVSSESRETRKLLSILEESSLPLLYPVVVVLVHCFDFTVVPLAQKMENLVWIRELAKEAKGRNVLLSGVLLNHSQDEQKLQESLVQSAAIIAALVKERNSALVGQLLVA

Target ORF information:

RefSeq Version	NM_001008386.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CDP-L-ribitol pyrophosphorylase A (Crppa), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008386.1

ORF Insert Sequence:

ATGGAGTCCG GGCCGTGCAG CAGGCCCGCT GAGCCTCGGC ATTGCGTGAG CGGCCGGGCG 
GGCGCGGGTT TAGCGTTCCC GGCGTTCCCA TTGTCCGCTG CCGGGGCGGA GCCCGGGAGC 
CGCATTGGAA CTGTAGCCGC TGTGCTGCCG GCTGGGGGCT GCGGAGAAAG GATGGGCGTC 
CGCACCCCGA AGCAGTTCTG CCGGGTCCTG GAGAGGCCGC TCATCAGCTA CACACTGCAG 
GCTATGGAGA GAGTATGCTG GATAAAGGAC ATTGTTGTGA CAGTGACAGG GGAGAACATG 
GAAGCGATGA GAAGCATCAT TCAGAGGTAT GGGCATAAGC GCATCTCACT AGCTGAGGCC 
GGAGCCACGC GCCACAGATC AATTTTCAAT GGACTGAAAG CCCTGGCAGA AGATCAGCCA 
GGCTGTGAAC TCACTAGACC AGAAGTTGTG ATTATCCACG ATGCCGTGAG ACCTTTTGTT 
GAGGAAGATA TCCTCCTGAG AGTTGTCCTA GCAGCTAAGG AGCATGGGGC AGCAGGAGCA 
ATTCGACCTC TGGTGTCCAC TGTCGTCAGT CCGTCTGCTG ATGGTCACTT AGACCACTCA 
CTGGACCGTG CCAAGCACAG GGCAAGCGAA ATGCCCCAGG CTTTTCACTT TGATGTGATC 
TATGAAGCGT ATCAGAAGTG TAGTGATTTT GACTTGGAAT TTGGAACAGA GTGCTTGCAG 
TTGGCCCTAA AATACTGTCA CAGGAAAGCA AAACTTGTAG AAGGGACCCC TGACCTCTGG 
AAGGTGACCT ACAAACAAGA CCTGTGTGCA GCTGAAGCCA TGATTAAGGA AAAAATTTCA 
CAAGAGATTT GTGTGGTCGT GAACACAAAA GATGAAGAAT CTGTAGGACA TCTTCTTGAG 
GAAGTGCTAA GAAATGAACT AAATTGTATT AAAGTCACAT CCACAGTTTT GGATCGCACC 
AGTGGAGACA TTGAGAACTT CATAGACCAA TGCTACAGTT TCATCTGTGT GAATGTTGTG 
TCCTCTGAGA GTCGAGAAAC CAGGAAGTTA CTGAGTATCC TCGAAGAGAG CAGCCTTCCT 
CTTCTGTATC CCGTCGTTGT CGTTTTGGTG CATTGCTTTG ATTTCACGGT AGTGCCGCTC 
GCTCAGAAGA TGGAGAACCT GGTGTGGATC AGGGAATTAG CAAAGGAAGC AAAAGGAAGG 
AATGTTCTAT TAAGTGGAGT CCTCCTAAAT CACTCACAGG ATGAGCAGAA GCTACAAGAG 
AGTTTAGTAC AAAGTGCAGC CATCATAGCT GCCTTGGTTA AGGAAAGAAA TTCTGCACTC 
GTCGGGCAGC TCCTGGTGGC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Crppa ( XM_008764603.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008762825.1 Rattus norvegicus isoprenoid synthase domain containing (Ispd), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa48975
Clone ID Related Accession (Same CDS sequence)	XM_008764603.2
Accession Version	XM_008764603.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	isoprenoid synthase domain-containing protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008764603.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTCCG GGCCGTGCAG CAGGCCCGCT GAGCCTCGGC ATTGCGTGAG CGGCCGGGCG 
GGCGCGGGTT TAGCGTTCCC GGCGTTCCCA TTGTCCGCTG CCGGGGCGGA GCCCGGGAGC 
CGCATTGGAA CTGTAGCCGC TGTGCTGCCG GCTGGGGGCT GCGGAGAAAG GATGGGCGTC 
CGCACCCCGA AGCAGTTCTG CCGGGTCCTG GAGAGGCCGC TCATCAGCTA CACACTGCAG 
GCTATGGAGA GAGTATGCTG GATAAAGGAC ATTGTTGTGA CAGTGACAGG GGAGAACATG 
GAAGCGATGA GAAGCATCAT TCAGAGGTAT GGGCATAAGC GCATCTCACT AGCTGAGGCC 
GGAGCCACGC GCCACAGATC AATTTTCAAT GGACTGAAAG CCCTGGCAGA AGATCAGCCA 
GGCTGTGAAC TCACTAGACC AGAAGTTGTG ATTATCCACG ATGCCGTGAG ACCTTTTGTT 
GAGGAAGATA TCCTCCTGAG AGTTGTCCTA GCAGCTAAGG AGCATGGGGC AGCAGGAGCA 
ATTCGACCTC TGGTGTCCAC TGTCGTCAGT CCGTCTGCTG ATGGTCACTT AGACCACTCA 
CTGGACCGTG CCAAGCACAG GGCAAGCGAA ATGCCCCAGG CTTTTCACTT TGATGTGATC 
TATGAAGCGT ATCAGAAGTG TAGTGATTTT GACTTGGAAT TTGGAACAGA GTGCTTGCAG 
TTGGCCCTAA AATACTGTCA CAGGAAAGCA AAACTTGTAG AAGGGACCCC TGACCTCTGG 
AAGGTGACCT ACAAACAAGA CCTGTGTGCA GCTGAAGCCA TGATTAAGGG TGTTCTATTT 
TCTTCTGAAA GAGTGATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008762825.1
CDS	1441..2301
Translation	MESGPCSRPAEPRHCVSGRAGAGLAFPAFPLSAAGAEPGSRIGTVAAVLPAGGCGERMGVRTPKQFCRVLERPLISYTLQAMERVCWIKDIVVTVTGENMEAMRSIIQRYGHKRISLAEAGATRHRSIFNGLKALAEDQPGCELTRPEVVIIHDAVRPFVEEDILLRVVLAAKEHGAAGAIRPLVSTVVSPSADGHLDHSLDRAKHRASEMPQAFHFDVIYEAYQKCSDFDLEFGTECLQLALKYCHRKAKLVEGTPDLWKVTYKQDLCAAEAMIKGVLFSSERVI

Target ORF information:

RefSeq Version	XM_008764603.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus isoprenoid synthase domain containing (Ispd), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008764603.2

ORF Insert Sequence:

ATGGAGTCCG GGCCGTGCAG CAGGCCCGCT GAGCCTCGGC ATTGCGTGAG CGGCCGGGCG 
GGCGCGGGTT TAGCGTTCCC GGCGTTCCCA TTGTCCGCTG CCGGGGCGGA GCCCGGGAGC 
CGCATTGGAA CTGTAGCCGC TGTGCTGCCG GCTGGGGGCT GCGGAGAAAG GATGGGCGTC 
CGCACCCCGA AGCAGTTCTG CCGGGTCCTG GAGAGGCCGC TCATCAGCTA CACACTGCAG 
GCTATGGAGA GAGTATGCTG GATAAAGGAC ATTGTTGTGA CAGTGACAGG GGAGAACATG 
GAAGCGATGA GAAGCATCAT TCAGAGGTAT GGGCATAAGC GCATCTCACT AGCTGAGGCC 
GGAGCCACGC GCCACAGATC AATTTTCAAT GGACTGAAAG CCCTGGCAGA AGATCAGCCA 
GGCTGTGAAC TCACTAGACC AGAAGTTGTG ATTATCCACG ATGCCGTGAG ACCTTTTGTT 
GAGGAAGATA TCCTCCTGAG AGTTGTCCTA GCAGCTAAGG AGCATGGGGC AGCAGGAGCA 
ATTCGACCTC TGGTGTCCAC TGTCGTCAGT CCGTCTGCTG ATGGTCACTT AGACCACTCA 
CTGGACCGTG CCAAGCACAG GGCAAGCGAA ATGCCCCAGG CTTTTCACTT TGATGTGATC 
TATGAAGCGT ATCAGAAGTG TAGTGATTTT GACTTGGAAT TTGGAACAGA GTGCTTGCAG 
TTGGCCCTAA AATACTGTCA CAGGAAAGCA AAACTTGTAG AAGGGACCCC TGACCTCTGG 
AAGGTGACCT ACAAACAAGA CCTGTGTGCA GCTGAAGCCA TGATTAAGGG TGTTCTATTT 
TCTTCTGAAA GAGTGATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.
Chemistry & biology22(12)1643-52(2015 Dec)
Riemersma M,Froese DS,van Tol W,Engelke UF,Kopec J,van Scherpenzeel M,Ashikov A,Krojer T,von Delft F,Tessari M,Buczkowska A,Swiezewska E,Jae LT,Brummelkamp TR,Manya H,Endo T,van Bokhoven H,Yue WW,Lefeber DJ

Dystroglycan organizes axon guidance cue localization and axonal pathfinding.
Neuron76(5)931-44(2012 Dec)
Wright KM,Lyon KA,Leung H,Leahy DJ,Ma L,Ginty DD

Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of ?-dystroglycan.
Nature genetics44(5)581-5(2012 May)
Roscioli T,Kamsteeg EJ,Buysse K,Maystadt I,van Reeuwijk J,van den Elzen C,van Beusekom E,Riemersma M,Pfundt R,Vissers LE,Schraders M,Altunoglu U,Buckley MF,Brunner HG,Grisart B,Zhou H,Veltman JA,Gilissen C,Mancini GM,Delr?e P,Willemsen MA,Ramad?a DP,Chitayat D,Bennett C,Sheridan E,Peeters EA,Tan-Sindhunata GM,de Die-Smulders CE,Devriendt K,Kayserili H,El-Hashash OA,Stemple DL,Lefeber DJ,Lin YY,van Bokhoven H

ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome.
Nature genetics44(5)575-80(2012 May)
Willer T,Lee H,Lommel M,Yoshida-Moriguchi T,de Bernabe DB,Venzke D,Cirak S,Schachter H,Vajsar J,Voit T,Muntoni F,Loder AS,Dobyns WB,Winder TL,Strahl S,Mathews KD,Nelson SF,Moore SA,Campbell KP

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Crppa cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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