Kdm6b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kdm6b
Entrez Gene ID	363630
Full Name	lysine demethylase 6B
Synonyms	Jmjd3
General protein information	Preferred Names lysine demethylase 6B Names lysine-specific demethylase 6B jumonji domain-containing 3 lysine (K)-specific demethylase 6B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597421.1	XP_017452910.1	lysine-specific demethylase 6B isoform X1
NM_001108829.1	NP_001102299.1	lysine-specific demethylase 6B

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Kdm6b	NP_001017426.1
Pan troglodytes (chimpanzee)	KDM6B	XP_003315411.1
Rattus norvegicus (Norway rat)	Kdm6b	NP_001102299.1
Canis lupus familiaris (dog)	KDM6B	XP_005620054.1
Bos taurus (cattle)	KDM6B	XP_003587460.2
Homo sapiens (human)	KDM6B	NP_001073893.1
	KDM6B	XP_001110616.1

Gene Ontology
Bibliography

Related articles in PubMed

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
Tumber A, Nuzzi A, Hookway ES, Hatch SB, Velupillai S, Johansson C, Kawamura A, Savitsky P, Yapp C, Szykowska A, Wu N, Bountra C, Strain-Damerell C, Burgess-Brown NA, Ruda GF, Fedorov O, Munro S, England KS, Nowak RP, Schofield CJ, La Thangue NB, Pawlyn C, Davies F, Morgan G, Athanasou N, M?ller S, Oppermann U, Brennan PE
Cell chemical biology24(3)371-380(2017 Mar)

Decreased Methylation Level of H3K27me3 Increases Seizure Susceptibility.
Wang Z, Zhang Y, Fang J, Yu F, Heng D, Fan Y, Xu J, Peng B, Liu W, Han S, He X
Molecular neurobiology(2016 Nov)

Jmjd3 mediates blood-spinal cord barrier disruption after spinal cord injury by regulating MMP-3 and MMP-9 expressions.
Lee JY, Na WH, Choi HY, Lee KH, Ju BG, Yune TY
Neurobiology of disease9566-81(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the fast transient expression of Bdnf promoters II and VI after neuronal stimulation is dependent on acetylation of histone H3K27 by CREB-p/CBP.
Title: Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons.

Stat1 and Stat3 cooperate with Jmjd3 to induce the expression of pro-inflammatory genes.
Title: The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia.

Jmjd3-mediated H3K27me3 demethylation is crucial for IL-6 gene activation in endothelial cells
Title: Molecular mechanism of Jmjd3-mediated interleukin-6 gene regulation in endothelial cells underlying spinal cord injury.

The following Kdm6b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kdm6b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08448	NM_001108829.1 Latest version!	Rattus norvegicus lysine demethylase 6B (Kdm6b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$727.30 $1039.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kdm6b ( NM_001108829.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102299.1 Rattus norvegicus lysine demethylase 6B (Kdm6b), mRNA.

Price & Availability↑

CloneID	ORa08448
Clone ID Related Accession (Same CDS sequence)	NM_001108829.1
Accession Version	NM_001108829.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4086bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Rattus norvegicus(Norway rat)
Product	lysine-specific demethylase 6B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473948.1. On or before Oct 4, 2007 this sequence version replaced XM_001079385.1, XM_343919.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCCTCCTG CCGCACTCTC AGGCCCCTCA GGAGAGGAAG GCCTCAGCCC TGGAGGCAAG 
CGCAGGAGAG GCTGCAGCTC TGAACAGGAG CAGCGGCACT CGCTGCCTCA CCCTCATCCA 
TACCCAGCTC CTGCCTACAC TGCTCATCCG CCCAGCCACC GGCTGGGCCC GGCCACACCC 
CTTGGTCCAG GTCCCCGACC CCCAGGAGCA GAGAGCCATG GCTGCCTGCC TGCCACCCGT 
CCCCCCGGAA GTGACCTTAG AGAGAGCAGA GTTCAGAGGT CGCGGATGGA CTCCAGCGTT 
TCACCAGCAG CATCTACCGC CTGCGTGCCT TACGCCCCTT CCCGGCCCCC TGGCCTCCCC 
GGCACCAGCA GCAGCAGCAG TAGCAGTAAC AACACTGGTC TTCGGGGTGT GGAGCCGAGC 
CCAGGCATTC CTGGCGCTGA CCATTACCAA AACCCTGCGT TGGAGATAGC CCCTCACCAG 
GCCCGCCTGG GTCCCTCCGC ACACAGCAGT CGGAAACCAT TTTTGACAGC CCCTGCTGCC 
GCTCCCCACT TATCCCTACC ATCCGGGACC CCTTCATCCC CTCCACCCCC ATGTCCTCGC 
CTCTTGCGCC CTCCACCACC CCCTGCTTGG ATGAAGGGCT CAGCCTGCCG CTCAGCTCGA 
GAGGATGGAG AGATCTTAGG GGAGCTCTTC TTTGGTGCTG AGGGACCTCC CCGTCCTCCT 
CCCCCACCCC TTCCCCACCG TGATGGCTTC TTGGGGCCTC CAAACCCCCG CTTTTCTGTG 
GGCACTCAGG ATTCGCATAC CCCTCCCACT CCCCCAACCA CCACCAGCAG CAGCAGCAGC 
AGCAGCAGCA GCAACAGCCA CAGCAGTAGT CCTACTGGGC CTGTGCCCTT CCCACCACCT 
CCCTATCTGG CCAGAAGTAT AGACCCCCTT CCCAGGCCAT CTAGCCCAAC ACTGAGCTCC 
CAGGACCCAC CTCTTCCACC ACTGACTCTT GCCCTGCCTC CAGCCCCTCC CTCCTCCTGC 
CACCAAAATA CCTCAGGAAG CTTCAGGCGC TCGGAGAGCC CCCGGCCCAG GGTCTCCTTC 
CCAAAGACCC CCGAGGTGGG GCAGGGGCCA CCTCCAGGCT CTCTGAGTAA AGCCCCCCAG 
CCTGTGCCAC CTGGGGTTGG AGAGCTGCCT GCCCGAGGCC CGAGGCTCTT TGATTTTCCA 
CCAACTCCAC TGGAGGACCA GTTTGAAGAG CCAGCTGAAT TCAAGATCCT CCCTGATGGG 
CTAGCTAACA TCATGAAGAT GCTGGATGAA TCCATTAGAA AGGAGGAAGA GCAGCAGCAG 
CAAGAGGCAG GCGCGGTTCC CCCACCCCCA CTCAAAGAGC CCTTTGCATC TCTACGGTCT 
TCACTTCCCA GTGACACAGC CCCAGCTGCC ACCACTGCTG CTGCAACTCC CACCACCACC 
ACCACCACCA CCACCCAAGA AGAGGAGAAG AAGCCACCAC CAGCCCTGCC ACCACCACCG 
CCTCTAGCCA AGTTTCCTCC ACCACCCCAG CCCCCACCAC CTCCACCAGC CAGCCCAGCC 
AGCCTGCTCA AATCATTGGC CTCTGTTCTT GAGGGGCAAA AGTACTGTTA TCGGGGGACT 
GGAGCAGCCG TTTCAACCAG GCCCGGGTCC GTGCCCGCCA CTCAGTATTC CCCTAGTCCT 
GCATCAGGTG CTACCGCCCC ACCACCCACT TCAGTGGCCC CTAGCGCCCA GGGCTCCCCC 
AAGCCCTCTG TTTCCTCGTC ATCTCAGTTC TCTACCTCAG GTGGGCCTTG GGTCCGAGAG 
CGCAGGGCAG GTGAAGAGCC AGCACCAGGC CCCGTGACCC CTGCCCAGTT GCCCCCACCT 
CTGCCGCTGC CCCCTGCTCG TTCTGAGTCT GAGGTGCTAG AAGAAATCAG TCGGGCTTGT 
GAGACCCTTG TAGAGCGGGT GGGCCGGAGT GCCATCAACC CAGCAGACCC AGTGGACATA 
GCAGACCCAG TGGACAGTGG GACTGAGCCA CAGCCGCCTC CTGCACAGGC CAAGGAGGAG 
AGTGGGGGAG TGGCAGTGGC GGCAGCAGGT CCAGGTAGTG GTAAGCGTCG TCAGAAGGAG 
CATCGGAGGC ACAGACGGAC CTGTAGGGAC AGTGTGGGTC GTAGGCCCCG TGAGGGGAGG 
GCCAAGGCCA AGGCCAAGGC TCCCAAAGAA AAAAGCCGAA GGGTGCTGGG GAACTTGGAC 
TTGCAGAGTG AAGAGATCCA GGGCCGGGAG AAGGCCCGGC CTGATGTAGG TGGGGCTTCC 
AAAGTCAAGA CGCCCACAAC TCCAGCGCCC CCACCTGCTC CTGCCCCCTC TGCTCAGCCA 
ACACCCCCAT CAGCTCCTGT CCCTGGGAAG AAGACTCGAG AGGAAGCTCC AGGGCCTCCA 
GGTGTGAGCC GTGCAGATAT GCTGAAGCTT CGGTCGCTTA GTGAGGGGCC ACCTAAGGAG 
CTGAAGATCA GGCTCATCAA GGTGGAGAGT GGGGACAAGG AGACCTTCAT CGCCTCTGAG 
GTAGAAGAGC GGCGGCTGCG CATGGCAGAC CTCACCATCA GCCACTGCGC TGCTGATGTC 
ATGCGTGCCA GCAAGAATGC CAAGGTGAAA GGGAAATTCC GAGAGTCCTA CCTTTCCCCT 
GCCCAGTCTG TGAAACCGAA GATCAACACT GAGGAGAAGC TGCCCCGGGA AAAACTCAAC 
CCTCCTACAC CCAGCATTTA TTTGGAGAGC AAACGAGACG CCTTCTCGCC GGTCCTGCTG 
CAGTTCTGTA CAGATCCCCG GAACCCCATC ACTGTCATCA GGGGCCTGGC AGGTTCACTT 
CGGCTCAACT TAGGCCTTTT TTCCACCAAG ACTCTGGTGG AGGCGAGCGG TGAACACACA 
GTGGAGGTCC GTACCCAAGT GCAGCAGCCC TCAGACGAGA ACTGGGATCT GACAGGTACC 
AGACAGATCT GGCCCTGTGA GAGCTCCCGT TCACACACCA CCATCGCTAA ATATGCACAG 
TACCAGGCTT CGTCCTTCCA GGAGTCACTG CAGGAGGAGA AAGAGAGTGA GGATGAGGAA 
TCCGAGGAAC CAGACAGCAC TACAGGAACC TCTCCCAGCA GTGCACCAGA CCCCAAGAAC 
CATCACATCA TCAAGTTTGG CACAAACATC GACCTGTCTG ATGCCAAGAG GTGGAAGCCA 
CAACTACAGG AGCTGCTGAA ACTGCCTGCC TTCATGCGAG TAACATCCAC AGGCAACATG 
CTTAGCCATG TGGGACACAC CATCCTGGGC ATGAACACCG TGCAGCTATA CATGAAGGTT 
CCTGGCAGTC GAACGCCAGG CCACCAGGAG AATAACAATT TTTGCTCTGT CAATATCAAC 
ATTGGCCCCG GGGACTGCGA GTGGTTCGCG GTACATGAGC ACTATTGGGA GACCATCAGC 
GCCTTCTGCG ATCGGCATGG TGTGGATTAC TTGACTGGTT CCTGGTGGCC AATCTTGGAT 
GACCTCTATG CGTCCAATAT TCCTGTTTAC CGCTTCGTGC AGCGCCCTGG AGACCTTGTG 
TGGATTAATG CAGGGACTGT GCATTGGGTG CAGGCTACTG GCTGGTGCAA CAACATTGCC 
TGGAACGTGG GGCCCCTCAC CGCCTATCAA TACCAGCTGG CCCTGGAGCG ATATGAGTGG 
AACGAGGTGA AGAACGTCAA GTCCATTGTA CCCATGATTC ATGTGTCCTG GAACGTAGCT 
CGAACGGTCA AGATCAGTGA TCCTGACTTG TTCAAAATGA TCAAGTTCTG CCTCCTGCAG 
TCAATGAAGC ACTGCCAGGT GCAGCGGGAG AGCCTGGTGC GGGCAGGGAA GAAAATCGCT 
TACCAAGGCC GCGTCAAGGA CGAGCCTGCC TACTACTGCA ACGAATGCGA TGTGGAGGTG 
TTCAACATCC TGTTCGTTAC AAGTGAGAAT GGCAGCCGAA ACACGTACCT GGTGCACTGC 
GAGGGCTGTG CGCGCCGTCG CAGTGCGGGC CTACAGGGCG TGGTGGTGCT AGAGCAGTAC 
CGCACAGAGG AGCTGGCACA GGCCTATGAT GCCTTCACAC TGGCTCCTGC CAGCACGTCG 
CGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102299.1
CDS	421..4506
Translation	MPPAALSGPSGEEGLSPGGKRRRGCSSEQEQRHSLPHPHPYPAPAYTAHPPSHRLGPATPLGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAASTACVPYAPSRPPGLPGTSSSSSSSNNTGLRGVEPSPGIPGADHYQNPALEIAPHQARLGPSAHSSRKPFLTAPAAAPHLSLPSGTPSSPPPPCPRLLRPPPPPAWMKGSACRSAREDGEILGELFFGAEGPPRPPPPPLPHRDGFLGPPNPRFSVGTQDSHTPPTPPTTTSSSSSSSSSNSHSSSPTGPVPFPPPPYLARSIDPLPRPSSPTLSSQDPPLPPLTLALPPAPPSSCHQNTSGSFRRSESPRPRVSFPKTPEVGQGPPPGSLSKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQQEAGAVPPPPLKEPFASLRSSLPSDTAPAATTAAATPTTTTTTTTQEEEKKPPPALPPPPPLAKFPPPPQPPPPPPASPASLLKSLASVLEGQKYCYRGTGAAVSTRPGSVPATQYSPSPASGATAPPPTSVAPSAQGSPKPSVSSSSQFSTSGGPWVRERRAGEEPAPGPVTPAQLPPPLPLPPARSESEVLEEISRACETLVERVGRSAINPADPVDIADPVDSGTEPQPPPAQAKEESGGVAVAAAGPGSGKRRQKEHRRHRRTCRDSVGRRPREGRAKAKAKAPKEKSRRVLGNLDLQSEEIQGREKARPDVGGASKVKTPTTPAPPPAPAPSAQPTPPSAPVPGKKTREEAPGPPGVSRADMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVMRASKNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTSPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLAPASTSR

Target ORF information:

RefSeq Version	NM_001108829.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysine demethylase 6B (Kdm6b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108829.1

ORF Insert Sequence:

ATGCCTCCTG CCGCACTCTC AGGCCCCTCA GGAGAGGAAG GCCTCAGCCC TGGAGGCAAG 
CGCAGGAGAG GCTGCAGCTC TGAACAGGAG CAGCGGCACT CGCTGCCTCA CCCTCATCCA 
TACCCAGCTC CTGCCTACAC TGCTCATCCG CCCAGCCACC GGCTGGGCCC GGCCACACCC 
CTTGGTCCAG GTCCCCGACC CCCAGGAGCA GAGAGCCATG GCTGCCTGCC TGCCACCCGT 
CCCCCCGGAA GTGACCTTAG AGAGAGCAGA GTTCAGAGGT CGCGGATGGA CTCCAGCGTT 
TCACCAGCAG CATCTACCGC CTGCGTGCCT TACGCCCCTT CCCGGCCCCC TGGCCTCCCC 
GGCACCAGCA GCAGCAGCAG TAGCAGTAAC AACACTGGTC TTCGGGGTGT GGAGCCGAGC 
CCAGGCATTC CTGGCGCTGA CCATTACCAA AACCCTGCGT TGGAGATAGC CCCTCACCAG 
GCCCGCCTGG GTCCCTCCGC ACACAGCAGT CGGAAACCAT TTTTGACAGC CCCTGCTGCC 
GCTCCCCACT TATCCCTACC ATCCGGGACC CCTTCATCCC CTCCACCCCC ATGTCCTCGC 
CTCTTGCGCC CTCCACCACC CCCTGCTTGG ATGAAGGGCT CAGCCTGCCG CTCAGCTCGA 
GAGGATGGAG AGATCTTAGG GGAGCTCTTC TTTGGTGCTG AGGGACCTCC CCGTCCTCCT 
CCCCCACCCC TTCCCCACCG TGATGGCTTC TTGGGGCCTC CAAACCCCCG CTTTTCTGTG 
GGCACTCAGG ATTCGCATAC CCCTCCCACT CCCCCAACCA CCACCAGCAG CAGCAGCAGC 
AGCAGCAGCA GCAACAGCCA CAGCAGTAGT CCTACTGGGC CTGTGCCCTT CCCACCACCT 
CCCTATCTGG CCAGAAGTAT AGACCCCCTT CCCAGGCCAT CTAGCCCAAC ACTGAGCTCC 
CAGGACCCAC CTCTTCCACC ACTGACTCTT GCCCTGCCTC CAGCCCCTCC CTCCTCCTGC 
CACCAAAATA CCTCAGGAAG CTTCAGGCGC TCGGAGAGCC CCCGGCCCAG GGTCTCCTTC 
CCAAAGACCC CCGAGGTGGG GCAGGGGCCA CCTCCAGGCT CTCTGAGTAA AGCCCCCCAG 
CCTGTGCCAC CTGGGGTTGG AGAGCTGCCT GCCCGAGGCC CGAGGCTCTT TGATTTTCCA 
CCAACTCCAC TGGAGGACCA GTTTGAAGAG CCAGCTGAAT TCAAGATCCT CCCTGATGGG 
CTAGCTAACA TCATGAAGAT GCTGGATGAA TCCATTAGAA AGGAGGAAGA GCAGCAGCAG 
CAAGAGGCAG GCGCGGTTCC CCCACCCCCA CTCAAAGAGC CCTTTGCATC TCTACGGTCT 
TCACTTCCCA GTGACACAGC CCCAGCTGCC ACCACTGCTG CTGCAACTCC CACCACCACC 
ACCACCACCA CCACCCAAGA AGAGGAGAAG AAGCCACCAC CAGCCCTGCC ACCACCACCG 
CCTCTAGCCA AGTTTCCTCC ACCACCCCAG CCCCCACCAC CTCCACCAGC CAGCCCAGCC 
AGCCTGCTCA AATCATTGGC CTCTGTTCTT GAGGGGCAAA AGTACTGTTA TCGGGGGACT 
GGAGCAGCCG TTTCAACCAG GCCCGGGTCC GTGCCCGCCA CTCAGTATTC CCCTAGTCCT 
GCATCAGGTG CTACCGCCCC ACCACCCACT TCAGTGGCCC CTAGCGCCCA GGGCTCCCCC 
AAGCCCTCTG TTTCCTCGTC ATCTCAGTTC TCTACCTCAG GTGGGCCTTG GGTCCGAGAG 
CGCAGGGCAG GTGAAGAGCC AGCACCAGGC CCCGTGACCC CTGCCCAGTT GCCCCCACCT 
CTGCCGCTGC CCCCTGCTCG TTCTGAGTCT GAGGTGCTAG AAGAAATCAG TCGGGCTTGT 
GAGACCCTTG TAGAGCGGGT GGGCCGGAGT GCCATCAACC CAGCAGACCC AGTGGACATA 
GCAGACCCAG TGGACAGTGG GACTGAGCCA CAGCCGCCTC CTGCACAGGC CAAGGAGGAG 
AGTGGGGGAG TGGCAGTGGC GGCAGCAGGT CCAGGTAGTG GTAAGCGTCG TCAGAAGGAG 
CATCGGAGGC ACAGACGGAC CTGTAGGGAC AGTGTGGGTC GTAGGCCCCG TGAGGGGAGG 
GCCAAGGCCA AGGCCAAGGC TCCCAAAGAA AAAAGCCGAA GGGTGCTGGG GAACTTGGAC 
TTGCAGAGTG AAGAGATCCA GGGCCGGGAG AAGGCCCGGC CTGATGTAGG TGGGGCTTCC 
AAAGTCAAGA CGCCCACAAC TCCAGCGCCC CCACCTGCTC CTGCCCCCTC TGCTCAGCCA 
ACACCCCCAT CAGCTCCTGT CCCTGGGAAG AAGACTCGAG AGGAAGCTCC AGGGCCTCCA 
GGTGTGAGCC GTGCAGATAT GCTGAAGCTT CGGTCGCTTA GTGAGGGGCC ACCTAAGGAG 
CTGAAGATCA GGCTCATCAA GGTGGAGAGT GGGGACAAGG AGACCTTCAT CGCCTCTGAG 
GTAGAAGAGC GGCGGCTGCG CATGGCAGAC CTCACCATCA GCCACTGCGC TGCTGATGTC 
ATGCGTGCCA GCAAGAATGC CAAGGTGAAA GGGAAATTCC GAGAGTCCTA CCTTTCCCCT 
GCCCAGTCTG TGAAACCGAA GATCAACACT GAGGAGAAGC TGCCCCGGGA AAAACTCAAC 
CCTCCTACAC CCAGCATTTA TTTGGAGAGC AAACGAGACG CCTTCTCGCC GGTCCTGCTG 
CAGTTCTGTA CAGATCCCCG GAACCCCATC ACTGTCATCA GGGGCCTGGC AGGTTCACTT 
CGGCTCAACT TAGGCCTTTT TTCCACCAAG ACTCTGGTGG AGGCGAGCGG TGAACACACA 
GTGGAGGTCC GTACCCAAGT GCAGCAGCCC TCAGACGAGA ACTGGGATCT GACAGGTACC 
AGACAGATCT GGCCCTGTGA GAGCTCCCGT TCACACACCA CCATCGCTAA ATATGCACAG 
TACCAGGCTT CGTCCTTCCA GGAGTCACTG CAGGAGGAGA AAGAGAGTGA GGATGAGGAA 
TCCGAGGAAC CAGACAGCAC TACAGGAACC TCTCCCAGCA GTGCACCAGA CCCCAAGAAC 
CATCACATCA TCAAGTTTGG CACAAACATC GACCTGTCTG ATGCCAAGAG GTGGAAGCCA 
CAACTACAGG AGCTGCTGAA ACTGCCTGCC TTCATGCGAG TAACATCCAC AGGCAACATG 
CTTAGCCATG TGGGACACAC CATCCTGGGC ATGAACACCG TGCAGCTATA CATGAAGGTT 
CCTGGCAGTC GAACGCCAGG CCACCAGGAG AATAACAATT TTTGCTCTGT CAATATCAAC 
ATTGGCCCCG GGGACTGCGA GTGGTTCGCG GTACATGAGC ACTATTGGGA GACCATCAGC 
GCCTTCTGCG ATCGGCATGG TGTGGATTAC TTGACTGGTT CCTGGTGGCC AATCTTGGAT 
GACCTCTATG CGTCCAATAT TCCTGTTTAC CGCTTCGTGC AGCGCCCTGG AGACCTTGTG 
TGGATTAATG CAGGGACTGT GCATTGGGTG CAGGCTACTG GCTGGTGCAA CAACATTGCC 
TGGAACGTGG GGCCCCTCAC CGCCTATCAA TACCAGCTGG CCCTGGAGCG ATATGAGTGG 
AACGAGGTGA AGAACGTCAA GTCCATTGTA CCCATGATTC ATGTGTCCTG GAACGTAGCT 
CGAACGGTCA AGATCAGTGA TCCTGACTTG TTCAAAATGA TCAAGTTCTG CCTCCTGCAG 
TCAATGAAGC ACTGCCAGGT GCAGCGGGAG AGCCTGGTGC GGGCAGGGAA GAAAATCGCT 
TACCAAGGCC GCGTCAAGGA CGAGCCTGCC TACTACTGCA ACGAATGCGA TGTGGAGGTG 
TTCAACATCC TGTTCGTTAC AAGTGAGAAT GGCAGCCGAA ACACGTACCT GGTGCACTGC 
GAGGGCTGTG CGCGCCGTCG CAGTGCGGGC CTACAGGGCG TGGTGGTGCT AGAGCAGTAC 
CGCACAGAGG AGCTGGCACA GGCCTATGAT GCCTTCACAC TGGCTCCTGC CAGCACGTCG 
CGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
Cell chemical biology24(3)371-380(2017 Mar)
Tumber A,Nuzzi A,Hookway ES,Hatch SB,Velupillai S,Johansson C,Kawamura A,Savitsky P,Yapp C,Szykowska A,Wu N,Bountra C,Strain-Damerell C,Burgess-Brown NA,Ruda GF,Fedorov O,Munro S,England KS,Nowak RP,Schofield CJ,La Thangue NB,Pawlyn C,Davies F,Morgan G,Athanasou N,M?ller S,Oppermann U,Brennan PE

Decreased Methylation Level of H3K27me3 Increases Seizure Susceptibility.
Molecular neurobiology(2016 Nov)
Wang Z,Zhang Y,Fang J,Yu F,Heng D,Fan Y,Xu J,Peng B,Liu W,Han S,He X

Jmjd3 mediates blood-spinal cord barrier disruption after spinal cord injury by regulating MMP-3 and MMP-9 expressions.
Neurobiology of disease9566-81(2016 Nov)
Lee JY,Na WH,Choi HY,Lee KH,Ju BG,Yune TY