Gmppb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gmppb
Entrez Gene ID	363145
Full Name	GDP-mannose pyrophosphorylase B
Synonyms	RGD1560458
General protein information	Preferred Names GDP-mannose pyrophosphorylase B Names mannose-1-phosphate guanyltransferase beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q32

mRNA and Protein(s)

mRNA	Protein	Name
XM_006243811.3	XP_006243873.1	mannose-1-phosphate guanyltransferase beta isoform X1
NM_001108781.1	NP_001102251.1	mannose-1-phosphate guanyltransferase beta

Pathways from BioSystems

Homologies

Homo sapiens (human)	GMPPB	NP_037466.2
	GMPPB	XP_001106890.1
Danio rerio (zebrafish)	gmppb	NP_001003491.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001299	XP_001689367.1
Caenorhabditis elegans (roundworm)	tag-335	NP_502333.2
Kluyveromyces lactis	KLLA0E05435g	XP_454190.1
Oryza sativa (rice)	Os01g0847200	NP_001044795.1
Canis lupus familiaris (dog)	GMPPB	XP_003639816.1
Neurospora crassa	NCU11213	XP_958811.1
Arabidopsis thaliana (thale cress)	CYT1	NP_181507.1
Gallus gallus (chicken)	GMPPB	XP_004944488.1
Eremothecium gossypii	AGOS_AFR599W	NP_986146.1
Magnaporthe oryzae (rice blast fungus)	MGG_01288	XP_003714211.1
Rattus norvegicus (Norway rat)	Gmppb	NP_001102251.1
Drosophila melanogaster (fruit fly)	CG1129	NP_649498.1
Saccharomyces cerevisiae (baker's yeast)	PSA1	NP_010228.1
Oryza sativa (rice)	Os03g0268400	NP_001049673.1
Pan troglodytes (chimpanzee)	GMPPB	XP_516466.1
Bos taurus (cattle)	GMPPB	NP_001039633.1
Mus musculus (house mouse)	Gmppb	NP_808578.1
Schizosaccharomyces pombe (fission yeast)	mpg1	NP_588405.1
Xenopus tropicalis (tropical clawed frog)	gmppb	NP_001008434.1

Gene Ontology
Bibliography

Related articles in PubMed

GMPPB-Associated Dystroglycanopathy: Emerging Common Variants with Phenotype Correlation.
Jensen BS, Willer T, Saade DN, Cox MO, Mozaffar T, Scavina M, Stefans VA, Winder TL, Campbell KP, Moore SA, Mathews KD
Human mutation36(12)1159-63(2015 Dec)

Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of ?-dystroglycan.
Carss KJ, Stevens E, Foley AR, Cirak S, Riemersma M, Torelli S, Hoischen A, Willer T, van Scherpenzeel M, Moore SA, Messina S, Bertini E, B?nnemann CG, Abdenur JE, Grosmann CM, Kesari A, Punetha J, Quinlivan R, Waddell LB, Young HK, Wraige E, Yau S, Brodd L, Feng L, Sewry C, MacArthur DG, North KN, Hoffman E, Stemple DL, Hurles ME, van Bokhoven H, Campbell KP, Lefeber DJ, , Lin YY, Muntoni F
American journal of human genetics93(1)29-41(2013 Jul)

Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins.
Ning B, Elbein AD
European journal of biochemistry267(23)6866-74(2000 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Gmppb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gmppb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08343	NM_001108781.1 Latest version!	Rattus norvegicus GDP-mannose pyrophosphorylase B (Gmppb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa31599	XM_006243811.3 Latest version!	Rattus norvegicus GDP-mannose pyrophosphorylase B (Gmppb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gmppb ( NM_001108781.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102251.1 Rattus norvegicus GDP-mannose pyrophosphorylase B (Gmppb), mRNA.

Price & Availability↑

CloneID	ORa08343
Clone ID Related Accession (Same CDS sequence)	NM_001108781.1
Accession Version	NM_001108781.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	mannose-1-phosphate guanyltransferase beta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473954.2. On or before Oct 4, 2007 this sequence version replaced XM_001074797.1, XM_343482.3. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAAGGCAC TGATCTTGGT GGGTGGGTAT GGGACACGGT TGCGGCCGCT GACGCTGAGC 
ACTCCGAAGC CATTGGTGGA CTTCTGCAAT AAGCCCATTT TGCTGCACCA AGTGGAGGCA 
CTTGCCGCGG CGGGTGTAGA CCATGTGATC CTAGCAGTGA GCTACATGTC ACAGATGTTG 
GAGAAGGAAA TGAAGGCACA AGAGCAAAGG CTTGGAATCC GAATCTCTAT GTCTCATGAA 
GAGGAGCCTT TGGGAACAGC TGGGCCTCTG GCCTTGGCCC GAGACCTACT CTCTGAGACT 
GCCGATCCTT TCTTCGTTCT CAACAGTGAT GTGATATGTG ATTTCCCCTT CCAAGCCATG 
GTGCAGTTTC ATCGACACCA TGGCCAAGAG GGCTCCATCT TGGTAACCAA GGTGGAAGAG 
CCTTCCAAGT ACGGTGTGGT GGTGTGCGAG GCTGACACAG GCCGCATTCA CCGTTTTGTT 
GAGAAGCCGC AGGTATTTGT GTCCAATAAG ATCAATGCAG GCATGTACAT CCTGAGCCCT 
GCTGTGCTGC AGCGCATCCA GCTGAAGCCT ACATCCATTG AGAAGGAGAT CTTCCCAGTT 
ATGGCCAAGG AGGGGCAGCT ATATGCCATG GAGCTGCAGG GCTTCTGGAT GGACATTGGA 
CAGCCTAAGG ACTTCCTCAC TGGCATGTGC CTCTTCCTAC AGTCACTGAG ACAGAAGCAT 
CCAGAGAGAC TGTACTCAGG CCCTGGCGTT GTGGGGAATG TGCTTGTGGA CCCAAGTGCC 
CGTATCGGTC AGAACTGCAG CATTGGCCCC AATGTGAGCC TGGGTCCCGG TGTGGTGGTG 
GAGGACGGCG TGTGCATCCG GCGGTGCACG GTGCTTCGTG ATGCTCACAT CCGCTCCCAT 
TCCTGGCTTG AGTCATGCAT CGTGGGCTGG CGCTGCCGTG TAGGCCAATG GGTGCGCATG 
GAGAATGTCA CAGTGCTGGG TGAGGATGTC ATAGTTAATG ATGAACTTTA CCTCAACGGA 
GCCAGCGTGC TGCCCCACAA GTCTATCGGG GAGTCGGTGC CAGAACCTCG TATTATCATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102251.1
CDS	229..1311
Translation	MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQMLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLKPTSIEKEIFPVMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKHPERLYSGPGVVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDAHIRSHSWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM

Target ORF information:

RefSeq Version	NM_001108781.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GDP-mannose pyrophosphorylase B (Gmppb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108781.1

ORF Insert Sequence:

ATGAAGGCAC TGATCTTGGT GGGTGGGTAT GGGACACGGT TGCGGCCGCT GACGCTGAGC 
ACTCCGAAGC CATTGGTGGA CTTCTGCAAT AAGCCCATTT TGCTGCACCA AGTGGAGGCA 
CTTGCCGCGG CGGGTGTAGA CCATGTGATC CTAGCAGTGA GCTACATGTC ACAGATGTTG 
GAGAAGGAAA TGAAGGCACA AGAGCAAAGG CTTGGAATCC GAATCTCTAT GTCTCATGAA 
GAGGAGCCTT TGGGAACAGC TGGGCCTCTG GCCTTGGCCC GAGACCTACT CTCTGAGACT 
GCCGATCCTT TCTTCGTTCT CAACAGTGAT GTGATATGTG ATTTCCCCTT CCAAGCCATG 
GTGCAGTTTC ATCGACACCA TGGCCAAGAG GGCTCCATCT TGGTAACCAA GGTGGAAGAG 
CCTTCCAAGT ACGGTGTGGT GGTGTGCGAG GCTGACACAG GCCGCATTCA CCGTTTTGTT 
GAGAAGCCGC AGGTATTTGT GTCCAATAAG ATCAATGCAG GCATGTACAT CCTGAGCCCT 
GCTGTGCTGC AGCGCATCCA GCTGAAGCCT ACATCCATTG AGAAGGAGAT CTTCCCAGTT 
ATGGCCAAGG AGGGGCAGCT ATATGCCATG GAGCTGCAGG GCTTCTGGAT GGACATTGGA 
CAGCCTAAGG ACTTCCTCAC TGGCATGTGC CTCTTCCTAC AGTCACTGAG ACAGAAGCAT 
CCAGAGAGAC TGTACTCAGG CCCTGGCGTT GTGGGGAATG TGCTTGTGGA CCCAAGTGCC 
CGTATCGGTC AGAACTGCAG CATTGGCCCC AATGTGAGCC TGGGTCCCGG TGTGGTGGTG 
GAGGACGGCG TGTGCATCCG GCGGTGCACG GTGCTTCGTG ATGCTCACAT CCGCTCCCAT 
TCCTGGCTTG AGTCATGCAT CGTGGGCTGG CGCTGCCGTG TAGGCCAATG GGTGCGCATG 
GAGAATGTCA CAGTGCTGGG TGAGGATGTC ATAGTTAATG ATGAACTTTA CCTCAACGGA 
GCCAGCGTGC TGCCCCACAA GTCTATCGGG GAGTCGGTGC CAGAACCTCG TATTATCATG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gmppb ( XM_006243811.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243873.1 Rattus norvegicus GDP-mannose pyrophosphorylase B (Gmppb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa31599
Clone ID Related Accession (Same CDS sequence)	XM_006243811.3
Accession Version	XM_006243811.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mannose-1-phosphate guanyltransferase beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243811.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCCGCC TCCGGCCGGA ACTCCGGGCC AGCCGGTCTC CAACCAGTTC CTCCTCCTCC 
TGTGTTCTGG CTGCCCCTAG ACCCCCACAT CAAGACGCCA TGAAGGCACT GATCTTGGTG 
GGTGGGTATG GGACACGGTT GCGGCCGCTG ACGCTGAGCA CTCCGAAGCC ATTGGTGGAC 
TTCTGCAATA AGCCCATTTT GCTGCACCAA GTGGAGGCAC TTGCCGCGGC GGGTGTAGAC 
CATGTGATCC TAGCAGTGAG CTACATGTCA CAGATGTTGG AGAAGGAAAT GAAGGCACAA 
GAGCAAAGGC TTGGAATCCG AATCTCTATG TCTCATGAAG AGGAGCCTTT GGGAACAGCT 
GGGCCTCTGG CCTTGGCCCG AGACCTACTC TCTGAGACTG CCGATCCTTT CTTCGTTCTC 
AACAGTGATG TGATATGTGA TTTCCCCTTC CAAGCCATGG TGCAGTTTCA TCGACACCAT 
GGCCAAGAGG GCTCCATCTT GGTAACCAAG GTGGAAGAGC CTTCCAAGTA CGGTGTGGTG 
GTGTGCGAGG CTGACACAGG CCGCATTCAC CGTTTTGTTG AGAAGCCGCA GGTATTTGTG 
TCCAATAAGA TCAATGCAGG CATGTACATC CTGAGCCCTG CTGTGCTGCA GCGCATCCAG 
CTGAAGCCTA CATCCATTGA GAAGGAGATC TTCCCAGTTA TGGCCAAGGA GGGGCAGCTA 
TATGCCATGG AGCTGCAGGG CTTCTGGATG GACATTGGAC AGCCTAAGGA CTTCCTCACT 
GGCATGTGCC TCTTCCTACA GTCACTGAGA CAGAAGCATC CAGAGAGACT GTACTCAGGC 
CCTGGCGTTG TGGGGAATGT GCTTGTGGAC CCAAGTGCCC GTATCGGTCA GAACTGCAGC 
ATTGGCCCCA ATGTGAGCCT GGGTCCCGGT GTGGTGGTGG AGGACGGCGT GTGCATCCGG 
CGGTGCACGG TGCTTCGTGA TGCTCACATC CGCTCCCATT CCTGGCTTGA GTCATGCATC 
GTGGGCTGGC GCTGCCGTGT AGGCCAATGG GTGCGCATGG AGAATGTCAC AGTGCTGGGT 
GAGGATGTCA TAGTTAATGA TGAACTTTAC CTCAACGGAG CCAGCGTGCT GCCCCACAAG 
TCTATCGGGG AGTCGGTGCC AGAACCTCGT ATTATCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243873.1
CDS	410..1591
Translation	MRRLRPELRASRSPTSSSSSCVLAAPRPPHQDAMKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQMLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLKPTSIEKEIFPVMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKHPERLYSGPGVVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDAHIRSHSWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM

Target ORF information:

RefSeq Version	XM_006243811.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GDP-mannose pyrophosphorylase B (Gmppb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243811.3

ORF Insert Sequence:

ATGCGCCGCC TCCGGCCGGA ACTCCGGGCC AGCCGGTCTC CAACCAGTTC CTCCTCCTCC 
TGTGTTCTGG CTGCCCCTAG ACCCCCACAT CAAGACGCCA TGAAGGCACT GATCTTGGTG 
GGTGGGTATG GGACACGGTT GCGGCCGCTG ACGCTGAGCA CTCCGAAGCC ATTGGTGGAC 
TTCTGCAATA AGCCCATTTT GCTGCACCAA GTGGAGGCAC TTGCCGCGGC GGGTGTAGAC 
CATGTGATCC TAGCAGTGAG CTACATGTCA CAGATGTTGG AGAAGGAAAT GAAGGCACAA 
GAGCAAAGGC TTGGAATCCG AATCTCTATG TCTCATGAAG AGGAGCCTTT GGGAACAGCT 
GGGCCTCTGG CCTTGGCCCG AGACCTACTC TCTGAGACTG CCGATCCTTT CTTCGTTCTC 
AACAGTGATG TGATATGTGA TTTCCCCTTC CAAGCCATGG TGCAGTTTCA TCGACACCAT 
GGCCAAGAGG GCTCCATCTT GGTAACCAAG GTGGAAGAGC CTTCCAAGTA CGGTGTGGTG 
GTGTGCGAGG CTGACACAGG CCGCATTCAC CGTTTTGTTG AGAAGCCGCA GGTATTTGTG 
TCCAATAAGA TCAATGCAGG CATGTACATC CTGAGCCCTG CTGTGCTGCA GCGCATCCAG 
CTGAAGCCTA CATCCATTGA GAAGGAGATC TTCCCAGTTA TGGCCAAGGA GGGGCAGCTA 
TATGCCATGG AGCTGCAGGG CTTCTGGATG GACATTGGAC AGCCTAAGGA CTTCCTCACT 
GGCATGTGCC TCTTCCTACA GTCACTGAGA CAGAAGCATC CAGAGAGACT GTACTCAGGC 
CCTGGCGTTG TGGGGAATGT GCTTGTGGAC CCAAGTGCCC GTATCGGTCA GAACTGCAGC 
ATTGGCCCCA ATGTGAGCCT GGGTCCCGGT GTGGTGGTGG AGGACGGCGT GTGCATCCGG 
CGGTGCACGG TGCTTCGTGA TGCTCACATC CGCTCCCATT CCTGGCTTGA GTCATGCATC 
GTGGGCTGGC GCTGCCGTGT AGGCCAATGG GTGCGCATGG AGAATGTCAC AGTGCTGGGT 
GAGGATGTCA TAGTTAATGA TGAACTTTAC CTCAACGGAG CCAGCGTGCT GCCCCACAAG 
TCTATCGGGG AGTCGGTGCC AGAACCTCGT ATTATCATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GMPPB-Associated Dystroglycanopathy: Emerging Common Variants with Phenotype Correlation.
Human mutation36(12)1159-63(2015 Dec)
Jensen BS,Willer T,Saade DN,Cox MO,Mozaffar T,Scavina M,Stefans VA,Winder TL,Campbell KP,Moore SA,Mathews KD

Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of ?-dystroglycan.
American journal of human genetics93(1)29-41(2013 Jul)
Carss KJ,Stevens E,Foley AR,Cirak S,Riemersma M,Torelli S,Hoischen A,Willer T,van Scherpenzeel M,Moore SA,Messina S,Bertini E,B?nnemann CG,Abdenur JE,Grosmann CM,Kesari A,Punetha J,Quinlivan R,Waddell LB,Young HK,Wraige E,Yau S,Brodd L,Feng L,Sewry C,MacArthur DG,North KN,Hoffman E,Stemple DL,Hurles ME,van Bokhoven H,Campbell KP,Lefeber DJ,,Lin YY,Muntoni F

Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins.
European journal of biochemistry267(23)6866-74(2000 Dec)
Ning B,Elbein AD