Stat6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Stat6
Entrez Gene ID	362896
Full Name	signal transducer and activator of transcription 6
General protein information	Preferred Names signal transducer and activator of transcription 6 Names signal transducer and activator of transcription 6 signal transducer and activator of transcription 6, interleukin-4 induced signal transducer and transcription activator 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001044250.1	NP_001037715.1	signal transducer and activator of transcription 6

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	STAT6	XP_003431490.1
Bos taurus (cattle)	STAT6	NP_001192430.1
	STAT6	XP_002798683.1
Danio rerio (zebrafish)	stat6	NP_001124062.1
Homo sapiens (human)	STAT6	NP_001171550.1
Rattus norvegicus (Norway rat)	Stat6	NP_001037715.1
Xenopus tropicalis (tropical clawed frog)	stat6	XP_002939755.1
Pan troglodytes (chimpanzee)	STAT6	XP_003952193.1
Mus musculus (house mouse)	Stat6	NP_033310.2

Gene Ontology
Bibliography

Related articles in PubMed

Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-?B pathway in ischemia/reperfusion injury after renal transplantation.
Zhang J, Zhao D, Na N, Li H, Miao B, Hong L, Huang Z
International journal of molecular medicine41(1)25-32(2018 Jan)

Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.
Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A
Cell157(6)1292-308(2014 Jun)

The phosphorylation of STAT6 during ischemic reperfusion in rat cerebral cortex.
Jang SS, Choi JH, Im DS, Park S, Park JS, Park SM, Joe EH, Jou I, Suh YH
Neuroreport25(1)18-22(2014 Jan)

Interleukin-4 induces up-regulation of endothelial cell claudin-5 through activation of FoxO1: role in protection from complement-mediated injury.
Dalmasso AP, Goldish D, Benson BA, Tsai AK, Wasiluk KR, Vercellotti GM
The Journal of biological chemistry289(2)838-47(2014 Jan)

[Relationship of reduced lung function with Th1/Th2 polarization, STAT4/6 expression in rats of chronic obstructive pulmonary disease].
Wang C, Li Z
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology29(12)1233-6(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We found that pSTAT6 significantly decreases at 1 and 12 h following ischemic reperfusion.
Title: The phosphorylation of STAT6 during ischemic reperfusion in rat cerebral cortex.

STAT4 and STAT6 involve in the regulation of Th1/Th2 cell
Title: [Relationship of reduced lung function with Th1/Th2 polarization, STAT4/6 expression in rats of chronic obstructive pulmonary disease].

STAT6 in astrocytes is much more sensitive to reactive oxygen species (ROS)-dependent phosphorylation than is microglial STAT6; therefore, astrocytes may function as ROS sensors.
Title: Astrocytes, but not microglia, rapidly sense H?O?via STAT6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release.

IL-13 down-regulates mucus secretion via STAT6-FOXA2 pathway in vitro.
Title: [Molecular mechanism of interleukin-13-induced mucus hypersecretion in rat airway].

Achyranthes bidentata polysaccharides inhibited expression of STAT6 in asthmatic rats.
Title: [Effect of achyranthes bidentata polysaccharides on signal transducer and activator of transcription 6 and its mRNA expression in a rat model of asthma].

The following Stat6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Stat6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12628	NM_001044250.1 Latest version!	Rattus norvegicus signal transducer and activator of transcription 6 (Stat6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$496.30 $709.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Stat6 ( NM_001044250.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001037715.1 Rattus norvegicus signal transducer and activator of transcription 6 (Stat6), mRNA.

Price & Availability↑

CloneID	ORa12628
Clone ID Related Accession (Same CDS sequence)	NM_001044250.1
Accession Version	NM_001044250.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2526bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	signal transducer and activator of transcription 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ462201.1. On or before Aug 28, 2006 this sequence version replaced XM_343223.3, XM_001057138.1, XM_001057192.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ462201.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCTCTGT GGAGTCTAGT TTCCAAGATG TCCCCAGAAA AACTGCAACG GCTCTATGTT 
GACTTTCCAC AACACCTGCG GCATCTTCTG GCCGAATGGC TGGAGAATCA GCCCTGGGAG 
TTCCTGGTTG GTTCAGATGC TTTCTGTTAC AACATGGCTA GTGCCCTACT TTCTGCCACT 
GTCCAGCGTC TTCAGGCCTC TGCAGGAGAG CAGGGGAAAG GAAGCAGCCT CTTGCAGCAC 
ATCAGCACCT TGGAGAGCAT CTATCAGAGG GACCCCCTGA AGCTGGTGGC CACCATCAGA 
CAAATACTTC AAGGGGAGAA AAAAGCTGTT ATAGAAGAGT TCCACCACCT GCCAGGGCCC 
TTCCATCGAA AGCAGGAAGA ACTCAAGTTT ACTACAGCCC TGGGCAGGCT TCAGCACCGA 
GTAAGGGAGA CCAGGATTCT CCGAGAATCT CTGCAGCAGG GGACCAAGAC TGCGCAAGTG 
TCTCTGAAGA ACTTGATAGA CCCTCCTGCC AATGGCACTG GTCCAAGTGA GGATCTGGCC 
ACGATGCTGC AGGGGACTGT GGGGGACTTG GAGGCCACCC AGGCTCTAGT GCTGAAAAGG 
ATTCAGATTT GGAAGCGGCA ACAGCAGCTG GCAGGGAATG GCACACCCTT TGAGGAGAGC 
CTGGCAGGGC TGCAGGAGAG GTGTGAAAGC CTGGTGGAAA TTTATTCCCA GCTGCAGCAG 
GAGATTGGAG CAGCCAGTGG GGAGCTTGAG CCCAAGACCC GGGCATCGCT CATAAGCCGT 
CTGGATGAAG TCCTGCGAAC CCTTGTGACC AGCTCTTTCC TGGTGGAGAA GCAGCCCCCA 
CAGGTTCTGA AGACACAGAC TAAGTTTCAG GCTGGGGTTC GATTCCTACT GGGTCTGCAG 
TTCCTAGGGA CCTCAGCCAA GCCTCCACTG GTCAGAGCTG ACATGGTGAC AGAGAAACAG 
GCCAGAGAAC TAAGCCTGCC CCAGGGGTCT GGGGCTGGAG TGGAGAGCAC AGGAGAGATC 
ATGAACAATA CTGTACCTCT GGAGAACAGT GTTCCTGGGA ACTGCTGCTC TGCCCTCTTC 
AAGAACCTGC TCCTGAAGAA AATCAAGCGC TGTGAGCGGA AGGGTACAGA GTCTGTCACC 
GAAGAGAAGT GCGCTGTGCT CTTCTCTACG AGCTTCATGC TGGGCCCCAA CAAACACCTC 
ATCCAGCTTC AGGCCCTGTC TCTGCCCTTG GTGGTCATCG TTCATGGCAA CCAAGACAAC 
AATGCCAAAG CTACCATCCT GTGGGATAAT GCCTTCTCTG AGATGGACCG AGTGCCCTTT 
GTGGTAGCTG AGCGAGTGCC CTGGGAGAAA ATGTGTGAAA CTCTGAACCT CAAGTTTATG 
GCTGAGGTGG GGACCAGCCG GGGACTGCTA CCAGAACACT TCCTGTTCCT GGCCCAGAAG 
ATCTTCAATG ACAACAGCCT TAGCATAGAG GCCTTTCAGC ACCGCTGTGT GTCTTGGTCA 
CAGTTCAACA AGGAGATTCT ACTGGGCCGA GGCTTCACTT TTTGGCAGTG GTTTGATGGT 
GTCCTGGACC TCACTAAACG CTGTCTTCGG AGCTACTGGT CAGATCGGCT GATCATCGGC 
TTTATCAGTA AGCAATATGT CACTAGCCTT CTCCTCAACG AGCCAGATGG AACCTTCCTC 
CTCCGCTTTA GCGACTCTGA GATTGGGGGC ATCACCATTG CCCATGTCAT CCGGGGTCAG 
GATGGCTCCT CACAGATAGA GAACATCCAG CCGTTTTCTG CCAAAGACCT ATCCATTCGC 
TCACTGGGGG ACCGAATCCG AGATCTTGCT CAATTAAAAA ACCTCTACCC CAAGAAACCC 
AAGGATGAGG CTTTTCGGAG CCACTATAAG CCGGAACAGA TGGGAAAGGA CGGGAGGGGT 
TATGTCTCAA CTACTATCAA GATGACTGTG GAAAGGGACC AGCCCCTTCC TACTCCAGAG 
CCCCAGATGC CTGCCATGGT GGCCCCTTAT GATCTTGGAA TGGCCCCTGA TGCTTCCATG 
CAACTCAGCT CAGATATGGT GTATCCTCCA CAGTCTCATT CCATCCACTC ATTTCAGAGC 
ATCCCCCTAG AAGAGTCCAT GAGTGTACTG CCACCCTTTC AGGAGCCTCA CCTCCAAATG 
CCCCCCACCA TGAGCCAGAT AAGCATGCCC TTTGACCAGC CTCATCCCCA GGGCCTGCTC 
CAGTGCCAGT CCCAGGAGCA TGCGGTGTCC AGCCCTGAAC CCTTGCTGTG TTCAGATGTC 
ACTATGGCGG AAGACAGCTG CCTAACTCAG CCTGTGCAAG GTTTCCCCCA GGGCACCTGG 
GTCAGCGAAG GCATGTACCC TCCCCTGATG CCTCCCACTG AACAGGACCT CACCAAGCTT 
CTCCTAGAGG GCCAAGGGGA AGGTGGAGGA TCCATAGGGA CTCAGCCCCT CCTGCAACCA 
TCTTCTTATG GGCAATCGGG GATCTCAATG TCCCACCTGG ACCTAAGGAC CAACCCCAGT 
TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001037715.1
CDS	84..2609
Translation	MSLWSLVSKMSPEKLQRLYVDFPQHLRHLLAEWLENQPWEFLVGSDAFCYNMASALLSATVQRLQASAGEQGKGSSLLQHISTLESIYQRDPLKLVATIRQILQGEKKAVIEEFHHLPGPFHRKQEELKFTTALGRLQHRVRETRILRESLQQGTKTAQVSLKNLIDPPANGTGPSEDLATMLQGTVGDLEATQALVLKRIQIWKRQQQLAGNGTPFEESLAGLQERCESLVEIYSQLQQEIGAASGELEPKTRASLISRLDEVLRTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLQFLGTSAKPPLVRADMVTEKQARELSLPQGSGAGVESTGEIMNNTVPLENSVPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFMLGPNKHLIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTSRGLLPEHFLFLAQKIFNDNSLSIEAFQHRCVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSSQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVSTTIKMTVERDQPLPTPEPQMPAMVAPYDLGMAPDASMQLSSDMVYPPQSHSIHSFQSIPLEESMSVLPPFQEPHLQMPPTMSQISMPFDQPHPQGLLQCQSQEHAVSSPEPLLCSDVTMAEDSCLTQPVQGFPQGTWVSEGMYPPLMPPTEQDLTKLLLEGQGEGGGSIGTQPLLQPSSYGQSGISMSHLDLRTNPSW

Target ORF information:

RefSeq Version	NM_001044250.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus signal transducer and activator of transcription 6 (Stat6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001044250.1

ORF Insert Sequence:

ATGTCTCTGT GGAGTCTAGT TTCCAAGATG TCCCCAGAAA AACTGCAACG GCTCTATGTT 
GACTTTCCAC AACACCTGCG GCATCTTCTG GCCGAATGGC TGGAGAATCA GCCCTGGGAG 
TTCCTGGTTG GTTCAGATGC TTTCTGTTAC AACATGGCTA GTGCCCTACT TTCTGCCACT 
GTCCAGCGTC TTCAGGCCTC TGCAGGAGAG CAGGGGAAAG GAAGCAGCCT CTTGCAGCAC 
ATCAGCACCT TGGAGAGCAT CTATCAGAGG GACCCCCTGA AGCTGGTGGC CACCATCAGA 
CAAATACTTC AAGGGGAGAA AAAAGCTGTT ATAGAAGAGT TCCACCACCT GCCAGGGCCC 
TTCCATCGAA AGCAGGAAGA ACTCAAGTTT ACTACAGCCC TGGGCAGGCT TCAGCACCGA 
GTAAGGGAGA CCAGGATTCT CCGAGAATCT CTGCAGCAGG GGACCAAGAC TGCGCAAGTG 
TCTCTGAAGA ACTTGATAGA CCCTCCTGCC AATGGCACTG GTCCAAGTGA GGATCTGGCC 
ACGATGCTGC AGGGGACTGT GGGGGACTTG GAGGCCACCC AGGCTCTAGT GCTGAAAAGG 
ATTCAGATTT GGAAGCGGCA ACAGCAGCTG GCAGGGAATG GCACACCCTT TGAGGAGAGC 
CTGGCAGGGC TGCAGGAGAG GTGTGAAAGC CTGGTGGAAA TTTATTCCCA GCTGCAGCAG 
GAGATTGGAG CAGCCAGTGG GGAGCTTGAG CCCAAGACCC GGGCATCGCT CATAAGCCGT 
CTGGATGAAG TCCTGCGAAC CCTTGTGACC AGCTCTTTCC TGGTGGAGAA GCAGCCCCCA 
CAGGTTCTGA AGACACAGAC TAAGTTTCAG GCTGGGGTTC GATTCCTACT GGGTCTGCAG 
TTCCTAGGGA CCTCAGCCAA GCCTCCACTG GTCAGAGCTG ACATGGTGAC AGAGAAACAG 
GCCAGAGAAC TAAGCCTGCC CCAGGGGTCT GGGGCTGGAG TGGAGAGCAC AGGAGAGATC 
ATGAACAATA CTGTACCTCT GGAGAACAGT GTTCCTGGGA ACTGCTGCTC TGCCCTCTTC 
AAGAACCTGC TCCTGAAGAA AATCAAGCGC TGTGAGCGGA AGGGTACAGA GTCTGTCACC 
GAAGAGAAGT GCGCTGTGCT CTTCTCTACG AGCTTCATGC TGGGCCCCAA CAAACACCTC 
ATCCAGCTTC AGGCCCTGTC TCTGCCCTTG GTGGTCATCG TTCATGGCAA CCAAGACAAC 
AATGCCAAAG CTACCATCCT GTGGGATAAT GCCTTCTCTG AGATGGACCG AGTGCCCTTT 
GTGGTAGCTG AGCGAGTGCC CTGGGAGAAA ATGTGTGAAA CTCTGAACCT CAAGTTTATG 
GCTGAGGTGG GGACCAGCCG GGGACTGCTA CCAGAACACT TCCTGTTCCT GGCCCAGAAG 
ATCTTCAATG ACAACAGCCT TAGCATAGAG GCCTTTCAGC ACCGCTGTGT GTCTTGGTCA 
CAGTTCAACA AGGAGATTCT ACTGGGCCGA GGCTTCACTT TTTGGCAGTG GTTTGATGGT 
GTCCTGGACC TCACTAAACG CTGTCTTCGG AGCTACTGGT CAGATCGGCT GATCATCGGC 
TTTATCAGTA AGCAATATGT CACTAGCCTT CTCCTCAACG AGCCAGATGG AACCTTCCTC 
CTCCGCTTTA GCGACTCTGA GATTGGGGGC ATCACCATTG CCCATGTCAT CCGGGGTCAG 
GATGGCTCCT CACAGATAGA GAACATCCAG CCGTTTTCTG CCAAAGACCT ATCCATTCGC 
TCACTGGGGG ACCGAATCCG AGATCTTGCT CAATTAAAAA ACCTCTACCC CAAGAAACCC 
AAGGATGAGG CTTTTCGGAG CCACTATAAG CCGGAACAGA TGGGAAAGGA CGGGAGGGGT 
TATGTCTCAA CTACTATCAA GATGACTGTG GAAAGGGACC AGCCCCTTCC TACTCCAGAG 
CCCCAGATGC CTGCCATGGT GGCCCCTTAT GATCTTGGAA TGGCCCCTGA TGCTTCCATG 
CAACTCAGCT CAGATATGGT GTATCCTCCA CAGTCTCATT CCATCCACTC ATTTCAGAGC 
ATCCCCCTAG AAGAGTCCAT GAGTGTACTG CCACCCTTTC AGGAGCCTCA CCTCCAAATG 
CCCCCCACCA TGAGCCAGAT AAGCATGCCC TTTGACCAGC CTCATCCCCA GGGCCTGCTC 
CAGTGCCAGT CCCAGGAGCA TGCGGTGTCC AGCCCTGAAC CCTTGCTGTG TTCAGATGTC 
ACTATGGCGG AAGACAGCTG CCTAACTCAG CCTGTGCAAG GTTTCCCCCA GGGCACCTGG 
GTCAGCGAAG GCATGTACCC TCCCCTGATG CCTCCCACTG AACAGGACCT CACCAAGCTT 
CTCCTAGAGG GCCAAGGGGA AGGTGGAGGA TCCATAGGGA CTCAGCCCCT CCTGCAACCA 
TCTTCTTATG GGCAATCGGG GATCTCAATG TCCCACCTGG ACCTAAGGAC CAACCCCAGT 
TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-?B pathway in ischemia/reperfusion injury after renal transplantation.
International journal of molecular medicine41(1)25-32(2018 Jan)
Zhang J,Zhao D,Na N,Li H,Miao B,Hong L,Huang Z

Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.
Cell157(6)1292-308(2014 Jun)
Qiu Y,Nguyen KD,Odegaard JI,Cui X,Tian X,Locksley RM,Palmiter RD,Chawla A

The phosphorylation of STAT6 during ischemic reperfusion in rat cerebral cortex.
Neuroreport25(1)18-22(2014 Jan)
Jang SS,Choi JH,Im DS,Park S,Park JS,Park SM,Joe EH,Jou I,Suh YH

Interleukin-4 induces up-regulation of endothelial cell claudin-5 through activation of FoxO1: role in protection from complement-mediated injury.
The Journal of biological chemistry289(2)838-47(2014 Jan)
Dalmasso AP,Goldish D,Benson BA,Tsai AK,Wasiluk KR,Vercellotti GM

[Relationship of reduced lung function with Th1/Th2 polarization, STAT4/6 expression in rats of chronic obstructive pulmonary disease].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology29(12)1233-6(2013 Dec)
Wang C,Li Z

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Stat6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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