Atcay cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atcay
Entrez Gene ID	362826
Full Name	ATCAY, caytaxin
General protein information	Preferred Names ATCAY, caytaxin Names caytaxin ataxia, cerebellar, Cayman type
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001040190.1	NP_001035280.1	caytaxin

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ATCAY	NP_001075898.1
Rattus norvegicus (Norway rat)	Atcay	NP_001035280.1
Xenopus tropicalis (tropical clawed frog)	atcay	XP_002941432.2
Homo sapiens (human)	ATCAY	NP_149053.1
Canis lupus familiaris (dog)	ATCAY	XP_542168.5
Mus musculus (house mouse)	Atcay	NP_848777.1
Gallus gallus (chicken)	ATCAY	XP_004948797.1
Danio rerio (zebrafish)	LOC799499	XP_005161664.1
Danio rerio (zebrafish)	atcaya	XP_005161661.1

Gene Ontology
Bibliography

Related articles in PubMed

BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis.
Sun J, Pan CQ, Chew TW, Liang F, Burmeister M, Low BC
Developmental cell34(5)555-68(2015 Sep)

Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains.
Aoyama T, Hata S, Nakao T, Tanigawa Y, Oka C, Kawaichi M
Journal of cell science122(Pt 22)4177-85(2009 Nov)

Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons.
Buschdorf JP, Chew LL, Soh UJ, Liou YC, Low BC
PloS one3(7)e2686(2008 Jul)

Caytaxin deficiency disrupts signaling pathways in cerebellar cortex.
Xiao J, Gong S, Ledoux MS
Neuroscience144(2)439-61(2007 Jan)

Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels.
Buschdorf JP, Li Chew L, Zhang B, Cao Q, Liang FY, Liou YC, Zhou YT, Low BC
Journal of cell science119(Pt 16)3337-50(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

precise targeting of the cholinergic machinery through BNIP-H is essential for the local production of acetylcholine for morphogenesis and neurotransmission
Title: BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis.

nerve growth factor may stimulate the interaction of BNIP-H with Pin1 by releasing its intramolecular inhibition
Title: Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons.

The data of this study indicate that caytaxin plays a critical role in the molecular response of Purkinje cells to climbing fiber input. Caytaxin may also contribute to maturational events in cerebellar cortex.
Title: Caytaxin deficiency disrupts signaling pathways in cerebellar cortex.

The above data, disease phenotypes, and mutant animals suggest that Caytaxin may be essential for synaptic function.
Title: Expression and localization of Cayman ataxia-related protein, Caytaxin, is regulated in a developmental- and spatial-dependent manner.

Atcay mRNA is found in all brain neuronal populations.In cerebellum, it is in the molecular, Purkinje & granular layers. It may have a vital role in the development & neurophysiology of cerebellar cortex.
Title: Caytaxin deficiency causes generalized dystonia in rats.

The following Atcay gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atcay cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09893	NM_001040190.1 Latest version!	Rattus norvegicus ATCAY kinesin light chain interacting caytaxin (Atcay), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atcay ( NM_001040190.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001035280.1 Rattus norvegicus ATCAY kinesin light chain interacting caytaxin (Atcay), mRNA.

Price & Availability↑

CloneID	ORa09893
Clone ID Related Accession (Same CDS sequence)	NM_001040190.1
Accession Version	NM_001040190.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	caytaxin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY611623.1. On or before Jun 25, 2006 this sequence version replaced XM_343154.3, XM_001070287.1. ##Evidence-Data-START## Transcript exon combination :: AY611623.1, BC128695.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGACCA CAGAAGCTAC ATTACGAATG GAAAATGTGG ACGTGAGGGA TGAATGGCAG 
GATGAGGATC TGCCCAGACC GCTCCCAGAA GACACCGGGG AGGATCACCT GGGCGGCACG 
GTGGAAGACT CCTCCTCTCC TCCCTCCACC CTAAACCTGA GTGGAGCACA TCGGAAGAGA 
AAGACGCTGG TGGCCCCAGA GATCAACATC TCTCTGGACC AAAGTGAGGG CTCTCTGCTG 
TCTGATGACT TCCTCGACAC CCCTGATGAC CTGGACATCA ATGTGGATGA CATTGAGACG 
CCAGATGAAA CTGACTCTCT GGAGTTCTTG GGAAATGGCA ATGAGCTTGA GTGGGAAGAT 
GACACCCCAG TGGCCACCGC TAAAAACATG CCTGGTGACA GCGCAGACCT GTTTGGGGAC 
GGCTCTGGGG AAGACGGCAG TGCAGCCAAT GGCCGTCTGT GGCGGACTGT CATCATCGGG 
GAGCAGGAGC ATCGCATTGA CCTGCATATG ATCCGGCCCT ACATGAAGGT GGTGACCCAC 
GGAGGATACT ACGGAGAAGG TCTCAACGCC ATCATCGTCT TTGCGGCCTG CTTCCTGCCA 
GATAGCAGCT CTCCAGACTA CCACTACATC ATGGAGAATC TCTTCCTGTA CGTCATCAGC 
AGCCTAGAGC TGCTAGTGGC TGAGGACTAC ATGATCGTGT ACCTGAATGG TGCCACGCCC 
CGGAGGAGGA TGCCGGGCAT TGGCTGGCTG AAGAAGTGTT ACCACATGAT TGACAGGAGA 
CTGAGGAAGA ATCTAAAGTC CCTGATCATC GTCCACCCCT CCTGGTTCAT TCGCACCGTG 
CTGGCCATCT CCCGGCCCTT CATCAGTGTC AAGTTCATCA GTAAAATCCA GTATGTGCAC 
AGCCTCGAGG AGCTGGAGCA GCTCATCCCC ATGGAGCACG TGCAGCTGCC AGCCTGTGTC 
CTGCAATATG AAGAACAGAG ACTCCGAGCC AAGAGGGAGA GCGCTCGGCC ACCGCAGCCC 
GAGTTCCTCC TGCCCAGGTC TGAAGAAAAA CCAGAGACTG TGGAAGAAGA GGACAGGGCA 
GCAGAGGTGA CAGAGGACCA GGAAACGAGC ATGTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035280.1
CDS	477..1595
Translation	MGTTEATLRMENVDVRDEWQDEDLPRPLPEDTGEDHLGGTVEDSSSPPSTLNLSGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLGNGNELEWEDDTPVATAKNMPGDSADLFGDGSGEDGSAANGRLWRTVIIGEQEHRIDLHMIRPYMKVVTHGGYYGEGLNAIIVFAACFLPDSSSPDYHYIMENLFLYVISSLELLVAEDYMIVYLNGATPRRRMPGIGWLKKCYHMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFISKIQYVHSLEELEQLIPMEHVQLPACVLQYEEQRLRAKRESARPPQPEFLLPRSEEKPETVEEEDRAAEVTEDQETSMS

Target ORF information:

RefSeq Version	NM_001040190.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATCAY kinesin light chain interacting caytaxin (Atcay), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040190.1

ORF Insert Sequence:

ATGGGGACCA CAGAAGCTAC ATTACGAATG GAAAATGTGG ACGTGAGGGA TGAATGGCAG 
GATGAGGATC TGCCCAGACC GCTCCCAGAA GACACCGGGG AGGATCACCT GGGCGGCACG 
GTGGAAGACT CCTCCTCTCC TCCCTCCACC CTAAACCTGA GTGGAGCACA TCGGAAGAGA 
AAGACGCTGG TGGCCCCAGA GATCAACATC TCTCTGGACC AAAGTGAGGG CTCTCTGCTG 
TCTGATGACT TCCTCGACAC CCCTGATGAC CTGGACATCA ATGTGGATGA CATTGAGACG 
CCAGATGAAA CTGACTCTCT GGAGTTCTTG GGAAATGGCA ATGAGCTTGA GTGGGAAGAT 
GACACCCCAG TGGCCACCGC TAAAAACATG CCTGGTGACA GCGCAGACCT GTTTGGGGAC 
GGCTCTGGGG AAGACGGCAG TGCAGCCAAT GGCCGTCTGT GGCGGACTGT CATCATCGGG 
GAGCAGGAGC ATCGCATTGA CCTGCATATG ATCCGGCCCT ACATGAAGGT GGTGACCCAC 
GGAGGATACT ACGGAGAAGG TCTCAACGCC ATCATCGTCT TTGCGGCCTG CTTCCTGCCA 
GATAGCAGCT CTCCAGACTA CCACTACATC ATGGAGAATC TCTTCCTGTA CGTCATCAGC 
AGCCTAGAGC TGCTAGTGGC TGAGGACTAC ATGATCGTGT ACCTGAATGG TGCCACGCCC 
CGGAGGAGGA TGCCGGGCAT TGGCTGGCTG AAGAAGTGTT ACCACATGAT TGACAGGAGA 
CTGAGGAAGA ATCTAAAGTC CCTGATCATC GTCCACCCCT CCTGGTTCAT TCGCACCGTG 
CTGGCCATCT CCCGGCCCTT CATCAGTGTC AAGTTCATCA GTAAAATCCA GTATGTGCAC 
AGCCTCGAGG AGCTGGAGCA GCTCATCCCC ATGGAGCACG TGCAGCTGCC AGCCTGTGTC 
CTGCAATATG AAGAACAGAG ACTCCGAGCC AAGAGGGAGA GCGCTCGGCC ACCGCAGCCC 
GAGTTCCTCC TGCCCAGGTC TGAAGAAAAA CCAGAGACTG TGGAAGAAGA GGACAGGGCA 
GCAGAGGTGA CAGAGGACCA GGAAACGAGC ATGTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis.
Developmental cell34(5)555-68(2015 Sep)
Sun J,Pan CQ,Chew TW,Liang F,Burmeister M,Low BC

Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains.
Journal of cell science122(Pt 22)4177-85(2009 Nov)
Aoyama T,Hata S,Nakao T,Tanigawa Y,Oka C,Kawaichi M

Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons.
PloS one3(7)e2686(2008 Jul)
Buschdorf JP,Chew LL,Soh UJ,Liou YC,Low BC

Caytaxin deficiency disrupts signaling pathways in cerebellar cortex.
Neuroscience144(2)439-61(2007 Jan)
Xiao J,Gong S,Ledoux MS

Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels.
Journal of cell science119(Pt 16)3337-50(2006 Aug)
Buschdorf JP,Li Chew L,Zhang B,Cao Q,Liang FY,Liou YC,Zhou YT,Low BC

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Atcay cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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