Eif4ebp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Eif4ebp2
Entrez Gene ID	361845
Full Name	eukaryotic translation initiation factor 4E binding protein 2
General protein information	Preferred Names eukaryotic translation initiation factor 4E binding protein 2 Names eukaryotic translation initiation factor 4E-binding protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20q11

mRNA and Protein(s)

mRNA	Protein	Name
XM_008772891.1	XP_008771113.1	eukaryotic translation initiation factor 4E-binding protein 2 isoform X1
NM_001033069.1	NP_001028241.1	eukaryotic translation initiation factor 4E-binding protein 2

Pathways from BioSystems

Homologies

	EIF4EBP2	XP_002805739.1
Mus musculus (house mouse)	Eif4ebp2	NP_034254.1
Xenopus tropicalis (tropical clawed frog)	eif4ebp2	NP_989333.1
Pan troglodytes (chimpanzee)	EIF4EBP2	XP_003312651.1
Homo sapiens (human)	EIF4EBP2	NP_004087.1
Canis lupus familiaris (dog)	EIF4EBP2	XP_546145.2
Bos taurus (cattle)	EIF4EBP2	NP_001178078.1
Rattus norvegicus (Norway rat)	Eif4ebp2	NP_001028241.1
Danio rerio (zebrafish)	eif4ebp2	NP_997968.1

Gene Ontology
Bibliography

Related articles in PubMed

Dissociation of eIF4E-binding protein 2 (4E-BP2) from eIF4E independent of Thr37/Thr46 phosphorylation in the ischemic stress response.
Ayuso MI, Martinez-Alonso E, Salvador N, Bonova P, Regidor I, Alc?zar A
PloS one10(3)e0121958(2015)

The translational repressor eIF4E-binding protein 2 (4E-BP2) correlates with selective delayed neuronal death after ischemia.
Ayuso MI, Mart?nez-Alonso E, Cid C, Alonso de Leci?ana M, Alc?zar A
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism33(8)1173-81(2013 Aug)

Autism-related deficits via dysregulated eIF4E-dependent translational control.
Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N
Nature493(7432)371-7(2013 Jan)

Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission.
Bidinosti M, Ran I, Sanchez-Carbente MR, Martineau Y, Gingras AC, Gkogkas C, Raught B, Bramham CR, Sossin WS, Costa-Mattioli M, DesGroseillers L, Lacaille JC, Sonenberg N
Molecular cell37(6)797-808(2010 Mar)

Behavioral alterations in mice lacking the translation repressor 4E-BP2.
Banko JL, Merhav M, Stern E, Sonenberg N, Rosenblum K, Klann E
Neurobiology of learning and memory87(2)248-56(2007 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cerebral ischemia and subsequent reperfusion induced dephosphorylation and phosphorylation of 4E-BP2 at Thr37/Thr46. The induced phosphorylation coincided with the release of 4E-BP2 from eIF4E, although two phosphorylated 4E-BP2 forms were bound to eIF4E.
Title: Dissociation of eIF4E-binding protein 2 (4E-BP2) from eIF4E independent of Thr37/Thr46 phosphorylation in the ischemic stress response.

4E-BP2 as a novel target for protection of vulnerable neurons in ischemic injury
Title: The translational repressor eIF4E-binding protein 2 (4E-BP2) correlates with selective delayed neuronal death after ischemia.

The following Eif4ebp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eif4ebp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08445	NM_001033069.1 Latest version!	Rattus norvegicus eukaryotic translation initiation factor 4E binding protein 2 (Eif4ebp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa08445	XM_008772891.1 Latest version!	Rattus norvegicus eukaryotic translation initiation factor 4E binding protein 2 (Eif4ebp2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Eif4ebp2 ( NM_001033069.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001028241.1 Rattus norvegicus eukaryotic translation initiation factor 4E binding protein 2 (Eif4ebp2), mRNA.

Price & Availability↑

CloneID	ORa08445
Clone ID Related Accession (Same CDS sequence)	XM_008772891.1 , NM_001033069.1
Accession Version	NM_001033069.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-08-03
Organism	Rattus norvegicus(Norway rat)
Product	eukaryotic translation initiation factor 4E-binding protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC100638.1. On Sep 9, 2005 this sequence version replaced XM_342139.2. ##Evidence-Data-START## Transcript exon combination :: BC100638.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCCGCGT CGGCCGGTGG TGGACACCAG CCCAGCCAGA GCCGCGCCAT TCCGACACGC 
ACCGTGGCTA TTAGCGACGC AGCGCAGCTA CCTCAGGACT ACTGCACCAC GCCCGGGGGG 
ACGCTGTTCT CCACAACACC GGGAGGAACA CGAATCATTT ATGACCGAAA GTTTCTGTTG 
GACCGTCGCA ATTCTCCCAT GGCGCAGACC CCACCTTGCC ATCTGCCCAA TATCCCTGGA 
GTCACCAGTC CTGGCGCCTT AATGGAAGAC TCCAAAGTAG AAGTGAACAA CTTGAACAAC 
CTGAACAATC ACGACAGGAA GCACGCAGTT GGGGATGAGG CTCAGTTTGA GATGGACATC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028241.1
CDS	117..479
Translation	MSASAGGGHQPSQSRAIPTRTVAISDAAQLPQDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGALMEDSKVEVNNLNNLNNHDRKHAVGDEAQFEMDI

Target ORF information:

RefSeq Version	NM_001033069.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus eukaryotic translation initiation factor 4E binding protein 2 (Eif4ebp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033069.1

ORF Insert Sequence:

ATGTCCGCGT CGGCCGGTGG TGGACACCAG CCCAGCCAGA GCCGCGCCAT TCCGACACGC 
ACCGTGGCTA TTAGCGACGC AGCGCAGCTA CCTCAGGACT ACTGCACCAC GCCCGGGGGG 
ACGCTGTTCT CCACAACACC GGGAGGAACA CGAATCATTT ATGACCGAAA GTTTCTGTTG 
GACCGTCGCA ATTCTCCCAT GGCGCAGACC CCACCTTGCC ATCTGCCCAA TATCCCTGGA 
GTCACCAGTC CTGGCGCCTT AATGGAAGAC TCCAAAGTAG AAGTGAACAA CTTGAACAAC 
CTGAACAATC ACGACAGGAA GCACGCAGTT GGGGATGAGG CTCAGTTTGA GATGGACATC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Eif4ebp2 ( XM_008772891.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008771113.1 Rattus norvegicus eukaryotic translation initiation factor 4E binding protein 2 (Eif4ebp2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa08445
Clone ID Related Accession (Same CDS sequence)	XM_008772891.1 , NM_001033069.1
Accession Version	XM_008772891.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	eukaryotic translation initiation factor 4E-binding protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005119.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCGCGT CGGCCGGTGG TGGACACCAG CCCAGCCAGA GCCGCGCCAT TCCGACACGC 
ACCGTGGCTA TTAGCGACGC AGCGCAGCTA CCTCAGGACT ACTGCACCAC GCCCGGGGGG 
ACGCTGTTCT CCACAACACC GGGAGGAACA CGAATCATTT ATGACCGAAA GTTTCTGTTG 
GACCGTCGCA ATTCTCCCAT GGCGCAGACC CCACCTTGCC ATCTGCCCAA TATCCCTGGA 
GTCACCAGTC CTGGCGCCTT AATGGAAGAC TCCAAAGTAG AAGTGAACAA CTTGAACAAC 
CTGAACAATC ACGACAGGAA GCACGCAGTT GGGGATGAGG CTCAGTTTGA GATGGACATC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008771113.1
CDS	55..417
Translation	MSASAGGGHQPSQSRAIPTRTVAISDAAQLPQDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGALMEDSKVEVNNLNNLNNHDRKHAVGDEAQFEMDI

Target ORF information:

RefSeq Version	XM_008772891.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus eukaryotic translation initiation factor 4E binding protein 2 (Eif4ebp2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008772891.1

ORF Insert Sequence:

ATGTCCGCGT CGGCCGGTGG TGGACACCAG CCCAGCCAGA GCCGCGCCAT TCCGACACGC 
ACCGTGGCTA TTAGCGACGC AGCGCAGCTA CCTCAGGACT ACTGCACCAC GCCCGGGGGG 
ACGCTGTTCT CCACAACACC GGGAGGAACA CGAATCATTT ATGACCGAAA GTTTCTGTTG 
GACCGTCGCA ATTCTCCCAT GGCGCAGACC CCACCTTGCC ATCTGCCCAA TATCCCTGGA 
GTCACCAGTC CTGGCGCCTT AATGGAAGAC TCCAAAGTAG AAGTGAACAA CTTGAACAAC 
CTGAACAATC ACGACAGGAA GCACGCAGTT GGGGATGAGG CTCAGTTTGA GATGGACATC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dissociation of eIF4E-binding protein 2 (4E-BP2) from eIF4E independent of Thr37/Thr46 phosphorylation in the ischemic stress response.
PloS one10(3)e0121958(2015)
Ayuso MI,Martinez-Alonso E,Salvador N,Bonova P,Regidor I,Alc?zar A

The translational repressor eIF4E-binding protein 2 (4E-BP2) correlates with selective delayed neuronal death after ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism33(8)1173-81(2013 Aug)
Ayuso MI,Mart?nez-Alonso E,Cid C,Alonso de Leci?ana M,Alc?zar A

Autism-related deficits via dysregulated eIF4E-dependent translational control.
Nature493(7432)371-7(2013 Jan)
Gkogkas CG,Khoutorsky A,Ran I,Rampakakis E,Nevarko T,Weatherill DB,Vasuta C,Yee S,Truitt M,Dallaire P,Major F,Lasko P,Ruggero D,Nader K,Lacaille JC,Sonenberg N

Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission.
Molecular cell37(6)797-808(2010 Mar)
Bidinosti M,Ran I,Sanchez-Carbente MR,Martineau Y,Gingras AC,Gkogkas C,Raught B,Bramham CR,Sossin WS,Costa-Mattioli M,DesGroseillers L,Lacaille JC,Sonenberg N

Behavioral alterations in mice lacking the translation repressor 4E-BP2.
Neurobiology of learning and memory87(2)248-56(2007 Feb)
Banko JL,Merhav M,Stern E,Sonenberg N,Rosenblum K,Klann E

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Eif4ebp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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