Aldh18a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aldh18a1
Entrez Gene ID	361755
Full Name	aldehyde dehydrogenase 18 family, member A1
Synonyms	Pycs
General protein information	Preferred Names aldehyde dehydrogenase 18 family, member A1 Names delta-1-pyrroline-5-carboxylate synthase pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q54

mRNA and Protein(s)

mRNA	Protein	Name
XM_006231345.2	XP_006231407.1	delta-1-pyrroline-5-carboxylate synthase isoform X1
XM_017589453.1	XP_017444942.1	delta-1-pyrroline-5-carboxylate synthase isoform X1
NM_001108524.1	NP_001101994.1	delta-1-pyrroline-5-carboxylate synthase
XM_006231346.2	XP_006231408.1	delta-1-pyrroline-5-carboxylate synthase isoform X2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ALDH18A1	XP_005637610.1
Mus musculus (house mouse)	Aldh18a1	NP_062672.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002518	XP_312421.4
Arabidopsis thaliana (thale cress)	P5CS1	NP_181510.1
Homo sapiens (human)	ALDH18A1	NP_002851.2
Pan troglodytes (chimpanzee)	ALDH18A1	XP_001156006.3
Bos taurus (cattle)	ALDH18A1	NP_001039646.1
Danio rerio (zebrafish)	LOC100332705	XP_005156399.1
Oryza sativa (rice)	Os01g0848200	NP_001044802.1
Caenorhabditis elegans (roundworm)	alh-13	NP_510132.1
Oryza sativa (rice)	Os05g0455500	NP_001055723.1
Gallus gallus (chicken)	ALDH18A1	XP_004942438.1
Drosophila melanogaster (fruit fly)	CG7470	NP_001246877.1
	ALDH18A1	XP_001099461.2
Rattus norvegicus (Norway rat)	Aldh18a1	NP_001101994.1
Danio rerio (zebrafish)	aldh18a1	NP_001077015.1
Arabidopsis thaliana (thale cress)	P5CS2	NP_191120.2
Xenopus tropicalis (tropical clawed frog)	aldh18a1	NP_001017306.1

Gene Ontology
Bibliography

Related articles in PubMed

ALDH18A1 gene mutations cause dominant spastic paraplegia SPG9: loss of function effect and plausibility of a dominant negative mechanism.
Panza E, Escamilla-Honrubia JM, Marco-Mar?n C, Gougeard N, De Michele G, Morra VB, Liguori R, Salviati L, Donati MA, Cusano R, Pippucci T, Ravazzolo R, N?meth AH, Smithson S, Davies S, Hurst JA, Bordo D, Rubio V, Seri M
Brain : a journal of neurology139(Pt 1)e3(2016 Jan)

Recurrent De Novo Mutations Affecting Residue Arg138 of Pyrroline-5-Carboxylate Synthase Cause a Progeroid Form of Autosomal-Dominant Cutis Laxa.
Fischer-Zirnsak B, Escande-Beillard N, Ganesh J, Tan YX, Al Bughaili M, Lin AE, Sahai I, Bahena P, Reichert SL, Loh A, Wright GD, Liu J, Rahikkala E, Pivnick EK, Choudhri AF, Kr?ger U, Zemojtel T, van Ravenswaaij-Arts C, Mostafavi R, Stolte-Dijkstra I, Symoens S, Pajunen L, Al-Gazali L, Meierhofer D, Robinson PN, Mundlos S, Villarroel CE, Byers P, Masri A, Robertson SP, Schwarze U, Callewaert B, Reversade B, Kornak U
American journal of human genetics97(3)483-92(2015 Sep)

Alteration of ornithine metabolism leads to dominant and recessive hereditary spastic paraplegia.
Coutelier M, Goizet C, Durr A, Habarou F, Morais S, Dionne-Laporte A, Tao F, Konop J, Stoll M, Charles P, Jacoupy M, Matusiak R, Alonso I, Tallaksen C, Mairey M, Kennerson M, Gaussen M, Schule R, Janin M, Morice-Picard F, Durand CM, Depienne C, Calvas P, Coutinho P, Saudubray JM, Rouleau G, Brice A, Nicholson G, Darios F, Loureiro JL, Zuchner S, Ottolenghi C, Mochel F, Stevanin G
Brain : a journal of neurology138(Pt 8)2191-205(2015 Aug)

Severe congenital cutis laxa with cardiovascular manifestations due to homozygous deletions in ALDH18A1.
Fischer B, Callewaert B, Schr?ter P, Coucke PJ, Schlack C, Ott CE, Morroni M, Homann W, Mundlos S, Morava E, Ficcadenti A, Kornak U
Molecular genetics and metabolism112(4)310-6(2014 Aug)

Loss of ALDH18A1 function is associated with a cellular lipid droplet phenotype suggesting a link between autosomal recessive cutis laxa type 3A and Warburg Micro syndrome.
Handley MT, M?garban? A, Meynert AM, Brown S, Freyer E, Taylor MS, Jackson IJ, Aligianis IA
Molecular genetics & genomic medicine2(4)319-25(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Aldh18a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aldh18a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa11742	NM_001108524.1 Latest version!	Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa11742	XM_006231345.2 Latest version!	Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa11742	XM_017589453.1 Latest version!	Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa24076	XM_006231346.2 Latest version!	Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aldh18a1 ( NM_001108524.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101994.1 Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), mRNA.

Price & Availability↑

CloneID	ORa11742
Clone ID Related Accession (Same CDS sequence)	XM_006231345.2 , XM_017589453.1 , NM_001108524.1
Accession Version	NM_001108524.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2388bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	delta-1-pyrroline-5-carboxylate synthase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473986.1. On or before Oct 4, 2007 this sequence version replaced XM_342048.3, XM_001057126.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGTTGAGAC ATGTGCAACG CTCCGGGCTC CAGCCCTTCA GCCAACGTCT GCTACCGTGG 
GTCCAGTCCA TAGCTCTGCC CAGATCTCAT CGCGTCCAGC CTTCAGCTAT TAGACATGTT 
CGTTCCTGGA GCAACATCCC CTTTATCACG GTACCCCTCA GTCGTGCTCA TGGCAAGCCC 
TTTGCCCACC GAAGCGAGCT GAAGCACGCC AAGAGAATTG TAGTGAAACT CGGCAGTGCC 
GTGGTGACCA GAGGAGATGA GTGTGGCCTG GCACTGGGGC GCCTGGCGTC TATTGTCGAA 
CAGGTCTCGG TGCTGCAGAA TCAGGGCCGA GAGATGATGC TGGTGACCAG TGGAGCGGTC 
GCCTTCGGCA AGCAGCGCCT GCGCCACGAG ATCCTTCTGT CTCAGAGCGT GCGGCAAGCC 
CTGCACTCAG GACAGAACCA TCTGAAGGAG ATGGCAATTC CAGTCTTAGA GGCCCGAGCC 
TGCGCAGCCG CTGGACAGAG TGGGCTGATG GCCTTGTACG AGGCCATGTT TACACAGTAC 
AGCATCTGTG CTGCCCAGAT TTTGGTGACC AACCTGGATT TCCACGACGA GCAGAAGCGC 
AGAAATCTCA ACGGCACACT ACACGAGCTG CTTCGGATGA ACATCGTCCC CATTGTCAAC 
ACCAACGACG CCGTTGTCCC CCCAGCTGAG CCCAACAGTG ATCTTCAGGG GGTAAATGTG 
ATTAGCGTTA AGGACAACGA TAGCCTAGCT GCCCGTCTGG CCGTGGAGAT GAAAACTGAC 
CTCCTGATTG TCCTCTCAGA TGTGGAAGGC CTCTTTGACA GCCCCCCAGG CTCAGATGAT 
GCAAAACTCA TTGATATATT CTACCCGGGA GATCAGCAGT CTGTGACATT TGGAACCAAG 
TCTAGAGTGG GCCTAGGGGG CATGGAAGCC AAGGTGAAAG CCGCCCTCTG GGCTTTGCAA 
GGTGGCACTT CTGTCGTCAT TGCCAACGGA ACCCACCCCA AGGTGTCTGG GCACGTCATC 
ACAGACATCG TGGAGGGAAA GAAAGTTGGC ACCTTCTTTT CAGAAGTAAA GCCTGCTGGC 
CCTACGGTGG AGCAGCAGGG GGAGATGGCT CGGTCTGGAG GGAGAATGCT GGCCACCTTA 
GAGCCTGAAC AGAGAGCTGA AATTATCAAT CATCTGGCTG ACCTGCTGAC GGACCAGCGG 
GAAGAGATCC TGTTAGCCAA CAAAAAAGAC TTGGAGGAAG CAGAGGGAAG ACTTGCAGGC 
CCCCTGCTGA AGCGTCTCAG CCTCTCCACG TCTAAACTGA ACAGCCTGGC CATCGGGCTG 
CGGCAGATCG CAGCCTCCTC TCAGGAGAGC GTAGGCCGTG TCCTGCGCCG GACTCGGATT 
GCCAAAAACC TGGAGTTAGA ACAAGTGACT GTCCCAATAG GTGTTTTACT GGTGATCTTT 
GAGTCTCGTC CTGACTGTCT ACCCCAGGTG GCAGCCTTGG CCATTGCGAG TGGCAACGGC 
TTGTTGCTCA AAGGCGGGAA GGAGGCTATG CACAGCAACC GCATTCTTCA CCTCCTGACC 
CAGGAGGCCC TCTCCATCCA TGGAGTCAAG GAGGCCATAC AGCTGGTAAA CACCAGAGAA 
GAAGTGGAGG ATCTCTGCCG CCTGGACAAA ATAATTGACC TGATCATCCC TCGAGGCTCC 
TCCCAGCTGG TCAGAGACAT CCAGAAAGCT GCCAAGGGGA TCCCAGTGAT GGGCCACAGC 
GAAGGGATCT GCCACATGTA CGTGGATTCT GAAGCCAGTG TGGACAAGGT CACCCGACTT 
GTCAGAGACT CCAAATGTGA GTACCCAGCT GCCTGTAACG CCCTGGAGAC TTTGCTCATC 
CACCGAGATC TGCTGAGAAC ACCCTTATTT GACCAGATCA TTGACATGCT CAGAGTGGAA 
CAGGTAAAAA TTCACGCAGG CCCCAAGTTT GCCTCCTACC TGACCTTCAG CCCCTCAGAA 
GTGAAGTCAC TCCGGACAGA GTACGGGGAC CTGGAAGTGT GCATCGAAGT GGTGGACAGC 
GTCCAGGAAG CCATTGATCA CATCCATAAG TACGGCAGCT CCCACACAGA TGTCATCGTC 
ACCGAGAACG AGAAAACAGC CGAGTTCTTC CTCCAGCATG TGGACAGTGC CTGCGTGTTC 
TGGAACGCCA GTACCCGCTT CTCTGATGGC TACCGATTTG GACTGGGAGC TGAAGTAGGA 
ATCAGTACAT CACGAATCCA TGCCCGGGGA CCAGTAGGAC TCGAGGGATT GCTAACTACT 
AAGTGGTTGC TTCGAGGGCA AGACCACGTG GTCTCAGACT TCTCAGAGCA CGGAAGGCTA 
AAGTATCTTC ACGAGAACCT CCCTGTTCCC CAGAGGCATT TCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101994.1
CDS	162..2549
Translation	MLRHVQRSGLQPFSQRLLPWVQSIALPRSHRVQPSAIRHVRSWSNIPFITVPLSRAHGKPFAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNHLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPAEPNSDLQGVNVISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGLGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPTVEQQGEMARSGGRMLATLEPEQRAEIINHLADLLTDQREEILLANKKDLEEAEGRLAGPLLKRLSLSTSKLNSLAIGLRQIAASSQESVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGNGLLLKGGKEAMHSNRILHLLTQEALSIHGVKEAIQLVNTREEVEDLCRLDKIIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLEVCIEVVDSVQEAIDHIHKYGSSHTDVIVTENEKTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGQDHVVSDFSEHGRLKYLHENLPVPQRHFS

Target ORF information:

RefSeq Version	NM_001108524.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108524.1

ORF Insert Sequence:

ATGTTGAGAC ATGTGCAACG CTCCGGGCTC CAGCCCTTCA GCCAACGTCT GCTACCGTGG 
GTCCAGTCCA TAGCTCTGCC CAGATCTCAT CGCGTCCAGC CTTCAGCTAT TAGACATGTT 
CGTTCCTGGA GCAACATCCC CTTTATCACG GTACCCCTCA GTCGTGCTCA TGGCAAGCCC 
TTTGCCCACC GAAGCGAGCT GAAGCACGCC AAGAGAATTG TAGTGAAACT CGGCAGTGCC 
GTGGTGACCA GAGGAGATGA GTGTGGCCTG GCACTGGGGC GCCTGGCGTC TATTGTCGAA 
CAGGTCTCGG TGCTGCAGAA TCAGGGCCGA GAGATGATGC TGGTGACCAG TGGAGCGGTC 
GCCTTCGGCA AGCAGCGCCT GCGCCACGAG ATCCTTCTGT CTCAGAGCGT GCGGCAAGCC 
CTGCACTCAG GACAGAACCA TCTGAAGGAG ATGGCAATTC CAGTCTTAGA GGCCCGAGCC 
TGCGCAGCCG CTGGACAGAG TGGGCTGATG GCCTTGTACG AGGCCATGTT TACACAGTAC 
AGCATCTGTG CTGCCCAGAT TTTGGTGACC AACCTGGATT TCCACGACGA GCAGAAGCGC 
AGAAATCTCA ACGGCACACT ACACGAGCTG CTTCGGATGA ACATCGTCCC CATTGTCAAC 
ACCAACGACG CCGTTGTCCC CCCAGCTGAG CCCAACAGTG ATCTTCAGGG GGTAAATGTG 
ATTAGCGTTA AGGACAACGA TAGCCTAGCT GCCCGTCTGG CCGTGGAGAT GAAAACTGAC 
CTCCTGATTG TCCTCTCAGA TGTGGAAGGC CTCTTTGACA GCCCCCCAGG CTCAGATGAT 
GCAAAACTCA TTGATATATT CTACCCGGGA GATCAGCAGT CTGTGACATT TGGAACCAAG 
TCTAGAGTGG GCCTAGGGGG CATGGAAGCC AAGGTGAAAG CCGCCCTCTG GGCTTTGCAA 
GGTGGCACTT CTGTCGTCAT TGCCAACGGA ACCCACCCCA AGGTGTCTGG GCACGTCATC 
ACAGACATCG TGGAGGGAAA GAAAGTTGGC ACCTTCTTTT CAGAAGTAAA GCCTGCTGGC 
CCTACGGTGG AGCAGCAGGG GGAGATGGCT CGGTCTGGAG GGAGAATGCT GGCCACCTTA 
GAGCCTGAAC AGAGAGCTGA AATTATCAAT CATCTGGCTG ACCTGCTGAC GGACCAGCGG 
GAAGAGATCC TGTTAGCCAA CAAAAAAGAC TTGGAGGAAG CAGAGGGAAG ACTTGCAGGC 
CCCCTGCTGA AGCGTCTCAG CCTCTCCACG TCTAAACTGA ACAGCCTGGC CATCGGGCTG 
CGGCAGATCG CAGCCTCCTC TCAGGAGAGC GTAGGCCGTG TCCTGCGCCG GACTCGGATT 
GCCAAAAACC TGGAGTTAGA ACAAGTGACT GTCCCAATAG GTGTTTTACT GGTGATCTTT 
GAGTCTCGTC CTGACTGTCT ACCCCAGGTG GCAGCCTTGG CCATTGCGAG TGGCAACGGC 
TTGTTGCTCA AAGGCGGGAA GGAGGCTATG CACAGCAACC GCATTCTTCA CCTCCTGACC 
CAGGAGGCCC TCTCCATCCA TGGAGTCAAG GAGGCCATAC AGCTGGTAAA CACCAGAGAA 
GAAGTGGAGG ATCTCTGCCG CCTGGACAAA ATAATTGACC TGATCATCCC TCGAGGCTCC 
TCCCAGCTGG TCAGAGACAT CCAGAAAGCT GCCAAGGGGA TCCCAGTGAT GGGCCACAGC 
GAAGGGATCT GCCACATGTA CGTGGATTCT GAAGCCAGTG TGGACAAGGT CACCCGACTT 
GTCAGAGACT CCAAATGTGA GTACCCAGCT GCCTGTAACG CCCTGGAGAC TTTGCTCATC 
CACCGAGATC TGCTGAGAAC ACCCTTATTT GACCAGATCA TTGACATGCT CAGAGTGGAA 
CAGGTAAAAA TTCACGCAGG CCCCAAGTTT GCCTCCTACC TGACCTTCAG CCCCTCAGAA 
GTGAAGTCAC TCCGGACAGA GTACGGGGAC CTGGAAGTGT GCATCGAAGT GGTGGACAGC 
GTCCAGGAAG CCATTGATCA CATCCATAAG TACGGCAGCT CCCACACAGA TGTCATCGTC 
ACCGAGAACG AGAAAACAGC CGAGTTCTTC CTCCAGCATG TGGACAGTGC CTGCGTGTTC 
TGGAACGCCA GTACCCGCTT CTCTGATGGC TACCGATTTG GACTGGGAGC TGAAGTAGGA 
ATCAGTACAT CACGAATCCA TGCCCGGGGA CCAGTAGGAC TCGAGGGATT GCTAACTACT 
AAGTGGTTGC TTCGAGGGCA AGACCACGTG GTCTCAGACT TCTCAGAGCA CGGAAGGCTA 
AAGTATCTTC ACGAGAACCT CCCTGTTCCC CAGAGGCATT TCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aldh18a1 ( XM_006231345.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006231407.1 Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa11742
Clone ID Related Accession (Same CDS sequence)	XM_006231345.2 , XM_017589453.1 , NM_001108524.1
Accession Version	XM_006231345.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2388bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	delta-1-pyrroline-5-carboxylate synthase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006231345.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGAGAC ATGTGCAACG CTCCGGGCTC CAGCCCTTCA GCCAACGTCT GCTACCGTGG 
GTCCAGTCCA TAGCTCTGCC CAGATCTCAT CGCGTCCAGC CTTCAGCTAT TAGACATGTT 
CGTTCCTGGA GCAACATCCC CTTTATCACG GTACCCCTCA GTCGTGCTCA TGGCAAGCCC 
TTTGCCCACC GAAGCGAGCT GAAGCACGCC AAGAGAATTG TAGTGAAACT CGGCAGTGCC 
GTGGTGACCA GAGGAGATGA GTGTGGCCTG GCACTGGGGC GCCTGGCGTC TATTGTCGAA 
CAGGTCTCGG TGCTGCAGAA TCAGGGCCGA GAGATGATGC TGGTGACCAG TGGAGCGGTC 
GCCTTCGGCA AGCAGCGCCT GCGCCACGAG ATCCTTCTGT CTCAGAGCGT GCGGCAAGCC 
CTGCACTCAG GACAGAACCA TCTGAAGGAG ATGGCAATTC CAGTCTTAGA GGCCCGAGCC 
TGCGCAGCCG CTGGACAGAG TGGGCTGATG GCCTTGTACG AGGCCATGTT TACACAGTAC 
AGCATCTGTG CTGCCCAGAT TTTGGTGACC AACCTGGATT TCCACGACGA GCAGAAGCGC 
AGAAATCTCA ACGGCACACT ACACGAGCTG CTTCGGATGA ACATCGTCCC CATTGTCAAC 
ACCAACGACG CCGTTGTCCC CCCAGCTGAG CCCAACAGTG ATCTTCAGGG GGTAAATGTG 
ATTAGCGTTA AGGACAACGA TAGCCTAGCT GCCCGTCTGG CCGTGGAGAT GAAAACTGAC 
CTCCTGATTG TCCTCTCAGA TGTGGAAGGC CTCTTTGACA GCCCCCCAGG CTCAGATGAT 
GCAAAACTCA TTGATATATT CTACCCGGGA GATCAGCAGT CTGTGACATT TGGAACCAAG 
TCTAGAGTGG GCCTAGGGGG CATGGAAGCC AAGGTGAAAG CCGCCCTCTG GGCTTTGCAA 
GGTGGCACTT CTGTCGTCAT TGCCAACGGA ACCCACCCCA AGGTGTCTGG GCACGTCATC 
ACAGACATCG TGGAGGGAAA GAAAGTTGGC ACCTTCTTTT CAGAAGTAAA GCCTGCTGGC 
CCTACGGTGG AGCAGCAGGG GGAGATGGCT CGGTCTGGAG GGAGAATGCT GGCCACCTTA 
GAGCCTGAAC AGAGAGCTGA AATTATCAAT CATCTGGCTG ACCTGCTGAC GGACCAGCGG 
GAAGAGATCC TGTTAGCCAA CAAAAAAGAC TTGGAGGAAG CAGAGGGAAG ACTTGCAGGC 
CCCCTGCTGA AGCGTCTCAG CCTCTCCACG TCTAAACTGA ACAGCCTGGC CATCGGGCTG 
CGGCAGATCG CAGCCTCCTC TCAGGAGAGC GTAGGCCGTG TCCTGCGCCG GACTCGGATT 
GCCAAAAACC TGGAGTTAGA ACAAGTGACT GTCCCAATAG GTGTTTTACT GGTGATCTTT 
GAGTCTCGTC CTGACTGTCT ACCCCAGGTG GCAGCCTTGG CCATTGCGAG TGGCAACGGC 
TTGTTGCTCA AAGGCGGGAA GGAGGCTATG CACAGCAACC GCATTCTTCA CCTCCTGACC 
CAGGAGGCCC TCTCCATCCA TGGAGTCAAG GAGGCCATAC AGCTGGTAAA CACCAGAGAA 
GAAGTGGAGG ATCTCTGCCG CCTGGACAAA ATAATTGACC TGATCATCCC TCGAGGCTCC 
TCCCAGCTGG TCAGAGACAT CCAGAAAGCT GCCAAGGGGA TCCCAGTGAT GGGCCACAGC 
GAAGGGATCT GCCACATGTA CGTGGATTCT GAAGCCAGTG TGGACAAGGT CACCCGACTT 
GTCAGAGACT CCAAATGTGA GTACCCAGCT GCCTGTAACG CCCTGGAGAC TTTGCTCATC 
CACCGAGATC TGCTGAGAAC ACCCTTATTT GACCAGATCA TTGACATGCT CAGAGTGGAA 
CAGGTAAAAA TTCACGCAGG CCCCAAGTTT GCCTCCTACC TGACCTTCAG CCCCTCAGAA 
GTGAAGTCAC TCCGGACAGA GTACGGGGAC CTGGAAGTGT GCATCGAAGT GGTGGACAGC 
GTCCAGGAAG CCATTGATCA CATCCATAAG TACGGCAGCT CCCACACAGA TGTCATCGTC 
ACCGAGAACG AGAAAACAGC CGAGTTCTTC CTCCAGCATG TGGACAGTGC CTGCGTGTTC 
TGGAACGCCA GTACCCGCTT CTCTGATGGC TACCGATTTG GACTGGGAGC TGAAGTAGGA 
ATCAGTACAT CACGAATCCA TGCCCGGGGA CCAGTAGGAC TCGAGGGATT GCTAACTACT 
AAGTGGTTGC TTCGAGGGCA AGACCACGTG GTCTCAGACT TCTCAGAGCA CGGAAGGCTA 
AAGTATCTTC ACGAGAACCT CCCTGTTCCC CAGAGGCATT TCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006231407.1
CDS	190..2577
Translation	MLRHVQRSGLQPFSQRLLPWVQSIALPRSHRVQPSAIRHVRSWSNIPFITVPLSRAHGKPFAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNHLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPAEPNSDLQGVNVISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGLGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPTVEQQGEMARSGGRMLATLEPEQRAEIINHLADLLTDQREEILLANKKDLEEAEGRLAGPLLKRLSLSTSKLNSLAIGLRQIAASSQESVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGNGLLLKGGKEAMHSNRILHLLTQEALSIHGVKEAIQLVNTREEVEDLCRLDKIIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLEVCIEVVDSVQEAIDHIHKYGSSHTDVIVTENEKTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGQDHVVSDFSEHGRLKYLHENLPVPQRHFS

Target ORF information:

RefSeq Version	XM_006231345.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006231345.2

ORF Insert Sequence:

ATGTTGAGAC ATGTGCAACG CTCCGGGCTC CAGCCCTTCA GCCAACGTCT GCTACCGTGG 
GTCCAGTCCA TAGCTCTGCC CAGATCTCAT CGCGTCCAGC CTTCAGCTAT TAGACATGTT 
CGTTCCTGGA GCAACATCCC CTTTATCACG GTACCCCTCA GTCGTGCTCA TGGCAAGCCC 
TTTGCCCACC GAAGCGAGCT GAAGCACGCC AAGAGAATTG TAGTGAAACT CGGCAGTGCC 
GTGGTGACCA GAGGAGATGA GTGTGGCCTG GCACTGGGGC GCCTGGCGTC TATTGTCGAA 
CAGGTCTCGG TGCTGCAGAA TCAGGGCCGA GAGATGATGC TGGTGACCAG TGGAGCGGTC 
GCCTTCGGCA AGCAGCGCCT GCGCCACGAG ATCCTTCTGT CTCAGAGCGT GCGGCAAGCC 
CTGCACTCAG GACAGAACCA TCTGAAGGAG ATGGCAATTC CAGTCTTAGA GGCCCGAGCC 
TGCGCAGCCG CTGGACAGAG TGGGCTGATG GCCTTGTACG AGGCCATGTT TACACAGTAC 
AGCATCTGTG CTGCCCAGAT TTTGGTGACC AACCTGGATT TCCACGACGA GCAGAAGCGC 
AGAAATCTCA ACGGCACACT ACACGAGCTG CTTCGGATGA ACATCGTCCC CATTGTCAAC 
ACCAACGACG CCGTTGTCCC CCCAGCTGAG CCCAACAGTG ATCTTCAGGG GGTAAATGTG 
ATTAGCGTTA AGGACAACGA TAGCCTAGCT GCCCGTCTGG CCGTGGAGAT GAAAACTGAC 
CTCCTGATTG TCCTCTCAGA TGTGGAAGGC CTCTTTGACA GCCCCCCAGG CTCAGATGAT 
GCAAAACTCA TTGATATATT CTACCCGGGA GATCAGCAGT CTGTGACATT TGGAACCAAG 
TCTAGAGTGG GCCTAGGGGG CATGGAAGCC AAGGTGAAAG CCGCCCTCTG GGCTTTGCAA 
GGTGGCACTT CTGTCGTCAT TGCCAACGGA ACCCACCCCA AGGTGTCTGG GCACGTCATC 
ACAGACATCG TGGAGGGAAA GAAAGTTGGC ACCTTCTTTT CAGAAGTAAA GCCTGCTGGC 
CCTACGGTGG AGCAGCAGGG GGAGATGGCT CGGTCTGGAG GGAGAATGCT GGCCACCTTA 
GAGCCTGAAC AGAGAGCTGA AATTATCAAT CATCTGGCTG ACCTGCTGAC GGACCAGCGG 
GAAGAGATCC TGTTAGCCAA CAAAAAAGAC TTGGAGGAAG CAGAGGGAAG ACTTGCAGGC 
CCCCTGCTGA AGCGTCTCAG CCTCTCCACG TCTAAACTGA ACAGCCTGGC CATCGGGCTG 
CGGCAGATCG CAGCCTCCTC TCAGGAGAGC GTAGGCCGTG TCCTGCGCCG GACTCGGATT 
GCCAAAAACC TGGAGTTAGA ACAAGTGACT GTCCCAATAG GTGTTTTACT GGTGATCTTT 
GAGTCTCGTC CTGACTGTCT ACCCCAGGTG GCAGCCTTGG CCATTGCGAG TGGCAACGGC 
TTGTTGCTCA AAGGCGGGAA GGAGGCTATG CACAGCAACC GCATTCTTCA CCTCCTGACC 
CAGGAGGCCC TCTCCATCCA TGGAGTCAAG GAGGCCATAC AGCTGGTAAA CACCAGAGAA 
GAAGTGGAGG ATCTCTGCCG CCTGGACAAA ATAATTGACC TGATCATCCC TCGAGGCTCC 
TCCCAGCTGG TCAGAGACAT CCAGAAAGCT GCCAAGGGGA TCCCAGTGAT GGGCCACAGC 
GAAGGGATCT GCCACATGTA CGTGGATTCT GAAGCCAGTG TGGACAAGGT CACCCGACTT 
GTCAGAGACT CCAAATGTGA GTACCCAGCT GCCTGTAACG CCCTGGAGAC TTTGCTCATC 
CACCGAGATC TGCTGAGAAC ACCCTTATTT GACCAGATCA TTGACATGCT CAGAGTGGAA 
CAGGTAAAAA TTCACGCAGG CCCCAAGTTT GCCTCCTACC TGACCTTCAG CCCCTCAGAA 
GTGAAGTCAC TCCGGACAGA GTACGGGGAC CTGGAAGTGT GCATCGAAGT GGTGGACAGC 
GTCCAGGAAG CCATTGATCA CATCCATAAG TACGGCAGCT CCCACACAGA TGTCATCGTC 
ACCGAGAACG AGAAAACAGC CGAGTTCTTC CTCCAGCATG TGGACAGTGC CTGCGTGTTC 
TGGAACGCCA GTACCCGCTT CTCTGATGGC TACCGATTTG GACTGGGAGC TGAAGTAGGA 
ATCAGTACAT CACGAATCCA TGCCCGGGGA CCAGTAGGAC TCGAGGGATT GCTAACTACT 
AAGTGGTTGC TTCGAGGGCA AGACCACGTG GTCTCAGACT TCTCAGAGCA CGGAAGGCTA 
AAGTATCTTC ACGAGAACCT CCCTGTTCCC CAGAGGCATT TCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aldh18a1 ( XM_017589453.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444942.1 Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), transcript variant X2, mRNA.

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CloneID	ORa11742
Clone ID Related Accession (Same CDS sequence)	XM_006231345.2 , XM_017589453.1 , NM_001108524.1
Accession Version	XM_017589453.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2388bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	delta-1-pyrroline-5-carboxylate synthase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGAGAC ATGTGCAACG CTCCGGGCTC CAGCCCTTCA GCCAACGTCT GCTACCGTGG 
GTCCAGTCCA TAGCTCTGCC CAGATCTCAT CGCGTCCAGC CTTCAGCTAT TAGACATGTT 
CGTTCCTGGA GCAACATCCC CTTTATCACG GTACCCCTCA GTCGTGCTCA TGGCAAGCCC 
TTTGCCCACC GAAGCGAGCT GAAGCACGCC AAGAGAATTG TAGTGAAACT CGGCAGTGCC 
GTGGTGACCA GAGGAGATGA GTGTGGCCTG GCACTGGGGC GCCTGGCGTC TATTGTCGAA 
CAGGTCTCGG TGCTGCAGAA TCAGGGCCGA GAGATGATGC TGGTGACCAG TGGAGCGGTC 
GCCTTCGGCA AGCAGCGCCT GCGCCACGAG ATCCTTCTGT CTCAGAGCGT GCGGCAAGCC 
CTGCACTCAG GACAGAACCA TCTGAAGGAG ATGGCAATTC CAGTCTTAGA GGCCCGAGCC 
TGCGCAGCCG CTGGACAGAG TGGGCTGATG GCCTTGTACG AGGCCATGTT TACACAGTAC 
AGCATCTGTG CTGCCCAGAT TTTGGTGACC AACCTGGATT TCCACGACGA GCAGAAGCGC 
AGAAATCTCA ACGGCACACT ACACGAGCTG CTTCGGATGA ACATCGTCCC CATTGTCAAC 
ACCAACGACG CCGTTGTCCC CCCAGCTGAG CCCAACAGTG ATCTTCAGGG GGTAAATGTG 
ATTAGCGTTA AGGACAACGA TAGCCTAGCT GCCCGTCTGG CCGTGGAGAT GAAAACTGAC 
CTCCTGATTG TCCTCTCAGA TGTGGAAGGC CTCTTTGACA GCCCCCCAGG CTCAGATGAT 
GCAAAACTCA TTGATATATT CTACCCGGGA GATCAGCAGT CTGTGACATT TGGAACCAAG 
TCTAGAGTGG GCCTAGGGGG CATGGAAGCC AAGGTGAAAG CCGCCCTCTG GGCTTTGCAA 
GGTGGCACTT CTGTCGTCAT TGCCAACGGA ACCCACCCCA AGGTGTCTGG GCACGTCATC 
ACAGACATCG TGGAGGGAAA GAAAGTTGGC ACCTTCTTTT CAGAAGTAAA GCCTGCTGGC 
CCTACGGTGG AGCAGCAGGG GGAGATGGCT CGGTCTGGAG GGAGAATGCT GGCCACCTTA 
GAGCCTGAAC AGAGAGCTGA AATTATCAAT CATCTGGCTG ACCTGCTGAC GGACCAGCGG 
GAAGAGATCC TGTTAGCCAA CAAAAAAGAC TTGGAGGAAG CAGAGGGAAG ACTTGCAGGC 
CCCCTGCTGA AGCGTCTCAG CCTCTCCACG TCTAAACTGA ACAGCCTGGC CATCGGGCTG 
CGGCAGATCG CAGCCTCCTC TCAGGAGAGC GTAGGCCGTG TCCTGCGCCG GACTCGGATT 
GCCAAAAACC TGGAGTTAGA ACAAGTGACT GTCCCAATAG GTGTTTTACT GGTGATCTTT 
GAGTCTCGTC CTGACTGTCT ACCCCAGGTG GCAGCCTTGG CCATTGCGAG TGGCAACGGC 
TTGTTGCTCA AAGGCGGGAA GGAGGCTATG CACAGCAACC GCATTCTTCA CCTCCTGACC 
CAGGAGGCCC TCTCCATCCA TGGAGTCAAG GAGGCCATAC AGCTGGTAAA CACCAGAGAA 
GAAGTGGAGG ATCTCTGCCG CCTGGACAAA ATAATTGACC TGATCATCCC TCGAGGCTCC 
TCCCAGCTGG TCAGAGACAT CCAGAAAGCT GCCAAGGGGA TCCCAGTGAT GGGCCACAGC 
GAAGGGATCT GCCACATGTA CGTGGATTCT GAAGCCAGTG TGGACAAGGT CACCCGACTT 
GTCAGAGACT CCAAATGTGA GTACCCAGCT GCCTGTAACG CCCTGGAGAC TTTGCTCATC 
CACCGAGATC TGCTGAGAAC ACCCTTATTT GACCAGATCA TTGACATGCT CAGAGTGGAA 
CAGGTAAAAA TTCACGCAGG CCCCAAGTTT GCCTCCTACC TGACCTTCAG CCCCTCAGAA 
GTGAAGTCAC TCCGGACAGA GTACGGGGAC CTGGAAGTGT GCATCGAAGT GGTGGACAGC 
GTCCAGGAAG CCATTGATCA CATCCATAAG TACGGCAGCT CCCACACAGA TGTCATCGTC 
ACCGAGAACG AGAAAACAGC CGAGTTCTTC CTCCAGCATG TGGACAGTGC CTGCGTGTTC 
TGGAACGCCA GTACCCGCTT CTCTGATGGC TACCGATTTG GACTGGGAGC TGAAGTAGGA 
ATCAGTACAT CACGAATCCA TGCCCGGGGA CCAGTAGGAC TCGAGGGATT GCTAACTACT 
AAGTGGTTGC TTCGAGGGCA AGACCACGTG GTCTCAGACT TCTCAGAGCA CGGAAGGCTA 
AAGTATCTTC ACGAGAACCT CCCTGTTCCC CAGAGGCATT TCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444942.1
CDS	30..2417
Translation	MLRHVQRSGLQPFSQRLLPWVQSIALPRSHRVQPSAIRHVRSWSNIPFITVPLSRAHGKPFAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNHLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPAEPNSDLQGVNVISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGLGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPTVEQQGEMARSGGRMLATLEPEQRAEIINHLADLLTDQREEILLANKKDLEEAEGRLAGPLLKRLSLSTSKLNSLAIGLRQIAASSQESVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGNGLLLKGGKEAMHSNRILHLLTQEALSIHGVKEAIQLVNTREEVEDLCRLDKIIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLEVCIEVVDSVQEAIDHIHKYGSSHTDVIVTENEKTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGQDHVVSDFSEHGRLKYLHENLPVPQRHFS

Target ORF information:

RefSeq Version	XM_017589453.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589453.1

ORF Insert Sequence:

ATGTTGAGAC ATGTGCAACG CTCCGGGCTC CAGCCCTTCA GCCAACGTCT GCTACCGTGG 
GTCCAGTCCA TAGCTCTGCC CAGATCTCAT CGCGTCCAGC CTTCAGCTAT TAGACATGTT 
CGTTCCTGGA GCAACATCCC CTTTATCACG GTACCCCTCA GTCGTGCTCA TGGCAAGCCC 
TTTGCCCACC GAAGCGAGCT GAAGCACGCC AAGAGAATTG TAGTGAAACT CGGCAGTGCC 
GTGGTGACCA GAGGAGATGA GTGTGGCCTG GCACTGGGGC GCCTGGCGTC TATTGTCGAA 
CAGGTCTCGG TGCTGCAGAA TCAGGGCCGA GAGATGATGC TGGTGACCAG TGGAGCGGTC 
GCCTTCGGCA AGCAGCGCCT GCGCCACGAG ATCCTTCTGT CTCAGAGCGT GCGGCAAGCC 
CTGCACTCAG GACAGAACCA TCTGAAGGAG ATGGCAATTC CAGTCTTAGA GGCCCGAGCC 
TGCGCAGCCG CTGGACAGAG TGGGCTGATG GCCTTGTACG AGGCCATGTT TACACAGTAC 
AGCATCTGTG CTGCCCAGAT TTTGGTGACC AACCTGGATT TCCACGACGA GCAGAAGCGC 
AGAAATCTCA ACGGCACACT ACACGAGCTG CTTCGGATGA ACATCGTCCC CATTGTCAAC 
ACCAACGACG CCGTTGTCCC CCCAGCTGAG CCCAACAGTG ATCTTCAGGG GGTAAATGTG 
ATTAGCGTTA AGGACAACGA TAGCCTAGCT GCCCGTCTGG CCGTGGAGAT GAAAACTGAC 
CTCCTGATTG TCCTCTCAGA TGTGGAAGGC CTCTTTGACA GCCCCCCAGG CTCAGATGAT 
GCAAAACTCA TTGATATATT CTACCCGGGA GATCAGCAGT CTGTGACATT TGGAACCAAG 
TCTAGAGTGG GCCTAGGGGG CATGGAAGCC AAGGTGAAAG CCGCCCTCTG GGCTTTGCAA 
GGTGGCACTT CTGTCGTCAT TGCCAACGGA ACCCACCCCA AGGTGTCTGG GCACGTCATC 
ACAGACATCG TGGAGGGAAA GAAAGTTGGC ACCTTCTTTT CAGAAGTAAA GCCTGCTGGC 
CCTACGGTGG AGCAGCAGGG GGAGATGGCT CGGTCTGGAG GGAGAATGCT GGCCACCTTA 
GAGCCTGAAC AGAGAGCTGA AATTATCAAT CATCTGGCTG ACCTGCTGAC GGACCAGCGG 
GAAGAGATCC TGTTAGCCAA CAAAAAAGAC TTGGAGGAAG CAGAGGGAAG ACTTGCAGGC 
CCCCTGCTGA AGCGTCTCAG CCTCTCCACG TCTAAACTGA ACAGCCTGGC CATCGGGCTG 
CGGCAGATCG CAGCCTCCTC TCAGGAGAGC GTAGGCCGTG TCCTGCGCCG GACTCGGATT 
GCCAAAAACC TGGAGTTAGA ACAAGTGACT GTCCCAATAG GTGTTTTACT GGTGATCTTT 
GAGTCTCGTC CTGACTGTCT ACCCCAGGTG GCAGCCTTGG CCATTGCGAG TGGCAACGGC 
TTGTTGCTCA AAGGCGGGAA GGAGGCTATG CACAGCAACC GCATTCTTCA CCTCCTGACC 
CAGGAGGCCC TCTCCATCCA TGGAGTCAAG GAGGCCATAC AGCTGGTAAA CACCAGAGAA 
GAAGTGGAGG ATCTCTGCCG CCTGGACAAA ATAATTGACC TGATCATCCC TCGAGGCTCC 
TCCCAGCTGG TCAGAGACAT CCAGAAAGCT GCCAAGGGGA TCCCAGTGAT GGGCCACAGC 
GAAGGGATCT GCCACATGTA CGTGGATTCT GAAGCCAGTG TGGACAAGGT CACCCGACTT 
GTCAGAGACT CCAAATGTGA GTACCCAGCT GCCTGTAACG CCCTGGAGAC TTTGCTCATC 
CACCGAGATC TGCTGAGAAC ACCCTTATTT GACCAGATCA TTGACATGCT CAGAGTGGAA 
CAGGTAAAAA TTCACGCAGG CCCCAAGTTT GCCTCCTACC TGACCTTCAG CCCCTCAGAA 
GTGAAGTCAC TCCGGACAGA GTACGGGGAC CTGGAAGTGT GCATCGAAGT GGTGGACAGC 
GTCCAGGAAG CCATTGATCA CATCCATAAG TACGGCAGCT CCCACACAGA TGTCATCGTC 
ACCGAGAACG AGAAAACAGC CGAGTTCTTC CTCCAGCATG TGGACAGTGC CTGCGTGTTC 
TGGAACGCCA GTACCCGCTT CTCTGATGGC TACCGATTTG GACTGGGAGC TGAAGTAGGA 
ATCAGTACAT CACGAATCCA TGCCCGGGGA CCAGTAGGAC TCGAGGGATT GCTAACTACT 
AAGTGGTTGC TTCGAGGGCA AGACCACGTG GTCTCAGACT TCTCAGAGCA CGGAAGGCTA 
AAGTATCTTC ACGAGAACCT CCCTGTTCCC CAGAGGCATT TCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Aldh18a1 ( XM_006231346.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006231408.1 Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa24076
Clone ID Related Accession (Same CDS sequence)	XM_006231346.2
Accession Version	XM_006231346.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2382bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	delta-1-pyrroline-5-carboxylate synthase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006231346.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGAGAC ATGTGCAACG CTCCGGGCTC CAGCCCTTCA GCCAACGTCT GCTACCGTGG 
GTCCAGTCCA TAGCTCTGCC CAGATCTCAT CGCGTCCAGC CTTCAGCTAT TAGACATGTT 
CGTTCCTGGA GCAACATCCC CTTTATCACG GTACCCCTCA GTCGTGCTCA TGGCAAGCCC 
TTTGCCCACC GAAGCGAGCT GAAGCACGCC AAGAGAATTG TAGTGAAACT CGGCAGTGCC 
GTGGTGACCA GAGGAGATGA GTGTGGCCTG GCACTGGGGC GCCTGGCGTC TATTGTCGAA 
CAGGTCTCGG TGCTGCAGAA TCAGGGCCGA GAGATGATGC TGGTGACCAG TGGAGCGGTC 
GCCTTCGGCA AGCAGCGCCT GCGCCACGAG ATCCTTCTGT CTCAGAGCGT GCGGCAAGCC 
CTGCACTCAG GACAGAACCA TCTGAAGGAG ATGGCAATTC CAGTCTTAGA GGCCCGAGCC 
TGCGCAGCCG CTGGACAGAG TGGGCTGATG GCCTTGTACG AGGCCATGTT TACACAGTAC 
AGCATCTGTG CTGCCCAGAT TTTGGTGACC AACCTGGATT TCCACGACGA GCAGAAGCGC 
AGAAATCTCA ACGGCACACT ACACGAGCTG CTTCGGATGA ACATCGTCCC CATTGTCAAC 
ACCAACGACG CCGTTGTCCC CCCAGCTGAG CCCAACAGTG ATCTTCAGGG GGTGATTAGC 
GTTAAGGACA ACGATAGCCT AGCTGCCCGT CTGGCCGTGG AGATGAAAAC TGACCTCCTG 
ATTGTCCTCT CAGATGTGGA AGGCCTCTTT GACAGCCCCC CAGGCTCAGA TGATGCAAAA 
CTCATTGATA TATTCTACCC GGGAGATCAG CAGTCTGTGA CATTTGGAAC CAAGTCTAGA 
GTGGGCCTAG GGGGCATGGA AGCCAAGGTG AAAGCCGCCC TCTGGGCTTT GCAAGGTGGC 
ACTTCTGTCG TCATTGCCAA CGGAACCCAC CCCAAGGTGT CTGGGCACGT CATCACAGAC 
ATCGTGGAGG GAAAGAAAGT TGGCACCTTC TTTTCAGAAG TAAAGCCTGC TGGCCCTACG 
GTGGAGCAGC AGGGGGAGAT GGCTCGGTCT GGAGGGAGAA TGCTGGCCAC CTTAGAGCCT 
GAACAGAGAG CTGAAATTAT CAATCATCTG GCTGACCTGC TGACGGACCA GCGGGAAGAG 
ATCCTGTTAG CCAACAAAAA AGACTTGGAG GAAGCAGAGG GAAGACTTGC AGGCCCCCTG 
CTGAAGCGTC TCAGCCTCTC CACGTCTAAA CTGAACAGCC TGGCCATCGG GCTGCGGCAG 
ATCGCAGCCT CCTCTCAGGA GAGCGTAGGC CGTGTCCTGC GCCGGACTCG GATTGCCAAA 
AACCTGGAGT TAGAACAAGT GACTGTCCCA ATAGGTGTTT TACTGGTGAT CTTTGAGTCT 
CGTCCTGACT GTCTACCCCA GGTGGCAGCC TTGGCCATTG CGAGTGGCAA CGGCTTGTTG 
CTCAAAGGCG GGAAGGAGGC TATGCACAGC AACCGCATTC TTCACCTCCT GACCCAGGAG 
GCCCTCTCCA TCCATGGAGT CAAGGAGGCC ATACAGCTGG TAAACACCAG AGAAGAAGTG 
GAGGATCTCT GCCGCCTGGA CAAAATAATT GACCTGATCA TCCCTCGAGG CTCCTCCCAG 
CTGGTCAGAG ACATCCAGAA AGCTGCCAAG GGGATCCCAG TGATGGGCCA CAGCGAAGGG 
ATCTGCCACA TGTACGTGGA TTCTGAAGCC AGTGTGGACA AGGTCACCCG ACTTGTCAGA 
GACTCCAAAT GTGAGTACCC AGCTGCCTGT AACGCCCTGG AGACTTTGCT CATCCACCGA 
GATCTGCTGA GAACACCCTT ATTTGACCAG ATCATTGACA TGCTCAGAGT GGAACAGGTA 
AAAATTCACG CAGGCCCCAA GTTTGCCTCC TACCTGACCT TCAGCCCCTC AGAAGTGAAG 
TCACTCCGGA CAGAGTACGG GGACCTGGAA GTGTGCATCG AAGTGGTGGA CAGCGTCCAG 
GAAGCCATTG ATCACATCCA TAAGTACGGC AGCTCCCACA CAGATGTCAT CGTCACCGAG 
AACGAGAAAA CAGCCGAGTT CTTCCTCCAG CATGTGGACA GTGCCTGCGT GTTCTGGAAC 
GCCAGTACCC GCTTCTCTGA TGGCTACCGA TTTGGACTGG GAGCTGAAGT AGGAATCAGT 
ACATCACGAA TCCATGCCCG GGGACCAGTA GGACTCGAGG GATTGCTAAC TACTAAGTGG 
TTGCTTCGAG GGCAAGACCA CGTGGTCTCA GACTTCTCAG AGCACGGAAG GCTAAAGTAT 
CTTCACGAGA ACCTCCCTGT TCCCCAGAGG CATTTCAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006231408.1
CDS	190..2571
Translation	MLRHVQRSGLQPFSQRLLPWVQSIALPRSHRVQPSAIRHVRSWSNIPFITVPLSRAHGKPFAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNHLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPAEPNSDLQGVISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGLGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPTVEQQGEMARSGGRMLATLEPEQRAEIINHLADLLTDQREEILLANKKDLEEAEGRLAGPLLKRLSLSTSKLNSLAIGLRQIAASSQESVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGNGLLLKGGKEAMHSNRILHLLTQEALSIHGVKEAIQLVNTREEVEDLCRLDKIIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLEVCIEVVDSVQEAIDHIHKYGSSHTDVIVTENEKTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGQDHVVSDFSEHGRLKYLHENLPVPQRHFS

Target ORF information:

RefSeq Version	XM_006231346.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006231346.2

ORF Insert Sequence:

ATGTTGAGAC ATGTGCAACG CTCCGGGCTC CAGCCCTTCA GCCAACGTCT GCTACCGTGG 
GTCCAGTCCA TAGCTCTGCC CAGATCTCAT CGCGTCCAGC CTTCAGCTAT TAGACATGTT 
CGTTCCTGGA GCAACATCCC CTTTATCACG GTACCCCTCA GTCGTGCTCA TGGCAAGCCC 
TTTGCCCACC GAAGCGAGCT GAAGCACGCC AAGAGAATTG TAGTGAAACT CGGCAGTGCC 
GTGGTGACCA GAGGAGATGA GTGTGGCCTG GCACTGGGGC GCCTGGCGTC TATTGTCGAA 
CAGGTCTCGG TGCTGCAGAA TCAGGGCCGA GAGATGATGC TGGTGACCAG TGGAGCGGTC 
GCCTTCGGCA AGCAGCGCCT GCGCCACGAG ATCCTTCTGT CTCAGAGCGT GCGGCAAGCC 
CTGCACTCAG GACAGAACCA TCTGAAGGAG ATGGCAATTC CAGTCTTAGA GGCCCGAGCC 
TGCGCAGCCG CTGGACAGAG TGGGCTGATG GCCTTGTACG AGGCCATGTT TACACAGTAC 
AGCATCTGTG CTGCCCAGAT TTTGGTGACC AACCTGGATT TCCACGACGA GCAGAAGCGC 
AGAAATCTCA ACGGCACACT ACACGAGCTG CTTCGGATGA ACATCGTCCC CATTGTCAAC 
ACCAACGACG CCGTTGTCCC CCCAGCTGAG CCCAACAGTG ATCTTCAGGG GGTGATTAGC 
GTTAAGGACA ACGATAGCCT AGCTGCCCGT CTGGCCGTGG AGATGAAAAC TGACCTCCTG 
ATTGTCCTCT CAGATGTGGA AGGCCTCTTT GACAGCCCCC CAGGCTCAGA TGATGCAAAA 
CTCATTGATA TATTCTACCC GGGAGATCAG CAGTCTGTGA CATTTGGAAC CAAGTCTAGA 
GTGGGCCTAG GGGGCATGGA AGCCAAGGTG AAAGCCGCCC TCTGGGCTTT GCAAGGTGGC 
ACTTCTGTCG TCATTGCCAA CGGAACCCAC CCCAAGGTGT CTGGGCACGT CATCACAGAC 
ATCGTGGAGG GAAAGAAAGT TGGCACCTTC TTTTCAGAAG TAAAGCCTGC TGGCCCTACG 
GTGGAGCAGC AGGGGGAGAT GGCTCGGTCT GGAGGGAGAA TGCTGGCCAC CTTAGAGCCT 
GAACAGAGAG CTGAAATTAT CAATCATCTG GCTGACCTGC TGACGGACCA GCGGGAAGAG 
ATCCTGTTAG CCAACAAAAA AGACTTGGAG GAAGCAGAGG GAAGACTTGC AGGCCCCCTG 
CTGAAGCGTC TCAGCCTCTC CACGTCTAAA CTGAACAGCC TGGCCATCGG GCTGCGGCAG 
ATCGCAGCCT CCTCTCAGGA GAGCGTAGGC CGTGTCCTGC GCCGGACTCG GATTGCCAAA 
AACCTGGAGT TAGAACAAGT GACTGTCCCA ATAGGTGTTT TACTGGTGAT CTTTGAGTCT 
CGTCCTGACT GTCTACCCCA GGTGGCAGCC TTGGCCATTG CGAGTGGCAA CGGCTTGTTG 
CTCAAAGGCG GGAAGGAGGC TATGCACAGC AACCGCATTC TTCACCTCCT GACCCAGGAG 
GCCCTCTCCA TCCATGGAGT CAAGGAGGCC ATACAGCTGG TAAACACCAG AGAAGAAGTG 
GAGGATCTCT GCCGCCTGGA CAAAATAATT GACCTGATCA TCCCTCGAGG CTCCTCCCAG 
CTGGTCAGAG ACATCCAGAA AGCTGCCAAG GGGATCCCAG TGATGGGCCA CAGCGAAGGG 
ATCTGCCACA TGTACGTGGA TTCTGAAGCC AGTGTGGACA AGGTCACCCG ACTTGTCAGA 
GACTCCAAAT GTGAGTACCC AGCTGCCTGT AACGCCCTGG AGACTTTGCT CATCCACCGA 
GATCTGCTGA GAACACCCTT ATTTGACCAG ATCATTGACA TGCTCAGAGT GGAACAGGTA 
AAAATTCACG CAGGCCCCAA GTTTGCCTCC TACCTGACCT TCAGCCCCTC AGAAGTGAAG 
TCACTCCGGA CAGAGTACGG GGACCTGGAA GTGTGCATCG AAGTGGTGGA CAGCGTCCAG 
GAAGCCATTG ATCACATCCA TAAGTACGGC AGCTCCCACA CAGATGTCAT CGTCACCGAG 
AACGAGAAAA CAGCCGAGTT CTTCCTCCAG CATGTGGACA GTGCCTGCGT GTTCTGGAAC 
GCCAGTACCC GCTTCTCTGA TGGCTACCGA TTTGGACTGG GAGCTGAAGT AGGAATCAGT 
ACATCACGAA TCCATGCCCG GGGACCAGTA GGACTCGAGG GATTGCTAAC TACTAAGTGG 
TTGCTTCGAG GGCAAGACCA CGTGGTCTCA GACTTCTCAG AGCACGGAAG GCTAAAGTAT 
CTTCACGAGA ACCTCCCTGT TCCCCAGAGG CATTTCAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ALDH18A1 gene mutations cause dominant spastic paraplegia SPG9: loss of function effect and plausibility of a dominant negative mechanism.
Brain : a journal of neurology139(Pt 1)e3(2016 Jan)
Panza E,Escamilla-Honrubia JM,Marco-Mar?n C,Gougeard N,De Michele G,Morra VB,Liguori R,Salviati L,Donati MA,Cusano R,Pippucci T,Ravazzolo R,N?meth AH,Smithson S,Davies S,Hurst JA,Bordo D,Rubio V,Seri M

Recurrent De Novo Mutations Affecting Residue Arg138 of Pyrroline-5-Carboxylate Synthase Cause a Progeroid Form of Autosomal-Dominant Cutis Laxa.
American journal of human genetics97(3)483-92(2015 Sep)
Fischer-Zirnsak B,Escande-Beillard N,Ganesh J,Tan YX,Al Bughaili M,Lin AE,Sahai I,Bahena P,Reichert SL,Loh A,Wright GD,Liu J,Rahikkala E,Pivnick EK,Choudhri AF,Kr?ger U,Zemojtel T,van Ravenswaaij-Arts C,Mostafavi R,Stolte-Dijkstra I,Symoens S,Pajunen L,Al-Gazali L,Meierhofer D,Robinson PN,Mundlos S,Villarroel CE,Byers P,Masri A,Robertson SP,Schwarze U,Callewaert B,Reversade B,Kornak U

Alteration of ornithine metabolism leads to dominant and recessive hereditary spastic paraplegia.
Brain : a journal of neurology138(Pt 8)2191-205(2015 Aug)
Coutelier M,Goizet C,Durr A,Habarou F,Morais S,Dionne-Laporte A,Tao F,Konop J,Stoll M,Charles P,Jacoupy M,Matusiak R,Alonso I,Tallaksen C,Mairey M,Kennerson M,Gaussen M,Schule R,Janin M,Morice-Picard F,Durand CM,Depienne C,Calvas P,Coutinho P,Saudubray JM,Rouleau G,Brice A,Nicholson G,Darios F,Loureiro JL,Zuchner S,Ottolenghi C,Mochel F,Stevanin G

Severe congenital cutis laxa with cardiovascular manifestations due to homozygous deletions in ALDH18A1.
Molecular genetics and metabolism112(4)310-6(2014 Aug)
Fischer B,Callewaert B,Schr?ter P,Coucke PJ,Schlack C,Ott CE,Morroni M,Homann W,Mundlos S,Morava E,Ficcadenti A,Kornak U

Loss of ALDH18A1 function is associated with a cellular lipid droplet phenotype suggesting a link between autosomal recessive cutis laxa type 3A and Warburg Micro syndrome.
Molecular genetics & genomic medicine2(4)319-25(2014 Jul)
Handley MT,M?garban? A,Meynert AM,Brown S,Freyer E,Taylor MS,Jackson IJ,Aligianis IA

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Aldh18a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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