Was cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Was
Entrez Gene ID	317371
Full Name	Wiskott-Aldrich syndrome
Synonyms	WASP
General protein information	Preferred Names Wiskott-Aldrich syndrome Names wiskott-Aldrich syndrome protein Wiskott-Aldrich syndrome homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108248.1	NP_001101718.1	wiskott-Aldrich syndrome protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	WAS	NP_000368.1
	LOC714474	XP_001104246.2
Rattus norvegicus (Norway rat)	Was	NP_001101718.1
Canis lupus familiaris (dog)	WAS	XP_548986.2
Danio rerio (zebrafish)	wasa	XP_699919.5
Mus musculus (house mouse)	Was	NP_033541.1

Gene Ontology
Bibliography

Related articles in PubMed

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek M, Saito T, W?lfing C, Malissen B, Malissen M
Nature immunology14(8)858-66(2013 Aug)

Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1.
Lafouresse F, Cotta-de-Almeida V, Malet-Engra G, Galy A, Valitutti S, Dupr? L
Immunology137(2)183-96(2012 Oct)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome.
Taylor MD, Sadhukhan S, Kottangada P, Ramgopal A, Sarkar K, D'Silva S, Selvakumar A, Candotti F, Vyas YM
Science translational medicine2(37)37ra44(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Serine phosphorylation of WASP enhanced the ability of WASP to stimulate actin polymerization in mammalian cell lysates
Title: Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase.

The following Was gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Was cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00314	NM_001108248.1 Latest version!	Rattus norvegicus WASP actin nucleation promoting factor (Was), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Was ( NM_001108248.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101718.1 Rattus norvegicus WASP actin nucleation promoting factor (Was), mRNA.

Price & Availability↑

CloneID	ORa00314
Clone ID Related Accession (Same CDS sequence)	NM_001108248.1
Accession Version	NM_001108248.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	wiskott-Aldrich syndrome protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474078.1. On or before Oct 4, 2007 this sequence version replaced XM_228784.4, XM_001063310.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2689594, SAMEA2689597 [ECO:0000350] ##Evidence-Data-END##

ATGAGTAGTG GCCCTGTAGG AGGCAGGTCT GGGGGCCGAG GGGGACCAGC AGTTCAGCAG 
AACATTCCTT CCAACCTCCT CCAGGACCAT GAGAACCAGA GACTCTTCGA GCTTCTCGGC 
CGAAAATGCT GGACACTGGC AACTGCAGTT GTTCAGCTGT ACCTGGCACT GCCCCCTGGA 
GCTGAGCACT GGACCATGGA ACACTGCGGG GCTGTGTGCT TCGTGAAGGA TAACCCTCAG 
AAGTCGTACT TCATCCGCCT TTATGGCCTA CAGGCTGGTC GACTACTCTG GGAACAGGAG 
CTATACTCAC AGCTGGTTTA CCTTACTCCT ACCCCATTCT TCCACACCTT TGCTGGAGAT 
GACTGTCAAG TAGGACTGAA CTTTTCGGAT GAGAGTGAAG CCCAGGCCTT CCGGGCCTTG 
GTGCAGGAGA AGATACAAAA AAGGAATCAG AGGCAAAGTG GAGAAAGACG CCAGCTACCA 
CTGACACCAG CACCAACCAA TGAGGAGAGA AGAGGAGGGC TCCCACCTGT GCCCCCACAT 
CCCGGTGGAG ATCATGGGGG CCCATCAGGT GGTCCACTAT CTCTGGGACT TGTGACAGTT 
GACATTCAGA ATCCTGACAT CACAAGTTCA CGTTACCGTG GGCTCCCTGC ACCTGGCCCT 
GGCCCAACTG ATAAGAAACG CTCAGGAAAA AAGAAGATCA GTAAAGCTGA TATTGGTGCA 
CCAAGTGGAT TCAAACACGT CAGCCACGTG GGCTGGGATC CACAGAACGG ATTTGATGTG 
AACAACCTCG ACCCGGATCT GCGCAGTTTG TTCTCTAGGG CAGGGATCAG TGAGGCCCAA 
CTCACTGACG CAGAGACCTC CAAGCTCATC TATGACTTTA TTGAGGACCA GGGTGGTCTA 
GAGGCAGTCC GGCAGGAGAT GAGGCGCCAG GAGCCACCAC CACCACCACC ATGCCGAGGA 
GGAGGAGGAA ACCCCTGGAG CTATGGAGAA CTCAGTACCG CAAGCACTCC CTCAGCAGTC 
AGAAGGCCTA GTGGGTGCCC TGATGCATGT CATGCAGAAG AGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101718.1
CDS	28..1095
Translation	MSSGPVGGRSGGRGGPAVQQNIPSNLLQDHENQRLFELLGRKCWTLATAVVQLYLALPPGAEHWTMEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYLTPTPFFHTFAGDDCQVGLNFSDESEAQAFRALVQEKIQKRNQRQSGERRQLPLTPAPTNEERRGGLPPVPPHPGGDHGGPSGGPLSLGLVTVDIQNPDITSSRYRGLPAPGPGPTDKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQEMRRQEPPPPPPCRGGGGNPWSYGELSTASTPSAVRRPSGCPDACHAEEE

Target ORF information:

RefSeq Version	NM_001108248.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus WASP actin nucleation promoting factor (Was), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108248.1

ORF Insert Sequence:

ATGAGTAGTG GCCCTGTAGG AGGCAGGTCT GGGGGCCGAG GGGGACCAGC AGTTCAGCAG 
AACATTCCTT CCAACCTCCT CCAGGACCAT GAGAACCAGA GACTCTTCGA GCTTCTCGGC 
CGAAAATGCT GGACACTGGC AACTGCAGTT GTTCAGCTGT ACCTGGCACT GCCCCCTGGA 
GCTGAGCACT GGACCATGGA ACACTGCGGG GCTGTGTGCT TCGTGAAGGA TAACCCTCAG 
AAGTCGTACT TCATCCGCCT TTATGGCCTA CAGGCTGGTC GACTACTCTG GGAACAGGAG 
CTATACTCAC AGCTGGTTTA CCTTACTCCT ACCCCATTCT TCCACACCTT TGCTGGAGAT 
GACTGTCAAG TAGGACTGAA CTTTTCGGAT GAGAGTGAAG CCCAGGCCTT CCGGGCCTTG 
GTGCAGGAGA AGATACAAAA AAGGAATCAG AGGCAAAGTG GAGAAAGACG CCAGCTACCA 
CTGACACCAG CACCAACCAA TGAGGAGAGA AGAGGAGGGC TCCCACCTGT GCCCCCACAT 
CCCGGTGGAG ATCATGGGGG CCCATCAGGT GGTCCACTAT CTCTGGGACT TGTGACAGTT 
GACATTCAGA ATCCTGACAT CACAAGTTCA CGTTACCGTG GGCTCCCTGC ACCTGGCCCT 
GGCCCAACTG ATAAGAAACG CTCAGGAAAA AAGAAGATCA GTAAAGCTGA TATTGGTGCA 
CCAAGTGGAT TCAAACACGT CAGCCACGTG GGCTGGGATC CACAGAACGG ATTTGATGTG 
AACAACCTCG ACCCGGATCT GCGCAGTTTG TTCTCTAGGG CAGGGATCAG TGAGGCCCAA 
CTCACTGACG CAGAGACCTC CAAGCTCATC TATGACTTTA TTGAGGACCA GGGTGGTCTA 
GAGGCAGTCC GGCAGGAGAT GAGGCGCCAG GAGCCACCAC CACCACCACC ATGCCGAGGA 
GGAGGAGGAA ACCCCTGGAG CTATGGAGAA CTCAGTACCG CAAGCACTCC CTCAGCAGTC 
AGAAGGCCTA GTGGGTGCCC TGATGCATGT CATGCAGAAG AGGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Nature immunology14(8)858-66(2013 Aug)
Liang Y,Cucchetti M,Roncagalli R,Yokosuka T,Malzac A,Bertosio E,Imbert J,Nijman IJ,Suchanek M,Saito T,W?lfing C,Malissen B,Malissen M

Wiskott-Aldrich syndrome protein controls antigen-presenting cell-driven CD4+ T-cell motility by regulating adhesion to intercellular adhesion molecule-1.
Immunology137(2)183-96(2012 Oct)
Lafouresse F,Cotta-de-Almeida V,Malet-Engra G,Galy A,Valitutti S,Dupr? L

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome.
Science translational medicine2(37)37ra44(2010 Jun)
Taylor MD,Sadhukhan S,Kottangada P,Ramgopal A,Sarkar K,D'Silva S,Selvakumar A,Candotti F,Vyas YM

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Was cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報