Itgb1bp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itgb1bp2
Entrez Gene ID	317258
Full Name	integrin subunit beta 1 binding protein 2
Synonyms	RGD1565015
General protein information	Preferred Names integrin subunit beta 1 binding protein 2 Names integrin beta-1-binding protein 2 melusin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108245.2	NP_001101715.1	integrin beta-1-binding protein 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ITGB1BP2	XP_420200.3
Homo sapiens (human)	ITGB1BP2	NP_036410.1
Pan troglodytes (chimpanzee)	ITGB1BP2	XP_521119.1
	ITGB1BP2	XP_001091670.1
Rattus norvegicus (Norway rat)	Itgb1bp2	NP_001101715.1
Canis lupus familiaris (dog)	ITGB1BP2	XP_538074.2
Bos taurus (cattle)	ITGB1BP2	NP_001192661.1
Mus musculus (house mouse)	Itgb1bp2	NP_038740.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of cardiac melusin gene expression by hypertrophic stimuli in the rat.
Aro J, Tokola H, Ronkainen VP, Koivisto E, Tenhunen O, Ilves M, Szokodi I, Ruskoaho H, Rys? J
Acta physiologica (Oxford, England)207(3)470-84(2013 Mar)

Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure.
Waardenberg AJ, Bernardo BC, Ng DC, Shepherd PR, Cemerlang N, Sbroggi? M, Wells CA, Dalrymple BP, Brancaccio M, Lin RC, McMullen JR
The Journal of biological chemistry286(35)30837-46(2011 Sep)

Chp-1 and melusin, two CHORD containing proteins in vertebrates.
Brancaccio M, Menini N, Bongioanni D, Ferretti R, De Acetis M, Silengo L, Tarone G
FEBS letters551(1-3)47-52(2003 Sep)

Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload.
Brancaccio M, Fratta L, Notte A, Hirsch E, Poulet R, Guazzone S, De Acetis M, Vecchione C, Marino G, Altruda F, Silengo L, Tarone G, Lembo G
Nature medicine9(1)68-75(2003 Jan)

Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain.
Brancaccio M, Guazzone S, Menini N, Sibona E, Hirsch E, De Andrea M, Rocchi M, Altruda F, Tarone G, Silengo L
The Journal of biological chemistry274(41)29282-8(1999 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Multiple hypertrophic stimuli regulate melusin expression predominately in the atria, which may represent a necessary initial step in early adaptive remodelling processes in left ventricular hypertrophy.
Title: Regulation of cardiac melusin gene expression by hypertrophic stimuli in the rat.

PI3K regulates the expression of genes essential for cardiac structure and Z-disc signaling, interacts with melusin, and is critical for Z-disc alignment
Title: Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure.

The following Itgb1bp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itgb1bp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06968	NM_001108245.2 Latest version!	Rattus norvegicus integrin subunit beta 1 binding protein 2 (Itgb1bp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itgb1bp2 ( NM_001108245.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101715.1 Rattus norvegicus integrin subunit beta 1 binding protein 2 (Itgb1bp2), mRNA.

Price & Availability↑

CloneID	ORa06968
Clone ID Related Accession (Same CDS sequence)	NM_001108245.2
Accession Version	NM_001108245.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	integrin beta-1-binding protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07039199.1, FM116382.1 and FM118664.1. On Mar 22, 2013 this sequence version replaced NM_001108245.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: FQ216044.1, FQ224925.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689596, SAMEA2689600 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTCTGC TCTGCTATAA CAAAGGCTGT GGGCAACACT TTGACCCCAA TACCAATCTC 
CCTGATTCCT GCCGTTATCA CCCTGGGGTC CCAATCTTTC ATGATGCACT TAAGGGTTGG 
TCCTGCTGCC GAAAGCGAAC TGTAGATTTC TCTGAGTTCT TAAACATCAA GGGCTGTACT 
GTGGGACCAC ACTGTGCTGA GAAGCTTCCT GAGGTCCCTC AGCCTGAGGG CCCTGCCACA 
AGTTCACTTC AGGAGCAAAA ACCTCTGAAT ACAATTCCAA AGTCAGCAGA GACTTTGCTC 
CGAGAAAGGC CTAAGTCTGA GATGCCTCCG AAACTGCTAC CACTTCTTAT ATCTCAAGCC 
CTGGGAGTGG CGTTGGAACA GAAAGAATTA GACCAGGAAC CTGGAGCAGG ACTTGACAAT 
AGTCTGATCT GGACTGGTTC CAGCTGCCAG AACCCAGGAT GTGATGCTGT TTACCAAGGT 
CCTGAGAGTG ATGCTACTCC GTGTACCTAT CATCCAGGTG CACCTCGGTT TCATGAGGGA 
ATGAAGTCTT GGAGCTGTTG TGGTATCCAG ACTCTGGATT TTGGGGCATT CCTGGCACAG 
CCAGGATGTA GAGTTGGTAG ACACGATTGG GCAAAGCAGC TGCCAGCATC TTGCCGCCAT 
GATTGGCACC AGACAGATTC TTTGGTAGTG CTCACGGTCT ATGGCCAGAT TCCACTTCCT 
GCATTCAACT GGGTGAAGGC CAGTCAAACT GAGCTTCATG TCCACATTGT CTTTGATGGT 
AACCGTGTGT TCCAAGCACA GATGAAGCTC TGGGGGGTCA TAAACGTGGA GCAGAGCTCT 
GTCTCTTTGA TGCCATCACG GGTTGAAATC TCCCTGGTCA AGGCTGACCC AGGATCCTGG 
GCCCAGCTGG AGCACCCCGA TTCACTAGCT GAGAAGGCTA GGGCAGGGGT TTTACTAGAG 
ATGGATGAGG AAGAATCTGA GGATTCAGAT GATGACCTGA GCTGGACAGA AGAGGAAGAT 
GAAGACGAGG AAGAAGCTAT GGGGGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101715.1
CDS	59..1108
Translation	MSLLCYNKGCGQHFDPNTNLPDSCRYHPGVPIFHDALKGWSCCRKRTVDFSEFLNIKGCTVGPHCAEKLPEVPQPEGPATSSLQEQKPLNTIPKSAETLLRERPKSEMPPKLLPLLISQALGVALEQKELDQEPGAGLDNSLIWTGSSCQNPGCDAVYQGPESDATPCTYHPGAPRFHEGMKSWSCCGIQTLDFGAFLAQPGCRVGRHDWAKQLPASCRHDWHQTDSLVVLTVYGQIPLPAFNWVKASQTELHVHIVFDGNRVFQAQMKLWGVINVEQSSVSLMPSRVEISLVKADPGSWAQLEHPDSLAEKARAGVLLEMDEEESEDSDDDLSWTEEEDEDEEEAMGE

Target ORF information:

RefSeq Version	NM_001108245.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus integrin subunit beta 1 binding protein 2 (Itgb1bp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108245.2

ORF Insert Sequence:

ATGTCTCTGC TCTGCTATAA CAAAGGCTGT GGGCAACACT TTGACCCCAA TACCAATCTC 
CCTGATTCCT GCCGTTATCA CCCTGGGGTC CCAATCTTTC ATGATGCACT TAAGGGTTGG 
TCCTGCTGCC GAAAGCGAAC TGTAGATTTC TCTGAGTTCT TAAACATCAA GGGCTGTACT 
GTGGGACCAC ACTGTGCTGA GAAGCTTCCT GAGGTCCCTC AGCCTGAGGG CCCTGCCACA 
AGTTCACTTC AGGAGCAAAA ACCTCTGAAT ACAATTCCAA AGTCAGCAGA GACTTTGCTC 
CGAGAAAGGC CTAAGTCTGA GATGCCTCCG AAACTGCTAC CACTTCTTAT ATCTCAAGCC 
CTGGGAGTGG CGTTGGAACA GAAAGAATTA GACCAGGAAC CTGGAGCAGG ACTTGACAAT 
AGTCTGATCT GGACTGGTTC CAGCTGCCAG AACCCAGGAT GTGATGCTGT TTACCAAGGT 
CCTGAGAGTG ATGCTACTCC GTGTACCTAT CATCCAGGTG CACCTCGGTT TCATGAGGGA 
ATGAAGTCTT GGAGCTGTTG TGGTATCCAG ACTCTGGATT TTGGGGCATT CCTGGCACAG 
CCAGGATGTA GAGTTGGTAG ACACGATTGG GCAAAGCAGC TGCCAGCATC TTGCCGCCAT 
GATTGGCACC AGACAGATTC TTTGGTAGTG CTCACGGTCT ATGGCCAGAT TCCACTTCCT 
GCATTCAACT GGGTGAAGGC CAGTCAAACT GAGCTTCATG TCCACATTGT CTTTGATGGT 
AACCGTGTGT TCCAAGCACA GATGAAGCTC TGGGGGGTCA TAAACGTGGA GCAGAGCTCT 
GTCTCTTTGA TGCCATCACG GGTTGAAATC TCCCTGGTCA AGGCTGACCC AGGATCCTGG 
GCCCAGCTGG AGCACCCCGA TTCACTAGCT GAGAAGGCTA GGGCAGGGGT TTTACTAGAG 
ATGGATGAGG AAGAATCTGA GGATTCAGAT GATGACCTGA GCTGGACAGA AGAGGAAGAT 
GAAGACGAGG AAGAAGCTAT GGGGGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of cardiac melusin gene expression by hypertrophic stimuli in the rat.
Acta physiologica (Oxford, England)207(3)470-84(2013 Mar)
Aro J,Tokola H,Ronkainen VP,Koivisto E,Tenhunen O,Ilves M,Szokodi I,Ruskoaho H,Rys? J

Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure.
The Journal of biological chemistry286(35)30837-46(2011 Sep)
Waardenberg AJ,Bernardo BC,Ng DC,Shepherd PR,Cemerlang N,Sbroggi? M,Wells CA,Dalrymple BP,Brancaccio M,Lin RC,McMullen JR

Chp-1 and melusin, two CHORD containing proteins in vertebrates.
FEBS letters551(1-3)47-52(2003 Sep)
Brancaccio M,Menini N,Bongioanni D,Ferretti R,De Acetis M,Silengo L,Tarone G

Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload.
Nature medicine9(1)68-75(2003 Jan)
Brancaccio M,Fratta L,Notte A,Hirsch E,Poulet R,Guazzone S,De Acetis M,Vecchione C,Marino G,Altruda F,Silengo L,Tarone G,Lembo G

Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain.
The Journal of biological chemistry274(41)29282-8(1999 Oct)
Brancaccio M,Guazzone S,Menini N,Sibona E,Hirsch E,De Andrea M,Rocchi M,Altruda F,Tarone G,Silengo L

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Itgb1bp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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