Csk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Csk
Entrez Gene ID	315707
Full Name	C-terminal Src kinase
General protein information	Preferred Names C-terminal Src kinase Names tyrosine-protein kinase CSK C-SRC kinase CSK, non-receptor tyrosine kinase c-src tyrosine kinase protein-tyrosine kinase (CSK)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24

mRNA and Protein(s)

mRNA	Protein	Name
XM_006243163.1	XP_006243225.1	tyrosine-protein kinase CSK isoform X1
NM_001030039.1	NP_001025210.1	tyrosine-protein kinase CSK
XM_006243164.3	XP_006243226.1	tyrosine-protein kinase CSK isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Csk	NP_001025210.1
Drosophila melanogaster (fruit fly)	Csk	NP_788638.1
Homo sapiens (human)	CSK	NP_004374.1
Bos taurus (cattle)	CSK	NP_001068865.1
Danio rerio (zebrafish)	csk	NP_001071067.1
Xenopus tropicalis (tropical clawed frog)	csk	NP_001135615.1
Mus musculus (house mouse)	Csk	NP_031809.2
Gallus gallus (chicken)	CSK	NP_990756.1
Caenorhabditis elegans (roundworm)	csk-1	NP_001021778.1
Pan troglodytes (chimpanzee)	CSK	XP_001138334.3
	CSK	XP_001101521.1
Canis lupus familiaris (dog)	CSK	XP_005638681.1

Gene Ontology
Bibliography

Related articles in PubMed

Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes.
Gonz?lez-S?nchez A, Jara?z-Rodr?guez M, Dom?nguez-Prieto M, Herrero-Gonz?lez S, Medina JM, Tabernero A
Oncotarget7(31)49819-49833(2016 Aug)

Csk regulates angiotensin II-induced podocyte apoptosis.
Zhang L, Ren Z, Yang Q, Ding G
Apoptosis : an international journal on programmed cell death21(7)846-55(2016 Jul)

C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility.
Senda Y, Murata-Kamiya N, Hatakeyama M
Cancer science107(7)972-80(2016 Jul)

A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat.
Sarmiento J, Wallis RH, Ning T, Marandi L, Chao G, Veillette A, Lernmark ?, Paterson AD, Poussier P
Journal of immunology (Baltimore, Md. : 1950)194(2)615-29(2015 Jan)

Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains.
Tanaka H, Akagi K, Oneyama C, Tanaka M, Sasaki Y, Kanou T, Lee YH, Yokogawa D, Dobenecker MW, Nakagawa A, Okada M, Ikegami T
The Journal of biological chemistry288(21)15240-54(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

an allosteric connection between Cbp binding and Csk activation that arises from residues in the betaB/betaC loop of the SH2 domain.
Title: Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains.

Recognition of Src-family kinases (SFKs) by Csk is mainly governed by interactions between motifs located distally from the active site of Csk and determinants spatially separate from the carboxyl-terminal regulatory tyrosine residue in SFKs.
Title: Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of ?-synuclein as a potential CHK physiological substrate.

Neph1 but not nephrin specifically binds to adaptor protein Grb2 and tyrosine kinase Csk in a phosphorylation-dependent manner.
Title: Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.

These results suggest novel roles for ZO proteins as Src/Csk scaffolds potentially involved in the regulation of Src transformation.
Title: Proteomic identification of ZO-1/2 as a novel scaffold for Src/Csk regulatory circuit.

Adrenomedullin attenuates the angiotensin II-induced increase in reactive oxygen species in vascular smooth muscle cells via activation of Csk, thereby inhibiting Src activity
Title: Adrenomedullin inhibits angiotensin II-induced oxidative stress via Csk-mediated inhibition of Src activity.

The following Csk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Csk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa08090	NM_001030039.1 Latest version!	Rattus norvegicus C-terminal Src kinase (Csk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa08090	XM_006243163.1 Latest version!	Rattus norvegicus c-src tyrosine kinase (Csk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa08090	XM_006243164.3 Latest version!	Rattus norvegicus c-src tyrosine kinase (Csk), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Csk ( NM_001030039.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001025210.1 Rattus norvegicus C-terminal Src kinase (Csk), mRNA.

Price & Availability↑

CloneID	ORa08090
Clone ID Related Accession (Same CDS sequence)	XM_006243163.1 , NM_001030039.1 , XM_006243164.3
Accession Version	NM_001030039.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase CSK
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC098863.1. On Aug 5, 2005 this sequence version replaced XM_236290.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC098863.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCGGCTA TACAGGCCTC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 
CATGGCACTG CCGAGCAAGA CCTTCCCTTC TGCAAAGGAG ATGTGCTCAC CATTGTGGCT 
GTCACCAAGG ACCCCAACTG GTACAAAGCC AAAAACAAAG TGGGCCGTGA GGGCATCATC 
CCAGCCAACT ATGTCCAGAA GCGTGAGGGT GTGAAGGCAG GCACCAAGCT CAGCCTTATG 
CCCTGGTTCC ACGGCAAGAT CACACGGGAG CAGGCGGAGC GGCTTCTCTA CCCACCAGAG 
ACAGGCCTGT TCCTGGTGCG GGAAAGCACC AACTACCCTG GGGACTACAC ACTGTGTGTG 
AGCTGTGAAG GCAAGGTGGA GCACTACCGC ATCATGTATC ACGCGAGCAA GCTGAGCATT 
GATGAGGAGG TGTACTTCGA GAACCTCATG CAGCTGGTGG AGCACTACAC CACAGATGCC 
GACGGACTCT GCACTCGCCT CATCAAACCA AAGGTCATGG AGGGCACAGT GGCGGCCCAA 
GATGAATTCT ACCGCAGTGG CTGGGCCCTG AACATGAAGG AACTGAAGCT GCTACAGACG 
ATAGGAAAGG GGGAGTTTGG AGATGTGATG CTGGGGGATT ACCGAGGCAA CAAAGTTGCA 
GTCAAGTGCA TTAAGAATGA TGCTACAGCC CAGGCCTTCC TGGCTGAAGC CTCTGTCATG 
ACGCAGCTTC GGCACAGCAA CCTAGTCCAG CTACTGGGTG TGATTGTGGA GGAGAAGGGT 
GGGCTCTACA TCGTCACAGA GTACATGGCC AAGGGGAGTT TGGTGGACTA TCTTCGATCA 
CGTGGTCGTT CGGTGCTAGG CGGAGACTGT CTCCTCAAAT TCTCACTAGA CGTCTGTGAA 
GCCATGGAGT ACCTGGAGGG TAACAATTTT GTGCACCGGG ACTTGGCTGC CCGGAATGTG 
CTGGTGTCTG AGGACAACGT GGCCAAAGTC AGTGACTTTG GCCTCACTAA GGAAGCTTCC 
AGCACTCAGG ACACAGGCAA ACTGCCAGTC AAGTGGACAG CTCCTGAAGC CTTGAGAGAG 
AAGAAATTTT CCACCAAGTC TGATGTGTGG AGTTTCGGAA TCCTTCTCTG GGAAATCTAT 
TCCTTCGGGC GAGTGCCTTA CCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAA 
AAGGGCTATA AGATGGACGC TCCGGATGGC TGCCCACCCG CAGTCTATGA TGTTATGAAG 
AACTGCTGGC ACCTGGATGC TGCCACGCGG CCCACCTTTC TGCAGCTTCG AGAGCAGCTC 
GAGCACATCA GAACCCATGA GCTGCACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025210.1
CDS	48..1400
Translation	MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL

Target ORF information:

RefSeq Version	NM_001030039.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-terminal Src kinase (Csk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001030039.1

ORF Insert Sequence:

ATGTCGGCTA TACAGGCCTC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 
CATGGCACTG CCGAGCAAGA CCTTCCCTTC TGCAAAGGAG ATGTGCTCAC CATTGTGGCT 
GTCACCAAGG ACCCCAACTG GTACAAAGCC AAAAACAAAG TGGGCCGTGA GGGCATCATC 
CCAGCCAACT ATGTCCAGAA GCGTGAGGGT GTGAAGGCAG GCACCAAGCT CAGCCTTATG 
CCCTGGTTCC ACGGCAAGAT CACACGGGAG CAGGCGGAGC GGCTTCTCTA CCCACCAGAG 
ACAGGCCTGT TCCTGGTGCG GGAAAGCACC AACTACCCTG GGGACTACAC ACTGTGTGTG 
AGCTGTGAAG GCAAGGTGGA GCACTACCGC ATCATGTATC ACGCGAGCAA GCTGAGCATT 
GATGAGGAGG TGTACTTCGA GAACCTCATG CAGCTGGTGG AGCACTACAC CACAGATGCC 
GACGGACTCT GCACTCGCCT CATCAAACCA AAGGTCATGG AGGGCACAGT GGCGGCCCAA 
GATGAATTCT ACCGCAGTGG CTGGGCCCTG AACATGAAGG AACTGAAGCT GCTACAGACG 
ATAGGAAAGG GGGAGTTTGG AGATGTGATG CTGGGGGATT ACCGAGGCAA CAAAGTTGCA 
GTCAAGTGCA TTAAGAATGA TGCTACAGCC CAGGCCTTCC TGGCTGAAGC CTCTGTCATG 
ACGCAGCTTC GGCACAGCAA CCTAGTCCAG CTACTGGGTG TGATTGTGGA GGAGAAGGGT 
GGGCTCTACA TCGTCACAGA GTACATGGCC AAGGGGAGTT TGGTGGACTA TCTTCGATCA 
CGTGGTCGTT CGGTGCTAGG CGGAGACTGT CTCCTCAAAT TCTCACTAGA CGTCTGTGAA 
GCCATGGAGT ACCTGGAGGG TAACAATTTT GTGCACCGGG ACTTGGCTGC CCGGAATGTG 
CTGGTGTCTG AGGACAACGT GGCCAAAGTC AGTGACTTTG GCCTCACTAA GGAAGCTTCC 
AGCACTCAGG ACACAGGCAA ACTGCCAGTC AAGTGGACAG CTCCTGAAGC CTTGAGAGAG 
AAGAAATTTT CCACCAAGTC TGATGTGTGG AGTTTCGGAA TCCTTCTCTG GGAAATCTAT 
TCCTTCGGGC GAGTGCCTTA CCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAA 
AAGGGCTATA AGATGGACGC TCCGGATGGC TGCCCACCCG CAGTCTATGA TGTTATGAAG 
AACTGCTGGC ACCTGGATGC TGCCACGCGG CCCACCTTTC TGCAGCTTCG AGAGCAGCTC 
GAGCACATCA GAACCCATGA GCTGCACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Csk ( XM_006243163.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243225.1 Rattus norvegicus c-src tyrosine kinase (Csk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa08090
Clone ID Related Accession (Same CDS sequence)	XM_006243163.1 , NM_001030039.1 , XM_006243164.3
Accession Version	XM_006243163.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase CSK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGCTA TACAGGCCTC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 
CATGGCACTG CCGAGCAAGA CCTTCCCTTC TGCAAAGGAG ATGTGCTCAC CATTGTGGCT 
GTCACCAAGG ACCCCAACTG GTACAAAGCC AAAAACAAAG TGGGCCGTGA GGGCATCATC 
CCAGCCAACT ATGTCCAGAA GCGTGAGGGT GTGAAGGCAG GCACCAAGCT CAGCCTTATG 
CCCTGGTTCC ACGGCAAGAT CACACGGGAG CAGGCGGAGC GGCTTCTCTA CCCACCAGAG 
ACAGGCCTGT TCCTGGTGCG GGAAAGCACC AACTACCCTG GGGACTACAC ACTGTGTGTG 
AGCTGTGAAG GCAAGGTGGA GCACTACCGC ATCATGTATC ACGCGAGCAA GCTGAGCATT 
GATGAGGAGG TGTACTTCGA GAACCTCATG CAGCTGGTGG AGCACTACAC CACAGATGCC 
GACGGACTCT GCACTCGCCT CATCAAACCA AAGGTCATGG AGGGCACAGT GGCGGCCCAA 
GATGAATTCT ACCGCAGTGG CTGGGCCCTG AACATGAAGG AACTGAAGCT GCTACAGACG 
ATAGGAAAGG GGGAGTTTGG AGATGTGATG CTGGGGGATT ACCGAGGCAA CAAAGTTGCA 
GTCAAGTGCA TTAAGAATGA TGCTACAGCC CAGGCCTTCC TGGCTGAAGC CTCTGTCATG 
ACGCAGCTTC GGCACAGCAA CCTAGTCCAG CTACTGGGTG TGATTGTGGA GGAGAAGGGT 
GGGCTCTACA TCGTCACAGA GTACATGGCC AAGGGGAGTT TGGTGGACTA TCTTCGATCA 
CGTGGTCGTT CGGTGCTAGG CGGAGACTGT CTCCTCAAAT TCTCACTAGA CGTCTGTGAA 
GCCATGGAGT ACCTGGAGGG TAACAATTTT GTGCACCGGG ACTTGGCTGC CCGGAATGTG 
CTGGTGTCTG AGGACAACGT GGCCAAAGTC AGTGACTTTG GCCTCACTAA GGAAGCTTCC 
AGCACTCAGG ACACAGGCAA ACTGCCAGTC AAGTGGACAG CTCCTGAAGC CTTGAGAGAG 
AAGAAATTTT CCACCAAGTC TGATGTGTGG AGTTTCGGAA TCCTTCTCTG GGAAATCTAT 
TCCTTCGGGC GAGTGCCTTA CCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAA 
AAGGGCTATA AGATGGACGC TCCGGATGGC TGCCCACCCG CAGTCTATGA TGTTATGAAG 
AACTGCTGGC ACCTGGATGC TGCCACGCGG CCCACCTTTC TGCAGCTTCG AGAGCAGCTC 
GAGCACATCA GAACCCATGA GCTGCACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243225.1
CDS	694..2046
Translation	MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL

Target ORF information:

RefSeq Version	XM_006243163.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus c-src tyrosine kinase (Csk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243163.1

ORF Insert Sequence:

ATGTCGGCTA TACAGGCCTC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 
CATGGCACTG CCGAGCAAGA CCTTCCCTTC TGCAAAGGAG ATGTGCTCAC CATTGTGGCT 
GTCACCAAGG ACCCCAACTG GTACAAAGCC AAAAACAAAG TGGGCCGTGA GGGCATCATC 
CCAGCCAACT ATGTCCAGAA GCGTGAGGGT GTGAAGGCAG GCACCAAGCT CAGCCTTATG 
CCCTGGTTCC ACGGCAAGAT CACACGGGAG CAGGCGGAGC GGCTTCTCTA CCCACCAGAG 
ACAGGCCTGT TCCTGGTGCG GGAAAGCACC AACTACCCTG GGGACTACAC ACTGTGTGTG 
AGCTGTGAAG GCAAGGTGGA GCACTACCGC ATCATGTATC ACGCGAGCAA GCTGAGCATT 
GATGAGGAGG TGTACTTCGA GAACCTCATG CAGCTGGTGG AGCACTACAC CACAGATGCC 
GACGGACTCT GCACTCGCCT CATCAAACCA AAGGTCATGG AGGGCACAGT GGCGGCCCAA 
GATGAATTCT ACCGCAGTGG CTGGGCCCTG AACATGAAGG AACTGAAGCT GCTACAGACG 
ATAGGAAAGG GGGAGTTTGG AGATGTGATG CTGGGGGATT ACCGAGGCAA CAAAGTTGCA 
GTCAAGTGCA TTAAGAATGA TGCTACAGCC CAGGCCTTCC TGGCTGAAGC CTCTGTCATG 
ACGCAGCTTC GGCACAGCAA CCTAGTCCAG CTACTGGGTG TGATTGTGGA GGAGAAGGGT 
GGGCTCTACA TCGTCACAGA GTACATGGCC AAGGGGAGTT TGGTGGACTA TCTTCGATCA 
CGTGGTCGTT CGGTGCTAGG CGGAGACTGT CTCCTCAAAT TCTCACTAGA CGTCTGTGAA 
GCCATGGAGT ACCTGGAGGG TAACAATTTT GTGCACCGGG ACTTGGCTGC CCGGAATGTG 
CTGGTGTCTG AGGACAACGT GGCCAAAGTC AGTGACTTTG GCCTCACTAA GGAAGCTTCC 
AGCACTCAGG ACACAGGCAA ACTGCCAGTC AAGTGGACAG CTCCTGAAGC CTTGAGAGAG 
AAGAAATTTT CCACCAAGTC TGATGTGTGG AGTTTCGGAA TCCTTCTCTG GGAAATCTAT 
TCCTTCGGGC GAGTGCCTTA CCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAA 
AAGGGCTATA AGATGGACGC TCCGGATGGC TGCCCACCCG CAGTCTATGA TGTTATGAAG 
AACTGCTGGC ACCTGGATGC TGCCACGCGG CCCACCTTTC TGCAGCTTCG AGAGCAGCTC 
GAGCACATCA GAACCCATGA GCTGCACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Csk ( XM_006243164.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243226.1 Rattus norvegicus c-src tyrosine kinase (Csk), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa08090
Clone ID Related Accession (Same CDS sequence)	XM_006243163.1 , NM_001030039.1 , XM_006243164.3
Accession Version	XM_006243164.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase CSK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243164.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGCTA TACAGGCCTC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 
CATGGCACTG CCGAGCAAGA CCTTCCCTTC TGCAAAGGAG ATGTGCTCAC CATTGTGGCT 
GTCACCAAGG ACCCCAACTG GTACAAAGCC AAAAACAAAG TGGGCCGTGA GGGCATCATC 
CCAGCCAACT ATGTCCAGAA GCGTGAGGGT GTGAAGGCAG GCACCAAGCT CAGCCTTATG 
CCCTGGTTCC ACGGCAAGAT CACACGGGAG CAGGCGGAGC GGCTTCTCTA CCCACCAGAG 
ACAGGCCTGT TCCTGGTGCG GGAAAGCACC AACTACCCTG GGGACTACAC ACTGTGTGTG 
AGCTGTGAAG GCAAGGTGGA GCACTACCGC ATCATGTATC ACGCGAGCAA GCTGAGCATT 
GATGAGGAGG TGTACTTCGA GAACCTCATG CAGCTGGTGG AGCACTACAC CACAGATGCC 
GACGGACTCT GCACTCGCCT CATCAAACCA AAGGTCATGG AGGGCACAGT GGCGGCCCAA 
GATGAATTCT ACCGCAGTGG CTGGGCCCTG AACATGAAGG AACTGAAGCT GCTACAGACG 
ATAGGAAAGG GGGAGTTTGG AGATGTGATG CTGGGGGATT ACCGAGGCAA CAAAGTTGCA 
GTCAAGTGCA TTAAGAATGA TGCTACAGCC CAGGCCTTCC TGGCTGAAGC CTCTGTCATG 
ACGCAGCTTC GGCACAGCAA CCTAGTCCAG CTACTGGGTG TGATTGTGGA GGAGAAGGGT 
GGGCTCTACA TCGTCACAGA GTACATGGCC AAGGGGAGTT TGGTGGACTA TCTTCGATCA 
CGTGGTCGTT CGGTGCTAGG CGGAGACTGT CTCCTCAAAT TCTCACTAGA CGTCTGTGAA 
GCCATGGAGT ACCTGGAGGG TAACAATTTT GTGCACCGGG ACTTGGCTGC CCGGAATGTG 
CTGGTGTCTG AGGACAACGT GGCCAAAGTC AGTGACTTTG GCCTCACTAA GGAAGCTTCC 
AGCACTCAGG ACACAGGCAA ACTGCCAGTC AAGTGGACAG CTCCTGAAGC CTTGAGAGAG 
AAGAAATTTT CCACCAAGTC TGATGTGTGG AGTTTCGGAA TCCTTCTCTG GGAAATCTAT 
TCCTTCGGGC GAGTGCCTTA CCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAA 
AAGGGCTATA AGATGGACGC TCCGGATGGC TGCCCACCCG CAGTCTATGA TGTTATGAAG 
AACTGCTGGC ACCTGGATGC TGCCACGCGG CCCACCTTTC TGCAGCTTCG AGAGCAGCTC 
GAGCACATCA GAACCCATGA GCTGCACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243226.1
CDS	307..1659
Translation	MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL

Target ORF information:

RefSeq Version	XM_006243164.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus c-src tyrosine kinase (Csk), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243164.3

ORF Insert Sequence:

ATGTCGGCTA TACAGGCCTC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 
CATGGCACTG CCGAGCAAGA CCTTCCCTTC TGCAAAGGAG ATGTGCTCAC CATTGTGGCT 
GTCACCAAGG ACCCCAACTG GTACAAAGCC AAAAACAAAG TGGGCCGTGA GGGCATCATC 
CCAGCCAACT ATGTCCAGAA GCGTGAGGGT GTGAAGGCAG GCACCAAGCT CAGCCTTATG 
CCCTGGTTCC ACGGCAAGAT CACACGGGAG CAGGCGGAGC GGCTTCTCTA CCCACCAGAG 
ACAGGCCTGT TCCTGGTGCG GGAAAGCACC AACTACCCTG GGGACTACAC ACTGTGTGTG 
AGCTGTGAAG GCAAGGTGGA GCACTACCGC ATCATGTATC ACGCGAGCAA GCTGAGCATT 
GATGAGGAGG TGTACTTCGA GAACCTCATG CAGCTGGTGG AGCACTACAC CACAGATGCC 
GACGGACTCT GCACTCGCCT CATCAAACCA AAGGTCATGG AGGGCACAGT GGCGGCCCAA 
GATGAATTCT ACCGCAGTGG CTGGGCCCTG AACATGAAGG AACTGAAGCT GCTACAGACG 
ATAGGAAAGG GGGAGTTTGG AGATGTGATG CTGGGGGATT ACCGAGGCAA CAAAGTTGCA 
GTCAAGTGCA TTAAGAATGA TGCTACAGCC CAGGCCTTCC TGGCTGAAGC CTCTGTCATG 
ACGCAGCTTC GGCACAGCAA CCTAGTCCAG CTACTGGGTG TGATTGTGGA GGAGAAGGGT 
GGGCTCTACA TCGTCACAGA GTACATGGCC AAGGGGAGTT TGGTGGACTA TCTTCGATCA 
CGTGGTCGTT CGGTGCTAGG CGGAGACTGT CTCCTCAAAT TCTCACTAGA CGTCTGTGAA 
GCCATGGAGT ACCTGGAGGG TAACAATTTT GTGCACCGGG ACTTGGCTGC CCGGAATGTG 
CTGGTGTCTG AGGACAACGT GGCCAAAGTC AGTGACTTTG GCCTCACTAA GGAAGCTTCC 
AGCACTCAGG ACACAGGCAA ACTGCCAGTC AAGTGGACAG CTCCTGAAGC CTTGAGAGAG 
AAGAAATTTT CCACCAAGTC TGATGTGTGG AGTTTCGGAA TCCTTCTCTG GGAAATCTAT 
TCCTTCGGGC GAGTGCCTTA CCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAA 
AAGGGCTATA AGATGGACGC TCCGGATGGC TGCCCACCCG CAGTCTATGA TGTTATGAAG 
AACTGCTGGC ACCTGGATGC TGCCACGCGG CCCACCTTTC TGCAGCTTCG AGAGCAGCTC 
GAGCACATCA GAACCCATGA GCTGCACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes.
Oncotarget7(31)49819-49833(2016 Aug)
Gonz?lez-S?nchez A,Jara?z-Rodr?guez M,Dom?nguez-Prieto M,Herrero-Gonz?lez S,Medina JM,Tabernero A

Csk regulates angiotensin II-induced podocyte apoptosis.
Apoptosis : an international journal on programmed cell death21(7)846-55(2016 Jul)
Zhang L,Ren Z,Yang Q,Ding G

C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility.
Cancer science107(7)972-80(2016 Jul)
Senda Y,Murata-Kamiya N,Hatakeyama M

A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat.
Journal of immunology (Baltimore, Md. : 1950)194(2)615-29(2015 Jan)
Sarmiento J,Wallis RH,Ning T,Marandi L,Chao G,Veillette A,Lernmark ?,Paterson AD,Poussier P

Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains.
The Journal of biological chemistry288(21)15240-54(2013 May)
Tanaka H,Akagi K,Oneyama C,Tanaka M,Sasaki Y,Kanou T,Lee YH,Yokogawa D,Dobenecker MW,Nakagawa A,Okada M,Ikegami T

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Csk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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