Mad2l2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mad2l2
Entrez Gene ID	313702
Full Name	mitotic arrest deficient 2 like 2
General protein information	Preferred Names mitotic arrest deficient 2 like 2 Names mitotic spindle assembly checkpoint protein MAD2B MAD2 mitotic arrest deficient-like 2 MAD2-like protein 2 mitotic arrest deficient 2-like protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36

mRNA and Protein(s)

mRNA	Protein	Name
XM_006239390.3	XP_006239452.1	mitotic spindle assembly checkpoint protein MAD2B isoform X1
XM_006239391.3	XP_006239453.1	mitotic spindle assembly checkpoint protein MAD2B isoform X2
NM_001012106.1	NP_001012106.1	mitotic spindle assembly checkpoint protein MAD2B
XM_008764256.2	XP_008762478.1	mitotic spindle assembly checkpoint protein MAD2B isoform X1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Involvement of AMPK in regulating the degradation of MAD2B under high glucose in neuronal cells.
Meng X, Chu G, Ye C, Tang H, Qiu P, Hu Y, Li M, Zhang C
Journal of cellular and molecular medicine21(6)1150-1158(2017 Jun)

MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.
Tang H, Fan D, Lei CT, Ye C, Gao P, Chen S, Meng XF, Su H, Zhang C
Journal of molecular medicine (Berlin, Germany)94(11)1297-1307(2016 Nov)

MAD2B contributes to podocyte injury of diabetic nephropathy via inducing cyclin B1 and Skp2 accumulation.
Su H, Wan Q, Tian XJ, He FF, Gao P, Tang H, Ye C, Fan D, Chen S, Wang YM, Meng XF, Zhang C
American journal of physiology. Renal physiology308(7)F728-36(2015 Apr)

Protection of neurons from high glucose-induced injury by deletion of MAD2B.
Meng X, Wang X, Tian X, Yang Z, Li M, Zhang C
Journal of cellular and molecular medicine18(5)844-51(2014 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Skp2, a confirmed APC/C-CDH1 substrate and E-cadherin destroyer, was increased in TGF-beta1-treated proximal tubular epithelial cells, which could be blocked by MAD2B depletion.
Title: MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.

that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression
Title: MAD2B contributes to podocyte injury of diabetic nephropathy via inducing cyclin B1 and Skp2 accumulation.

hyperglycaemia induced neuronal apoptosis through inducing expression of MAD2B, which represents a novel mechanism of diabetic encephalopathy.
Title: Protection of neurons from high glucose-induced injury by deletion of MAD2B.

The following Mad2l2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mad2l2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa02317	NM_001012106.1 Latest version!	Rattus norvegicus mitotic arrest deficient 2 like 2 (Mad2l2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa02317	XM_006239390.3 Latest version!	Rattus norvegicus MAD2 mitotic arrest deficient-like 2 (yeast) (Mad2l2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa02317	XM_008764256.2 Latest version!	Rattus norvegicus MAD2 mitotic arrest deficient-like 2 (yeast) (Mad2l2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa28898	XM_006239391.3 Latest version!	Rattus norvegicus MAD2 mitotic arrest deficient-like 2 (yeast) (Mad2l2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mad2l2 ( NM_001012106.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001012106.1 Rattus norvegicus mitotic arrest deficient 2 like 2 (Mad2l2), mRNA.

Price & Availability↑

CloneID	ORa02317
Clone ID Related Accession (Same CDS sequence)	XM_006239390.3 , NM_001012106.1 , XM_008764256.2
Accession Version	NM_001012106.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	mitotic spindle assembly checkpoint protein MAD2B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC087687.1. On Feb 11, 2005 this sequence version replaced XM_233669.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC087687.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689601 [ECO:0000348] ##Evidence-Data-END##

ATGACCACCC TCACGCGCCA AGACCTCAAC TTCGGCCAAG TGGTGGCCGA CGTGCTCTCC 
GAGTTCCTGG AGGTGGCCGT GCACTTGATC CTCTATGTGC GCGAGGTCTA CCCGGTGGGC 
ATCTTTCAGA AGCGCAAGAA GTACAACGTG CCGGTTCAGA TGTCCTGCCA CCCAGAGCTG 
AACCAGTACA TCCAGGACAC ACTTCACTGC GTCAAACCAC TCCTGGAGAA GAACGATGTG 
GAGAAGGTGG TGGTGGTGAT TTTGGATAAG GAACACCGCC CAGTGGAGAA GTTTGTCTTT 
GAGATCACTC AGCCACCCTT GCTGTCCATC AAGCTAGGTG GCCTCAAACA GACCGTTTCT 
CTAACTGTCT TGGGGTCCTG GAGGTATGCA GACTTGAGCG GTACCCTGGG TGTCCTCTCG 
ACAGCTGAAT ATTTGAGTGA CCTAAAGGGA CCTTTGTACC CTACCTCTAT TCAGTCAGTT 
CAGACTCCCT CCTGTCTCAT GTGGAGCAGC TGCTTCGAGC CTTCATTCTT AAGATTAGTG 
TGTGTGACGC TGTCCTCGAC CATAATCCTC CAGGCTGCAC GTTTACAGTT CTCGTGCACA 
CAAGAGAAGC TGCCACTCGG AACATGGAGA AGATACAGGT CATCAAGGAC TTCCCCTGGA 
TCCTGGCAGA TGAGCAAGAT GTCCACATGC ATGATCCCCG GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012106.1
CDS	70..774
Translation	MTTLTRQDLNFGQVVADVLSEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSIKLGGLKQTVSLTVLGSWRYADLSGTLGVLSTAEYLSDLKGPLYPTSIQSVQTPSCLMWSSCFEPSFLRLVCVTLSSTIILQAARLQFSCTQEKLPLGTWRRYRSSRTSPGSWQMSKMSTCMIPG

Target ORF information:

RefSeq Version	NM_001012106.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitotic arrest deficient 2 like 2 (Mad2l2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012106.1

ORF Insert Sequence:

ATGACCACCC TCACGCGCCA AGACCTCAAC TTCGGCCAAG TGGTGGCCGA CGTGCTCTCC 
GAGTTCCTGG AGGTGGCCGT GCACTTGATC CTCTATGTGC GCGAGGTCTA CCCGGTGGGC 
ATCTTTCAGA AGCGCAAGAA GTACAACGTG CCGGTTCAGA TGTCCTGCCA CCCAGAGCTG 
AACCAGTACA TCCAGGACAC ACTTCACTGC GTCAAACCAC TCCTGGAGAA GAACGATGTG 
GAGAAGGTGG TGGTGGTGAT TTTGGATAAG GAACACCGCC CAGTGGAGAA GTTTGTCTTT 
GAGATCACTC AGCCACCCTT GCTGTCCATC AAGCTAGGTG GCCTCAAACA GACCGTTTCT 
CTAACTGTCT TGGGGTCCTG GAGGTATGCA GACTTGAGCG GTACCCTGGG TGTCCTCTCG 
ACAGCTGAAT ATTTGAGTGA CCTAAAGGGA CCTTTGTACC CTACCTCTAT TCAGTCAGTT 
CAGACTCCCT CCTGTCTCAT GTGGAGCAGC TGCTTCGAGC CTTCATTCTT AAGATTAGTG 
TGTGTGACGC TGTCCTCGAC CATAATCCTC CAGGCTGCAC GTTTACAGTT CTCGTGCACA 
CAAGAGAAGC TGCCACTCGG AACATGGAGA AGATACAGGT CATCAAGGAC TTCCCCTGGA 
TCCTGGCAGA TGAGCAAGAT GTCCACATGC ATGATCCCCG GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mad2l2 ( XM_006239390.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006239452.1 Rattus norvegicus MAD2 mitotic arrest deficient-like 2 (yeast) (Mad2l2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa02317
Clone ID Related Accession (Same CDS sequence)	XM_006239390.3 , NM_001012106.1 , XM_008764256.2
Accession Version	XM_006239390.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mitotic spindle assembly checkpoint protein MAD2B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006239390.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCACCC TCACGCGCCA AGACCTCAAC TTCGGCCAAG TGGTGGCCGA CGTGCTCTCC 
GAGTTCCTGG AGGTGGCCGT GCACTTGATC CTCTATGTGC GCGAGGTCTA CCCGGTGGGC 
ATCTTTCAGA AGCGCAAGAA GTACAACGTG CCGGTTCAGA TGTCCTGCCA CCCAGAGCTG 
AACCAGTACA TCCAGGACAC ACTTCACTGC GTCAAACCAC TCCTGGAGAA GAACGATGTG 
GAGAAGGTGG TGGTGGTGAT TTTGGATAAG GAACACCGCC CAGTGGAGAA GTTTGTCTTT 
GAGATCACTC AGCCACCCTT GCTGTCCATC AAGCTAGGTG GCCTCAAACA GACCGTTTCT 
CTAACTGTCT TGGGGTCCTG GAGGTATGCA GACTTGAGCG GTACCCTGGG TGTCCTCTCG 
ACAGCTGAAT ATTTGAGTGA CCTAAAGGGA CCTTTGTACC CTACCTCTAT TCAGTCAGTT 
CAGACTCCCT CCTGTCTCAT GTGGAGCAGC TGCTTCGAGC CTTCATTCTT AAGATTAGTG 
TGTGTGACGC TGTCCTCGAC CATAATCCTC CAGGCTGCAC GTTTACAGTT CTCGTGCACA 
CAAGAGAAGC TGCCACTCGG AACATGGAGA AGATACAGGT CATCAAGGAC TTCCCCTGGA 
TCCTGGCAGA TGAGCAAGAT GTCCACATGC ATGATCCCCG GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006239452.1
CDS	259..963
Translation	MTTLTRQDLNFGQVVADVLSEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSIKLGGLKQTVSLTVLGSWRYADLSGTLGVLSTAEYLSDLKGPLYPTSIQSVQTPSCLMWSSCFEPSFLRLVCVTLSSTIILQAARLQFSCTQEKLPLGTWRRYRSSRTSPGSWQMSKMSTCMIPG

Target ORF information:

RefSeq Version	XM_006239390.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MAD2 mitotic arrest deficient-like 2 (yeast) (Mad2l2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006239390.3

ORF Insert Sequence:

ATGACCACCC TCACGCGCCA AGACCTCAAC TTCGGCCAAG TGGTGGCCGA CGTGCTCTCC 
GAGTTCCTGG AGGTGGCCGT GCACTTGATC CTCTATGTGC GCGAGGTCTA CCCGGTGGGC 
ATCTTTCAGA AGCGCAAGAA GTACAACGTG CCGGTTCAGA TGTCCTGCCA CCCAGAGCTG 
AACCAGTACA TCCAGGACAC ACTTCACTGC GTCAAACCAC TCCTGGAGAA GAACGATGTG 
GAGAAGGTGG TGGTGGTGAT TTTGGATAAG GAACACCGCC CAGTGGAGAA GTTTGTCTTT 
GAGATCACTC AGCCACCCTT GCTGTCCATC AAGCTAGGTG GCCTCAAACA GACCGTTTCT 
CTAACTGTCT TGGGGTCCTG GAGGTATGCA GACTTGAGCG GTACCCTGGG TGTCCTCTCG 
ACAGCTGAAT ATTTGAGTGA CCTAAAGGGA CCTTTGTACC CTACCTCTAT TCAGTCAGTT 
CAGACTCCCT CCTGTCTCAT GTGGAGCAGC TGCTTCGAGC CTTCATTCTT AAGATTAGTG 
TGTGTGACGC TGTCCTCGAC CATAATCCTC CAGGCTGCAC GTTTACAGTT CTCGTGCACA 
CAAGAGAAGC TGCCACTCGG AACATGGAGA AGATACAGGT CATCAAGGAC TTCCCCTGGA 
TCCTGGCAGA TGAGCAAGAT GTCCACATGC ATGATCCCCG GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mad2l2 ( XM_008764256.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008762478.1 Rattus norvegicus MAD2 mitotic arrest deficient-like 2 (yeast) (Mad2l2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa02317
Clone ID Related Accession (Same CDS sequence)	XM_006239390.3 , NM_001012106.1 , XM_008764256.2
Accession Version	XM_008764256.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mitotic spindle assembly checkpoint protein MAD2B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008764256.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCACCC TCACGCGCCA AGACCTCAAC TTCGGCCAAG TGGTGGCCGA CGTGCTCTCC 
GAGTTCCTGG AGGTGGCCGT GCACTTGATC CTCTATGTGC GCGAGGTCTA CCCGGTGGGC 
ATCTTTCAGA AGCGCAAGAA GTACAACGTG CCGGTTCAGA TGTCCTGCCA CCCAGAGCTG 
AACCAGTACA TCCAGGACAC ACTTCACTGC GTCAAACCAC TCCTGGAGAA GAACGATGTG 
GAGAAGGTGG TGGTGGTGAT TTTGGATAAG GAACACCGCC CAGTGGAGAA GTTTGTCTTT 
GAGATCACTC AGCCACCCTT GCTGTCCATC AAGCTAGGTG GCCTCAAACA GACCGTTTCT 
CTAACTGTCT TGGGGTCCTG GAGGTATGCA GACTTGAGCG GTACCCTGGG TGTCCTCTCG 
ACAGCTGAAT ATTTGAGTGA CCTAAAGGGA CCTTTGTACC CTACCTCTAT TCAGTCAGTT 
CAGACTCCCT CCTGTCTCAT GTGGAGCAGC TGCTTCGAGC CTTCATTCTT AAGATTAGTG 
TGTGTGACGC TGTCCTCGAC CATAATCCTC CAGGCTGCAC GTTTACAGTT CTCGTGCACA 
CAAGAGAAGC TGCCACTCGG AACATGGAGA AGATACAGGT CATCAAGGAC TTCCCCTGGA 
TCCTGGCAGA TGAGCAAGAT GTCCACATGC ATGATCCCCG GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008762478.1
CDS	472..1176
Translation	MTTLTRQDLNFGQVVADVLSEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSIKLGGLKQTVSLTVLGSWRYADLSGTLGVLSTAEYLSDLKGPLYPTSIQSVQTPSCLMWSSCFEPSFLRLVCVTLSSTIILQAARLQFSCTQEKLPLGTWRRYRSSRTSPGSWQMSKMSTCMIPG

Target ORF information:

RefSeq Version	XM_008764256.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MAD2 mitotic arrest deficient-like 2 (yeast) (Mad2l2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008764256.2

ORF Insert Sequence:

ATGACCACCC TCACGCGCCA AGACCTCAAC TTCGGCCAAG TGGTGGCCGA CGTGCTCTCC 
GAGTTCCTGG AGGTGGCCGT GCACTTGATC CTCTATGTGC GCGAGGTCTA CCCGGTGGGC 
ATCTTTCAGA AGCGCAAGAA GTACAACGTG CCGGTTCAGA TGTCCTGCCA CCCAGAGCTG 
AACCAGTACA TCCAGGACAC ACTTCACTGC GTCAAACCAC TCCTGGAGAA GAACGATGTG 
GAGAAGGTGG TGGTGGTGAT TTTGGATAAG GAACACCGCC CAGTGGAGAA GTTTGTCTTT 
GAGATCACTC AGCCACCCTT GCTGTCCATC AAGCTAGGTG GCCTCAAACA GACCGTTTCT 
CTAACTGTCT TGGGGTCCTG GAGGTATGCA GACTTGAGCG GTACCCTGGG TGTCCTCTCG 
ACAGCTGAAT ATTTGAGTGA CCTAAAGGGA CCTTTGTACC CTACCTCTAT TCAGTCAGTT 
CAGACTCCCT CCTGTCTCAT GTGGAGCAGC TGCTTCGAGC CTTCATTCTT AAGATTAGTG 
TGTGTGACGC TGTCCTCGAC CATAATCCTC CAGGCTGCAC GTTTACAGTT CTCGTGCACA 
CAAGAGAAGC TGCCACTCGG AACATGGAGA AGATACAGGT CATCAAGGAC TTCCCCTGGA 
TCCTGGCAGA TGAGCAAGAT GTCCACATGC ATGATCCCCG GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mad2l2 ( XM_006239391.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006239453.1 Rattus norvegicus MAD2 mitotic arrest deficient-like 2 (yeast) (Mad2l2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa28898
Clone ID Related Accession (Same CDS sequence)	XM_006239391.3
Accession Version	XM_006239391.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mitotic spindle assembly checkpoint protein MAD2B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006239391.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCACCC TCACGCGCCA AGACCTCAAC TTCGGCCAAG TGGTGGCCGA CGTGCTCTCC 
GAGTTCCTGG AGGTGGCCGT GCACTTGATC CTCTATGTGC GCGAGGTCTA CCCGGTGGGC 
ATCTTTCAGA AGCGCAAGAA GTACAACGTG CCGGTTCAGA TGTCCTGCCA CCCAGAGCTG 
AACCAGTACA TCCAGGACAC ACTTCACTGC GTCAAACCAC TCCTGGAGAA GAACGATGTG 
GAGAAGGTGG TGGTGGTGAT TTTGGATAAG GAACACCGCC CAGTGGAGAA GTTTGTCTTT 
GAGATCACTC AGCCACCCTT GCTGTCCATC AATTCAGACT CCCTCCTGTC TCATGTGGAG 
CAGCTGCTTC GAGCCTTCAT TCTTAAGATT AGTGTGTGTG ACGCTGTCCT CGACCATAAT 
CCTCCAGGCT GCACGTTTAC AGTTCTCGTG CACACAAGAG AAGCTGCCAC TCGGAACATG 
GAGAAGATAC AGGTCATCAA GGACTTCCCC TGGATCCTGG CAGATGAGCA AGATGTCCAC 
ATGCATGATC CCCGGTTGAT ACCCCTGAAA ACCATGACTT CGGACATTTT AAAGATGCAA 
CTTTACGTAG AAGAGCGAGC TCATAAAAAC AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006239453.1
CDS	740..1375
Translation	MTTLTRQDLNFGQVVADVLSEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSINSDSLLSHVEQLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNMEKIQVIKDFPWILADEQDVHMHDPRLIPLKTMTSDILKMQLYVEERAHKNS

Target ORF information:

RefSeq Version	XM_006239391.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MAD2 mitotic arrest deficient-like 2 (yeast) (Mad2l2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006239391.3

ORF Insert Sequence:

ATGACCACCC TCACGCGCCA AGACCTCAAC TTCGGCCAAG TGGTGGCCGA CGTGCTCTCC 
GAGTTCCTGG AGGTGGCCGT GCACTTGATC CTCTATGTGC GCGAGGTCTA CCCGGTGGGC 
ATCTTTCAGA AGCGCAAGAA GTACAACGTG CCGGTTCAGA TGTCCTGCCA CCCAGAGCTG 
AACCAGTACA TCCAGGACAC ACTTCACTGC GTCAAACCAC TCCTGGAGAA GAACGATGTG 
GAGAAGGTGG TGGTGGTGAT TTTGGATAAG GAACACCGCC CAGTGGAGAA GTTTGTCTTT 
GAGATCACTC AGCCACCCTT GCTGTCCATC AATTCAGACT CCCTCCTGTC TCATGTGGAG 
CAGCTGCTTC GAGCCTTCAT TCTTAAGATT AGTGTGTGTG ACGCTGTCCT CGACCATAAT 
CCTCCAGGCT GCACGTTTAC AGTTCTCGTG CACACAAGAG AAGCTGCCAC TCGGAACATG 
GAGAAGATAC AGGTCATCAA GGACTTCCCC TGGATCCTGG CAGATGAGCA AGATGTCCAC 
ATGCATGATC CCCGGTTGAT ACCCCTGAAA ACCATGACTT CGGACATTTT AAAGATGCAA 
CTTTACGTAG AAGAGCGAGC TCATAAAAAC AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Involvement of AMPK in regulating the degradation of MAD2B under high glucose in neuronal cells.
Journal of cellular and molecular medicine21(6)1150-1158(2017 Jun)
Meng X,Chu G,Ye C,Tang H,Qiu P,Hu Y,Li M,Zhang C

MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.
Journal of molecular medicine (Berlin, Germany)94(11)1297-1307(2016 Nov)
Tang H,Fan D,Lei CT,Ye C,Gao P,Chen S,Meng XF,Su H,Zhang C

MAD2B contributes to podocyte injury of diabetic nephropathy via inducing cyclin B1 and Skp2 accumulation.
American journal of physiology. Renal physiology308(7)F728-36(2015 Apr)
Su H,Wan Q,Tian XJ,He FF,Gao P,Tang H,Ye C,Fan D,Chen S,Wang YM,Meng XF,Zhang C

Protection of neurons from high glucose-induced injury by deletion of MAD2B.
Journal of cellular and molecular medicine18(5)844-51(2014 May)
Meng X,Wang X,Tian X,Yang Z,Li M,Zhang C

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Mad2l2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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