Ns5atp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ns5atp4
Entrez Gene ID	311934
Full Name	NS5A (hepatitis C virus) transactivated protein 4
Synonyms	NICE-3
General protein information	Preferred Names NS5A (hepatitis C virus) transactivated protein 4 Names NS5A (hepatitis C virus) transactivated protein 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_207607.1	NP_997490.1	NS5A (hepatitis C virus) transactivated protein 4

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gm7664	XP_006517553.1
Rattus norvegicus (Norway rat)	Ns5atp4	NP_997490.1

Gene Ontology
Bibliography

Related articles in PubMed

Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment.
Li H, Yang X, Yang G, Hong Z, Zhou L, Yin P, Xiao Y, Chen L, Chung RT, Zhang L
Journal of virology88(11)5956-66(2014 Jun)

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A.
Helbig KJ, Eyre NS, Yip E, Narayana S, Li K, Fiches G, McCartney EM, Jangra RK, Lemon SM, Beard MR
Hepatology (Baltimore, Md.)54(5)1506-17(2011 Nov)

Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles.
Masaki T, Suzuki R, Murakami K, Aizaki H, Ishii K, Murayama A, Date T, Matsuura Y, Miyamura T, Wakita T, Suzuki T
Journal of virology82(16)7964-76(2008 Aug)

Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypes.
Dal Pero F, Di Maira G, Marin O, Bortoletto G, Pinna LA, Alberti A, Ruzzene M, Gerotto M
Journal of hepatology47(6)768-76(2007 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment.
Title: Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment.

We propose that viperin interacts with NS5A and the host factor, VAP-A, to limit hepatitis C virus replication at the replication complex.
Title: The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A.

NS5A plays a key role in regulating the early phase of HCV particle formation by interacting with core protein and its C-terminal serine cluster is a determinant of the NS5A-core interaction
Title: Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles.

The number of predicted CK2 sites correlated with the degree of in vitro and in vivo phosphorylation of NS5A by CK2. CK2-dependent phosphorylation of NS5A is heterogeneous among different HCV genotypes and clinical isolates.
Title: Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypes.

The following Ns5atp4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ns5atp4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42247	NM_207607.1 Latest version!	Rattus norvegicus NS5A (hepatitis C virus) transactivated protein 4 (Ns5atp4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ns5atp4 ( NM_207607.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_997490.1 Rattus norvegicus NS5A (hepatitis C virus) transactivated protein 4 (Ns5atp4), mRNA.

Price & Availability↑

CloneID	ORa42247
Clone ID Related Accession (Same CDS sequence)	NM_207607.1
Accession Version	NM_207607.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-12-23
Organism	Rattus norvegicus(Norway rat)
Product	NS5A (hepatitis C virus) transactivated protein 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY533136.1. On Aug 30, 2004 this sequence version replaced XM_231257.2. ##Evidence-Data-START## Transcript exon combination :: AY533136.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCGTCTA GTAGTAACTG GCTGTCCGGA GTGAATGTCG TTCTTGTGAC GGCGTACGGG 
AGCCTGGTAT TCGTACTGCT GTTTATTTTT GTGAAGAAAC AAATCATGCG CTTTGCATTG 
AAATCTAGTA GGGGACCTCA TGCCCCTGTG GGACACAATG CCCCGAAGGA CTTAAAAGAG 
GAGATCGATA TTCAGCTATC CAGAGTTCAG GATATCAAGT ATGAAGCGCA GCTCCTTGCA 
GATGATGATA CCAGACTACT ACAGCTGAAA ACCCAGGGGG ATCAAAGTTG CTACAACTAT 
CTGTACAGGA TGAAAGCTCT AGATGCCATC CGTGCCTCTG AGATCCCATT TCACGCTGAA 
GGCCGGCACC TCTGTTCTTT AATGGGTAAG AATTACTACT TGCTAGATCT GCGGAACACT 
AGCACTCCTT TTAAGGGTGT TCCAAAGACC CTCACTGATA CCCTCCTGGA CGGATATGAG 
ACAGCTCGCA ATGGGACAGG GGTCTTTGGC CAGAGCGAGT ACTTGCGTTA TCAGGAGGCC 
TTGAGTGAGC TGGTCACTGT GGTCAAAGCA CGAATTGGGC GCTCTCAGAG ACAACACCAG 
TCAGCAGCTA AAGACCTAAC TGAGTCGTCT GAAATGTCGC CAAAAACCAT TCAGGTCACG 
TATCTGTCCT CCAGTCAGAA GAGCAAACGC CCTAAGCACT TCCTCGAACT GAAGAGCTTT 
AAAGACAACT ACAGCACACT GGAGAGCTCT CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997490.1
CDS	1..756
Translation	MASSSNWLSGVNVVLVTAYGSLVFVLLFIFVKKQIMRFALKSSRGPHAPVGHNAPKDLKEEIDIQLSRVQDIKYEAQLLADDDTRLLQLKTQGDQSCYNYLYRMKALDAIRASEIPFHAEGRHLCSLMGKNYYLLDLRNTSTPFKGVPKTLTDTLLDGYETARNGTGVFGQSEYLRYQEALSELVTVVKARIGRSQRQHQSAAKDLTESSEMSPKTIQVTYLSSSQKSKRPKHFLELKSFKDNYSTLESSL

Target ORF information:

RefSeq Version	NM_207607.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NS5A (hepatitis C virus) transactivated protein 4 (Ns5atp4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207607.1

ORF Insert Sequence:

ATGGCGTCTA GTAGTAACTG GCTGTCCGGA GTGAATGTCG TTCTTGTGAC GGCGTACGGG 
AGCCTGGTAT TCGTACTGCT GTTTATTTTT GTGAAGAAAC AAATCATGCG CTTTGCATTG 
AAATCTAGTA GGGGACCTCA TGCCCCTGTG GGACACAATG CCCCGAAGGA CTTAAAAGAG 
GAGATCGATA TTCAGCTATC CAGAGTTCAG GATATCAAGT ATGAAGCGCA GCTCCTTGCA 
GATGATGATA CCAGACTACT ACAGCTGAAA ACCCAGGGGG ATCAAAGTTG CTACAACTAT 
CTGTACAGGA TGAAAGCTCT AGATGCCATC CGTGCCTCTG AGATCCCATT TCACGCTGAA 
GGCCGGCACC TCTGTTCTTT AATGGGTAAG AATTACTACT TGCTAGATCT GCGGAACACT 
AGCACTCCTT TTAAGGGTGT TCCAAAGACC CTCACTGATA CCCTCCTGGA CGGATATGAG 
ACAGCTCGCA ATGGGACAGG GGTCTTTGGC CAGAGCGAGT ACTTGCGTTA TCAGGAGGCC 
TTGAGTGAGC TGGTCACTGT GGTCAAAGCA CGAATTGGGC GCTCTCAGAG ACAACACCAG 
TCAGCAGCTA AAGACCTAAC TGAGTCGTCT GAAATGTCGC CAAAAACCAT TCAGGTCACG 
TATCTGTCCT CCAGTCAGAA GAGCAAACGC CCTAAGCACT TCCTCGAACT GAAGAGCTTT 
AAAGACAACT ACAGCACACT GGAGAGCTCT CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment.
Journal of virology88(11)5956-66(2014 Jun)
Li H,Yang X,Yang G,Hong Z,Zhou L,Yin P,Xiao Y,Chen L,Chung RT,Zhang L

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A.
Hepatology (Baltimore, Md.)54(5)1506-17(2011 Nov)
Helbig KJ,Eyre NS,Yip E,Narayana S,Li K,Fiches G,McCartney EM,Jangra RK,Lemon SM,Beard MR

Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles.
Journal of virology82(16)7964-76(2008 Aug)
Masaki T,Suzuki R,Murakami K,Aizaki H,Ishii K,Murayama A,Date T,Matsuura Y,Miyamura T,Wakita T,Suzuki T

Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypes.
Journal of hepatology47(6)768-76(2007 Dec)
Dal Pero F,Di Maira G,Marin O,Bortoletto G,Pinna LA,Alberti A,Ruzzene M,Gerotto M

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Ns5atp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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