Otud7b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Otud7b
Entrez Gene ID	310677
Full Name	OTU deubiquitinase 7B
Synonyms	RGD1308111
General protein information	Preferred Names OTU deubiquitinase 7B Names OTU domain-containing protein 7B OTU domain containing 7B cellular zinc finger anti-NF-kappaB Cezanne
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107697.1	NP_001101167.1	OTU domain-containing protein 7B
XM_006232957.3	XP_006233019.1	OTU domain-containing protein 7B isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	OTUD7B	NP_064590.2
Mus musculus (house mouse)	Otud7b	NP_001020784.1
Gallus gallus (chicken)	OTUD7B	XP_423720.4
Xenopus tropicalis (tropical clawed frog)	otud7b	XP_002938519.2
	OTUD7B	XP_001098171.1
Rattus norvegicus (Norway rat)	Otud7b	NP_001101167.1
Danio rerio (zebrafish)	otud7b	NP_001071212.1
Bos taurus (cattle)	OTUD7B	NP_001137565.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010345	XP_311596.4
Pan troglodytes (chimpanzee)	OTUD7B	XP_001165401.1
Canis lupus familiaris (dog)	OTUD7B	XP_005630798.1

Gene Ontology
Bibliography

Related articles in PubMed

Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice.
Wilson R, Geyer SH, Reissig L, Rose J, Szumska D, Hardman E, Prin F, McGuire C, Ramirez-Solis R, White J, Galli A, Tudor C, Tuck E, Mazzeo CI, Smith JC, Robertson E, Adams DJ, Mohun T, Weninger WJ
Wellcome open research11(2016)

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D
Cell154(1)169-84(2013 Jul)

Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.
Luong le A, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JL, Harten S, Ashcroft M, Walmsley SR, Haskard DO, Maxwell PH, Walczak H, Pusey C, Evans PC
Circulation research112(12)1583-91(2013 Jun)

OTUD7B controls non-canonical NF-?B activation through deubiquitination of TRAF3.
Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC
Nature494(7437)371-4(2013 Feb)

DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.
McNally RS, Davis BK, Clements CM, Accavitti-Loper MA, Mak TW, Ting JP
The Journal of biological chemistry286(6)4098-106(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inflammatory responses to ischemia are controlled by a balance between ubiquitination and deubiquitination, and Cezanne is a key regulator of this process.
Title: Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.

The following Otud7b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Otud7b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13707	NM_001107697.1 Latest version!	Rattus norvegicus OTU deubiquitinase 7B (Otud7b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
ORa13707	XM_006232957.3 Latest version!	Rattus norvegicus OTU deubiquitinase 7B (Otud7b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Otud7b ( NM_001107697.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101167.1 Rattus norvegicus OTU deubiquitinase 7B (Otud7b), mRNA.

Price & Availability↑

CloneID	ORa13707
Clone ID Related Accession (Same CDS sequence)	NM_001107697.1 , XM_006232957.3
Accession Version	NM_001107697.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2526bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	OTU domain-containing protein 7B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474015.2. On or before Oct 4, 2007 this sequence version replaced XM_001058882.1, XM_227454.4. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACCCTGG ACATGGATGC TGTCCTGTCG GATTTTGTTC GTTCCACAGG TGCAGAGCCA 
GGGCTGGCTC GAGATCTTCT AGAAGGAAAG AACTGGGATG TGAGTGCTGC CCTCAGTGAC 
TTTGAACAAT TGCGCCAAGT CCATGCTGGG AACCTGTCCC CACCCTTTAG TGGAGGGAGT 
ACTTGCCCTA AGACCCCTGA AAAGGGGGGT TCGGATAGAG AGCCCACTCG CCCTTCTCGA 
CCCATCCTAC AGAGACAGGA TGACATCATT CAAGAAAAAC GCCTGTCTAG GGGCATCTCC 
CACGCCAGCT CCAGCATTGT TTCCCTGGCC CGCTCCCATG TCTCCTCCAA TGGTGGGGGT 
GGGGGGAGCA GTGAGCACCC CCTGGAAATG CCCATCTGTG CCTTCCAGCT TCCAGACCTC 
ACTGTGTACA AAGAAGACTT CCGCAGCTTC ATAGAGAGAG ACCTCATTGA GCAGTCCATG 
CTGGTTGCCT TGGAACAGGC AGGGCGTTTG AATTGGTGGG TCAGTGTGGA CTCCACCTGC 
CAGAGGCTGC TCCCTTTAGC AACTACTGGG GACGGGAACT GCCTCCTGCA TGCAGCCTCT 
CTTGGGATGT GGGGTTTCCA TGATAGAGAC TTGGTGCTGA GAAAAGCCTT GTATGCACTG 
ATGGAGAAGG GCGTTGAGAA GGAAGCACTG AAAAGGCGCT GGAGGTGGCA GCAAACACAA 
CAGAATAAAG AGTCAGGACT GGTGTATACG GAAGATGAGT GGCAGAAAGA ATGGAATGAA 
CTGATCAAAC TTGCCTCAAG TGAACCCAGA ATGCATCTAG GTACCAACGG AGCCAGTGGT 
GGAGGAGTGG AGAGTTCAGA AGAGCCGGTA TATGAGAGCC TAGAGGAATT CCATGTCTTC 
GTCCTTGCTC ATGTTCTCAA GAGGCCCATA GTGGTCGTGG CAGACACCAT GCTGAGGGAC 
TCTGGAGGGG AAGCATTTGC CCCTATCCCG TTTGGAGGGA TCTATCTGCC ATTGGAGGTC 
CCAGCCAGCC AGTGTCACCG ATCCCCTCTG GTGCTCGCCT ATGACCAGGC CCACTTCTCT 
GCACTTGTGT CGATGGAGCA GAAGGACAGC GCCAAGGAAC AAGCTGTGAT CCCACTCACA 
GATTCAGAGC ATAAGCTGCT GCCCCTGCAC TTTGCTGTGG ACCCAGGAAA GGGCTGGGAG 
TGGGGCAAAG ATGACAATGA CAATGTCCGC TTGGCCAGTG TAATCCTGTC TCTGGAAGTG 
AAGTTGCATC TGCTGCATAG CTATATGAAT GTGAAGTGGA TCCCTCTGTC TTCCGAGTCT 
CAAGCCCCTC TGGCCCAGCC CGAGTCCCCC ACAGCCTCAG CTGGAGATGA ACCCAGGTCC 
ACTCCTGAGT CAGGGGAGTC GGACAAGGAG TCGGTTGGCA GCAGTTCTAT CAGCAACGAG 
GGCAGCAGGC GGAAGGAGAA GTCAAAGCGC GACAGGGAGA AGGACAAGAA GAGAGCAGAT 
TCCGTGGCTA ACAAACTGGG CAGCTTTGGC AAAACCTTGG GCAGCAAGCT TAAGAAGAAC 
ATGGGGGGCC TGATGCATAG CAAGGGCCCC AAGCCTGGAG GGCTGGGGAG TGGGTCTGGA 
ATAAGCAGTG GTACGGAGAC ATTAGAGAAG AAGAAGAAGA ACAACGCATT GAAGAGCTGG 
AAGGGTGGCA AGGAGGAGGC AGCTGGCGAT GGGCCTGTGT CTGAGAAGCC CACATCTGAG 
CCTGTCGGCA ACGGAGGGAG CAAGTATAGC CAGGAGGTGA TGCAAAGCCT GAGCATTCTG 
AGGATCGCCA TGCAAGGGGA GGGCAAATAC ATTTTTGTCG GAACCCTGAA GATGGGCCAC 
CGGCACCAGT ATCAGGAGGA GATGATCCAG CGCTACCTTG CAGATGCTGA GGAGAGATTC 
CTGGCAGAGC AGAAGCAGAA GGAGGCTGAG AGGAAGATCA TGAATGGAGG GTTAGTTAGT 
GGGCCTCCTC CAGCCAAAAA GCCAGAGCCG GACGGCGGGG AGGACCAGCC CAGTGACTCC 
CCAGCAGAGT CCAAGGCAAC GGGCTTCTCT CCTGGTTACC CTGGGGGCTT TACTATTCCT 
CGACCTTCTG GGGGTGGAGT CCACTGCCAG GAACCTCGGA GGCAGTTGGC AGGGGGTCCA 
TGTGTAGGGG GCCTTCCATC GTATGCCACC TTTCCCAGAC AGTACCCTCC TGGGCGACCC 
TACTCCCACC AGGACAGCAT CCCATCTCTG GAGCCAGGCA AAGATGGAGT TCACAGGGGT 
GCCTTGTTAC CACCCCAGTT CCGTGTGGCT GACTCCTATA GCAATGGCTA CAGAGAGCCA 
CCAGAGCCAG ATGGATGGGC TGGAGCTCCC CGGGGACTTC CCCCAACCCA GACCAAATGC 
AAACAACCGA ACTGCAGCTT CTATGGACAC CCTGAGACAA ACAACTTCTG CTCTTGCTGT 
TACAGGGAAG AACTGAGGCG GAGGGAACGG GAACCTGGTG GGGAACTGCT GGCACACAGG 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101167.1
CDS	357..2882
Translation	MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVSAALSDFEQLRQVHAGNLSPPFSGGSTCPKTPEKGGSDREPTRPSRPILQRQDDIIQEKRLSRGISHASSSIVSLARSHVSSNGGGGGSSEHPLEMPICAFQLPDLTVYKEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDSTCQRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYALMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGASGGGVESSEEPVYESLEEFHVFVLAHVLKRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKDSAKEQAVIPLTDSEHKLLPLHFAVDPGKGWEWGKDDNDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSESQAPLAQPESPTASAGDEPRSTPESGESDKESVGSSSISNEGSRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGPKPGGLGSGSGISSGTETLEKKKKNNALKSWKGGKEEAAGDGPVSEKPTSEPVGNGGSKYSQEVMQSLSILRIAMQGEGKYIFVGTLKMGHRHQYQEEMIQRYLADAEERFLAEQKQKEAERKIMNGGLVSGPPPAKKPEPDGGEDQPSDSPAESKATGFSPGYPGGFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPSYATFPRQYPPGRPYSHQDSIPSLEPGKDGVHRGALLPPQFRVADSYSNGYREPPEPDGWAGAPRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPGGELLAHRF

Target ORF information:

RefSeq Version	NM_001107697.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus OTU deubiquitinase 7B (Otud7b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107697.1

ORF Insert Sequence:

ATGACCCTGG ACATGGATGC TGTCCTGTCG GATTTTGTTC GTTCCACAGG TGCAGAGCCA 
GGGCTGGCTC GAGATCTTCT AGAAGGAAAG AACTGGGATG TGAGTGCTGC CCTCAGTGAC 
TTTGAACAAT TGCGCCAAGT CCATGCTGGG AACCTGTCCC CACCCTTTAG TGGAGGGAGT 
ACTTGCCCTA AGACCCCTGA AAAGGGGGGT TCGGATAGAG AGCCCACTCG CCCTTCTCGA 
CCCATCCTAC AGAGACAGGA TGACATCATT CAAGAAAAAC GCCTGTCTAG GGGCATCTCC 
CACGCCAGCT CCAGCATTGT TTCCCTGGCC CGCTCCCATG TCTCCTCCAA TGGTGGGGGT 
GGGGGGAGCA GTGAGCACCC CCTGGAAATG CCCATCTGTG CCTTCCAGCT TCCAGACCTC 
ACTGTGTACA AAGAAGACTT CCGCAGCTTC ATAGAGAGAG ACCTCATTGA GCAGTCCATG 
CTGGTTGCCT TGGAACAGGC AGGGCGTTTG AATTGGTGGG TCAGTGTGGA CTCCACCTGC 
CAGAGGCTGC TCCCTTTAGC AACTACTGGG GACGGGAACT GCCTCCTGCA TGCAGCCTCT 
CTTGGGATGT GGGGTTTCCA TGATAGAGAC TTGGTGCTGA GAAAAGCCTT GTATGCACTG 
ATGGAGAAGG GCGTTGAGAA GGAAGCACTG AAAAGGCGCT GGAGGTGGCA GCAAACACAA 
CAGAATAAAG AGTCAGGACT GGTGTATACG GAAGATGAGT GGCAGAAAGA ATGGAATGAA 
CTGATCAAAC TTGCCTCAAG TGAACCCAGA ATGCATCTAG GTACCAACGG AGCCAGTGGT 
GGAGGAGTGG AGAGTTCAGA AGAGCCGGTA TATGAGAGCC TAGAGGAATT CCATGTCTTC 
GTCCTTGCTC ATGTTCTCAA GAGGCCCATA GTGGTCGTGG CAGACACCAT GCTGAGGGAC 
TCTGGAGGGG AAGCATTTGC CCCTATCCCG TTTGGAGGGA TCTATCTGCC ATTGGAGGTC 
CCAGCCAGCC AGTGTCACCG ATCCCCTCTG GTGCTCGCCT ATGACCAGGC CCACTTCTCT 
GCACTTGTGT CGATGGAGCA GAAGGACAGC GCCAAGGAAC AAGCTGTGAT CCCACTCACA 
GATTCAGAGC ATAAGCTGCT GCCCCTGCAC TTTGCTGTGG ACCCAGGAAA GGGCTGGGAG 
TGGGGCAAAG ATGACAATGA CAATGTCCGC TTGGCCAGTG TAATCCTGTC TCTGGAAGTG 
AAGTTGCATC TGCTGCATAG CTATATGAAT GTGAAGTGGA TCCCTCTGTC TTCCGAGTCT 
CAAGCCCCTC TGGCCCAGCC CGAGTCCCCC ACAGCCTCAG CTGGAGATGA ACCCAGGTCC 
ACTCCTGAGT CAGGGGAGTC GGACAAGGAG TCGGTTGGCA GCAGTTCTAT CAGCAACGAG 
GGCAGCAGGC GGAAGGAGAA GTCAAAGCGC GACAGGGAGA AGGACAAGAA GAGAGCAGAT 
TCCGTGGCTA ACAAACTGGG CAGCTTTGGC AAAACCTTGG GCAGCAAGCT TAAGAAGAAC 
ATGGGGGGCC TGATGCATAG CAAGGGCCCC AAGCCTGGAG GGCTGGGGAG TGGGTCTGGA 
ATAAGCAGTG GTACGGAGAC ATTAGAGAAG AAGAAGAAGA ACAACGCATT GAAGAGCTGG 
AAGGGTGGCA AGGAGGAGGC AGCTGGCGAT GGGCCTGTGT CTGAGAAGCC CACATCTGAG 
CCTGTCGGCA ACGGAGGGAG CAAGTATAGC CAGGAGGTGA TGCAAAGCCT GAGCATTCTG 
AGGATCGCCA TGCAAGGGGA GGGCAAATAC ATTTTTGTCG GAACCCTGAA GATGGGCCAC 
CGGCACCAGT ATCAGGAGGA GATGATCCAG CGCTACCTTG CAGATGCTGA GGAGAGATTC 
CTGGCAGAGC AGAAGCAGAA GGAGGCTGAG AGGAAGATCA TGAATGGAGG GTTAGTTAGT 
GGGCCTCCTC CAGCCAAAAA GCCAGAGCCG GACGGCGGGG AGGACCAGCC CAGTGACTCC 
CCAGCAGAGT CCAAGGCAAC GGGCTTCTCT CCTGGTTACC CTGGGGGCTT TACTATTCCT 
CGACCTTCTG GGGGTGGAGT CCACTGCCAG GAACCTCGGA GGCAGTTGGC AGGGGGTCCA 
TGTGTAGGGG GCCTTCCATC GTATGCCACC TTTCCCAGAC AGTACCCTCC TGGGCGACCC 
TACTCCCACC AGGACAGCAT CCCATCTCTG GAGCCAGGCA AAGATGGAGT TCACAGGGGT 
GCCTTGTTAC CACCCCAGTT CCGTGTGGCT GACTCCTATA GCAATGGCTA CAGAGAGCCA 
CCAGAGCCAG ATGGATGGGC TGGAGCTCCC CGGGGACTTC CCCCAACCCA GACCAAATGC 
AAACAACCGA ACTGCAGCTT CTATGGACAC CCTGAGACAA ACAACTTCTG CTCTTGCTGT 
TACAGGGAAG AACTGAGGCG GAGGGAACGG GAACCTGGTG GGGAACTGCT GGCACACAGG 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Otud7b ( XM_006232957.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233019.1 Rattus norvegicus OTU deubiquitinase 7B (Otud7b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13707
Clone ID Related Accession (Same CDS sequence)	NM_001107697.1 , XM_006232957.3
Accession Version	XM_006232957.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2526bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	OTU domain-containing protein 7B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006232957.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCCTGG ACATGGATGC TGTCCTGTCG GATTTTGTTC GTTCCACAGG TGCAGAGCCA 
GGGCTGGCTC GAGATCTTCT AGAAGGAAAG AACTGGGATG TGAGTGCTGC CCTCAGTGAC 
TTTGAACAAT TGCGCCAAGT CCATGCTGGG AACCTGTCCC CACCCTTTAG TGGAGGGAGT 
ACTTGCCCTA AGACCCCTGA AAAGGGGGGT TCGGATAGAG AGCCCACTCG CCCTTCTCGA 
CCCATCCTAC AGAGACAGGA TGACATCATT CAAGAAAAAC GCCTGTCTAG GGGCATCTCC 
CACGCCAGCT CCAGCATTGT TTCCCTGGCC CGCTCCCATG TCTCCTCCAA TGGTGGGGGT 
GGGGGGAGCA GTGAGCACCC CCTGGAAATG CCCATCTGTG CCTTCCAGCT TCCAGACCTC 
ACTGTGTACA AAGAAGACTT CCGCAGCTTC ATAGAGAGAG ACCTCATTGA GCAGTCCATG 
CTGGTTGCCT TGGAACAGGC AGGGCGTTTG AATTGGTGGG TCAGTGTGGA CTCCACCTGC 
CAGAGGCTGC TCCCTTTAGC AACTACTGGG GACGGGAACT GCCTCCTGCA TGCAGCCTCT 
CTTGGGATGT GGGGTTTCCA TGATAGAGAC TTGGTGCTGA GAAAAGCCTT GTATGCACTG 
ATGGAGAAGG GCGTTGAGAA GGAAGCACTG AAAAGGCGCT GGAGGTGGCA GCAAACACAA 
CAGAATAAAG AGTCAGGACT GGTGTATACG GAAGATGAGT GGCAGAAAGA ATGGAATGAA 
CTGATCAAAC TTGCCTCAAG TGAACCCAGA ATGCATCTAG GTACCAACGG AGCCAGTGGT 
GGAGGAGTGG AGAGTTCAGA AGAGCCGGTA TATGAGAGCC TAGAGGAATT CCATGTCTTC 
GTCCTTGCTC ATGTTCTCAA GAGGCCCATA GTGGTCGTGG CAGACACCAT GCTGAGGGAC 
TCTGGAGGGG AAGCATTTGC CCCTATCCCG TTTGGAGGGA TCTATCTGCC ATTGGAGGTC 
CCAGCCAGCC AGTGTCACCG ATCCCCTCTG GTGCTCGCCT ATGACCAGGC CCACTTCTCT 
GCACTTGTGT CGATGGAGCA GAAGGACAGC GCCAAGGAAC AAGCTGTGAT CCCACTCACA 
GATTCAGAGC ATAAGCTGCT GCCCCTGCAC TTTGCTGTGG ACCCAGGAAA GGGCTGGGAG 
TGGGGCAAAG ATGACAATGA CAATGTCCGC TTGGCCAGTG TAATCCTGTC TCTGGAAGTG 
AAGTTGCATC TGCTGCATAG CTATATGAAT GTGAAGTGGA TCCCTCTGTC TTCCGAGTCT 
CAAGCCCCTC TGGCCCAGCC CGAGTCCCCC ACAGCCTCAG CTGGAGATGA ACCCAGGTCC 
ACTCCTGAGT CAGGGGAGTC GGACAAGGAG TCGGTTGGCA GCAGTTCTAT CAGCAACGAG 
GGCAGCAGGC GGAAGGAGAA GTCAAAGCGC GACAGGGAGA AGGACAAGAA GAGAGCAGAT 
TCCGTGGCTA ACAAACTGGG CAGCTTTGGC AAAACCTTGG GCAGCAAGCT TAAGAAGAAC 
ATGGGGGGCC TGATGCATAG CAAGGGCCCC AAGCCTGGAG GGCTGGGGAG TGGGTCTGGA 
ATAAGCAGTG GTACGGAGAC ATTAGAGAAG AAGAAGAAGA ACAACGCATT GAAGAGCTGG 
AAGGGTGGCA AGGAGGAGGC AGCTGGCGAT GGGCCTGTGT CTGAGAAGCC CACATCTGAG 
CCTGTCGGCA ACGGAGGGAG CAAGTATAGC CAGGAGGTGA TGCAAAGCCT GAGCATTCTG 
AGGATCGCCA TGCAAGGGGA GGGCAAATAC ATTTTTGTCG GAACCCTGAA GATGGGCCAC 
CGGCACCAGT ATCAGGAGGA GATGATCCAG CGCTACCTTG CAGATGCTGA GGAGAGATTC 
CTGGCAGAGC AGAAGCAGAA GGAGGCTGAG AGGAAGATCA TGAATGGAGG GTTAGTTAGT 
GGGCCTCCTC CAGCCAAAAA GCCAGAGCCG GACGGCGGGG AGGACCAGCC CAGTGACTCC 
CCAGCAGAGT CCAAGGCAAC GGGCTTCTCT CCTGGTTACC CTGGGGGCTT TACTATTCCT 
CGACCTTCTG GGGGTGGAGT CCACTGCCAG GAACCTCGGA GGCAGTTGGC AGGGGGTCCA 
TGTGTAGGGG GCCTTCCATC GTATGCCACC TTTCCCAGAC AGTACCCTCC TGGGCGACCC 
TACTCCCACC AGGACAGCAT CCCATCTCTG GAGCCAGGCA AAGATGGAGT TCACAGGGGT 
GCCTTGTTAC CACCCCAGTT CCGTGTGGCT GACTCCTATA GCAATGGCTA CAGAGAGCCA 
CCAGAGCCAG ATGGATGGGC TGGAGCTCCC CGGGGACTTC CCCCAACCCA GACCAAATGC 
AAACAACCGA ACTGCAGCTT CTATGGACAC CCTGAGACAA ACAACTTCTG CTCTTGCTGT 
TACAGGGAAG AACTGAGGCG GAGGGAACGG GAACCTGGTG GGGAACTGCT GGCACACAGG 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233019.1
CDS	216..2741
Translation	MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVSAALSDFEQLRQVHAGNLSPPFSGGSTCPKTPEKGGSDREPTRPSRPILQRQDDIIQEKRLSRGISHASSSIVSLARSHVSSNGGGGGSSEHPLEMPICAFQLPDLTVYKEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDSTCQRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYALMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGASGGGVESSEEPVYESLEEFHVFVLAHVLKRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKDSAKEQAVIPLTDSEHKLLPLHFAVDPGKGWEWGKDDNDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSESQAPLAQPESPTASAGDEPRSTPESGESDKESVGSSSISNEGSRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGPKPGGLGSGSGISSGTETLEKKKKNNALKSWKGGKEEAAGDGPVSEKPTSEPVGNGGSKYSQEVMQSLSILRIAMQGEGKYIFVGTLKMGHRHQYQEEMIQRYLADAEERFLAEQKQKEAERKIMNGGLVSGPPPAKKPEPDGGEDQPSDSPAESKATGFSPGYPGGFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPSYATFPRQYPPGRPYSHQDSIPSLEPGKDGVHRGALLPPQFRVADSYSNGYREPPEPDGWAGAPRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPGGELLAHRF

Target ORF information:

RefSeq Version	XM_006232957.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus OTU deubiquitinase 7B (Otud7b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006232957.3

ORF Insert Sequence:

ATGACCCTGG ACATGGATGC TGTCCTGTCG GATTTTGTTC GTTCCACAGG TGCAGAGCCA 
GGGCTGGCTC GAGATCTTCT AGAAGGAAAG AACTGGGATG TGAGTGCTGC CCTCAGTGAC 
TTTGAACAAT TGCGCCAAGT CCATGCTGGG AACCTGTCCC CACCCTTTAG TGGAGGGAGT 
ACTTGCCCTA AGACCCCTGA AAAGGGGGGT TCGGATAGAG AGCCCACTCG CCCTTCTCGA 
CCCATCCTAC AGAGACAGGA TGACATCATT CAAGAAAAAC GCCTGTCTAG GGGCATCTCC 
CACGCCAGCT CCAGCATTGT TTCCCTGGCC CGCTCCCATG TCTCCTCCAA TGGTGGGGGT 
GGGGGGAGCA GTGAGCACCC CCTGGAAATG CCCATCTGTG CCTTCCAGCT TCCAGACCTC 
ACTGTGTACA AAGAAGACTT CCGCAGCTTC ATAGAGAGAG ACCTCATTGA GCAGTCCATG 
CTGGTTGCCT TGGAACAGGC AGGGCGTTTG AATTGGTGGG TCAGTGTGGA CTCCACCTGC 
CAGAGGCTGC TCCCTTTAGC AACTACTGGG GACGGGAACT GCCTCCTGCA TGCAGCCTCT 
CTTGGGATGT GGGGTTTCCA TGATAGAGAC TTGGTGCTGA GAAAAGCCTT GTATGCACTG 
ATGGAGAAGG GCGTTGAGAA GGAAGCACTG AAAAGGCGCT GGAGGTGGCA GCAAACACAA 
CAGAATAAAG AGTCAGGACT GGTGTATACG GAAGATGAGT GGCAGAAAGA ATGGAATGAA 
CTGATCAAAC TTGCCTCAAG TGAACCCAGA ATGCATCTAG GTACCAACGG AGCCAGTGGT 
GGAGGAGTGG AGAGTTCAGA AGAGCCGGTA TATGAGAGCC TAGAGGAATT CCATGTCTTC 
GTCCTTGCTC ATGTTCTCAA GAGGCCCATA GTGGTCGTGG CAGACACCAT GCTGAGGGAC 
TCTGGAGGGG AAGCATTTGC CCCTATCCCG TTTGGAGGGA TCTATCTGCC ATTGGAGGTC 
CCAGCCAGCC AGTGTCACCG ATCCCCTCTG GTGCTCGCCT ATGACCAGGC CCACTTCTCT 
GCACTTGTGT CGATGGAGCA GAAGGACAGC GCCAAGGAAC AAGCTGTGAT CCCACTCACA 
GATTCAGAGC ATAAGCTGCT GCCCCTGCAC TTTGCTGTGG ACCCAGGAAA GGGCTGGGAG 
TGGGGCAAAG ATGACAATGA CAATGTCCGC TTGGCCAGTG TAATCCTGTC TCTGGAAGTG 
AAGTTGCATC TGCTGCATAG CTATATGAAT GTGAAGTGGA TCCCTCTGTC TTCCGAGTCT 
CAAGCCCCTC TGGCCCAGCC CGAGTCCCCC ACAGCCTCAG CTGGAGATGA ACCCAGGTCC 
ACTCCTGAGT CAGGGGAGTC GGACAAGGAG TCGGTTGGCA GCAGTTCTAT CAGCAACGAG 
GGCAGCAGGC GGAAGGAGAA GTCAAAGCGC GACAGGGAGA AGGACAAGAA GAGAGCAGAT 
TCCGTGGCTA ACAAACTGGG CAGCTTTGGC AAAACCTTGG GCAGCAAGCT TAAGAAGAAC 
ATGGGGGGCC TGATGCATAG CAAGGGCCCC AAGCCTGGAG GGCTGGGGAG TGGGTCTGGA 
ATAAGCAGTG GTACGGAGAC ATTAGAGAAG AAGAAGAAGA ACAACGCATT GAAGAGCTGG 
AAGGGTGGCA AGGAGGAGGC AGCTGGCGAT GGGCCTGTGT CTGAGAAGCC CACATCTGAG 
CCTGTCGGCA ACGGAGGGAG CAAGTATAGC CAGGAGGTGA TGCAAAGCCT GAGCATTCTG 
AGGATCGCCA TGCAAGGGGA GGGCAAATAC ATTTTTGTCG GAACCCTGAA GATGGGCCAC 
CGGCACCAGT ATCAGGAGGA GATGATCCAG CGCTACCTTG CAGATGCTGA GGAGAGATTC 
CTGGCAGAGC AGAAGCAGAA GGAGGCTGAG AGGAAGATCA TGAATGGAGG GTTAGTTAGT 
GGGCCTCCTC CAGCCAAAAA GCCAGAGCCG GACGGCGGGG AGGACCAGCC CAGTGACTCC 
CCAGCAGAGT CCAAGGCAAC GGGCTTCTCT CCTGGTTACC CTGGGGGCTT TACTATTCCT 
CGACCTTCTG GGGGTGGAGT CCACTGCCAG GAACCTCGGA GGCAGTTGGC AGGGGGTCCA 
TGTGTAGGGG GCCTTCCATC GTATGCCACC TTTCCCAGAC AGTACCCTCC TGGGCGACCC 
TACTCCCACC AGGACAGCAT CCCATCTCTG GAGCCAGGCA AAGATGGAGT TCACAGGGGT 
GCCTTGTTAC CACCCCAGTT CCGTGTGGCT GACTCCTATA GCAATGGCTA CAGAGAGCCA 
CCAGAGCCAG ATGGATGGGC TGGAGCTCCC CGGGGACTTC CCCCAACCCA GACCAAATGC 
AAACAACCGA ACTGCAGCTT CTATGGACAC CCTGAGACAA ACAACTTCTG CTCTTGCTGT 
TACAGGGAAG AACTGAGGCG GAGGGAACGG GAACCTGGTG GGGAACTGCT GGCACACAGG 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice.
Wellcome open research11(2016)
Wilson R,Geyer SH,Reissig L,Rose J,Szumska D,Hardman E,Prin F,McGuire C,Ramirez-Solis R,White J,Galli A,Tudor C,Tuck E,Mazzeo CI,Smith JC,Robertson E,Adams DJ,Mohun T,Weninger WJ

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
Cell154(1)169-84(2013 Jul)
Mevissen TE,Hospenthal MK,Geurink PP,Elliott PR,Akutsu M,Arnaudo N,Ekkebus R,Kulathu Y,Wauer T,El Oualid F,Freund SM,Ovaa H,Komander D

Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.
Circulation research112(12)1583-91(2013 Jun)
Luong le A,Fragiadaki M,Smith J,Boyle J,Lutz J,Dean JL,Harten S,Ashcroft M,Walmsley SR,Haskard DO,Maxwell PH,Walczak H,Pusey C,Evans PC

OTUD7B controls non-canonical NF-?B activation through deubiquitination of TRAF3.
Nature494(7437)371-4(2013 Feb)
Hu H,Brittain GC,Chang JH,Puebla-Osorio N,Jin J,Zal A,Xiao Y,Cheng X,Chang M,Fu YX,Zal T,Zhu C,Sun SC

DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.
The Journal of biological chemistry286(6)4098-106(2011 Feb)
McNally RS,Davis BK,Clements CM,Accavitti-Loper MA,Mak TW,Ting JP

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Otud7b cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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