Ercc8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ercc8
Entrez Gene ID	310071
Full Name	ERCC excision repair 8, CSA ubiquitin ligase complex subunit
Synonyms	Ckn1
General protein information	Preferred Names ERCC excision repair 8, CSA ubiquitin ligase complex subunit Names DNA excision repair protein ERCC-8 Cockayne syndrome 1 (classical) excision repair cross-complementation group 8 excision repair cross-complementing rodent repair deficiency, complementation group 8 excision repaiross-complementing rodent repair deficiency, complementation group 8
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q14

mRNA and Protein(s)

mRNA	Protein	Name
XM_017590821.1	XP_017446310.1	DNA excision repair protein ERCC-8 isoform X1
XM_017590822.1	XP_017446311.1	DNA excision repair protein ERCC-8 isoform X2
NM_001107650.2	NP_001101120.2	DNA excision repair protein ERCC-8

Pathways from BioSystems

Homologies

Homo sapiens (human)	ERCC8	NP_000073.1
Arabidopsis thaliana (thale cress)	AT1G19750	NP_173405.2
Xenopus tropicalis (tropical clawed frog)	ercc8	NP_001017179.1
Pan troglodytes (chimpanzee)	ERCC8	XP_003310766.1
Bos taurus (cattle)	ERCC8	NP_001103651.1
Oryza sativa (rice)	Os01g0857900	NP_001044857.2
Rattus norvegicus (Norway rat)	Ercc8	NP_001101120.2
Arabidopsis thaliana (thale cress)	ATCSA-1	NP_001031098.1
Canis lupus familiaris (dog)	ERCC8	XP_544353.1
Mus musculus (house mouse)	Ercc8	NP_082318.2
Gallus gallus (chicken)	ERCC8	XP_424742.1
Danio rerio (zebrafish)	ercc8	NP_001005984.1
Schizosaccharomyces pombe (fission yeast)	ckn1	NP_595307.1

Gene Ontology
Bibliography

Related articles in PubMed

The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair.
Sin Y, Tanaka K, Saijo M
The Journal of biological chemistry291(3)1387-97(2016 Jan)

Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice.
Nagtegaal AP, Rainey RN, van der Pluijm I, Brandt RM, van der Horst GT, Borst JG, Segil N
The Journal of neuroscience : the official journal of the Society for Neuroscience35(10)4280-6(2015 Mar)

Noise exposure potentiates the subcellular distribution of nucleotide excision repair proteins within spiral ganglion neurons.
Guthrie OW, Xu H
Hearing research294(1-2)21-30(2012 Dec)

Dynamic compartmentalization of DNA repair proteins within spiral ganglion neurons in response to noise stress.
Guthrie OW
The International journal of neuroscience122(12)757-66(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ercc8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ercc8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13749	NM_001107650.2 Latest version!	Rattus norvegicus ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Ercc8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa59714	XM_017590821.1 Latest version!	Rattus norvegicus ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Ercc8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa59715	XM_017590822.1 Latest version!	Rattus norvegicus ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Ercc8), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ercc8 ( NM_001107650.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101120.2 Rattus norvegicus ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Ercc8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa13749
Clone ID Related Accession (Same CDS sequence)	NM_001107650.2
Accession Version	NM_001107650.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	DNA excision repair protein ERCC-8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07008024.1. On Aug 31, 2012 this sequence version replaced NM_001107650.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTTGAGCT TTTTGTCCGC TCGACAGTCA GGGTTGGAGG ACCCTCTTCG CTTGCGTAGA 
GCGCAGTCTA CACGGAGGGT CCTGGGCCTG GAGTTAAACA AAGACAGGGA TGTTGAAAGA 
GTCCACTGCA GCGGAGTCAA CACTCTGGAC ATTGAACCTG TCGAAGGACG ATACATGTTG 
TCAGGTGGTT CCGATGGTGT GATTGTACTC TATGACCTTG AGAACGCCAG CAGACAGCCC 
TATTACACAT GTAAAGCAGT GTGTTCCGTT GGCAGAAGCC ATCCTGATGT CCACAAATAC 
AGCGTGGAGA CGGTTCAGTG GTATCCTCAT GACACTGGCA TGTTCACATC CAGCTCATTT 
GATAAAACTC TGAAAGTATG GGATACAAAC ACATTGCAGG CTGCAGATGT GTTTAATTTT 
GAGGAAACAG TTTACAGTCA TCACATGTCC CCAGCAGCCA CCAAGCACTG TCTGGTAGCA 
GTTGGAACTA GAGGACCCAA GGTACAACTT TGTGACTTAA AGTCTGGATC CTGTTCTCAC 
ATTCTACAGG GTCACAGACA GGAAATATTG GCAGTTTCCT GGTCACCACG CTATGACTAT 
ATCTTGGCAA CAGCAAGCGC TGACAGTAGA GTAAAATTAT GGGATGTGAG AAGAGCATCA 
GGATGTTTGC TTACTCTTGA CCAGCATAAC GGGAAAAAGT CACAAGCTGT TGAATCAGCA 
AACACTGCTC ACAATGGGAA AGTTAACGGC TTATGTTTTA CAAGTGACGG GCTTCACCTG 
CTCACGGTTG GCACAGACAA CCGAATGAGG CTCTGGAATA GCTCCAGCGG GGACAACACA 
CTGGTAAACT ACGGGAAAGT GTGTAACAGC AGCAGGAAAG GGCTGAAGTT CACTGTCTCC 
CATGGCTGCA ACTCAGAGTT TGTGTTTGTT CCCTACGACA GCACCATTGC CATGTATGCA 
GTCTACTCAG GAGAGCGGCT CGCCATGCTT AAGGGACATT ACAAAAGTGT CGACTGCTGT 
GTGTTTCAGC CTAATTTCCA GGAACTTTAC AGTGGTAGCA GGGACTGCAA TATTCTCGCT 
TGGGTGCCAG CTTCATATGA ACCAGTTCCT GATGATGACG ATGAAGCTCC AACCAAATCG 
AGGTTGAACC CAGCATTCAC GGATGCCTGG AGCAGCAGTG ACGAGGACGG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101120.2
CDS	60..1253
Translation	MLSFLSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERVHCSGVNTLDIEPVEGRYMLSGGSDGVIVLYDLENASRQPYYTCKAVCSVGRSHPDVHKYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQAADVFNFEETVYSHHMSPAATKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLLTLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSSGDNTLVNYGKVCNSSRKGLKFTVSHGCNSEFVFVPYDSTIAMYAVYSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAWVPASYEPVPDDDDEAPTKSRLNPAFTDAWSSSDEDG

Target ORF information:

RefSeq Version	NM_001107650.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Ercc8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107650.2

ORF Insert Sequence:

ATGTTGAGCT TTTTGTCCGC TCGACAGTCA GGGTTGGAGG ACCCTCTTCG CTTGCGTAGA 
GCGCAGTCTA CACGGAGGGT CCTGGGCCTG GAGTTAAACA AAGACAGGGA TGTTGAAAGA 
GTCCACTGCA GCGGAGTCAA CACTCTGGAC ATTGAACCTG TCGAAGGACG ATACATGTTG 
TCAGGTGGTT CCGATGGTGT GATTGTACTC TATGACCTTG AGAACGCCAG CAGACAGCCC 
TATTACACAT GTAAAGCAGT GTGTTCCGTT GGCAGAAGCC ATCCTGATGT CCACAAATAC 
AGCGTGGAGA CGGTTCAGTG GTATCCTCAT GACACTGGCA TGTTCACATC CAGCTCATTT 
GATAAAACTC TGAAAGTATG GGATACAAAC ACATTGCAGG CTGCAGATGT GTTTAATTTT 
GAGGAAACAG TTTACAGTCA TCACATGTCC CCAGCAGCCA CCAAGCACTG TCTGGTAGCA 
GTTGGAACTA GAGGACCCAA GGTACAACTT TGTGACTTAA AGTCTGGATC CTGTTCTCAC 
ATTCTACAGG GTCACAGACA GGAAATATTG GCAGTTTCCT GGTCACCACG CTATGACTAT 
ATCTTGGCAA CAGCAAGCGC TGACAGTAGA GTAAAATTAT GGGATGTGAG AAGAGCATCA 
GGATGTTTGC TTACTCTTGA CCAGCATAAC GGGAAAAAGT CACAAGCTGT TGAATCAGCA 
AACACTGCTC ACAATGGGAA AGTTAACGGC TTATGTTTTA CAAGTGACGG GCTTCACCTG 
CTCACGGTTG GCACAGACAA CCGAATGAGG CTCTGGAATA GCTCCAGCGG GGACAACACA 
CTGGTAAACT ACGGGAAAGT GTGTAACAGC AGCAGGAAAG GGCTGAAGTT CACTGTCTCC 
CATGGCTGCA ACTCAGAGTT TGTGTTTGTT CCCTACGACA GCACCATTGC CATGTATGCA 
GTCTACTCAG GAGAGCGGCT CGCCATGCTT AAGGGACATT ACAAAAGTGT CGACTGCTGT 
GTGTTTCAGC CTAATTTCCA GGAACTTTAC AGTGGTAGCA GGGACTGCAA TATTCTCGCT 
TGGGTGCCAG CTTCATATGA ACCAGTTCCT GATGATGACG ATGAAGCTCC AACCAAATCG 
AGGTTGAACC CAGCATTCAC GGATGCCTGG AGCAGCAGTG ACGAGGACGG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ercc8 ( XM_017590821.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017446310.1 Rattus norvegicus ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Ercc8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa59714
Clone ID Related Accession (Same CDS sequence)	XM_017590821.1
Accession Version	XM_017590821.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	DNA excision repair protein ERCC-8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGAGCT TTTTGTCCGC TCGACAGTCA GGGTTGGAGG ACCCTCTTCG CTTGCGTAGA 
GCGCAGTCTA CACGGAGGGT CCTGGGCCTG GAGTTAAACA AAGACAGGGA TGTTGAAAGA 
GTCCACTGCA GCGGAGTCAA CACTCTGGAC ATTGAACCTG TCGAAGGACG ATACATGTTG 
TCAGGTGGTT CCGATGGTGT GATTGTACTC TATGACCTTG AGAACGCCAG CAGACAGCCC 
TATTACACAT GTAAAGCAGT GTGTTCCGTT GGCAGAAGCC ATCCTGATGT CCACAAATAC 
AGCGTGGAGA CGGTTCAGTG GTATCCTCAT GACACTGGCA TGTTCACATC CAGCTCATTT 
GATAAAACTC TGAAAGTATG GGATACAAAC ACATTGCAGG CTGCAGATGT GTTTAATTTT 
GAGGAAACAG TTTACAGTCA TCACATGTCC CCAGCAGCCA CCAAGCACTG TCTGGTAGCA 
GTTGGAACTA GAGGACCCAA GGTACAACTT TGTGACTTAA AGTCTGGATC CTGTTCTCAC 
ATTCTACAGG GTCACAGACA GGAAATATTG GCAGTTTCCT GGTCACCACG CTATGACTAT 
ATCTTGGCAA CAGCAAGCGC TGACAGTAGA GTAAAATTAT GGGATGTGAG AAGAGCATCA 
GGATGTTTGC TTACTCTTGA CCAGCATAAC GGGAAAAAGT CACAAGCTGT TGAATCAGCA 
AACACTGCTC ACAATGGGAA AGTTAACGGC TTATGTTTTA CAAGTGACGG GCTTCACCTG 
CTCACGGTTG GCACAGACAA CCGAATGAGG CTCTGGAATA GCTCCAGCGG GGACAACACA 
CTGGTAAACT ACGGGAAAGT GTGTAACAGC AGCAGGAAAG GGCTGAAGTT CACTGTCTCC 
CATGGCTGCA ACTCAGAGTT TGTGTTTGTT CCCTACGACA GCACCATTGC CATGTATGCA 
GTCTACTCAG GAGAGCGGCT CGCCATGCTT AAGGGACATT ACAAAAGTGT CGACTGCTGT 
GTGTTTCAGC CTAATTTCCA GGGCTTTGAA CTCAATTCTT CATGCTTCCA GAATAGCCTG 
GTTATCTATT TTCCTGGCCT CAGCCTGGGG AACTTTACAG TGGTAGCAGG GACTGCAATA 
TTCTCGCTTG GGTGCCAGCT TCATATGAAC CAGTTCCTGA TGATGACGAT GAAGCTCCAA 
CCAAATCGAG GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017446310.1
CDS	77..1291
Translation	MLSFLSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERVHCSGVNTLDIEPVEGRYMLSGGSDGVIVLYDLENASRQPYYTCKAVCSVGRSHPDVHKYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQAADVFNFEETVYSHHMSPAATKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLLTLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSSGDNTLVNYGKVCNSSRKGLKFTVSHGCNSEFVFVPYDSTIAMYAVYSGERLAMLKGHYKSVDCCVFQPNFQGFELNSSCFQNSLVIYFPGLSLGNFTVVAGTAIFSLGCQLHMNQFLMMTMKLQPNRG

Target ORF information:

RefSeq Version	XM_017590821.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Ercc8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017590821.1

ORF Insert Sequence:

ATGTTGAGCT TTTTGTCCGC TCGACAGTCA GGGTTGGAGG ACCCTCTTCG CTTGCGTAGA 
GCGCAGTCTA CACGGAGGGT CCTGGGCCTG GAGTTAAACA AAGACAGGGA TGTTGAAAGA 
GTCCACTGCA GCGGAGTCAA CACTCTGGAC ATTGAACCTG TCGAAGGACG ATACATGTTG 
TCAGGTGGTT CCGATGGTGT GATTGTACTC TATGACCTTG AGAACGCCAG CAGACAGCCC 
TATTACACAT GTAAAGCAGT GTGTTCCGTT GGCAGAAGCC ATCCTGATGT CCACAAATAC 
AGCGTGGAGA CGGTTCAGTG GTATCCTCAT GACACTGGCA TGTTCACATC CAGCTCATTT 
GATAAAACTC TGAAAGTATG GGATACAAAC ACATTGCAGG CTGCAGATGT GTTTAATTTT 
GAGGAAACAG TTTACAGTCA TCACATGTCC CCAGCAGCCA CCAAGCACTG TCTGGTAGCA 
GTTGGAACTA GAGGACCCAA GGTACAACTT TGTGACTTAA AGTCTGGATC CTGTTCTCAC 
ATTCTACAGG GTCACAGACA GGAAATATTG GCAGTTTCCT GGTCACCACG CTATGACTAT 
ATCTTGGCAA CAGCAAGCGC TGACAGTAGA GTAAAATTAT GGGATGTGAG AAGAGCATCA 
GGATGTTTGC TTACTCTTGA CCAGCATAAC GGGAAAAAGT CACAAGCTGT TGAATCAGCA 
AACACTGCTC ACAATGGGAA AGTTAACGGC TTATGTTTTA CAAGTGACGG GCTTCACCTG 
CTCACGGTTG GCACAGACAA CCGAATGAGG CTCTGGAATA GCTCCAGCGG GGACAACACA 
CTGGTAAACT ACGGGAAAGT GTGTAACAGC AGCAGGAAAG GGCTGAAGTT CACTGTCTCC 
CATGGCTGCA ACTCAGAGTT TGTGTTTGTT CCCTACGACA GCACCATTGC CATGTATGCA 
GTCTACTCAG GAGAGCGGCT CGCCATGCTT AAGGGACATT ACAAAAGTGT CGACTGCTGT 
GTGTTTCAGC CTAATTTCCA GGGCTTTGAA CTCAATTCTT CATGCTTCCA GAATAGCCTG 
GTTATCTATT TTCCTGGCCT CAGCCTGGGG AACTTTACAG TGGTAGCAGG GACTGCAATA 
TTCTCGCTTG GGTGCCAGCT TCATATGAAC CAGTTCCTGA TGATGACGAT GAAGCTCCAA 
CCAAATCGAG GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ercc8 ( XM_017590822.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017446311.1 Rattus norvegicus ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Ercc8), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa59715
Clone ID Related Accession (Same CDS sequence)	XM_017590822.1
Accession Version	XM_017590822.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	DNA excision repair protein ERCC-8 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGAGCT TTTTGTCCGC TCGACAGTCA GGGTTGGAGG ACCCTCTTCG CTTGCGTAGA 
GCGCAGTCTA CACGGAGGGT CCTGGGCCTG GAGTTAAACA AAGACAGGGA TGTTGAAAGA 
GTCCACTGCA GCGGAGTCAA CACTCTGGAC ATTGAACCTG TCGAAGGACG ATACATGTTG 
TCAGGTGGTT CCGATGGTGT GATTGTACTC TATGACCTTG AGAACGCCAG CAGACAGCCC 
TATTACACAT GTAAAGCAGT GTGTTCCGTT GGCAGAAGCC ATCCTGATGT CCACAAATAC 
AGCGTGGAGA CGGTTCAGTG GTATCCTCAT GACACTGGCA TGTTCACATC CAGCTCATTT 
GATAAAACTC TGAAAGTATG GGATACAAAC ACATTGCAGG CTGCAGATGT GTTTAATTTT 
GAGGAAACAG TTTACAGTCA TCACATGTCC CCAGCAGCCA CCAAGCACTG TCTGGTAGCA 
GTTGGAACTA GAGGACCCAA GGTACAACTT TGTGACTTAA AGTCTGGATC CTGTTCTCAC 
ATTCTACAGG GTCACAGACA GGAAATATTG GCAGTTTCCT GGTCACCACG CTATGACTAT 
ATCTTGGCAA CAGCAAGCGC TGACAGTAGA GTAAAATTAT GGGATGTGAG AAGAGCATCA 
GGATGTTTGC TTACTCTTGA CCAGCATAAC GGGAAAAAGT CACAAGCTGT TGAATCAGCA 
AACACTGCTC ACAATGGGAA AGTTAACGGC TTATGTTTTA CAAGTGACGG GCTTCACCTG 
CTCACGGTTG GCACAGACAA CCGAATGAGG CTCTGGAATA GCTCCAGCGG GGACAACACA 
CTGCACCATT GCCATGTATG CAGTCTACTC AGGAGAGCGG CTCGCCATGC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017446311.1
CDS	76..969
Translation	MLSFLSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERVHCSGVNTLDIEPVEGRYMLSGGSDGVIVLYDLENASRQPYYTCKAVCSVGRSHPDVHKYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQAADVFNFEETVYSHHMSPAATKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLLTLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSSGDNTLHHCHVCSLLRRAARHA

Target ORF information:

RefSeq Version	XM_017590822.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Ercc8), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017590822.1

ORF Insert Sequence:

ATGTTGAGCT TTTTGTCCGC TCGACAGTCA GGGTTGGAGG ACCCTCTTCG CTTGCGTAGA 
GCGCAGTCTA CACGGAGGGT CCTGGGCCTG GAGTTAAACA AAGACAGGGA TGTTGAAAGA 
GTCCACTGCA GCGGAGTCAA CACTCTGGAC ATTGAACCTG TCGAAGGACG ATACATGTTG 
TCAGGTGGTT CCGATGGTGT GATTGTACTC TATGACCTTG AGAACGCCAG CAGACAGCCC 
TATTACACAT GTAAAGCAGT GTGTTCCGTT GGCAGAAGCC ATCCTGATGT CCACAAATAC 
AGCGTGGAGA CGGTTCAGTG GTATCCTCAT GACACTGGCA TGTTCACATC CAGCTCATTT 
GATAAAACTC TGAAAGTATG GGATACAAAC ACATTGCAGG CTGCAGATGT GTTTAATTTT 
GAGGAAACAG TTTACAGTCA TCACATGTCC CCAGCAGCCA CCAAGCACTG TCTGGTAGCA 
GTTGGAACTA GAGGACCCAA GGTACAACTT TGTGACTTAA AGTCTGGATC CTGTTCTCAC 
ATTCTACAGG GTCACAGACA GGAAATATTG GCAGTTTCCT GGTCACCACG CTATGACTAT 
ATCTTGGCAA CAGCAAGCGC TGACAGTAGA GTAAAATTAT GGGATGTGAG AAGAGCATCA 
GGATGTTTGC TTACTCTTGA CCAGCATAAC GGGAAAAAGT CACAAGCTGT TGAATCAGCA 
AACACTGCTC ACAATGGGAA AGTTAACGGC TTATGTTTTA CAAGTGACGG GCTTCACCTG 
CTCACGGTTG GCACAGACAA CCGAATGAGG CTCTGGAATA GCTCCAGCGG GGACAACACA 
CTGCACCATT GCCATGTATG CAGTCTACTC AGGAGAGCGG CTCGCCATGC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair.
The Journal of biological chemistry291(3)1387-97(2016 Jan)
Sin Y,Tanaka K,Saijo M

Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience35(10)4280-6(2015 Mar)
Nagtegaal AP,Rainey RN,van der Pluijm I,Brandt RM,van der Horst GT,Borst JG,Segil N

Noise exposure potentiates the subcellular distribution of nucleotide excision repair proteins within spiral ganglion neurons.
Hearing research294(1-2)21-30(2012 Dec)
Guthrie OW,Xu H

Dynamic compartmentalization of DNA repair proteins within spiral ganglion neurons in response to noise stress.
The International journal of neuroscience122(12)757-66(2012 Dec)
Guthrie OW