Orai3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Orai3
Entrez Gene ID	309000
Full Name	ORAI calcium release-activated calcium modulator 3
Synonyms	RGD1306538
General protein information	Preferred Names ORAI calcium release-activated calcium modulator 3 Names protein orai-3 calcium release-activated calcium modulator 3 protein transmembrane protein 142C
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q37

mRNA and Protein(s)

mRNA	Protein	Name
NM_001014024.1	NP_001014046.1	protein orai-3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ORAI3	XP_003315113.1
Canis lupus familiaris (dog)	ORAI3	XP_849021.1
Mus musculus (house mouse)	Orai3	NP_940816.1
	ORAI3	XP_001111639.1
Homo sapiens (human)	ORAI3	NP_689501.1
Rattus norvegicus (Norway rat)	Orai3	NP_001014046.1
Bos taurus (cattle)	ORAI3	NP_001180131.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005071	XP_001688479.1

Gene Ontology
Bibliography

Related articles in PubMed

CRACM3 regulates the stability of non-excitable exocytotic vesicle fusion pores in a Ca(2+)-independent manner via molecular interaction with syntaxin4.
Liu S, Sahid MN, Takemasa E, Kiyoi T, Kuno M, Oshima Y, Maeyama K
Scientific reports628133(2016 Jun)

Emergence of Orai3 activity during cardiac hypertrophy.
Saliba Y, Keck M, Marchand A, Atassi F, Ouill? A, Cazorla O, Trebak M, Pavoine C, Lacampagne A, Hulot JS, Far?s N, Fauconnier J, Lompr? AM
Cardiovascular research105(3)248-59(2015 Mar)

Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia.
Zhang W, Zhang X, Gonz?lez-Cobos JC, Stolwijk JA, Matrougui K, Trebak M
The Journal of biological chemistry290(8)5015-27(2015 Feb)

Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.
Zhang X, Gonz?lez-Cobos JC, Schindl R, Muik M, Ruhle B, Motiani RK, Bisaillon JM, Zhang W, Fahrner M, Barroso M, Matrougui K, Romanin C, Trebak M
Molecular and cellular biology33(18)3715-23(2013 Sep)

Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.
Gonz?lez-Cobos JC, Zhang X, Zhang W, Ruhle B, Motiani RK, Schindl R, Muik M, Spinelli AM, Bisaillon JM, Shinde AV, Fahrner M, Singer HA, Matrougui K, Barroso M, Romanin C, Trebak M
Circulation research112(7)1013-25(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cardiac Orai3 is the essential partner of STIM1 and drives voltage-independent Ca(2+) entry in adult cardiomyocytes. Arachidonic acid-activated currents supported by Orai3 are present in adult cardiomyocytes and increased during hypertrophy.
Title: Emergence of Orai3 activity during cardiac hypertrophy.

LTC4S and Orai3 altered Akt signaling to promote VSMC migration and neointima formation.
Title: Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia.

The second coiled-coil domain of STIM1 is required for coupling to either Orai3 or Orai3/Orai1 channels.
Title: Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.

Orai channels are activated by different agonists/pathways and uncover a mechanism whereby leukotrieneC4 acts through hitherto unknown intracrine mode to elicit store-independent Ca(2+) signaling that promotes vascular occlusive disease.
Title: Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.

The following Orai3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Orai3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13060	NM_001014024.1 Latest version!	Rattus norvegicus ORAI calcium release-activated calcium modulator 3 (Orai3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Orai3 ( NM_001014024.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001014046.1 Rattus norvegicus ORAI calcium release-activated calcium modulator 3 (Orai3), mRNA.

Price & Availability↑

CloneID	ORa13060
Clone ID Related Accession (Same CDS sequence)	NM_001014024.1
Accession Version	NM_001014024.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Rattus norvegicus(Norway rat)
Product	protein orai-3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079355.1. On Apr 20, 2005 this sequence version replaced XM_219357.3. ##Evidence-Data-START## Transcript exon combination :: BC079355.1, EV773330.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGGCG GCGAGGGGGA CACGGGCGAA CAGGCCCCCC TGAACCCGGA GGTGGACAGC 
CCCGCGGGCT CAGCCACGTA CCGGGAGTTC GTGCACCGCG GCTACCTCGA CCTTATGGGG 
GCCAGTCAGC ACTCTCTGCG GGCGCTCAGC TGGCGCCGCC TCTACCTCAG CCGGGCTAAG 
CTCAAAGCCT CCAGTCGCAC TTCTGCTCTG CTGTCGGGCT TCGCCATGGT GGCAATGGTG 
GAGGTACAGC TGGAGAGCGA TCATGAATAC CCACCAGGCC TGCTAGTGGC ATTTAGTGCC 
TGCACCACTG TGTTAGTAGC TGTGCACCTG TTTGCACTCA TGGTCTCCAC ATGTCTGCTG 
CCCCATATTG AAGCCGTGAG CAACATCCAC AATCTCAACT CTGTCCACCA GTCACCACAC 
CAACGACTCC ACCGATATGT GGAGCTGGCC TGGGGCTTTT CTACTGCTTT GGGCACCTTT 
CTCTTCCTGG CTGAAGTTGT TTTGGTGGGC TGGGTCAAGT TTGTGCCCAT TGGGGCACCC 
ATGGACAAAC CAGCTCCTGT GGTACCTATG TCCCAGGTGC CACCCGTCAC TGTCTCCCTT 
AGTTTAGCTT CTAACCTCAC ACCATCATCT GCTTCTGTAG CCACAACACA GCAGCCTCCC 
AAAGCCTGTC CACCTCGGCA AGTGTGTGGT AGTGCTCATG GACCTGGCTG GCAGGCAGCT 
ATGGCCTCCA CGGCAATCAT GGTACCTGTG GGACTAGTGT TTATGGCCTT TGCCCTACAT 
TTCTACCGAT CCTTGGTGGC CCACAAGACA GACCGCCACA AGCAGGAACT GGAGGAACTC 
AGTCGCCTGC AGGGGGAGCT GCAGGCTGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014046.1
CDS	154..1026
Translation	MKGGEGDTGEQAPLNPEVDSPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAPMDKPAPVVPMSQVPPVTVSLSLASNLTPSSASVATTQQPPKACPPRQVCGSAHGPGWQAAMASTAIMVPVGLVFMAFALHFYRSLVAHKTDRHKQELEELSRLQGELQAV

Target ORF information:

RefSeq Version	NM_001014024.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ORAI calcium release-activated calcium modulator 3 (Orai3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014024.1

ORF Insert Sequence:

ATGAAGGGCG GCGAGGGGGA CACGGGCGAA CAGGCCCCCC TGAACCCGGA GGTGGACAGC 
CCCGCGGGCT CAGCCACGTA CCGGGAGTTC GTGCACCGCG GCTACCTCGA CCTTATGGGG 
GCCAGTCAGC ACTCTCTGCG GGCGCTCAGC TGGCGCCGCC TCTACCTCAG CCGGGCTAAG 
CTCAAAGCCT CCAGTCGCAC TTCTGCTCTG CTGTCGGGCT TCGCCATGGT GGCAATGGTG 
GAGGTACAGC TGGAGAGCGA TCATGAATAC CCACCAGGCC TGCTAGTGGC ATTTAGTGCC 
TGCACCACTG TGTTAGTAGC TGTGCACCTG TTTGCACTCA TGGTCTCCAC ATGTCTGCTG 
CCCCATATTG AAGCCGTGAG CAACATCCAC AATCTCAACT CTGTCCACCA GTCACCACAC 
CAACGACTCC ACCGATATGT GGAGCTGGCC TGGGGCTTTT CTACTGCTTT GGGCACCTTT 
CTCTTCCTGG CTGAAGTTGT TTTGGTGGGC TGGGTCAAGT TTGTGCCCAT TGGGGCACCC 
ATGGACAAAC CAGCTCCTGT GGTACCTATG TCCCAGGTGC CACCCGTCAC TGTCTCCCTT 
AGTTTAGCTT CTAACCTCAC ACCATCATCT GCTTCTGTAG CCACAACACA GCAGCCTCCC 
AAAGCCTGTC CACCTCGGCA AGTGTGTGGT AGTGCTCATG GACCTGGCTG GCAGGCAGCT 
ATGGCCTCCA CGGCAATCAT GGTACCTGTG GGACTAGTGT TTATGGCCTT TGCCCTACAT 
TTCTACCGAT CCTTGGTGGC CCACAAGACA GACCGCCACA AGCAGGAACT GGAGGAACTC 
AGTCGCCTGC AGGGGGAGCT GCAGGCTGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CRACM3 regulates the stability of non-excitable exocytotic vesicle fusion pores in a Ca(2+)-independent manner via molecular interaction with syntaxin4.
Scientific reports628133(2016 Jun)
Liu S,Sahid MN,Takemasa E,Kiyoi T,Kuno M,Oshima Y,Maeyama K

Emergence of Orai3 activity during cardiac hypertrophy.
Cardiovascular research105(3)248-59(2015 Mar)
Saliba Y,Keck M,Marchand A,Atassi F,Ouill? A,Cazorla O,Trebak M,Pavoine C,Lacampagne A,Hulot JS,Far?s N,Fauconnier J,Lompr? AM

Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia.
The Journal of biological chemistry290(8)5015-27(2015 Feb)
Zhang W,Zhang X,Gonz?lez-Cobos JC,Stolwijk JA,Matrougui K,Trebak M

Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.
Molecular and cellular biology33(18)3715-23(2013 Sep)
Zhang X,Gonz?lez-Cobos JC,Schindl R,Muik M,Ruhle B,Motiani RK,Bisaillon JM,Zhang W,Fahrner M,Barroso M,Matrougui K,Romanin C,Trebak M

Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.
Circulation research112(7)1013-25(2013 Mar)
Gonz?lez-Cobos JC,Zhang X,Zhang W,Ruhle B,Motiani RK,Schindl R,Muik M,Spinelli AM,Bisaillon JM,Shinde AV,Fahrner M,Singer HA,Matrougui K,Barroso M,Romanin C,Trebak M

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Orai3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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