Mesdc2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mesdc2
Entrez Gene ID	308796
Full Name	mesoderm development LRP chaperone
Synonyms	Mesdc2
General protein information	Preferred Names mesoderm development LRP chaperone Names LRP chaperone MESD LDLR chaperone MESD mesoderm development candiate 2 mesoderm development candidate 2 mesoderm development protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q31

mRNA and Protein(s)

mRNA	Protein	Name
NM_001008345.1	NP_001008346.1	LRP chaperone MESD precursor
XM_017589169.1	XP_017444658.1	LDLR chaperone MESD isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Mesdc2	NP_075892.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005081	XP_313960.3
Danio rerio (zebrafish)	mesdc2	NP_001074173.1
Drosophila melanogaster (fruit fly)	boca	NP_724578.1
Gallus gallus (chicken)	MESDC2	NP_001025722.1
Caenorhabditis elegans (roundworm)	bmy-1	NP_495003.2
Pan troglodytes (chimpanzee)	MESDC2	XP_510542.1
Bos taurus (cattle)	MESDC2	NP_001029641.1
Rattus norvegicus (Norway rat)	Mesdc2	NP_001008346.1
Xenopus tropicalis (tropical clawed frog)	mesdc2	XP_002932283.1
Homo sapiens (human)	MESDC2	NP_055969.1
Canis lupus familiaris (dog)	MESDC2	XP_545883.2

Gene Ontology
Bibliography

Related articles in PubMed

Mesd extrinsically promotes phagocytosis by retinal pigment epithelial cells.
Chen X, Guo F, LeBlanc ME, Ding Y, Zhang C, Shakya A, Li W
Cell biology and toxicology32(4)347-58(2016 Aug)

Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.
Hoshi T, Tezuka T, Yokoyama K, Iemura S, Natsume T, Yamanashi Y
FEBS letters587(23)3749-54(2013 Nov)

Inhibition of LRP5/6-mediated Wnt/?-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats.
Alapati D, Rong M, Chen S, Lin C, Li Y, Wu S
Pediatric research73(6)719-25(2013 Jun)

Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.
Chen J, Liu CC, Li Q, Nowak C, Bu G, Wang J
Structure (London, England : 1993)19(3)313-23(2011 Mar)

Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type ? propeller domains.
Collins MN, Hendrickson WA
Structure (London, England : 1993)19(3)324-36(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mesd also significantly attenuated hyperoxia-induced pulmonary hypertension (PH) and pulmonary vascular remodeling
Title: Inhibition of LRP5/6-mediated Wnt/?-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats.

The following Mesdc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mesdc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11645	NM_001008345.1 Latest version!	Rattus norvegicus mesoderm development LRP chaperone (Mesd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa56593	XM_017589169.1 Latest version!	Rattus norvegicus mesoderm development candidate 2 (Mesdc2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mesdc2 ( NM_001008345.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001008346.1 Rattus norvegicus mesoderm development LRP chaperone (Mesd), mRNA.

Price & Availability↑

CloneID	ORa11645
Clone ID Related Accession (Same CDS sequence)	NM_001008345.1
Accession Version	NM_001008345.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Rattus norvegicus(Norway rat)
Product	LRP chaperone MESD precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085892.1. On Dec 16, 2004 this sequence version replaced XM_218854.2. ##Evidence-Data-START## Transcript exon combination :: BC085892.1, EX493203.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCCT CCAGCTGGCT GCGCGCGGTT CTCCTGTTTC TATGTGCCTC GGACCTTCTG 
TTGCTCTCTC CTCCTGAAGC CTACGCGACC GATACTCCCG GCGAGGCCAT CACACCTCCA 
CGGAAAAAGA AGGACATCCG CGATTACAAC GATGCCGACA TGGCGCGACT TCTGGAGCAG 
TGGGAGAAAG ATGATGACAT AGAAGAAGGA GACCTTCCGG AACACAAGAG ACCATCGGCA 
CCTATCGACT TTTCAAAGCT AGACCCAGGC AAACCTGAGA GCATCTTGAA AATGACAAAG 
AAAGGGAAGA CTCTGATGAT GTTTGTCACC ATCTCAGGGA ACCCCACTGA GAAGGAGACA 
GAGGAAATCA CCAGCCTGTG GCAGGGTAGC CTGTTCAATG CCAACTATGA TGTTCAGAGG 
TTCATCGTGG GATCAGACCG TGCTATTTTC ATGCTCCGGG ATGGGAGCTA TGCCTGGGAG 
ATCAAGGACT TTTTGGTCAA TCAAGACAGG TGTGCTGAAG TCACTCTAGA GGGACAGATG 
TACCCTGGCA AAGGAGGAGG AAGCAAGGAG AAAAATAAAA CAAAGCCAGA GAAGGGTAAA 
AAGAAGGAGG GAGATCCCAA GCCACGGGCT TCCAAGGAAG ACAACCGAGC TGGGAGCAGA 
AGAGAAGACC TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008346.1
CDS	249..923
Translation	MAASSWLRAVLLFLCASDLLLLSPPEAYATDTPGEAITPPRKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPIDFSKLDPGKPESILKMTKKGKTLMMFVTISGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVNQDRCAEVTLEGQMYPGKGGGSKEKNKTKPEKGKKKEGDPKPRASKEDNRAGSRREDL

Target ORF information:

RefSeq Version	NM_001008345.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mesoderm development LRP chaperone (Mesd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008345.1

ORF Insert Sequence:

ATGGCGGCCT CCAGCTGGCT GCGCGCGGTT CTCCTGTTTC TATGTGCCTC GGACCTTCTG 
TTGCTCTCTC CTCCTGAAGC CTACGCGACC GATACTCCCG GCGAGGCCAT CACACCTCCA 
CGGAAAAAGA AGGACATCCG CGATTACAAC GATGCCGACA TGGCGCGACT TCTGGAGCAG 
TGGGAGAAAG ATGATGACAT AGAAGAAGGA GACCTTCCGG AACACAAGAG ACCATCGGCA 
CCTATCGACT TTTCAAAGCT AGACCCAGGC AAACCTGAGA GCATCTTGAA AATGACAAAG 
AAAGGGAAGA CTCTGATGAT GTTTGTCACC ATCTCAGGGA ACCCCACTGA GAAGGAGACA 
GAGGAAATCA CCAGCCTGTG GCAGGGTAGC CTGTTCAATG CCAACTATGA TGTTCAGAGG 
TTCATCGTGG GATCAGACCG TGCTATTTTC ATGCTCCGGG ATGGGAGCTA TGCCTGGGAG 
ATCAAGGACT TTTTGGTCAA TCAAGACAGG TGTGCTGAAG TCACTCTAGA GGGACAGATG 
TACCCTGGCA AAGGAGGAGG AAGCAAGGAG AAAAATAAAA CAAAGCCAGA GAAGGGTAAA 
AAGAAGGAGG GAGATCCCAA GCCACGGGCT TCCAAGGAAG ACAACCGAGC TGGGAGCAGA 
AGAGAAGACC TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mesdc2 ( XM_017589169.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444658.1 Rattus norvegicus mesoderm development candidate 2 (Mesdc2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa56593
Clone ID Related Accession (Same CDS sequence)	XM_017589169.1
Accession Version	XM_017589169.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	LDLR chaperone MESD isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTGCG ACCCGCCACC GGCTGTCGTG GAGATTCCAT CTCTGTTTCC CCGCAGAGCC 
CGCGGGCCCC GCGCATCCGA CGCCCCGGGG TGGTCGGCTC AGAAGAAAGA TGATGACATA 
GAAGAAGGAG ACCTTCCGGA ACACAAGAGA CCATCGGCAC CTATCGACTT TTCAAAGCTA 
GACCCAGGCA AACCTGAGAG CATCTTGAAA ATGACAAAGA AAGGGAAGAC TCTGATGATG 
TTTGTCACCA TCTCAGGGAA CCCCACTGAG AAGGAGACAG AGGAAATCAC CAGCCTGTGG 
CAGGGTAGCC TGTTCAATGC CAACTATGAT GTTCAGAGGT TCATCGTGGG ATCAGACCGT 
GCTATTTTCA TGCTCCGGGA TGGGAGCTAT GCCTGGGAGA TCAAGGACTT TTTGGTCAAT 
CAAGACAGGT GTGCTGAAGT CACTCTAGAG GGACAGATGT ACCCTGGCAA AGGAGGAGGA 
AGCAAGGAGA AAAATAAAAC AAAGCCAGAG AAGGGTAAAA AGAAGGAGGG AGATCCCAAG 
CCACGGGCTT CCAAGGAAGA CAACCGAGCT GGGAGCAGAA GAGAAGACCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444658.1
CDS	74..667
Translation	MACDPPPAVVEIPSLFPRRARGPRASDAPGWSAQKKDDDIEEGDLPEHKRPSAPIDFSKLDPGKPESILKMTKKGKTLMMFVTISGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVNQDRCAEVTLEGQMYPGKGGGSKEKNKTKPEKGKKKEGDPKPRASKEDNRAGSRREDL

Target ORF information:

RefSeq Version	XM_017589169.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mesoderm development candidate 2 (Mesdc2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589169.1

ORF Insert Sequence:

ATGGCCTGCG ACCCGCCACC GGCTGTCGTG GAGATTCCAT CTCTGTTTCC CCGCAGAGCC 
CGCGGGCCCC GCGCATCCGA CGCCCCGGGG TGGTCGGCTC AGAAGAAAGA TGATGACATA 
GAAGAAGGAG ACCTTCCGGA ACACAAGAGA CCATCGGCAC CTATCGACTT TTCAAAGCTA 
GACCCAGGCA AACCTGAGAG CATCTTGAAA ATGACAAAGA AAGGGAAGAC TCTGATGATG 
TTTGTCACCA TCTCAGGGAA CCCCACTGAG AAGGAGACAG AGGAAATCAC CAGCCTGTGG 
CAGGGTAGCC TGTTCAATGC CAACTATGAT GTTCAGAGGT TCATCGTGGG ATCAGACCGT 
GCTATTTTCA TGCTCCGGGA TGGGAGCTAT GCCTGGGAGA TCAAGGACTT TTTGGTCAAT 
CAAGACAGGT GTGCTGAAGT CACTCTAGAG GGACAGATGT ACCCTGGCAA AGGAGGAGGA 
AGCAAGGAGA AAAATAAAAC AAAGCCAGAG AAGGGTAAAA AGAAGGAGGG AGATCCCAAG 
CCACGGGCTT CCAAGGAAGA CAACCGAGCT GGGAGCAGAA GAGAAGACCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mesd extrinsically promotes phagocytosis by retinal pigment epithelial cells.
Cell biology and toxicology32(4)347-58(2016 Aug)
Chen X,Guo F,LeBlanc ME,Ding Y,Zhang C,Shakya A,Li W

Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.
FEBS letters587(23)3749-54(2013 Nov)
Hoshi T,Tezuka T,Yokoyama K,Iemura S,Natsume T,Yamanashi Y

Inhibition of LRP5/6-mediated Wnt/?-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats.
Pediatric research73(6)719-25(2013 Jun)
Alapati D,Rong M,Chen S,Lin C,Li Y,Wu S

Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.
Structure (London, England : 1993)19(3)313-23(2011 Mar)
Chen J,Liu CC,Li Q,Nowak C,Bu G,Wang J

Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type ? propeller domains.
Structure (London, England : 1993)19(3)324-36(2011 Mar)
Collins MN,Hendrickson WA