Lats1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lats1
Entrez Gene ID	308265
Full Name	large tumor suppressor kinase 1
Synonyms	RGD1564085
General protein information	Preferred Names large tumor suppressor kinase 1 Names serine/threonine-protein kinase LATS1 LATS, large tumor suppressor, homolog 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p13

mRNA and Protein(s)

mRNA	Protein	Name
XM_008758607.2	XP_008756829.1	serine/threonine-protein kinase LATS1 isoform X1
NM_001134543.2	NP_001128015.2	serine/threonine-protein kinase LATS1

Pathways from BioSystems

Homologies

Homo sapiens (human)	LATS1	NP_004681.1
Bos taurus (cattle)	LATS1	NP_001179795.1
Rattus norvegicus (Norway rat)	Lats1	NP_001128015.2
Gallus gallus (chicken)	LATS1	XP_004935664.1
Pan troglodytes (chimpanzee)	LATS1	XP_001173355.1
	LOC696131	XP_002808442.1
Mus musculus (house mouse)	Lats1	NP_034820.1
Danio rerio (zebrafish)	lats1	NP_001018346.1
Xenopus tropicalis (tropical clawed frog)	lats1	XP_002943506.2

Gene Ontology
Bibliography

Related articles in PubMed

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ER?.
Britschgi A, Duss S, Kim S, Couto JP, Brinkhaus H, Koren S, De Silva D, Mertz KD, Kaup D, Varga Z, Voshol H, Vissieres A, Leroy C, Roloff T, Stadler MB, Scheel CH, Miraglia LJ, Orth AP, Bonamy GM, Reddy VA, Bentires-Alj M
Nature541(7638)541-545(2017 01)

Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation.
Lorthongpanich C, Messerschmidt DM, Chan SW, Hong W, Knowles BB, Solter D
Genes & development27(13)1441-6(2013 Jul)

The Hippo pathway regulates Wnt/beta-catenin signaling.
Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R, Pawson T, Hunziker W, McNeill H, Wrana JL, Attisano L
Developmental cell18(4)579-91(2010 Apr)

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.
Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D
The EMBO journal29(2)376-86(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Lats1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lats1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa46599	XM_008758607.2 Latest version!	Rattus norvegicus large tumor suppressor kinase 1 (Lats1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa02856	NM_001134543.2 Latest version!	Rattus norvegicus large tumor suppressor kinase 1 (Lats1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lats1 ( XM_008758607.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008756829.1 Rattus norvegicus large tumor suppressor kinase 1 (Lats1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa46599
Clone ID Related Accession (Same CDS sequence)	XM_008758607.2
Accession Version	XM_008758607.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2019bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase LATS1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008758607.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAGGG GTGAAAAGCC AGAAGGGTAC AGACAGATGA GGCCTAAGAC CTTTCCTGCC 
AGCAACTACT CTGGCAGCAG CCGACAAATG CTGCAGGAGA TCCGAGAATC CCTTAGGAAT 
TTATCAAAGC CATCTGATGC CGCAAAGGCC GAGCATAACC TGAACAAGAT GTCGACCGAA 
GATCCCAGGC AGGTGAGAAA TCCGCCCAAA TTTGGCACAC ATCATAAAGC CTTGCAAGAA 
ATTCGAAACT CTCTACTACC TTTCGCAAAC GAGACGAGTT CTTCCCGGAT CCCTTCAGAA 
GTTAATCCAC AGATGTTTCA GGATTTGCAG GCTGCTGGCT TTGATGAGGA TATGGTTATT 
CAAGCTCTTC AGAAAACCAA TAACAGAAGC ATAGAAGCAG CTGTTGAATT CATTAGTAAA 
ATGAGTTATC AGGATCCTCG TCGAGAGCAG ATGGCTGCAG CAGCTGCCAG ACCTATCAAT 
GCCACCATGA AACCAGGAAA TGTGCAACAT TCAATTAGCC GAAAACAAAG CTGGAAAGGT 
TCTAAAGAGT CTTTAGTTCC TCAGAGACAC GGTCCATCTC TAGGAGAAAA TGTGGTTTAT 
CGATCTGAAA GTCCCAACTC ACAGGCGGAT GTAGGAAGAC CTCTGTCTGG ATCCGGCATT 
ACGGCATTTG CTCAAGCTCA CCCAAGCAAT GGACAGAGAG TGAACCCACC ACCACCACCT 
CAAGTTAGGA GTGTTACTCC TCCACCACCT CCACGAGGGC AGACCCCACC TCCACGAGGC 
ACAACTCCCC CTCCCCCCTC GTGGGAGCCT AACTCTCAGA CAAAGCGCTA CTCTGGGAAC 
ATGGAATATG TAATCTCCCG AATCTCTCCT GTTCCACCTG GGGCGTGGCA GGAGGGCTAC 
CCTCCACCAC CTCTTAACAC TTCCCCCATG AATCCCCCCA ACCAGGGACA GAGAGGCATC 
AGTTCTGTTC CAGTTGGCAG GCAACCAATC ATCATGCAAA GTACTAGCAA ATTTAACTTT 
ACACCAGGGA GACCTGGAGT TCAGAATGGT GGTGGTCAGA CTGATTTTAT CATGCACCAA 
AATGTTGTCC CCACTGGTGC TGTGAATCGG CAACCACCAC CACCATATCC TCTGACCCCA 
GCTAATGGAC AAAGCCCTTC TGCTTTGCAA GCAGGCGGTC CTGCTGCTCC ACCATCATTC 
TCCAATGGAA ATGTTCCTCC AACGATGATG GTGCCGAACA GGAACAGTCA TAACATGGAG 
CTGTATAATA TCAATGTCCC TGGACTGCAA ACAACTTGGC CCCAGTCGTC TTCTGCCCCT 
GTGCAATCAT CTCCAAGCAG TGGGCATGAA ATTCCTACGT GGCAACCTAA CATACCAGTG 
AGGTCAAATT CTTTTAATAA CCCACTAGGA AGTAGAGCAA GTCACTCTGC TAATTCTCAG 
CCTTCCGCCA CGACAGTTAC TGCCATCACA CCAGCTCCTA TTCAGCAGCC CGTGAAAAGC 
ATGCGCGTTC TGAAACCAGA GCTGCAGACT GCCTTAGCCC CAACCCATCC TTCTTGGATG 
CCACAGCCAG TTCAGACCGT TCAGCCTAGC CCTTTTTCTG AGGGTGCAGC TTCAAACGTG 
CCAGTCATCC CACCTGTGGC GGAAGCTCCA AGCTATCAGG GCCCACCACC ACCTTATCCA 
AAACATCTGC TACACCAAAC CCCATCTGTT CCTCCATATG AGTCAGCGAG TAAACCCTGC 
AAAGACGATC AGCCTAGCTC AGCCAAGGAA GAGGATAGTG AAAAGAGTTT GGACAGTGTT 
GACTCTGGGG ATAAAGAGAA GAAACAGATT ACAACTTCAC CTATCACTGT TCGGAAAAAC 
AAGAAAGACG AAGAGCGAAG AGAGTCTCGC ATTCAGAGTT ACTCCCCGCA GGCCTTTAAA 
TTCTTCATGG AGCAACACGT AGAGAACGTC CTGAAGTCTC ATCAGCAGCG TCTGCATCGC 
AAGAAGCAAC TAGAGAATGA AATGATGCGG CTGACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008756829.1
CDS	1009..3027
Translation	MKRGEKPEGYRQMRPKTFPASNYSGSSRQMLQEIRESLRNLSKPSDAAKAEHNLNKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETSSSRIPSEVNPQMFQDLQAAGFDEDMVIQALQKTNNRSIEAAVEFISKMSYQDPRREQMAAAAARPINATMKPGNVQHSISRKQSWKGSKESLVPQRHGPSLGENVVYRSESPNSQADVGRPLSGSGITAFAQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSTSKFNFTPGRPGVQNGGGQTDFIMHQNVVPTGAVNRQPPPPYPLTPANGQSPSALQAGGPAAPPSFSNGNVPPTMMVPNRNSHNMELYNINVPGLQTTWPQSSSAPVQSSPSSGHEIPTWQPNIPVRSNSFNNPLGSRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWMPQPVQTVQPSPFSEGAASNVPVIPPVAEAPSYQGPPPPYPKHLLHQTPSVPPYESASKPCKDDQPSSAKEEDSEKSLDSVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRLT

Target ORF information:

RefSeq Version	XM_008758607.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus large tumor suppressor kinase 1 (Lats1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008758607.2

ORF Insert Sequence:

ATGAAGAGGG GTGAAAAGCC AGAAGGGTAC AGACAGATGA GGCCTAAGAC CTTTCCTGCC 
AGCAACTACT CTGGCAGCAG CCGACAAATG CTGCAGGAGA TCCGAGAATC CCTTAGGAAT 
TTATCAAAGC CATCTGATGC CGCAAAGGCC GAGCATAACC TGAACAAGAT GTCGACCGAA 
GATCCCAGGC AGGTGAGAAA TCCGCCCAAA TTTGGCACAC ATCATAAAGC CTTGCAAGAA 
ATTCGAAACT CTCTACTACC TTTCGCAAAC GAGACGAGTT CTTCCCGGAT CCCTTCAGAA 
GTTAATCCAC AGATGTTTCA GGATTTGCAG GCTGCTGGCT TTGATGAGGA TATGGTTATT 
CAAGCTCTTC AGAAAACCAA TAACAGAAGC ATAGAAGCAG CTGTTGAATT CATTAGTAAA 
ATGAGTTATC AGGATCCTCG TCGAGAGCAG ATGGCTGCAG CAGCTGCCAG ACCTATCAAT 
GCCACCATGA AACCAGGAAA TGTGCAACAT TCAATTAGCC GAAAACAAAG CTGGAAAGGT 
TCTAAAGAGT CTTTAGTTCC TCAGAGACAC GGTCCATCTC TAGGAGAAAA TGTGGTTTAT 
CGATCTGAAA GTCCCAACTC ACAGGCGGAT GTAGGAAGAC CTCTGTCTGG ATCCGGCATT 
ACGGCATTTG CTCAAGCTCA CCCAAGCAAT GGACAGAGAG TGAACCCACC ACCACCACCT 
CAAGTTAGGA GTGTTACTCC TCCACCACCT CCACGAGGGC AGACCCCACC TCCACGAGGC 
ACAACTCCCC CTCCCCCCTC GTGGGAGCCT AACTCTCAGA CAAAGCGCTA CTCTGGGAAC 
ATGGAATATG TAATCTCCCG AATCTCTCCT GTTCCACCTG GGGCGTGGCA GGAGGGCTAC 
CCTCCACCAC CTCTTAACAC TTCCCCCATG AATCCCCCCA ACCAGGGACA GAGAGGCATC 
AGTTCTGTTC CAGTTGGCAG GCAACCAATC ATCATGCAAA GTACTAGCAA ATTTAACTTT 
ACACCAGGGA GACCTGGAGT TCAGAATGGT GGTGGTCAGA CTGATTTTAT CATGCACCAA 
AATGTTGTCC CCACTGGTGC TGTGAATCGG CAACCACCAC CACCATATCC TCTGACCCCA 
GCTAATGGAC AAAGCCCTTC TGCTTTGCAA GCAGGCGGTC CTGCTGCTCC ACCATCATTC 
TCCAATGGAA ATGTTCCTCC AACGATGATG GTGCCGAACA GGAACAGTCA TAACATGGAG 
CTGTATAATA TCAATGTCCC TGGACTGCAA ACAACTTGGC CCCAGTCGTC TTCTGCCCCT 
GTGCAATCAT CTCCAAGCAG TGGGCATGAA ATTCCTACGT GGCAACCTAA CATACCAGTG 
AGGTCAAATT CTTTTAATAA CCCACTAGGA AGTAGAGCAA GTCACTCTGC TAATTCTCAG 
CCTTCCGCCA CGACAGTTAC TGCCATCACA CCAGCTCCTA TTCAGCAGCC CGTGAAAAGC 
ATGCGCGTTC TGAAACCAGA GCTGCAGACT GCCTTAGCCC CAACCCATCC TTCTTGGATG 
CCACAGCCAG TTCAGACCGT TCAGCCTAGC CCTTTTTCTG AGGGTGCAGC TTCAAACGTG 
CCAGTCATCC CACCTGTGGC GGAAGCTCCA AGCTATCAGG GCCCACCACC ACCTTATCCA 
AAACATCTGC TACACCAAAC CCCATCTGTT CCTCCATATG AGTCAGCGAG TAAACCCTGC 
AAAGACGATC AGCCTAGCTC AGCCAAGGAA GAGGATAGTG AAAAGAGTTT GGACAGTGTT 
GACTCTGGGG ATAAAGAGAA GAAACAGATT ACAACTTCAC CTATCACTGT TCGGAAAAAC 
AAGAAAGACG AAGAGCGAAG AGAGTCTCGC ATTCAGAGTT ACTCCCCGCA GGCCTTTAAA 
TTCTTCATGG AGCAACACGT AGAGAACGTC CTGAAGTCTC ATCAGCAGCG TCTGCATCGC 
AAGAAGCAAC TAGAGAATGA AATGATGCGG CTGACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lats1 ( NM_001134543.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001128015.2 Rattus norvegicus large tumor suppressor kinase 1 (Lats1), mRNA.

Price & Availability↑

CloneID	ORa02856
Clone ID Related Accession (Same CDS sequence)	NM_001134543.2
Accession Version	NM_001134543.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-03
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase LATS1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FN804841.1 and AABR07000159.1. On Sep 7, 2012 this sequence version replaced NM_001134543.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGAGGG GTGAAAAGCC AGAAGGGTAC AGACAGATGA GGCCTAAGAC CTTTCCTGCC 
AGCAACTACT CTGGCAGCAG CCGACAAATG CTGCAGGAGA TCCGAGAATC CCTTAGGAAT 
TTATCAAAGC CATCTGATGC CGCAAAGGCC GAGCATAACC TGAACAAGAT GTCGACCGAA 
GATCCCAGGC AGGTGAGAAA TCCGCCCAAA TTTGGCACAC ATCATAAAGC CTTGCAAGAA 
ATTCGAAACT CTCTACTACC TTTCGCAAAC GAGACGAGTT CTTCCCGGAT CCCTTCAGAA 
GTTAATCCAC AGATGTTTCA GGATTTGCAG GCTGCTGGCT TTGATGAGGA TATGGTTATT 
CAAGCTCTTC AGAAAACCAA TAACAGAAGC ATAGAAGCAG CTGTTGAATT CATTAGTAAA 
ATGAGTTATC AGGATCCTCG TCGAGAGCAG ATGGCTGCAG CAGCTGCCAG ACCTATCAAT 
GCCACCATGA AACCAGGAAA TGTGCAACAT TCAATTAGCC GAAAACAAAG CTGGAAAGGT 
TCTAAAGAGT CTTTAGTTCC TCAGAGACAC GGTCCATCTC TAGGAGAAAA TGTGGTTTAT 
CGATCTGAAA GTCCCAACTC ACAGGCGGAT GTAGGAAGAC CTCTGTCTGG ATCCGGCATT 
ACGGCATTTG CTCAAGCTCA CCCAAGCAAT GGACAGAGAG TGAACCCACC ACCACCACCT 
CAAGTTAGGA GTGTTACTCC TCCACCACCT CCACGAGGGC AGACCCCACC TCCACGAGGC 
ACAACTCCCC CTCCCCCCTC GTGGGAGCCT AACTCTCAGA CAAAGCGCTA CTCTGGGAAC 
ATGGAATATG TAATCTCCCG AATCTCTCCT GTTCCACCTG GGGCGTGGCA GGAGGGCTAC 
CCTCCACCAC CTCTTAACAC TTCCCCCATG AATCCCCCCA ACCAGGGACA GAGAGGCATC 
AGTTCTGTTC CAGTTGGCAG GCAACCAATC ATCATGCAAA GTACTAGCAA ATTTAACTTT 
ACACCAGGGA GACCTGGAGT TCAGAATGGT GGTGGTCAGA CTGATTTTAT CATGCACCAA 
AATGTTGTCC CCACTGGTGC TGTGAATCGG CAACCACCAC CACCATATCC TCTGACCCCA 
GCTAATGGAC AAAGCCCTTC TGCTTTGCAA GCAGGCGGTC CTGCTGCTCC ACCATCATTC 
TCCAATGGAA ATGTTCCTCC AACGATGATG GTGCCGAACA GGAACAGTCA TAACATGGAG 
CTGTATAATA TCAATGTCCC TGGACTGCAA ACAACTTGGC CCCAGTCGTC TTCTGCCCCT 
GTGCAATCAT CTCCAAGCAG TGGGCATGAA ATTCCTACGT GGCAACCTAA CATACCAGTG 
AGGTCAAATT CTTTTAATAA CCCACTAGGA AGTAGAGCAA GTCACTCTGC TAATTCTCAG 
CCTTCCGCCA CGACAGTTAC TGCCATCACA CCAGCTCCTA TTCAGCAGCC CGTGAAAAGC 
ATGCGCGTTC TGAAACCAGA GCTGCAGACT GCCTTAGCCC CAACCCATCC TTCTTGGATG 
CCACAGCCAG TTCAGACCGT TCAGCCTAGC CCTTTTTCTG AGGGTGCAGC TTCAAACGTG 
CCAGTCATCC CACCTGTGGC GGAAGCTCCA AGCTATCAGG GCCCACCACC ACCTTATCCA 
AAACATCTGC TACACCAAAC CCCATCTGTT CCTCCATATG AGTCAGCGAG TAAACCCTGC 
AAAGACGATC AGCCTAGCTC AGCCAAGGAA GAGGATAGTG AAAAGAGTTT GGACAGTGTT 
GACTCTGGGG ATAAAGAGAA GAAACAGATT ACAACTTCAC CTATCACTGT TCGGAAAAAC 
AAGAAAGACG AAGAGCGAAG AGAGTCTCGC ATTCAGAGTT ACTCCCCGCA GGCCTTTAAA 
TTCTTCATGG AGCAACACGT AGAGAACGTC CTGAAGTCTC ATCAGCAGCG TCTGCATCGC 
AAGAAGCAAC TAGAGAATGA AATGATGCGG GTTGGATTAT CTCAAGATGC CCAGGATCAA 
ATGAGAAAGA TGCTTTGCCA GAAAGAGTCT AACTATATTC GTCTTAAAAG GGCTAAAATG 
GACAAGTCTA TGTTTGTAAA GATAAAGACA TTAGGAATAG GAGCATTTGG TGAAGTCTGT 
CTAGCAAGAA AAGTCGATAC GAAAGCTTTG TATGCAACAA AAACTCTACG AAAGAAAGAC 
GTTCTGCTCC GAAATCAGGT GGCTCATGTG AAAGCTGAGC GAGATATCCT AGCAGAAGCT 
GACAACGAGT GGGTGGTCCG CTTGTACTAC TCATTCCAGG ACAAGGACAA CTTGTACTTT 
GTGATGGACT ACATTCCTGG GGGTGATATG ATGAGCCTGT TAATTAGAAT GGGCATCTTT 
CCCGAAAACC TGGCACGATT CTACATAGCA GAACTTACCT GTGCAGTTGA AAGTGTTCAT 
AAAATGGGTT TTATTCATAG AGACATTAAA CCTGATAACA TTTTGATTGA CCGAGATGGA 
CATATTAAAT TGACTGACTT TGGCTTGTGC ACTGGCTTCA GATGGACACA TGACTCCAAG 
TACTACCAGA GTGGGGATCA CCCACGGCAA GATAGCATGG ATTTCAGTAG CGAATGGGGA 
GATCCTTCCA ACTGTCGGTG TGGGGACAGA CTGAAGCCAC TAGAGCGGAG AGCTGCTCGC 
CAGCACCAGC GATGTCTAGC TCACTCTCTG GTTGGGACTC CCAACTATAT AGCACCTGAA 
GTGCTACTAC GGACAGGATA TACACAGCTG TGTGATTGGT GGAGTGTTGG TGTTATTCTT 
TTTGAAATGT TGGTGGGACA ACCTCCTTTC TTGGCACAAA CACCATTAGA AACCCAAATG 
AAGGTTATCA ACTGGCAAAC TTCTCTTCAC ATCCCACCTC AAGCCAAGCT CAGTCCTGAA 
GCCTCTGACC TCATTATCAA ACTTTGCCGA GGACCAGAAG ACCGTCTAGG CAAGAACGGT 
GCTGATGAAA TAAAGGCTCA TCCATTTTTT AAGACCATTG ATTTCTCTAG TGATCTGAGA 
CAGCAGTCTG CTTCATACAT CCCCAAAATC ACGCACCCAA CAGACACGTC CAATTTTGAC 
CCTGTTGACC CTGATAAGTT GTGGAGCGAT GGTAACGAGG AAGAAAATAT CAACGACACT 
CTGAACGGAT GGTATAAAAA CGGAAAGCAC CCTGAGCATG CTTTCTATGA GTTTACCTTT 
CGGAGGTTCT TTGATGACAA TGGCTACCCA TATAATTATC CAAAGCCCAT CGAATATGAA 
TACGTTAGTT CCCAGGGCTC AGAGCAGCAG TCCGATGAAG ACGATCAACA CACAGGCTCA 
GATGTAAACA ACCGTGATCT AGTGTATGTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128015.2
CDS	355..3747
Translation	MKRGEKPEGYRQMRPKTFPASNYSGSSRQMLQEIRESLRNLSKPSDAAKAEHNLNKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETSSSRIPSEVNPQMFQDLQAAGFDEDMVIQALQKTNNRSIEAAVEFISKMSYQDPRREQMAAAAARPINATMKPGNVQHSISRKQSWKGSKESLVPQRHGPSLGENVVYRSESPNSQADVGRPLSGSGITAFAQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSTSKFNFTPGRPGVQNGGGQTDFIMHQNVVPTGAVNRQPPPPYPLTPANGQSPSALQAGGPAAPPSFSNGNVPPTMMVPNRNSHNMELYNINVPGLQTTWPQSSSAPVQSSPSSGHEIPTWQPNIPVRSNSFNNPLGSRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWMPQPVQTVQPSPFSEGAASNVPVIPPVAEAPSYQGPPPPYPKHLLHQTPSVPPYESASKPCKDDQPSSAKEEDSEKSLDSVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSSEWGDPSNCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDGNEEENINDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYVSSQGSEQQSDEDDQHTGSDVNNRDLVYV

Target ORF information:

RefSeq Version	NM_001134543.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus large tumor suppressor kinase 1 (Lats1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134543.2

ORF Insert Sequence:

ATGAAGAGGG GTGAAAAGCC AGAAGGGTAC AGACAGATGA GGCCTAAGAC CTTTCCTGCC 
AGCAACTACT CTGGCAGCAG CCGACAAATG CTGCAGGAGA TCCGAGAATC CCTTAGGAAT 
TTATCAAAGC CATCTGATGC CGCAAAGGCC GAGCATAACC TGAACAAGAT GTCGACCGAA 
GATCCCAGGC AGGTGAGAAA TCCGCCCAAA TTTGGCACAC ATCATAAAGC CTTGCAAGAA 
ATTCGAAACT CTCTACTACC TTTCGCAAAC GAGACGAGTT CTTCCCGGAT CCCTTCAGAA 
GTTAATCCAC AGATGTTTCA GGATTTGCAG GCTGCTGGCT TTGATGAGGA TATGGTTATT 
CAAGCTCTTC AGAAAACCAA TAACAGAAGC ATAGAAGCAG CTGTTGAATT CATTAGTAAA 
ATGAGTTATC AGGATCCTCG TCGAGAGCAG ATGGCTGCAG CAGCTGCCAG ACCTATCAAT 
GCCACCATGA AACCAGGAAA TGTGCAACAT TCAATTAGCC GAAAACAAAG CTGGAAAGGT 
TCTAAAGAGT CTTTAGTTCC TCAGAGACAC GGTCCATCTC TAGGAGAAAA TGTGGTTTAT 
CGATCTGAAA GTCCCAACTC ACAGGCGGAT GTAGGAAGAC CTCTGTCTGG ATCCGGCATT 
ACGGCATTTG CTCAAGCTCA CCCAAGCAAT GGACAGAGAG TGAACCCACC ACCACCACCT 
CAAGTTAGGA GTGTTACTCC TCCACCACCT CCACGAGGGC AGACCCCACC TCCACGAGGC 
ACAACTCCCC CTCCCCCCTC GTGGGAGCCT AACTCTCAGA CAAAGCGCTA CTCTGGGAAC 
ATGGAATATG TAATCTCCCG AATCTCTCCT GTTCCACCTG GGGCGTGGCA GGAGGGCTAC 
CCTCCACCAC CTCTTAACAC TTCCCCCATG AATCCCCCCA ACCAGGGACA GAGAGGCATC 
AGTTCTGTTC CAGTTGGCAG GCAACCAATC ATCATGCAAA GTACTAGCAA ATTTAACTTT 
ACACCAGGGA GACCTGGAGT TCAGAATGGT GGTGGTCAGA CTGATTTTAT CATGCACCAA 
AATGTTGTCC CCACTGGTGC TGTGAATCGG CAACCACCAC CACCATATCC TCTGACCCCA 
GCTAATGGAC AAAGCCCTTC TGCTTTGCAA GCAGGCGGTC CTGCTGCTCC ACCATCATTC 
TCCAATGGAA ATGTTCCTCC AACGATGATG GTGCCGAACA GGAACAGTCA TAACATGGAG 
CTGTATAATA TCAATGTCCC TGGACTGCAA ACAACTTGGC CCCAGTCGTC TTCTGCCCCT 
GTGCAATCAT CTCCAAGCAG TGGGCATGAA ATTCCTACGT GGCAACCTAA CATACCAGTG 
AGGTCAAATT CTTTTAATAA CCCACTAGGA AGTAGAGCAA GTCACTCTGC TAATTCTCAG 
CCTTCCGCCA CGACAGTTAC TGCCATCACA CCAGCTCCTA TTCAGCAGCC CGTGAAAAGC 
ATGCGCGTTC TGAAACCAGA GCTGCAGACT GCCTTAGCCC CAACCCATCC TTCTTGGATG 
CCACAGCCAG TTCAGACCGT TCAGCCTAGC CCTTTTTCTG AGGGTGCAGC TTCAAACGTG 
CCAGTCATCC CACCTGTGGC GGAAGCTCCA AGCTATCAGG GCCCACCACC ACCTTATCCA 
AAACATCTGC TACACCAAAC CCCATCTGTT CCTCCATATG AGTCAGCGAG TAAACCCTGC 
AAAGACGATC AGCCTAGCTC AGCCAAGGAA GAGGATAGTG AAAAGAGTTT GGACAGTGTT 
GACTCTGGGG ATAAAGAGAA GAAACAGATT ACAACTTCAC CTATCACTGT TCGGAAAAAC 
AAGAAAGACG AAGAGCGAAG AGAGTCTCGC ATTCAGAGTT ACTCCCCGCA GGCCTTTAAA 
TTCTTCATGG AGCAACACGT AGAGAACGTC CTGAAGTCTC ATCAGCAGCG TCTGCATCGC 
AAGAAGCAAC TAGAGAATGA AATGATGCGG GTTGGATTAT CTCAAGATGC CCAGGATCAA 
ATGAGAAAGA TGCTTTGCCA GAAAGAGTCT AACTATATTC GTCTTAAAAG GGCTAAAATG 
GACAAGTCTA TGTTTGTAAA GATAAAGACA TTAGGAATAG GAGCATTTGG TGAAGTCTGT 
CTAGCAAGAA AAGTCGATAC GAAAGCTTTG TATGCAACAA AAACTCTACG AAAGAAAGAC 
GTTCTGCTCC GAAATCAGGT GGCTCATGTG AAAGCTGAGC GAGATATCCT AGCAGAAGCT 
GACAACGAGT GGGTGGTCCG CTTGTACTAC TCATTCCAGG ACAAGGACAA CTTGTACTTT 
GTGATGGACT ACATTCCTGG GGGTGATATG ATGAGCCTGT TAATTAGAAT GGGCATCTTT 
CCCGAAAACC TGGCACGATT CTACATAGCA GAACTTACCT GTGCAGTTGA AAGTGTTCAT 
AAAATGGGTT TTATTCATAG AGACATTAAA CCTGATAACA TTTTGATTGA CCGAGATGGA 
CATATTAAAT TGACTGACTT TGGCTTGTGC ACTGGCTTCA GATGGACACA TGACTCCAAG 
TACTACCAGA GTGGGGATCA CCCACGGCAA GATAGCATGG ATTTCAGTAG CGAATGGGGA 
GATCCTTCCA ACTGTCGGTG TGGGGACAGA CTGAAGCCAC TAGAGCGGAG AGCTGCTCGC 
CAGCACCAGC GATGTCTAGC TCACTCTCTG GTTGGGACTC CCAACTATAT AGCACCTGAA 
GTGCTACTAC GGACAGGATA TACACAGCTG TGTGATTGGT GGAGTGTTGG TGTTATTCTT 
TTTGAAATGT TGGTGGGACA ACCTCCTTTC TTGGCACAAA CACCATTAGA AACCCAAATG 
AAGGTTATCA ACTGGCAAAC TTCTCTTCAC ATCCCACCTC AAGCCAAGCT CAGTCCTGAA 
GCCTCTGACC TCATTATCAA ACTTTGCCGA GGACCAGAAG ACCGTCTAGG CAAGAACGGT 
GCTGATGAAA TAAAGGCTCA TCCATTTTTT AAGACCATTG ATTTCTCTAG TGATCTGAGA 
CAGCAGTCTG CTTCATACAT CCCCAAAATC ACGCACCCAA CAGACACGTC CAATTTTGAC 
CCTGTTGACC CTGATAAGTT GTGGAGCGAT GGTAACGAGG AAGAAAATAT CAACGACACT 
CTGAACGGAT GGTATAAAAA CGGAAAGCAC CCTGAGCATG CTTTCTATGA GTTTACCTTT 
CGGAGGTTCT TTGATGACAA TGGCTACCCA TATAATTATC CAAAGCCCAT CGAATATGAA 
TACGTTAGTT CCCAGGGCTC AGAGCAGCAG TCCGATGAAG ACGATCAACA CACAGGCTCA 
GATGTAAACA ACCGTGATCT AGTGTATGTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ER?.
Nature541(7638)541-545(2017 01)
Britschgi A,Duss S,Kim S,Couto JP,Brinkhaus H,Koren S,De Silva D,Mertz KD,Kaup D,Varga Z,Voshol H,Vissieres A,Leroy C,Roloff T,Stadler MB,Scheel CH,Miraglia LJ,Orth AP,Bonamy GM,Reddy VA,Bentires-Alj M

Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation.
Genes & development27(13)1441-6(2013 Jul)
Lorthongpanich C,Messerschmidt DM,Chan SW,Hong W,Knowles BB,Solter D

The Hippo pathway regulates Wnt/beta-catenin signaling.
Developmental cell18(4)579-91(2010 Apr)
Varelas X,Miller BW,Sopko R,Song S,Gregorieff A,Fellouse FA,Sakuma R,Pawson T,Hunziker W,McNeill H,Wrana JL,Attisano L

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.
The EMBO journal29(2)376-86(2010 Jan)
Humbert N,Navaratnam N,Augert A,Da Costa M,Martien S,Wang J,Martinez D,Abbadie C,Carling D,de Launoit Y,Gil J,Bernard D

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Lats1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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