Mcc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mcc
Entrez Gene ID	307449
Full Name	mutated in colorectal cancers
Synonyms	RGD1561988
General protein information	Preferred Names mutated in colorectal cancers Names colorectal mutant cancer protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p11
Summary	human homolog is a putative colorectal tumor suppressor gene [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001170534.2	NP_001164005.2	colorectal mutant cancer protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	MCC	NP_001078846.1
Gallus gallus (chicken)	MCC	XP_413971.4
Canis lupus familiaris (dog)	MCC	XP_005619199.1
Rattus norvegicus (Norway rat)	Mcc	NP_001164005.1
Bos taurus (cattle)	MCC	NP_001076992.1
Pan troglodytes (chimpanzee)	MCC	XP_003310832.1
	MCC	XP_001082972.1
Danio rerio (zebrafish)	mcc	XP_003198612.1
Xenopus tropicalis (tropical clawed frog)	mcc	NP_001135595.1
Mus musculus (house mouse)	Mcc	NP_001078842.1

Gene Ontology
Bibliography

Related articles in PubMed

MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm.
Pangon L, Mladenova D, Watkins L, Van Kralingen C, Currey N, Al-Sohaily S, Lecine P, Borg JP, Kohonen-Corish MR
International journal of cancer136(1)55-64(2015 Jan)

MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.
Arnaud C, Sebbagh M, Nola S, Audebert S, Bidaut G, Hermant A, Gayet O, Dusetti NJ, Ollendorff V, Santoni MJ, Borg JP, L?cine P
FEBS letters583(14)2326-32(2009 Jul)

Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription.
Fukuyama R, Niculaita R, Ng KP, Obusez E, Sanchez J, Kalady M, Aung PP, Casey G, Sizemore N
Oncogene27(46)6044-55(2008 Oct)

Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.
Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A
Science (New York, N.Y.)251(4999)1366-70(1991 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mcc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mcc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa46505	NM_001170534.2 Latest version!	Rattus norvegicus MCC regulator of WNT signaling pathway (Mcc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mcc ( NM_001170534.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001164005.2 Rattus norvegicus MCC regulator of WNT signaling pathway (Mcc), mRNA.

Price & Availability↑

CloneID	ORa46505
Clone ID Related Accession (Same CDS sequence)	NM_001170534.2
Accession Version	NM_001170534.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3012bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-15
Organism	Rattus norvegicus(Norway rat)
Product	colorectal mutant cancer protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAHX01102182.1, AAHX01102189.1, AAHX01102191.1, AAHX01102198.1, AAHX01102199.1, AAHX01102200.1 and AAHX01102201.1. On Sep 27, 2014 this sequence version replaced NM_001170534.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence because no single transcript was available for the full length of the gene. The extent of this transcript is supported by orthologous data.

ATGGCGGCTG CAAGCGCTTG CAGCAGCAAC GGTAGCAGCA GCGACACGTC CAGCACCGAC 
GAGGAGGAGC GTCTGCGGCG GCTCTTCCAG ACGTGCGACA GCGACGGCGA TGGCTTCATC 
AGCTGGAATG ACTTGCTAAT GGTCTGCCGA CAGGTGAATA TGGAAGAGTC AGTGGCTGAG 
ATCATGAGCC AACTGGGCAC AGATGAGAAC GGGAAGATTT CCTTCCAAGA CTTCACAAGG 
TGCCACACGC AGCTTGTTAG AGAGATTAGG AAGGAGGAAG TAGACCTGTT CATGAAGTCA 
GACAAGTCTG GTAAAAAGAA GCTGAGGGAA AGAATCACTT CCTGGCCTAC GAGAAGTGAC 
AACAGTCTGG GTGCTTTGTC AGCAACCAGG GAGAGCTGGG CGTATGATTC AGGTGCCAGG 
GATCTCCAGA GCCCCGACTT GCAGAGCCAG CTGCCCCTCC AGAAGCTGCT GGAGTATGGT 
GAAAGCTCTT TGCCTCAGCA GGCTGTGCTC CACAAGCTTC TCACGCAGTC CCCGAATTTT 
GGCACTTCTA CAGGCGGAAG CTATCTAGAG CTGGCCAGTA CCCTCCACTT GGCAGCCCTG 
GCATCACTCA AGGGAGACAT AGTAGAGCTG AACAAACGTC TGCAACAAAC AGAGCGTGAA 
CGAGACCTCC TGGAAAAGAC GTTGGCCAAG GCACAGTGTG AGCAGTCACA CCTCATGAGA 
GAGCATGAAG ATGTTCAGGA ACGCACGACA CTCCGCTATG AGGAGCGCAT CACAGAGCTC 
CACAGCATCA TTGCAGAACT CAACAAGAAG ATAGACCGCT TGCAAGGTAC CACCATCAGG 
GAGGAAGATG AGTACTCAGA ACTTCGGTCA GAGCTCAGCC AGAGTCAACA AGAGGTCAAT 
GAAGACTCCA GAAGTGTGGA CCAAGACCAG ACCTCTGTGT CCATCCCTGA GAACCAGTCT 
ACTATGGTCA CTGCTGACAT GGACAACTGC AGTGACTTGA ACTCAGAACT GCAGAGAGTG 
CTGACTGGTC TGGAGAGCGT TGTCTGTGGC AGGAAGAAGA GCAGCTGCAG CCTCTCTGTG 
GCCGAGGTGG ACAGGCACAT TGAGCAGCTC ACTACGGCCA GCGAGCACTG TGACTTGGCC 
ATTAAGACAG TTGAGGAGAT CGAGGGAGTC CTTGGTCGGG ATCTGTATCC CAACCTGACT 
GAGGAGCGGT CCCGGTGGGA GAAAGAGCTG GCTGGATTGC GGGAAGAGAA TGAAAGTCTG 
ACAGCCATGC TGTGCAGCAA AGAGGAGGAG CTGAACCGAA CCAAGGCCAC TATGAATGCC 
ATCCGTGAGG AGCGGGACAG GCTTCGGAGG CGGGTCCGAG AGCTCCAAAC TCGGCTGCAG 
AGTGTACAAG CTACTGGACC TTCTAGCCCG GGTCGCCTCA CTCCTGCCAA TCGCCCAATT 
AACCCCAGCA CTGGGGAGCT AAGCACCAGC AGTAGCAGCA ATGACATCCC CATCGCTAAG 
ATTGCCGAGA GAGTAAAGCT ATCGAAGACG AGATCTGAAT CCTCATCATC TGACAGACCA 
GTCCTGGGCT CAGAAATCAG TAGTGTTGGG GTTTCCAGCA GTGTGGCAGA GCACCTGGCC 
CACTCACTTC AGGACTGCTC CAATATCCAG GAAATTTTTC AAACACTCTA CTCACACGGA 
TCTGCCATCT CTGAAAGCAA GATTAGAGAG TTTGAGGTGG AAACGGAGCG GTTGAATAGT 
CGTATTGAAC ACCTCAAATC GCAAAATGAT CTTCTCACCA TAACCCTGGA GGAATGTAAA 
AGCAACGCCG AAAGGATGAG CATGCTGGTG GGGAAGTACG AGTCCAATGC CACAGCCCTA 
AGGCTGGCCT TGCAGTACAG TGAGCAGTGC ATAGAAGCCT ATGAACTCCT GCTGGCCCTG 
GCTGAGACAG AGCAGAGCCT TATCCTGGGG CAATTCCGGG CAGCTGGTGT GGGCTCCTCC 
CCTGGAGACC AGTCAGGGGA TGAGAATATC ACTCAGATGC TTAAGAGGGC TCACGACTGC 
CGGAAGACTG CTGAGAACGC CGCCAAAGCC CTGCTCATGA AGCTGGATGG CAGCTGTGGG 
GGAGCCTTCA CAGTGGCTGG CTGCAGTGTG CAGCCCTGGG AGAGCCTGTC CTCCAACAGC 
CATACCAGCA CAACTAGCTC TACAGCCAGC AGCTGTGACA CAGAATTCAC TAAAGAAGAT 
GAACAAAGGC TGAAGGATTA TATCCAGCAG CTCAAGAATG ACAGAGCTGC AGTCAAGCTG 
ACCATGCTGG AGTTGGAGAG CATCCACATT GATCCACTCA GCTATGATGT CAAGCCAAGA 
GGCGACAGCC AGAGGCTGGA CCTGGAGAAT GCCGTGCTGA TGCAGGAGCT GATGGCCATG 
AAGGAGGAGA TGGCTGAGCT GAAAGCCCAG CTCTATCTGC TGGAGAAAGA GAAGAAAGCC 
CTGGAGCTGA AGCTGAGCAC GAGGGAAGCA CAGGAGCAGG CCTATCTGGT GCACATCGAG 
CACCTCAAGT CTGAAGTGGA GGAACAGAAG GAGCAACGGA TGCGGTCCCT GAGCTCCACA 
AGCAGCAGCG GCAAAGAGAA GCCTGGCAAG GAGAGTGCTG ATGCTGCCTC CCCAGCTTTG 
TCACTGGCTG AACTAAGGAC TAACAGTGAC AGTGAGCTGG CCACTGAGTT TGCCAACGCC 
ATCCGACGGG AAAAGAAGCT GAAGGCTAGA GTTCAAGAGC TGGTCAGCGC CTTGGAAAGA 
CTCACCAAAA GCAGTGAAAT CAGACACCAG CAGTCGGCAG AGTTTGTTAA TGACCTGAAA 
CGGGCCAACA GCAATCTGGT AGCTGCCTAT GAAAAAGCAA AGAAGAAGCA TCAAAACAAG 
CTGAAGAAGC TGGAATCTCA GATGATGGCC ATGGTGGAGC GACATGAGAC CCAAGTGAGA 
ATGCTGAAGC AGAGAATAGC ACTGCTGGAG GAAGAGCATT CCAGGCCACA TACCAACGAA 
ACTTCACTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001164005.2
CDS	20..3031
Translation	MAAASACSSNGSSSDTSSTDEEERLRRLFQTCDSDGDGFISWNDLLMVCRQVNMEESVAEIMSQLGTDENGKISFQDFTRCHTQLVREIRKEEVDLFMKSDKSGKKKLRERITSWPTRSDNSLGALSATRESWAYDSGARDLQSPDLQSQLPLQKLLEYGESSLPQQAVLHKLLTQSPNFGTSTGGSYLELASTLHLAALASLKGDIVELNKRLQQTERERDLLEKTLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSIIAELNKKIDRLQGTTIREEDEYSELRSELSQSQQEVNEDSRSVDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLESVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLTEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTPANRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSVGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAETEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFTVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSSGKEKPGKESADAASPALSLAELRTNSDSELATEFANAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEEHSRPHTNETSL

Target ORF information:

RefSeq Version	NM_001170534.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MCC regulator of WNT signaling pathway (Mcc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001170534.2

ORF Insert Sequence:

ATGGCGGCTG CAAGCGCTTG CAGCAGCAAC GGTAGCAGCA GCGACACGTC CAGCACCGAC 
GAGGAGGAGC GTCTGCGGCG GCTCTTCCAG ACGTGCGACA GCGACGGCGA TGGCTTCATC 
AGCTGGAATG ACTTGCTAAT GGTCTGCCGA CAGGTGAATA TGGAAGAGTC AGTGGCTGAG 
ATCATGAGCC AACTGGGCAC AGATGAGAAC GGGAAGATTT CCTTCCAAGA CTTCACAAGG 
TGCCACACGC AGCTTGTTAG AGAGATTAGG AAGGAGGAAG TAGACCTGTT CATGAAGTCA 
GACAAGTCTG GTAAAAAGAA GCTGAGGGAA AGAATCACTT CCTGGCCTAC GAGAAGTGAC 
AACAGTCTGG GTGCTTTGTC AGCAACCAGG GAGAGCTGGG CGTATGATTC AGGTGCCAGG 
GATCTCCAGA GCCCCGACTT GCAGAGCCAG CTGCCCCTCC AGAAGCTGCT GGAGTATGGT 
GAAAGCTCTT TGCCTCAGCA GGCTGTGCTC CACAAGCTTC TCACGCAGTC CCCGAATTTT 
GGCACTTCTA CAGGCGGAAG CTATCTAGAG CTGGCCAGTA CCCTCCACTT GGCAGCCCTG 
GCATCACTCA AGGGAGACAT AGTAGAGCTG AACAAACGTC TGCAACAAAC AGAGCGTGAA 
CGAGACCTCC TGGAAAAGAC GTTGGCCAAG GCACAGTGTG AGCAGTCACA CCTCATGAGA 
GAGCATGAAG ATGTTCAGGA ACGCACGACA CTCCGCTATG AGGAGCGCAT CACAGAGCTC 
CACAGCATCA TTGCAGAACT CAACAAGAAG ATAGACCGCT TGCAAGGTAC CACCATCAGG 
GAGGAAGATG AGTACTCAGA ACTTCGGTCA GAGCTCAGCC AGAGTCAACA AGAGGTCAAT 
GAAGACTCCA GAAGTGTGGA CCAAGACCAG ACCTCTGTGT CCATCCCTGA GAACCAGTCT 
ACTATGGTCA CTGCTGACAT GGACAACTGC AGTGACTTGA ACTCAGAACT GCAGAGAGTG 
CTGACTGGTC TGGAGAGCGT TGTCTGTGGC AGGAAGAAGA GCAGCTGCAG CCTCTCTGTG 
GCCGAGGTGG ACAGGCACAT TGAGCAGCTC ACTACGGCCA GCGAGCACTG TGACTTGGCC 
ATTAAGACAG TTGAGGAGAT CGAGGGAGTC CTTGGTCGGG ATCTGTATCC CAACCTGACT 
GAGGAGCGGT CCCGGTGGGA GAAAGAGCTG GCTGGATTGC GGGAAGAGAA TGAAAGTCTG 
ACAGCCATGC TGTGCAGCAA AGAGGAGGAG CTGAACCGAA CCAAGGCCAC TATGAATGCC 
ATCCGTGAGG AGCGGGACAG GCTTCGGAGG CGGGTCCGAG AGCTCCAAAC TCGGCTGCAG 
AGTGTACAAG CTACTGGACC TTCTAGCCCG GGTCGCCTCA CTCCTGCCAA TCGCCCAATT 
AACCCCAGCA CTGGGGAGCT AAGCACCAGC AGTAGCAGCA ATGACATCCC CATCGCTAAG 
ATTGCCGAGA GAGTAAAGCT ATCGAAGACG AGATCTGAAT CCTCATCATC TGACAGACCA 
GTCCTGGGCT CAGAAATCAG TAGTGTTGGG GTTTCCAGCA GTGTGGCAGA GCACCTGGCC 
CACTCACTTC AGGACTGCTC CAATATCCAG GAAATTTTTC AAACACTCTA CTCACACGGA 
TCTGCCATCT CTGAAAGCAA GATTAGAGAG TTTGAGGTGG AAACGGAGCG GTTGAATAGT 
CGTATTGAAC ACCTCAAATC GCAAAATGAT CTTCTCACCA TAACCCTGGA GGAATGTAAA 
AGCAACGCCG AAAGGATGAG CATGCTGGTG GGGAAGTACG AGTCCAATGC CACAGCCCTA 
AGGCTGGCCT TGCAGTACAG TGAGCAGTGC ATAGAAGCCT ATGAACTCCT GCTGGCCCTG 
GCTGAGACAG AGCAGAGCCT TATCCTGGGG CAATTCCGGG CAGCTGGTGT GGGCTCCTCC 
CCTGGAGACC AGTCAGGGGA TGAGAATATC ACTCAGATGC TTAAGAGGGC TCACGACTGC 
CGGAAGACTG CTGAGAACGC CGCCAAAGCC CTGCTCATGA AGCTGGATGG CAGCTGTGGG 
GGAGCCTTCA CAGTGGCTGG CTGCAGTGTG CAGCCCTGGG AGAGCCTGTC CTCCAACAGC 
CATACCAGCA CAACTAGCTC TACAGCCAGC AGCTGTGACA CAGAATTCAC TAAAGAAGAT 
GAACAAAGGC TGAAGGATTA TATCCAGCAG CTCAAGAATG ACAGAGCTGC AGTCAAGCTG 
ACCATGCTGG AGTTGGAGAG CATCCACATT GATCCACTCA GCTATGATGT CAAGCCAAGA 
GGCGACAGCC AGAGGCTGGA CCTGGAGAAT GCCGTGCTGA TGCAGGAGCT GATGGCCATG 
AAGGAGGAGA TGGCTGAGCT GAAAGCCCAG CTCTATCTGC TGGAGAAAGA GAAGAAAGCC 
CTGGAGCTGA AGCTGAGCAC GAGGGAAGCA CAGGAGCAGG CCTATCTGGT GCACATCGAG 
CACCTCAAGT CTGAAGTGGA GGAACAGAAG GAGCAACGGA TGCGGTCCCT GAGCTCCACA 
AGCAGCAGCG GCAAAGAGAA GCCTGGCAAG GAGAGTGCTG ATGCTGCCTC CCCAGCTTTG 
TCACTGGCTG AACTAAGGAC TAACAGTGAC AGTGAGCTGG CCACTGAGTT TGCCAACGCC 
ATCCGACGGG AAAAGAAGCT GAAGGCTAGA GTTCAAGAGC TGGTCAGCGC CTTGGAAAGA 
CTCACCAAAA GCAGTGAAAT CAGACACCAG CAGTCGGCAG AGTTTGTTAA TGACCTGAAA 
CGGGCCAACA GCAATCTGGT AGCTGCCTAT GAAAAAGCAA AGAAGAAGCA TCAAAACAAG 
CTGAAGAAGC TGGAATCTCA GATGATGGCC ATGGTGGAGC GACATGAGAC CCAAGTGAGA 
ATGCTGAAGC AGAGAATAGC ACTGCTGGAG GAAGAGCATT CCAGGCCACA TACCAACGAA 
ACTTCACTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm.
International journal of cancer136(1)55-64(2015 Jan)
Pangon L,Mladenova D,Watkins L,Van Kralingen C,Currey N,Al-Sohaily S,Lecine P,Borg JP,Kohonen-Corish MR

MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.
FEBS letters583(14)2326-32(2009 Jul)
Arnaud C,Sebbagh M,Nola S,Audebert S,Bidaut G,Hermant A,Gayet O,Dusetti NJ,Ollendorff V,Santoni MJ,Borg JP,L?cine P

Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription.
Oncogene27(46)6044-55(2008 Oct)
Fukuyama R,Niculaita R,Ng KP,Obusez E,Sanchez J,Kalady M,Aung PP,Casey G,Sizemore N

Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.
Science (New York, N.Y.)251(4999)1366-70(1991 Mar)
Kinzler KW,Nilbert MC,Vogelstein B,Bryan TM,Levy DB,Smith KJ,Preisinger AC,Hamilton SR,Hedge P,Markham A

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Mcc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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