Otop1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Otop1
Entrez Gene ID	305427
Full Name	otopetrin 1
General protein information	Preferred Names otopetrin 1 Names otopetrin-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q21
Summary	may play a role in the biosynthesis of otoconia, which are inner ear biominerals required for perception of gravity and linear acceleration [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_181433.1	NP_852098.1	proton channel OTOP1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	OTOP1	XP_545943.3
Mus musculus (house mouse)	Otop1	NP_766297.2
Rattus norvegicus (Norway rat)	Otop1	NP_852098.1
Gallus gallus (chicken)	OTOP1	XP_420790.3
Pan troglodytes (chimpanzee)	OTOP1	XP_526509.2
Bos taurus (cattle)	OTOP1	NP_001193713.1
Danio rerio (zebrafish)	otop1	NP_942098.1
Homo sapiens (human)	OTOP1	NP_819056.1
	OTOP1	XP_001097009.1
Xenopus tropicalis (tropical clawed frog)	otop1	XP_002939096.2

Gene Ontology
Bibliography

Related articles in PubMed

Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation.
Wang GX, Cho KW, Uhm M, Hu CR, Li S, Cozacov Z, Xu AE, Cheng JX, Saltiel AR, Lumeng CN, Lin JD
Diabetes63(4)1340-52(2014 Apr)

Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1.
Hurle B, Ignatova E, Massironi SM, Mashimo T, Rios X, Thalmann I, Thalmann R, Ornitz DM
Human molecular genetics12(7)777-89(2003 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Otop1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Otop1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04180	NM_181433.1 Latest version!	Rattus norvegicus otopetrin 1 (Otop1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Otop1 ( NM_181433.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_852098.1 Rattus norvegicus otopetrin 1 (Otop1), mRNA.

Price & Availability↑

CloneID	ORa04180
Clone ID Related Accession (Same CDS sequence)	NM_181433.1
Accession Version	NM_181433.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1803bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	proton channel OTOP1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BK000651.1. ##Evidence-Data-START## Transcript exon combination :: BK000651.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCTGGGG ACCGGGGCGC ACTATCTTCT CCCGCAGCAT CATCAGGCTC CCCGAGTGCC 
GCGCCGTCGG GGATCGCCGC ATGCCCTCCG CCCCCGTCTC CCCTAGCCCG GGCGTCTCCA 
CAAGCTTCCG GTCCCCGACG CGGTGCCAGC GTCCCGCAGA AGCTGGCGGA GACTCTGAGC 
AGCCAGTATG GACTGAACGT GTTCGTGGCG GGGCTTCTTT TCCTGCTGGC CTGGGCGGTG 
CACGCGACGG GTGTGGGCAA GAGCGACCTG TTGTGCGTAT TAACCGCACT CATGCTGCTG 
CAGCTGCTCT GGATGCTGTG GTACGTGGGT CGCAGCTACA TGCAGCGCCG CCTCATCCGC 
CCCAAGGACA CGCACGCGGG TGCGCGCTGG CTCCGCGGAA GCATCACATT GTTCGCATTC 
ATCACCATCG TCCTGGGGTG CCTGAAAGTC GCATACTTCA TTGGATTCTC AGAGTGCTTG 
TCAGCTACAG AGGGAGTTTT CCCAGTCACC CATGCAGTGC ATACATTGTT GCAGGTCTAT 
TTTCTCTGGG GCCACGCTAA AGATATTATC ATGTCTTTCA AAACACTGGA AAGGTTTGGG 
GTGATCCATT CAGTGTTCAC AAACCTGCTG CTGTGGGCCA ACAGCGTCCT GAATGAGTCA 
AAACACCAGC TGAATGAACA CAAGGAACGG CTGATCACTC TGGGCTTCGG CAACATCACC 
ATAGTTTTGG ATGACCACAC ACCACAGTGT AACTGCACAC CGCCTGCCCT CTGCTCTGCC 
CTCTCCCACG GGATTTACTA TCTGTACCCC TTCAACATTG AGTACCAGAT CCTGGCCTCG 
ACCATGCTCT ATGTGCTGTG GAAGAACATT GGGCGCAGGG TGGACAGCTC CCGGCACCAG 
AAGATGCAGT GCAGATTCGA CGGGGTCCTG GTGGGCTCAG TGCTGGGCCT GACAGTGCTG 
GCTGCCACCA TCGCGGTGGT TGTGGTGTAC ATGATCCATA TCGGGCGCTC CAAGTCCAAG 
AGTGAGTCGG CTCTTATCAT GTTCTATTTG TATGCGATCA CGGTGCTGCT GCTCATGGGG 
GCTGCGGGGC TGGTAGGAAG CTGGATTTAC AGGGTGGATG AGAAGTCTCT GGATGAGTCA 
AAGAACCCAG CCCGCAAGCT GGATGCTGAC CTCTTGGTGG CCACTGCCTC GGGTTCCTGG 
CTCCTCTCCT GGGGTTCCAT TTTGGCCATC GCCTGCGCTG AGACCCGCCC ACCGTACACC 
TGGTACAACC TCCCCTACTC TGTCCTGGTG ATCGTGGAGA AGTACGTCCA GAACATTTTC 
ATCATTGAGT CGGTGCACCT CGAGCCTGAG GGGGTCCCCG AGGATGTGCG CACTCTGCGT 
GTGGTCACCG TCTGCAGTGG GGAGGCTGCT GCACTGGCTG CATCGAGTCT CGGGAGCCAG 
GGGACGGCCC AGGATGGGTC ACCTGCTGTC AATGGGAATC TGCATCTGCA GCAGAGGTGT 
GAGAAAGAGG ACCAGGAGGC TGACTGGGAA GGAGCTACGG GGACAACCCG ATGTCTGGAC 
TTCCTTCAGG GAGGCATGAA GAGGAGGCTG CTCAGAAACA TCACAGCCTT TCTGTTCCTT 
TGCAACATCT CGCTTTGGAT TCCCCCTGCC TTTGGCTGCC GTCCCGAGTA TGACAACGGA 
CTGGAGGAAA TTGTCTTTGG CTTTGAACCC TGGATAATTG TGGTCAACCT GGCCATGCCC 
TTCTCCATTT TCTACAGGAT GCACGCAGCT GCCGCCCTCT TTGAGGTCTA TTGTAAAATC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852098.1
CDS	25..1827
Translation	MPGDRGALSSPAASSGSPSAAPSGIAACPPPPSPLARASPQASGPRRGASVPQKLAETLSSQYGLNVFVAGLLFLLAWAVHATGVGKSDLLCVLTALMLLQLLWMLWYVGRSYMQRRLIRPKDTHAGARWLRGSITLFAFITIVLGCLKVAYFIGFSECLSATEGVFPVTHAVHTLLQVYFLWGHAKDIIMSFKTLERFGVIHSVFTNLLLWANSVLNESKHQLNEHKERLITLGFGNITIVLDDHTPQCNCTPPALCSALSHGIYYLYPFNIEYQILASTMLYVLWKNIGRRVDSSRHQKMQCRFDGVLVGSVLGLTVLAATIAVVVVYMIHIGRSKSKSESALIMFYLYAITVLLLMGAAGLVGSWIYRVDEKSLDESKNPARKLDADLLVATASGSWLLSWGSILAIACAETRPPYTWYNLPYSVLVIVEKYVQNIFIIESVHLEPEGVPEDVRTLRVVTVCSGEAAALAASSLGSQGTAQDGSPAVNGNLHLQQRCEKEDQEADWEGATGTTRCLDFLQGGMKRRLLRNITAFLFLCNISLWIPPAFGCRPEYDNGLEEIVFGFEPWIIVVNLAMPFSIFYRMHAAAALFEVYCKI

Target ORF information:

RefSeq Version	NM_181433.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus otopetrin 1 (Otop1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181433.1

ORF Insert Sequence:

ATGCCTGGGG ACCGGGGCGC ACTATCTTCT CCCGCAGCAT CATCAGGCTC CCCGAGTGCC 
GCGCCGTCGG GGATCGCCGC ATGCCCTCCG CCCCCGTCTC CCCTAGCCCG GGCGTCTCCA 
CAAGCTTCCG GTCCCCGACG CGGTGCCAGC GTCCCGCAGA AGCTGGCGGA GACTCTGAGC 
AGCCAGTATG GACTGAACGT GTTCGTGGCG GGGCTTCTTT TCCTGCTGGC CTGGGCGGTG 
CACGCGACGG GTGTGGGCAA GAGCGACCTG TTGTGCGTAT TAACCGCACT CATGCTGCTG 
CAGCTGCTCT GGATGCTGTG GTACGTGGGT CGCAGCTACA TGCAGCGCCG CCTCATCCGC 
CCCAAGGACA CGCACGCGGG TGCGCGCTGG CTCCGCGGAA GCATCACATT GTTCGCATTC 
ATCACCATCG TCCTGGGGTG CCTGAAAGTC GCATACTTCA TTGGATTCTC AGAGTGCTTG 
TCAGCTACAG AGGGAGTTTT CCCAGTCACC CATGCAGTGC ATACATTGTT GCAGGTCTAT 
TTTCTCTGGG GCCACGCTAA AGATATTATC ATGTCTTTCA AAACACTGGA AAGGTTTGGG 
GTGATCCATT CAGTGTTCAC AAACCTGCTG CTGTGGGCCA ACAGCGTCCT GAATGAGTCA 
AAACACCAGC TGAATGAACA CAAGGAACGG CTGATCACTC TGGGCTTCGG CAACATCACC 
ATAGTTTTGG ATGACCACAC ACCACAGTGT AACTGCACAC CGCCTGCCCT CTGCTCTGCC 
CTCTCCCACG GGATTTACTA TCTGTACCCC TTCAACATTG AGTACCAGAT CCTGGCCTCG 
ACCATGCTCT ATGTGCTGTG GAAGAACATT GGGCGCAGGG TGGACAGCTC CCGGCACCAG 
AAGATGCAGT GCAGATTCGA CGGGGTCCTG GTGGGCTCAG TGCTGGGCCT GACAGTGCTG 
GCTGCCACCA TCGCGGTGGT TGTGGTGTAC ATGATCCATA TCGGGCGCTC CAAGTCCAAG 
AGTGAGTCGG CTCTTATCAT GTTCTATTTG TATGCGATCA CGGTGCTGCT GCTCATGGGG 
GCTGCGGGGC TGGTAGGAAG CTGGATTTAC AGGGTGGATG AGAAGTCTCT GGATGAGTCA 
AAGAACCCAG CCCGCAAGCT GGATGCTGAC CTCTTGGTGG CCACTGCCTC GGGTTCCTGG 
CTCCTCTCCT GGGGTTCCAT TTTGGCCATC GCCTGCGCTG AGACCCGCCC ACCGTACACC 
TGGTACAACC TCCCCTACTC TGTCCTGGTG ATCGTGGAGA AGTACGTCCA GAACATTTTC 
ATCATTGAGT CGGTGCACCT CGAGCCTGAG GGGGTCCCCG AGGATGTGCG CACTCTGCGT 
GTGGTCACCG TCTGCAGTGG GGAGGCTGCT GCACTGGCTG CATCGAGTCT CGGGAGCCAG 
GGGACGGCCC AGGATGGGTC ACCTGCTGTC AATGGGAATC TGCATCTGCA GCAGAGGTGT 
GAGAAAGAGG ACCAGGAGGC TGACTGGGAA GGAGCTACGG GGACAACCCG ATGTCTGGAC 
TTCCTTCAGG GAGGCATGAA GAGGAGGCTG CTCAGAAACA TCACAGCCTT TCTGTTCCTT 
TGCAACATCT CGCTTTGGAT TCCCCCTGCC TTTGGCTGCC GTCCCGAGTA TGACAACGGA 
CTGGAGGAAA TTGTCTTTGG CTTTGAACCC TGGATAATTG TGGTCAACCT GGCCATGCCC 
TTCTCCATTT TCTACAGGAT GCACGCAGCT GCCGCCCTCT TTGAGGTCTA TTGTAAAATC 
TAG