Rhoh cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rhoh
Entrez Gene ID	305341
Full Name	ras homolog family member H
General protein information	Preferred Names ras homolog family member H Names rho-related GTP-binding protein RhoH ras homolog gene family, member H
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013430.1	NP_001013448.1	rho-related GTP-binding protein RhoH

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Rhoh	NP_001074574.1
Pan troglodytes (chimpanzee)	RHOH	XP_003950362.1
Danio rerio (zebrafish)	rhoh	XP_005171000.1
Homo sapiens (human)	RHOH	NP_001265292.1
	RHOH	XP_001094054.1
Bos taurus (cattle)	RHOH	NP_001071592.1
Gallus gallus (chicken)	RHOH	XP_004936171.1
Canis lupus familiaris (dog)	RHOH	XP_005618669.1
Rattus norvegicus (Norway rat)	Rhoh	NP_001013448.1
Xenopus tropicalis (tropical clawed frog)	rhoh	NP_001120435.1

Gene Ontology
Bibliography

Related articles in PubMed

Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections.
Crequer A, Troeger A, Patin E, Ma CS, Picard C, Pedergnana V, Fieschi C, Lim A, Abhyankar A, Gineau L, Mueller-Fleckenstein I, Schmidt M, Taieb A, Krueger J, Abel L, Tangye SG, Orth G, Williams DA, Casanova JL, Jouanguy E
The Journal of clinical investigation122(9)3239-47(2012 Sep)

RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells.
Oda H, Fujimoto M, Patrick MS, Chida D, Sato Y, Azuma Y, Aoki H, Abe T, Suzuki H, Shirai M
Journal of immunology (Baltimore, Md. : 1950)182(2)957-62(2009 Jan)

RhoH is important for positive thymocyte selection and T-cell receptor signaling.
Dorn T, Kuhn U, Bungartz G, Stiller S, Bauer M, Ellwart J, Peters T, Scharffetter-Kochanek K, Semmrich M, Laschinger M, Holzmann B, Klinkert WE, Straten PT, K?llgaard T, Sixt M, Brakebusch C
Blood109(6)2346-55(2007 Mar)

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development.
Gu Y, Chae HD, Siefring JE, Jasti AC, Hildeman DA, Williams DA
Nature immunology7(11)1182-90(2006 Nov)

The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.
Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B
Molecular and cellular biology22(4)1158-71(2002 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Rhoh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rhoh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03962	NM_001013430.1 Latest version!	Rattus norvegicus ras homolog family member H (Rhoh), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rhoh ( NM_001013430.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013448.1 Rattus norvegicus ras homolog family member H (Rhoh), mRNA.

Price & Availability↑

CloneID	ORa03962
Clone ID Related Accession (Same CDS sequence)	NM_001013430.1
Accession Version	NM_001013430.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	rho-related GTP-binding protein RhoH
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091269.1. On Apr 20, 2005 this sequence version replaced XM_223404.2. ##Evidence-Data-START## Transcript exon combination :: BC091269.1, FQ232983.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCTGAGCT CTATCAAGTG TGTGCTGGTC GGCGACAGTG CTGTGGGAAA AACCTCACTG 
TTGGTGCGCT TCACCTCTGA GACCTTCCCC GAGGCCTACA AACCCACTGT GTATGAGAAT 
ACAGGTGTAG ACGTCTTCAT GGATGGCATC CAGATCAGCC TGGGTCTCTG GGACACTGCA 
GGCAATGATG CCTTCAGAAG CATCCGCCCC CTGTCCTACC AGCAGGCAGA TGTGGTACTA 
ATGTGTTACT CGGTGGCCAA CCATAGCTCG TTCCTGAACT TGAAGAACAA ATGGATTAGT 
GAGGTCAGGA GCAACCTACC CTGTACCCCG GTGCTGGTGG TGGCCACTCA GACTGACCAG 
AGAGAGATGG GACCTCACAG GGCTTCCTGC ATCAATGCCA TAGAAGGGAA GAGACTTGCC 
CAGGATGTGC GAGCCAAGGG CTACCTGGAG TGCTCAGCCC TTAGCAACCG GGGAGTCCAG 
CAGGTATTTG AATGTGCTGT CCGAACAGCT GTCAACCAGG CCAGGAGACG AAATAGAAGG 
AAGCTGTTTT CCATCAACGA ATGCAAGATC TTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013448.1
CDS	568..1143
Translation	MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTAGNDAFRSIRPLSYQQADVVLMCYSVANHSSFLNLKNKWISEVRSNLPCTPVLVVATQTDQREMGPHRASCINAIEGKRLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARRRNRRKLFSINECKIF

Target ORF information:

RefSeq Version	NM_001013430.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ras homolog family member H (Rhoh), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013430.1

ORF Insert Sequence:

ATGCTGAGCT CTATCAAGTG TGTGCTGGTC GGCGACAGTG CTGTGGGAAA AACCTCACTG 
TTGGTGCGCT TCACCTCTGA GACCTTCCCC GAGGCCTACA AACCCACTGT GTATGAGAAT 
ACAGGTGTAG ACGTCTTCAT GGATGGCATC CAGATCAGCC TGGGTCTCTG GGACACTGCA 
GGCAATGATG CCTTCAGAAG CATCCGCCCC CTGTCCTACC AGCAGGCAGA TGTGGTACTA 
ATGTGTTACT CGGTGGCCAA CCATAGCTCG TTCCTGAACT TGAAGAACAA ATGGATTAGT 
GAGGTCAGGA GCAACCTACC CTGTACCCCG GTGCTGGTGG TGGCCACTCA GACTGACCAG 
AGAGAGATGG GACCTCACAG GGCTTCCTGC ATCAATGCCA TAGAAGGGAA GAGACTTGCC 
CAGGATGTGC GAGCCAAGGG CTACCTGGAG TGCTCAGCCC TTAGCAACCG GGGAGTCCAG 
CAGGTATTTG AATGTGCTGT CCGAACAGCT GTCAACCAGG CCAGGAGACG AAATAGAAGG 
AAGCTGTTTT CCATCAACGA ATGCAAGATC TTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections.
The Journal of clinical investigation122(9)3239-47(2012 Sep)
Crequer A,Troeger A,Patin E,Ma CS,Picard C,Pedergnana V,Fieschi C,Lim A,Abhyankar A,Gineau L,Mueller-Fleckenstein I,Schmidt M,Taieb A,Krueger J,Abel L,Tangye SG,Orth G,Williams DA,Casanova JL,Jouanguy E

RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells.
Journal of immunology (Baltimore, Md. : 1950)182(2)957-62(2009 Jan)
Oda H,Fujimoto M,Patrick MS,Chida D,Sato Y,Azuma Y,Aoki H,Abe T,Suzuki H,Shirai M

RhoH is important for positive thymocyte selection and T-cell receptor signaling.
Blood109(6)2346-55(2007 Mar)
Dorn T,Kuhn U,Bungartz G,Stiller S,Bauer M,Ellwart J,Peters T,Scharffetter-Kochanek K,Semmrich M,Laschinger M,Holzmann B,Klinkert WE,Straten PT,K?llgaard T,Sixt M,Brakebusch C

RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development.
Nature immunology7(11)1182-90(2006 Nov)
Gu Y,Chae HD,Siefring JE,Jasti AC,Hildeman DA,Williams DA

The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.
Molecular and cellular biology22(4)1158-71(2002 Feb)
Li X,Bu X,Lu B,Avraham H,Flavell RA,Lim B

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Rhoh cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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