Srr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Srr
Entrez Gene ID	303306
Full Name	serine racemase
General protein information	Preferred Names serine racemase Names serine racemase D-serine ammonia-lyase D-serine dehydratase L-serine ammonia-lyase L-serine dehydratase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	catalyzes the conversion of L-serine to D-serine [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597302.1	XP_017452791.1	serine racemase isoform X2
XM_008768015.2	XP_008766237.1	serine racemase isoform X1
NM_198757.2	NP_942052.1	serine racemase

Pathways from BioSystems

Homologies

	SRR	XP_001087081.2
Xenopus tropicalis (tropical clawed frog)	srr	NP_001120018.1
Gallus gallus (chicken)	SRR	XP_001234891.1
Danio rerio (zebrafish)	si:ch73-263o4.3	XP_002661510.3
Schizosaccharomyces pombe (fission yeast)	SPCC320.14	NP_587715.1
Homo sapiens (human)	SRR	NP_068766.1
Pan troglodytes (chimpanzee)	SRR	XP_001156186.1
Bos taurus (cattle)	SRR	NP_001071433.1
Mus musculus (house mouse)	Srr	NP_038789.1
Danio rerio (zebrafish)	si:ch73-263o4.4	XP_002661511.2
Saccharomyces cerevisiae (baker's yeast)	SRY1	NP_012704.1
Rattus norvegicus (Norway rat)	Srr	NP_942052.1
Arabidopsis thaliana (thale cress)	SR	NP_192901.2
Oryza sativa (rice)	Os04g0555900	NP_001053521.1

Gene Ontology
Bibliography

Related articles in PubMed

Serine racemase inhibition induces nitric oxide-mediated neurovascular protection during cerebral ischemia.
Watanabe A, Sasaki T, Yukami T, Kanki H, Sakaguchi M, Takemori H, Kitagawa K, Mochizuki H
Neuroscience339139-149(2016 Dec)

Serine racemase is involved in d-aspartate biosynthesis.
Ito T, Hayashida M, Kobayashi S, Muto N, Hayashi A, Yoshimura T, Mori H
Journal of biochemistry160(6)345-353(2016 Dec)

Reduced serine racemase expression in aging rat cerebellum is associated with oxidative DNA stress and hypermethylation in the promoter.
Zhang H, Kuang XL, Chang Y, Lu J, Jiang H, Wu S
Brain research1629221-30(2015 Dec)

Nuclear Compartmentalization of Serine Racemase Regulates D-Serine Production: IMPLICATIONS FOR N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ACTIVATION.
Kolodney G, Dumin E, Safory H, Rosenberg D, Mori H, Radzishevsky I, Radzishevisky I, Wolosker H
The Journal of biological chemistry290(52)31037-50(2015 Dec)

Understanding the reaction mechanism and intermediate stabilization in mammalian serine racemase using multiscale quantum-classical simulations.
Nitoker N, Major DT
Biochemistry54(2)516-27(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study to demonstrate that serine racemase inhibitor alleviates neuronal ischemic injury. Serine racemase inhibition acts on the neurovascular unit as a neuroprotectant and ameliorant of reductions in regional cerebral blood flow.
Title: Serine racemase inhibition induces nitric oxide-mediated neurovascular protection during cerebral ischemia.

results indicate that SRR indeed acts as a d-Asp biosynthetic enzyme in some organs and/or tissues, and also provide evidences that there should be some additional enzyme for d-Asp synthesis in mammals.
Title: Serine racemase is involved in d-aspartate biosynthesis.

In aging cerebellum, oxidative DNA stress was associated with reduced serine racemase expression.
Title: Reduced serine racemase expression in aging rat cerebellum is associated with oxidative DNA stress and hypermethylation in the promoter.

that nuclear translocation of SR provides a fail-safe mechanism to prevent or limit secondary NMDAR-mediated toxicity in nearby synapses.
Title: Nuclear Compartmentalization of Serine Racemase Regulates D-Serine Production: IMPLICATIONS FOR N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ACTIVATION.

In serine racemase, similarly to the related enzyme alanine racemase, the unprotonated pyridoxal-5'-phosphate -substrate intermediate is stabilized mostly due to solvation effects contributed by water molecules and active-site residues.
Title: Understanding the reaction mechanism and intermediate stabilization in mammalian serine racemase using multiscale quantum-classical simulations.

The following Srr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Srr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa04977	NM_198757.2 Latest version!	Rattus norvegicus serine racemase (Srr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa04977	XM_008768015.2 Latest version!	Rattus norvegicus serine racemase (Srr), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa57353	XM_017597302.1 Latest version!	Rattus norvegicus serine racemase (Srr), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Srr ( NM_198757.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_942052.1 Rattus norvegicus serine racemase (Srr), mRNA.

Price & Availability↑

CloneID	ORa04977
Clone ID Related Accession (Same CDS sequence)	XM_008768015.2 , NM_198757.2
Accession Version	NM_198757.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	serine racemase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC082014.1. On Sep 16, 2004 this sequence version replaced NM_198757.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC082014.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTGTGCTC AGTACTGCAT CTCCTTTGCT GATGTTGAAA AAGCTCATCT CAACATTCAA 
GACTCTGTCC ACCTCACACC AGTGCTAACA AGCTCCATTT TGAATCAAAT AGCAGGGCGC 
AATCTCTTCT TCAAATGTGA ACTCTTCCAG AAAACTGGGT CTTTTAAGAT TCGAGGTGCC 
CTTAACGCCA TCAGAGGCTT AATTCCTGAT ACTTTAGAAG GGAAGCCCAA AGCCGTTGTT 
ACTCACAGCA GTGGAAACCA TGGCCAGGCT CTCACCTATG CTGCTAAACT GGAAGGAATT 
CCTGCTTACA TTGTGGTGCC CCAAACAGCT CCCAATTGCA AGAAACTGGC CATCCAAGCC 
TACGGAGCAT CTATAGTATA CAGTGAACCG AGTGATGAGT CCAGAGAAAA CGTCGCTCAA 
CGAATTATAC AAGAAACAGA AGGCATCTTG GTCCATCCCA ACCAGGAGCC TGCAGTGATA 
GCGGGACAAG GGACAATTGC CCTAGAAGTG CTGAACCAGG TTCCCTTGGT AGATGCGTTG 
GTGGTACCAG TAGGAGGAGG AGGAATGGTT GCTGGAATAG CCATTACAAT TAAGACCCTG 
AAACCTAGCG TGAAGGTGTA CGCTGCTGAA CCTTCCAATG CAGATGACTG CTACCAGTCT 
AAGCTGAAAG GAGAGCTGAC CCCCAATCTT CATCCTCCAG AGACCATAGC AGATGGCGTC 
AAGTCCAGCA TTGGCTTAAA TACCTGGCCT ATTATAAGGG ACCTTGTGGA CGATGTCTTC 
ACTGTCACGG AAGATGAAAT CAAGTATGCA ACCCAGCTGG TGTGGGAAAG AATGAAACTG 
CTCATTGAGC CTACTGCTGG CGTCGGATTG GCTGCAGTGC TATCTCAGCA TTTCCAAACT 
GTCTCTCCAG AAGTAAAGAA CATCTGTATT GTACTCAGTG GTGGGAATGT AGACTTAACC 
TCCCTAAGCT GGGTGAAGCA GGCGGAACGG CCGGCTCCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_942052.1
CDS	330..1331
Translation	MCAQYCISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGVKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSLSWVKQAERPAP

Target ORF information:

RefSeq Version	NM_198757.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serine racemase (Srr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198757.2

ORF Insert Sequence:

ATGTGTGCTC AGTACTGCAT CTCCTTTGCT GATGTTGAAA AAGCTCATCT CAACATTCAA 
GACTCTGTCC ACCTCACACC AGTGCTAACA AGCTCCATTT TGAATCAAAT AGCAGGGCGC 
AATCTCTTCT TCAAATGTGA ACTCTTCCAG AAAACTGGGT CTTTTAAGAT TCGAGGTGCC 
CTTAACGCCA TCAGAGGCTT AATTCCTGAT ACTTTAGAAG GGAAGCCCAA AGCCGTTGTT 
ACTCACAGCA GTGGAAACCA TGGCCAGGCT CTCACCTATG CTGCTAAACT GGAAGGAATT 
CCTGCTTACA TTGTGGTGCC CCAAACAGCT CCCAATTGCA AGAAACTGGC CATCCAAGCC 
TACGGAGCAT CTATAGTATA CAGTGAACCG AGTGATGAGT CCAGAGAAAA CGTCGCTCAA 
CGAATTATAC AAGAAACAGA AGGCATCTTG GTCCATCCCA ACCAGGAGCC TGCAGTGATA 
GCGGGACAAG GGACAATTGC CCTAGAAGTG CTGAACCAGG TTCCCTTGGT AGATGCGTTG 
GTGGTACCAG TAGGAGGAGG AGGAATGGTT GCTGGAATAG CCATTACAAT TAAGACCCTG 
AAACCTAGCG TGAAGGTGTA CGCTGCTGAA CCTTCCAATG CAGATGACTG CTACCAGTCT 
AAGCTGAAAG GAGAGCTGAC CCCCAATCTT CATCCTCCAG AGACCATAGC AGATGGCGTC 
AAGTCCAGCA TTGGCTTAAA TACCTGGCCT ATTATAAGGG ACCTTGTGGA CGATGTCTTC 
ACTGTCACGG AAGATGAAAT CAAGTATGCA ACCCAGCTGG TGTGGGAAAG AATGAAACTG 
CTCATTGAGC CTACTGCTGG CGTCGGATTG GCTGCAGTGC TATCTCAGCA TTTCCAAACT 
GTCTCTCCAG AAGTAAAGAA CATCTGTATT GTACTCAGTG GTGGGAATGT AGACTTAACC 
TCCCTAAGCT GGGTGAAGCA GGCGGAACGG CCGGCTCCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Srr ( XM_008768015.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766237.1 Rattus norvegicus serine racemase (Srr), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa04977
Clone ID Related Accession (Same CDS sequence)	XM_008768015.2 , NM_198757.2
Accession Version	XM_008768015.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serine racemase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008768015.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGTGCTC AGTACTGCAT CTCCTTTGCT GATGTTGAAA AAGCTCATCT CAACATTCAA 
GACTCTGTCC ACCTCACACC AGTGCTAACA AGCTCCATTT TGAATCAAAT AGCAGGGCGC 
AATCTCTTCT TCAAATGTGA ACTCTTCCAG AAAACTGGGT CTTTTAAGAT TCGAGGTGCC 
CTTAACGCCA TCAGAGGCTT AATTCCTGAT ACTTTAGAAG GGAAGCCCAA AGCCGTTGTT 
ACTCACAGCA GTGGAAACCA TGGCCAGGCT CTCACCTATG CTGCTAAACT GGAAGGAATT 
CCTGCTTACA TTGTGGTGCC CCAAACAGCT CCCAATTGCA AGAAACTGGC CATCCAAGCC 
TACGGAGCAT CTATAGTATA CAGTGAACCG AGTGATGAGT CCAGAGAAAA CGTCGCTCAA 
CGAATTATAC AAGAAACAGA AGGCATCTTG GTCCATCCCA ACCAGGAGCC TGCAGTGATA 
GCGGGACAAG GGACAATTGC CCTAGAAGTG CTGAACCAGG TTCCCTTGGT AGATGCGTTG 
GTGGTACCAG TAGGAGGAGG AGGAATGGTT GCTGGAATAG CCATTACAAT TAAGACCCTG 
AAACCTAGCG TGAAGGTGTA CGCTGCTGAA CCTTCCAATG CAGATGACTG CTACCAGTCT 
AAGCTGAAAG GAGAGCTGAC CCCCAATCTT CATCCTCCAG AGACCATAGC AGATGGCGTC 
AAGTCCAGCA TTGGCTTAAA TACCTGGCCT ATTATAAGGG ACCTTGTGGA CGATGTCTTC 
ACTGTCACGG AAGATGAAAT CAAGTATGCA ACCCAGCTGG TGTGGGAAAG AATGAAACTG 
CTCATTGAGC CTACTGCTGG CGTCGGATTG GCTGCAGTGC TATCTCAGCA TTTCCAAACT 
GTCTCTCCAG AAGTAAAGAA CATCTGTATT GTACTCAGTG GTGGGAATGT AGACTTAACC 
TCCCTAAGCT GGGTGAAGCA GGCGGAACGG CCGGCTCCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766237.1
CDS	143..1144
Translation	MCAQYCISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGVKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSLSWVKQAERPAP

Target ORF information:

RefSeq Version	XM_008768015.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serine racemase (Srr), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008768015.2

ORF Insert Sequence:

ATGTGTGCTC AGTACTGCAT CTCCTTTGCT GATGTTGAAA AAGCTCATCT CAACATTCAA 
GACTCTGTCC ACCTCACACC AGTGCTAACA AGCTCCATTT TGAATCAAAT AGCAGGGCGC 
AATCTCTTCT TCAAATGTGA ACTCTTCCAG AAAACTGGGT CTTTTAAGAT TCGAGGTGCC 
CTTAACGCCA TCAGAGGCTT AATTCCTGAT ACTTTAGAAG GGAAGCCCAA AGCCGTTGTT 
ACTCACAGCA GTGGAAACCA TGGCCAGGCT CTCACCTATG CTGCTAAACT GGAAGGAATT 
CCTGCTTACA TTGTGGTGCC CCAAACAGCT CCCAATTGCA AGAAACTGGC CATCCAAGCC 
TACGGAGCAT CTATAGTATA CAGTGAACCG AGTGATGAGT CCAGAGAAAA CGTCGCTCAA 
CGAATTATAC AAGAAACAGA AGGCATCTTG GTCCATCCCA ACCAGGAGCC TGCAGTGATA 
GCGGGACAAG GGACAATTGC CCTAGAAGTG CTGAACCAGG TTCCCTTGGT AGATGCGTTG 
GTGGTACCAG TAGGAGGAGG AGGAATGGTT GCTGGAATAG CCATTACAAT TAAGACCCTG 
AAACCTAGCG TGAAGGTGTA CGCTGCTGAA CCTTCCAATG CAGATGACTG CTACCAGTCT 
AAGCTGAAAG GAGAGCTGAC CCCCAATCTT CATCCTCCAG AGACCATAGC AGATGGCGTC 
AAGTCCAGCA TTGGCTTAAA TACCTGGCCT ATTATAAGGG ACCTTGTGGA CGATGTCTTC 
ACTGTCACGG AAGATGAAAT CAAGTATGCA ACCCAGCTGG TGTGGGAAAG AATGAAACTG 
CTCATTGAGC CTACTGCTGG CGTCGGATTG GCTGCAGTGC TATCTCAGCA TTTCCAAACT 
GTCTCTCCAG AAGTAAAGAA CATCTGTATT GTACTCAGTG GTGGGAATGT AGACTTAACC 
TCCCTAAGCT GGGTGAAGCA GGCGGAACGG CCGGCTCCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Srr ( XM_017597302.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452791.1 Rattus norvegicus serine racemase (Srr), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa57353
Clone ID Related Accession (Same CDS sequence)	XM_017597302.1
Accession Version	XM_017597302.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serine racemase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGTGCTC AGTACTGCAT CTCCTTTGCT GATGTTGAAA AAGCTCATCT CAACATTCAA 
GACTCTGTCC ACCTCACACC AGTGCTAACA AGCTCCATTT TGAATCAAAT AGCAGGGCGC 
AATCTCTTCT TCAAATGTGA ACTCTTCCAG AAAACTGGGT CTTTTAAGAT TCGAGGTGCC 
CTTAACGCCA TCAGAGGCTT AATTCCTGAT ACTTTAGAAG GGAAGCCCAA AGCCGTTGTT 
ACTCACAGCA GTGGAAACCA TGGCCAGGCT CTCACCTATG CTGCTAAACT GGAAGGAATT 
CCTGCTTACA TTGTGGTGCC CCAAACAGCT CCCAATTGCA AGAAACTGGC CATCCAAGCC 
TACGGAGCAT CTATAGTATA CAGTGAACCG AGTGATGAGT CCAGAGAAAA CGTCGCTCAA 
CGAATTATAC AAGAAACAGA AGGCATCTTG GTCCATCCCA ACCAGGAGCC TGCAGTGATA 
GCGGGACAAG GGACAATTGC CCTAGAAGTG CTGAACCAGG TTCCCTTGGT AGATGCGTTG 
GTGGTACCAG TAGGAGGAGG AGGAATGGTT GCTGGAATAG CCATTACAAT TAAGACCCTG 
AAACCTAGCG TGAAGGTGTA CGCTGCTGAA CCTTCCAATG CAGATGACTG CTACCAGTCT 
AAGCTGAAAG GAGAGCTGAC CCCCAATCTT CATCCTCCAG AGACCATAGC AGATGGCGTC 
AAGTCCAGCA TTGGCTTAAA TACCTGGCCT ATTATAAGGG ACCTTGTGGA CGATGTCTTC 
ACTGTCACGG AAGATGAAAT CAAGGTAAAC TCAGATGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452791.1
CDS	328..1149
Translation	MCAQYCISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGVKSSIGLNTWPIIRDLVDDVFTVTEDEIKVNSDA

Target ORF information:

RefSeq Version	XM_017597302.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serine racemase (Srr), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597302.1

ORF Insert Sequence:

ATGTGTGCTC AGTACTGCAT CTCCTTTGCT GATGTTGAAA AAGCTCATCT CAACATTCAA 
GACTCTGTCC ACCTCACACC AGTGCTAACA AGCTCCATTT TGAATCAAAT AGCAGGGCGC 
AATCTCTTCT TCAAATGTGA ACTCTTCCAG AAAACTGGGT CTTTTAAGAT TCGAGGTGCC 
CTTAACGCCA TCAGAGGCTT AATTCCTGAT ACTTTAGAAG GGAAGCCCAA AGCCGTTGTT 
ACTCACAGCA GTGGAAACCA TGGCCAGGCT CTCACCTATG CTGCTAAACT GGAAGGAATT 
CCTGCTTACA TTGTGGTGCC CCAAACAGCT CCCAATTGCA AGAAACTGGC CATCCAAGCC 
TACGGAGCAT CTATAGTATA CAGTGAACCG AGTGATGAGT CCAGAGAAAA CGTCGCTCAA 
CGAATTATAC AAGAAACAGA AGGCATCTTG GTCCATCCCA ACCAGGAGCC TGCAGTGATA 
GCGGGACAAG GGACAATTGC CCTAGAAGTG CTGAACCAGG TTCCCTTGGT AGATGCGTTG 
GTGGTACCAG TAGGAGGAGG AGGAATGGTT GCTGGAATAG CCATTACAAT TAAGACCCTG 
AAACCTAGCG TGAAGGTGTA CGCTGCTGAA CCTTCCAATG CAGATGACTG CTACCAGTCT 
AAGCTGAAAG GAGAGCTGAC CCCCAATCTT CATCCTCCAG AGACCATAGC AGATGGCGTC 
AAGTCCAGCA TTGGCTTAAA TACCTGGCCT ATTATAAGGG ACCTTGTGGA CGATGTCTTC 
ACTGTCACGG AAGATGAAAT CAAGGTAAAC TCAGATGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Serine racemase inhibition induces nitric oxide-mediated neurovascular protection during cerebral ischemia.
Neuroscience339139-149(2016 Dec)
Watanabe A,Sasaki T,Yukami T,Kanki H,Sakaguchi M,Takemori H,Kitagawa K,Mochizuki H

Serine racemase is involved in d-aspartate biosynthesis.
Journal of biochemistry160(6)345-353(2016 Dec)
Ito T,Hayashida M,Kobayashi S,Muto N,Hayashi A,Yoshimura T,Mori H

Reduced serine racemase expression in aging rat cerebellum is associated with oxidative DNA stress and hypermethylation in the promoter.
Brain research1629221-30(2015 Dec)
Zhang H,Kuang XL,Chang Y,Lu J,Jiang H,Wu S

Nuclear Compartmentalization of Serine Racemase Regulates D-Serine Production: IMPLICATIONS FOR N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ACTIVATION.
The Journal of biological chemistry290(52)31037-50(2015 Dec)
Kolodney G,Dumin E,Safory H,Rosenberg D,Mori H,Radzishevsky I,Radzishevisky I,Wolosker H

Understanding the reaction mechanism and intermediate stabilization in mammalian serine racemase using multiscale quantum-classical simulations.
Biochemistry54(2)516-27(2015 Jan)
Nitoker N,Major DT

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Srr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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