Maml1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Maml1
Entrez Gene ID	303101
Full Name	mastermind-like transcriptional coactivator 1
General protein information	Preferred Names mastermind-like transcriptional coactivator 1 Names mastermind-like protein 1 mastermind like 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q22

mRNA and Protein(s)

mRNA	Protein	Name
XM_006246251.2	XP_006246313.1	mastermind-like protein 1 isoform X1
NM_001106997.1	NP_001100467.1	mastermind-like protein 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Maml1	NP_001100467.1
Homo sapiens (human)	MAML1	NP_055572.1
	MAML1	XP_001105097.2
Bos taurus (cattle)	MAML1	XP_005208449.1
Gallus gallus (chicken)	MAML1	XP_414607.4
Mus musculus (house mouse)	Maml1	NP_780543.2
Danio rerio (zebrafish)	LOC567335	XP_005157273.1
Pan troglodytes (chimpanzee)	MAML1	XP_527150.3
Canis lupus familiaris (dog)	MAML1	XP_005626406.1
Xenopus tropicalis (tropical clawed frog)	maml1	XP_002941844.2

Gene Ontology
Bibliography

Related articles in PubMed

Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate.
Wang SY, Ren M, Jiang HZ, Wang J, Jiang HQ, Yin X, Qi Y, Wang XD, Dong GT, Wang TH, Yang YQ, Feng HL
Neuroscience301276-88(2015 Aug)

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.
Tiberi L, van den Ameele J, Dimidschstein J, Piccirilli J, Gall D, Herpoel A, Bilheu A, Bonnefont J, Iacovino M, Kyba M, Bouschet T, Vanderhaeghen P
Nature neuroscience15(12)1627-35(2012 Dec)

Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways.
Rentschler S, Harris BS, Kuznekoff L, Jain R, Manderfield L, Lu MM, Morley GE, Patel VV, Epstein JA
The Journal of clinical investigation121(2)525-33(2011 Feb)

Cell and molecular biology of Notch.
Fi?za UM, Arias AM
The Journal of endocrinology194(3)459-74(2007 Sep)

The notch regulator MAML1 interacts with p53 and functions as a coactivator.
Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V
The Journal of biological chemistry282(16)11969-81(2007 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Maml1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Maml1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05081	NM_001106997.1 Latest version!	Rattus norvegicus mastermind-like transcriptional coactivator 1 (Maml1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$461.30 $659.00
ORa33033	XM_006246251.2 Latest version!	Rattus norvegicus mastermind-like transcriptional coactivator 1 (Maml1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$559.30 $799.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Maml1 ( NM_001106997.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100467.1 Rattus norvegicus mastermind-like transcriptional coactivator 1 (Maml1), mRNA.

Price & Availability↑

CloneID	ORa05081
Clone ID Related Accession (Same CDS sequence)	NM_001106997.1
Accession Version	NM_001106997.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2355bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	mastermind-like protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473948.1. On or before Oct 4, 2007 this sequence version replaced XM_220373.4, XM_001071703.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGATCGCAG GGGCTGGCAG CTCTGTAGCT CAGAGCAACC TCATGCCTGA CCTCAACCTT 
AATGAGCAGG AGTGGAAGGA GCTCATCGAA GAGCTCAACA GGTCAGTGCC TGACGAAGAC 
ATGAAGGACC TGTTTACTGA GGACTTTGAG GAGAAGAAGG ATCCAGAGCC CCCTGGTTCT 
GCCACACAAA CCCCCTTGGC CCAGGACATT AATATCAAGA CTGAGTTCTC TCCAGCAGCC 
TTTGAGCAGG AGCAGTTAGG TTCTCCACAA GTAAGGGCTG GGTCTGCAGG CCAGACCTTT 
CTAGCACCCT CATCTGCCCC TGTGGGCACA GATTCTCCCA GCCTTGGGAA CTCTCAGACT 
CTGTTTCACA CCACTGGTCA ACCTGGGGTG GATAGTTCCA GTCCAAACCT GATGCCGGCA 
TCAGCCCAGG CCCAGAATGC ACCAAGAGCC CTCACAAGTG TGGTATTACC TAGCCAGGGC 
CCAGGAGGGG CCTCGGAGCT GTCCTCTGCT CACCAGCTCC AACAGATAGC TGCCAAGCAG 
AAACGTGAGC AGATGCTGCA GAATCCACAG CAAACTGCCC CAGCACCTGG CCCAGGCCAG 
CTGTCCACGT GGCAGCAGGC AGGACCCTCT CACAGTCCCT TAGATGCTCC TTATCCCATG 
GAGAAGCCTG CCAGCCCTTC TGGCTATAAG CAAGACTTTA CCAACTCAAA ACTGCTCATG 
ATGCCTAGTG TGAACAAGAG TTCTCCTCGG CCAGGAGGCC CCTACCTCCA ACCTAGCCAC 
TCCAACCTGC TGAGTCACCA GTCACCAAGT AACTTGAATC CGAACCCTGT GAACAACCAA 
GGGTCCATGC TAGATTATGG CAATACAAAA CCCCTGTCTC ATTACAAAGC AGACTGTGGC 
CAAGGTGGCC CTGGGTCGGG CCAGAACAAA CCAGCTTTGA TGGCATATCT TCCCCAGCAG 
CTGCCTCATC TGAGTAATGA GCAGAACTCC TTGTTTCTGA TGAAACCAAA GCCAGGAAAC 
ATGCCCTTCC GGTCATTGGT TCCACCTGGC CAGGAGCAGA ATCCTTCCAG TGTCCCTGTA 
CCAGCCCCAG CTGCCAGTGT GGGAACCCAG CCTAGTGTGT CGGTGGCCAG CACTCACAGC 
AGCTCTTACC TCAGCAGCCA GCAGCAGGCA GCTGTGATGA AGCAGCACCA GCTGCTCCTG 
GACCAGCAGA AGCAGAGAGA GCAGCAGCAG CTGCAGCAAC AGCAGTTCCT GCAGAGGCAG 
CACCTCCTGG CTGAGCAGGA GAAGCAACAG TTTCAGCGTC ATCTGACCCG CCCACCCCCC 
CAGTACCAAG ACCCAACACA AAGCACCTTC CAACAACAGG TTGGACAGTT CACAGGACCT 
TCTGCTGCTG TGCCTGGAAT GAACAACTTG GGTCCATCCA ATTCCAGCTG TCCTCGAGTG 
TTCCCTCAGC CTGGGACTCT GATGTCAATG GGTCCTGGAC ATGCCCCTGT TTCCTCTCTC 
CCCCCAAGCT CAGGCCAGCA GGACCGTGGA GTGGCCCAGT TTACTGGGTC CCAGAGTTTG 
CCTCACAACA GCCTTTATGG CATGGCATCA GGCCTAGCCC AGATAGTTGC CCAGCCCCCA 
CCACAGGCTA CCAGCACACA TGCCCACATT CCACGGCAGA CCAATGTGGG CCAAAATGCC 
TCCACCTCAG CTGCATATGG ACAGAACTCT CTGGGGAGTG CCAGCCTCTC CCAGCAGCAC 
AGTAAGGGAA CCCTGCCTCC TGGTTTAGCA AAGCCACAAG TCCCAAGGGT ATCAGCAGCC 
ATGGGAAGCC AGAATCCCTC ATGGCAACAT CAGGGGATGC CAAACCTGAG CAGCCAGACA 
CCTGGGAACA GCAGTGTGAG CCCCTTCACT GCGGCTTCCA GTTTCCACAG ACAGCAAGCC 
CACCTGAAAA TGTCTGCTCA GCAGTTCTCC CAGGCCATGC CCACCAGGCC CATGGCTCCT 
CTGAGTTCAG CAGCTGCAGC AGGGCCCATG CTGCCCTCAG TGAGCACACA GCAGAGGAAC 
AGTGCCCCTG CCCCTGCCCC TCCCCAAGCA GCCTCACAGC AGGGCTTGCC TGGCTTAAGT 
CCTTCAGGGC CTGAGCTGGG GGCCTTCGGC CAGAGCCCCA CTTCCCAGAT GAACAGCAGG 
CCTGGGCTGC ACTGTGCTCA GGCTTACCCT GTGAGGACCA TGGGCCAAGA GCTTCCCTTC 
GCTTACAGCG GGCAGCCAGG CAGCAGTGGT CTGTCCAGTG TGGCTGGACA CACCGACCTG 
ATCGACTCGC TGCTGAAGAA CAGGACTTCC GAGGAGTGGA TCAATGAATT GGATGATCTT 
CTAGGGTCAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100467.1
CDS	956..3310
Translation	MIAGAGSSVAQSNLMPDLNLNEQEWKELIEELNRSVPDEDMKDLFTEDFEEKKDPEPPGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLAPSSAPVGTDSPSLGNSQTLFHTTGQPGVDSSSPNLMPASAQAQNAPRALTSVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQTAPAPGPGQLSTWQQAGPSHSPLDAPYPMEKPASPSGYKQDFTNSKLLMMPSVNKSSPRPGGPYLQPSHSNLLSHQSPSNLNPNPVNNQGSMLDYGNTKPLSHYKADCGQGGPGSGQNKPALMAYLPQQLPHLSNEQNSLFLMKPKPGNMPFRSLVPPGQEQNPSSVPVPAPAASVGTQPSVSVASTHSSSYLSSQQQAAVMKQHQLLLDQQKQREQQQLQQQQFLQRQHLLAEQEKQQFQRHLTRPPPQYQDPTQSTFQQQVGQFTGPSAAVPGMNNLGPSNSSCPRVFPQPGTLMSMGPGHAPVSSLPPSSGQQDRGVAQFTGSQSLPHNSLYGMASGLAQIVAQPPPQATSTHAHIPRQTNVGQNASTSAAYGQNSLGSASLSQQHSKGTLPPGLAKPQVPRVSAAMGSQNPSWQHQGMPNLSSQTPGNSSVSPFTAASSFHRQQAHLKMSAQQFSQAMPTRPMAPLSSAAAAGPMLPSVSTQQRNSAPAPAPPQAASQQGLPGLSPSGPELGAFGQSPTSQMNSRPGLHCAQAYPVRTMGQELPFAYSGQPGSSGLSSVAGHTDLIDSLLKNRTSEEWINELDDLLGSQ

Target ORF information:

RefSeq Version	NM_001106997.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mastermind-like transcriptional coactivator 1 (Maml1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106997.1

ORF Insert Sequence:

ATGATCGCAG GGGCTGGCAG CTCTGTAGCT CAGAGCAACC TCATGCCTGA CCTCAACCTT 
AATGAGCAGG AGTGGAAGGA GCTCATCGAA GAGCTCAACA GGTCAGTGCC TGACGAAGAC 
ATGAAGGACC TGTTTACTGA GGACTTTGAG GAGAAGAAGG ATCCAGAGCC CCCTGGTTCT 
GCCACACAAA CCCCCTTGGC CCAGGACATT AATATCAAGA CTGAGTTCTC TCCAGCAGCC 
TTTGAGCAGG AGCAGTTAGG TTCTCCACAA GTAAGGGCTG GGTCTGCAGG CCAGACCTTT 
CTAGCACCCT CATCTGCCCC TGTGGGCACA GATTCTCCCA GCCTTGGGAA CTCTCAGACT 
CTGTTTCACA CCACTGGTCA ACCTGGGGTG GATAGTTCCA GTCCAAACCT GATGCCGGCA 
TCAGCCCAGG CCCAGAATGC ACCAAGAGCC CTCACAAGTG TGGTATTACC TAGCCAGGGC 
CCAGGAGGGG CCTCGGAGCT GTCCTCTGCT CACCAGCTCC AACAGATAGC TGCCAAGCAG 
AAACGTGAGC AGATGCTGCA GAATCCACAG CAAACTGCCC CAGCACCTGG CCCAGGCCAG 
CTGTCCACGT GGCAGCAGGC AGGACCCTCT CACAGTCCCT TAGATGCTCC TTATCCCATG 
GAGAAGCCTG CCAGCCCTTC TGGCTATAAG CAAGACTTTA CCAACTCAAA ACTGCTCATG 
ATGCCTAGTG TGAACAAGAG TTCTCCTCGG CCAGGAGGCC CCTACCTCCA ACCTAGCCAC 
TCCAACCTGC TGAGTCACCA GTCACCAAGT AACTTGAATC CGAACCCTGT GAACAACCAA 
GGGTCCATGC TAGATTATGG CAATACAAAA CCCCTGTCTC ATTACAAAGC AGACTGTGGC 
CAAGGTGGCC CTGGGTCGGG CCAGAACAAA CCAGCTTTGA TGGCATATCT TCCCCAGCAG 
CTGCCTCATC TGAGTAATGA GCAGAACTCC TTGTTTCTGA TGAAACCAAA GCCAGGAAAC 
ATGCCCTTCC GGTCATTGGT TCCACCTGGC CAGGAGCAGA ATCCTTCCAG TGTCCCTGTA 
CCAGCCCCAG CTGCCAGTGT GGGAACCCAG CCTAGTGTGT CGGTGGCCAG CACTCACAGC 
AGCTCTTACC TCAGCAGCCA GCAGCAGGCA GCTGTGATGA AGCAGCACCA GCTGCTCCTG 
GACCAGCAGA AGCAGAGAGA GCAGCAGCAG CTGCAGCAAC AGCAGTTCCT GCAGAGGCAG 
CACCTCCTGG CTGAGCAGGA GAAGCAACAG TTTCAGCGTC ATCTGACCCG CCCACCCCCC 
CAGTACCAAG ACCCAACACA AAGCACCTTC CAACAACAGG TTGGACAGTT CACAGGACCT 
TCTGCTGCTG TGCCTGGAAT GAACAACTTG GGTCCATCCA ATTCCAGCTG TCCTCGAGTG 
TTCCCTCAGC CTGGGACTCT GATGTCAATG GGTCCTGGAC ATGCCCCTGT TTCCTCTCTC 
CCCCCAAGCT CAGGCCAGCA GGACCGTGGA GTGGCCCAGT TTACTGGGTC CCAGAGTTTG 
CCTCACAACA GCCTTTATGG CATGGCATCA GGCCTAGCCC AGATAGTTGC CCAGCCCCCA 
CCACAGGCTA CCAGCACACA TGCCCACATT CCACGGCAGA CCAATGTGGG CCAAAATGCC 
TCCACCTCAG CTGCATATGG ACAGAACTCT CTGGGGAGTG CCAGCCTCTC CCAGCAGCAC 
AGTAAGGGAA CCCTGCCTCC TGGTTTAGCA AAGCCACAAG TCCCAAGGGT ATCAGCAGCC 
ATGGGAAGCC AGAATCCCTC ATGGCAACAT CAGGGGATGC CAAACCTGAG CAGCCAGACA 
CCTGGGAACA GCAGTGTGAG CCCCTTCACT GCGGCTTCCA GTTTCCACAG ACAGCAAGCC 
CACCTGAAAA TGTCTGCTCA GCAGTTCTCC CAGGCCATGC CCACCAGGCC CATGGCTCCT 
CTGAGTTCAG CAGCTGCAGC AGGGCCCATG CTGCCCTCAG TGAGCACACA GCAGAGGAAC 
AGTGCCCCTG CCCCTGCCCC TCCCCAAGCA GCCTCACAGC AGGGCTTGCC TGGCTTAAGT 
CCTTCAGGGC CTGAGCTGGG GGCCTTCGGC CAGAGCCCCA CTTCCCAGAT GAACAGCAGG 
CCTGGGCTGC ACTGTGCTCA GGCTTACCCT GTGAGGACCA TGGGCCAAGA GCTTCCCTTC 
GCTTACAGCG GGCAGCCAGG CAGCAGTGGT CTGTCCAGTG TGGCTGGACA CACCGACCTG 
ATCGACTCGC TGCTGAAGAA CAGGACTTCC GAGGAGTGGA TCAATGAATT GGATGATCTT 
CTAGGGTCAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Maml1 ( XM_006246251.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006246313.1 Rattus norvegicus mastermind-like transcriptional coactivator 1 (Maml1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa33033
Clone ID Related Accession (Same CDS sequence)	XM_006246251.2
Accession Version	XM_006246251.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3054bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mastermind-like protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006246251.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGCTAC CCACCTGCCC CATGGCGGAG TTCGCGCTGC CGCGGCACAG CGCGGTCATG 
GAGCGCCTCC GCCGACGCAT CGAGCTGTGC CGGCGCCACC ACAGCACCTG TGAGGCCCGC 
TACGAGGCTG TGTCTCCCGA GCGCCTGGAG CTCGAACGCC AGCATACCTT TGCCCTGCAC 
CAGCGCTGCA TCCAGGCCAA GGCCAAGCGC GCCGGCAAGC ACCGGCAGCC GCCCGCCGCC 
GCCACGGGCC CGGGAGCCGC TCCGGCCCCC GCCCCGGGCC CAGCGGCTGC GCGCCTGGAC 
TCAGCGGACG GCCCGGAGAA CGGCCGCCCG GTCGCGCATC TCCATGATCC AGTGAAGAGG 
AGTCTTGACA GCGCTGCCTC CCCTCAGAAT GGCGATCAAC CAAATGGCTA CGGAGACCTG 
TTTCCTGGGC ATAAGAAGAC CCGCCGGGAG GCCCCTCTGG GGGTCAGTGT ATCTGCCAAT 
GGGCTTCCTC CTGCTTCACC CCTGGGTCAG CCTGACAAGC CTCCTGTGGG AGATGCCCTG 
CAAACTGGTG GGAAGCATTC CCTGGGGCTA GATCCCATCA ACAAGAAATG TCTGGCAGAC 
TCAAGCATCC ACCTGAATGG AGGCAGCAAC TCCAGTGAGC CGTTCCCTCT AAGCCTGAGT 
AAGGAACTCA AGCAAGAGCC AGTGGACGAC CTGCCATGCA TGATCGCAGG GGCTGGCAGC 
TCTGTAGCTC AGAGCAACCT CATGCCTGAC CTCAACCTTA ATGAGCAGGA GTGGAAGGAG 
CTCATCGAAG AGCTCAACAG GTCAGTGCCT GACGAAGACA TGAAGGACCT GTTTACTGAG 
GACTTTGAGG AGAAGAAGGA TCCAGAGCCC CCTGGTTCTG CCACACAAAC CCCCTTGGCC 
CAGGACATTA ATATCAAGAC TGAGTTCTCT CCAGCAGCCT TTGAGCAGGA GCAGTTAGGT 
TCTCCACAAG TAAGGGCTGG GTCTGCAGGC CAGACCTTTC TAGCACCCTC ATCTGCCCCT 
GTGGGCACAG ATTCTCCCAG CCTTGGGAAC TCTCAGACTC TGTTTCACAC CACTGGTCAA 
CCTGGGGTGG ATAGTTCCAG TCCAAACCTG ATGCCGGCAT CAGCCCAGGC CCAGAATGCA 
CCAAGAGCCC TCACAAGTGT GGTATTACCT AGCCAGGGCC CAGGAGGGGC CTCGGAGCTG 
TCCTCTGCTC ACCAGCTCCA ACAGATAGCT GCCAAGCAGA AACGTGAGCA GATGCTGCAG 
AATCCACAGC AAACTGCCCC AGCACCTGGC CCAGGCCAGC TGTCCACGTG GCAGCAGGCA 
GGACCCTCTC ACAGTCCCTT AGATGCTCCT TATCCCATGG AGAAGCCTGC CAGCCCTTCT 
GGCTATAAGC AAGACTTTAC CAACTCAAAA CTGCTCATGA TGCCTAGTGT GAACAAGAGT 
TCTCCTCGGC CAGGAGGCCC CTACCTCCAA CCTAGCCACT CCAACCTGCT GAGTCACCAG 
TCACCAAGTA ACTTGAATCC GAACCCTGTG AACAACCAAG GGTCCATGCT AGATTATGGC 
AATACAAAAC CCCTGTCTCA TTACAAAGCA GACTGTGGCC AAGGTGGCCC TGGGTCGGGC 
CAGAACAAAC CAGCTTTGAT GGCATATCTT CCCCAGCAGC TGCCTCATCT GAGTAATGAG 
CAGAACTCCT TGTTTCTGAT GAAACCAAAG CCAGGAAACA TGCCCTTCCG GTCATTGGTT 
CCACCTGGCC AGGAGCAGAA TCCTTCCAGT GTCCCTGTAC CAGCCCCAGC TGCCAGTGTG 
GGAACCCAGC CTAGTGTGTC GGTGGCCAGC ACTCACAGCA GCTCTTACCT CAGCAGCCAG 
CAGCAGGCAG CTGTGATGAA GCAGCACCAG CTGCTCCTGG ACCAGCAGAA GCAGAGAGAG 
CAGCAGCAGC TGCAGCAACA GCAGTTCCTG CAGAGGCAGC ACCTCCTGGC TGAGCAGGAG 
AAGCAACAGT TTCAGCGTCA TCTGACCCGC CCACCCCCCC AGTACCAAGA CCCAACACAA 
AGCACCTTCC AACAACAGGT TGGACAGTTC ACAGGACCTT CTGCTGCTGT GCCTGGAATG 
AACAACTTGG GTCCATCCAA TTCCAGCTGT CCTCGAGTGT TCCCTCAGCC TGGGACTCTG 
ATGTCAATGG GTCCTGGACA TGCCCCTGTT TCCTCTCTCC CCCCAAGCTC AGGCCAGCAG 
GACCGTGGAG TGGCCCAGTT TACTGGGTCC CAGAGTTTGC CTCACAACAG CCTTTATGGC 
ATGGCATCAG GCCTAGCCCA GATAGTTGCC CAGCCCCCAC CACAGGCTAC CAGCACACAT 
GCCCACATTC CACGGCAGAC CAATGTGGGC CAAAATGCCT CCACCTCAGC TGCATATGGA 
CAGAACTCTC TGGGGAGTGC CAGCCTCTCC CAGCAGCACA GTAAGGGAAC CCTGCCTCCT 
GGTTTAGCAA AGCCACAAGT CCCAAGGGTA TCAGCAGCCA TGGGAAGCCA GAATCCCTCA 
TGGCAACATC AGGGGATGCC AAACCTGAGC AGCCAGACAC CTGGGAACAG CAGTGTGAGC 
CCCTTCACTG CGGCTTCCAG TTTCCACAGA CAGCAAGCCC ACCTGAAAAT GTCTGCTCAG 
CAGTTCTCCC AGGCCATGCC CACCAGGCCC ATGGCTCCTC TGAGTTCAGC AGCTGCAGCA 
GGGCCCATGC TGCCCTCAGT GAGCACACAG CAGAGGAACA GTGCCCCTGC CCCTGCCCCT 
CCCCAAGCAG CCTCACAGCA GGGCTTGCCT GGCTTAAGTC CTTCAGGGCC TGAGCTGGGG 
GCCTTCGGCC AGAGCCCCAC TTCCCAGATG AACAGCAGGC CTGGGCTGCA CTGTGCTCAG 
GCTTACCCTG TGAGGACCAT GGGCCAAGAG CTTCCCTTCG CTTACAGCGG GCAGCCAGGC 
AGCAGTGGTC TGTCCAGTGT GGCTGGACAC ACCGACCTGA TCGACTCGCT GCTGAAGAAC 
AGGACTTCCG AGGAGTGGAT CAATGAATTG GATGATCTTC TAGGGTCACA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006246313.1
CDS	1531..4584
Translation	MVLPTCPMAEFALPRHSAVMERLRRRIELCRRHHSTCEARYEAVSPERLELERQHTFALHQRCIQAKAKRAGKHRQPPAAATGPGAAPAPAPGPAAARLDSADGPENGRPVAHLHDPVKRSLDSAASPQNGDQPNGYGDLFPGHKKTRREAPLGVSVSANGLPPASPLGQPDKPPVGDALQTGGKHSLGLDPINKKCLADSSIHLNGGSNSSEPFPLSLSKELKQEPVDDLPCMIAGAGSSVAQSNLMPDLNLNEQEWKELIEELNRSVPDEDMKDLFTEDFEEKKDPEPPGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLAPSSAPVGTDSPSLGNSQTLFHTTGQPGVDSSSPNLMPASAQAQNAPRALTSVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQTAPAPGPGQLSTWQQAGPSHSPLDAPYPMEKPASPSGYKQDFTNSKLLMMPSVNKSSPRPGGPYLQPSHSNLLSHQSPSNLNPNPVNNQGSMLDYGNTKPLSHYKADCGQGGPGSGQNKPALMAYLPQQLPHLSNEQNSLFLMKPKPGNMPFRSLVPPGQEQNPSSVPVPAPAASVGTQPSVSVASTHSSSYLSSQQQAAVMKQHQLLLDQQKQREQQQLQQQQFLQRQHLLAEQEKQQFQRHLTRPPPQYQDPTQSTFQQQVGQFTGPSAAVPGMNNLGPSNSSCPRVFPQPGTLMSMGPGHAPVSSLPPSSGQQDRGVAQFTGSQSLPHNSLYGMASGLAQIVAQPPPQATSTHAHIPRQTNVGQNASTSAAYGQNSLGSASLSQQHSKGTLPPGLAKPQVPRVSAAMGSQNPSWQHQGMPNLSSQTPGNSSVSPFTAASSFHRQQAHLKMSAQQFSQAMPTRPMAPLSSAAAAGPMLPSVSTQQRNSAPAPAPPQAASQQGLPGLSPSGPELGAFGQSPTSQMNSRPGLHCAQAYPVRTMGQELPFAYSGQPGSSGLSSVAGHTDLIDSLLKNRTSEEWINELDDLLGSQ

Target ORF information:

RefSeq Version	XM_006246251.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mastermind-like transcriptional coactivator 1 (Maml1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006246251.2

ORF Insert Sequence:

ATGGTGCTAC CCACCTGCCC CATGGCGGAG TTCGCGCTGC CGCGGCACAG CGCGGTCATG 
GAGCGCCTCC GCCGACGCAT CGAGCTGTGC CGGCGCCACC ACAGCACCTG TGAGGCCCGC 
TACGAGGCTG TGTCTCCCGA GCGCCTGGAG CTCGAACGCC AGCATACCTT TGCCCTGCAC 
CAGCGCTGCA TCCAGGCCAA GGCCAAGCGC GCCGGCAAGC ACCGGCAGCC GCCCGCCGCC 
GCCACGGGCC CGGGAGCCGC TCCGGCCCCC GCCCCGGGCC CAGCGGCTGC GCGCCTGGAC 
TCAGCGGACG GCCCGGAGAA CGGCCGCCCG GTCGCGCATC TCCATGATCC AGTGAAGAGG 
AGTCTTGACA GCGCTGCCTC CCCTCAGAAT GGCGATCAAC CAAATGGCTA CGGAGACCTG 
TTTCCTGGGC ATAAGAAGAC CCGCCGGGAG GCCCCTCTGG GGGTCAGTGT ATCTGCCAAT 
GGGCTTCCTC CTGCTTCACC CCTGGGTCAG CCTGACAAGC CTCCTGTGGG AGATGCCCTG 
CAAACTGGTG GGAAGCATTC CCTGGGGCTA GATCCCATCA ACAAGAAATG TCTGGCAGAC 
TCAAGCATCC ACCTGAATGG AGGCAGCAAC TCCAGTGAGC CGTTCCCTCT AAGCCTGAGT 
AAGGAACTCA AGCAAGAGCC AGTGGACGAC CTGCCATGCA TGATCGCAGG GGCTGGCAGC 
TCTGTAGCTC AGAGCAACCT CATGCCTGAC CTCAACCTTA ATGAGCAGGA GTGGAAGGAG 
CTCATCGAAG AGCTCAACAG GTCAGTGCCT GACGAAGACA TGAAGGACCT GTTTACTGAG 
GACTTTGAGG AGAAGAAGGA TCCAGAGCCC CCTGGTTCTG CCACACAAAC CCCCTTGGCC 
CAGGACATTA ATATCAAGAC TGAGTTCTCT CCAGCAGCCT TTGAGCAGGA GCAGTTAGGT 
TCTCCACAAG TAAGGGCTGG GTCTGCAGGC CAGACCTTTC TAGCACCCTC ATCTGCCCCT 
GTGGGCACAG ATTCTCCCAG CCTTGGGAAC TCTCAGACTC TGTTTCACAC CACTGGTCAA 
CCTGGGGTGG ATAGTTCCAG TCCAAACCTG ATGCCGGCAT CAGCCCAGGC CCAGAATGCA 
CCAAGAGCCC TCACAAGTGT GGTATTACCT AGCCAGGGCC CAGGAGGGGC CTCGGAGCTG 
TCCTCTGCTC ACCAGCTCCA ACAGATAGCT GCCAAGCAGA AACGTGAGCA GATGCTGCAG 
AATCCACAGC AAACTGCCCC AGCACCTGGC CCAGGCCAGC TGTCCACGTG GCAGCAGGCA 
GGACCCTCTC ACAGTCCCTT AGATGCTCCT TATCCCATGG AGAAGCCTGC CAGCCCTTCT 
GGCTATAAGC AAGACTTTAC CAACTCAAAA CTGCTCATGA TGCCTAGTGT GAACAAGAGT 
TCTCCTCGGC CAGGAGGCCC CTACCTCCAA CCTAGCCACT CCAACCTGCT GAGTCACCAG 
TCACCAAGTA ACTTGAATCC GAACCCTGTG AACAACCAAG GGTCCATGCT AGATTATGGC 
AATACAAAAC CCCTGTCTCA TTACAAAGCA GACTGTGGCC AAGGTGGCCC TGGGTCGGGC 
CAGAACAAAC CAGCTTTGAT GGCATATCTT CCCCAGCAGC TGCCTCATCT GAGTAATGAG 
CAGAACTCCT TGTTTCTGAT GAAACCAAAG CCAGGAAACA TGCCCTTCCG GTCATTGGTT 
CCACCTGGCC AGGAGCAGAA TCCTTCCAGT GTCCCTGTAC CAGCCCCAGC TGCCAGTGTG 
GGAACCCAGC CTAGTGTGTC GGTGGCCAGC ACTCACAGCA GCTCTTACCT CAGCAGCCAG 
CAGCAGGCAG CTGTGATGAA GCAGCACCAG CTGCTCCTGG ACCAGCAGAA GCAGAGAGAG 
CAGCAGCAGC TGCAGCAACA GCAGTTCCTG CAGAGGCAGC ACCTCCTGGC TGAGCAGGAG 
AAGCAACAGT TTCAGCGTCA TCTGACCCGC CCACCCCCCC AGTACCAAGA CCCAACACAA 
AGCACCTTCC AACAACAGGT TGGACAGTTC ACAGGACCTT CTGCTGCTGT GCCTGGAATG 
AACAACTTGG GTCCATCCAA TTCCAGCTGT CCTCGAGTGT TCCCTCAGCC TGGGACTCTG 
ATGTCAATGG GTCCTGGACA TGCCCCTGTT TCCTCTCTCC CCCCAAGCTC AGGCCAGCAG 
GACCGTGGAG TGGCCCAGTT TACTGGGTCC CAGAGTTTGC CTCACAACAG CCTTTATGGC 
ATGGCATCAG GCCTAGCCCA GATAGTTGCC CAGCCCCCAC CACAGGCTAC CAGCACACAT 
GCCCACATTC CACGGCAGAC CAATGTGGGC CAAAATGCCT CCACCTCAGC TGCATATGGA 
CAGAACTCTC TGGGGAGTGC CAGCCTCTCC CAGCAGCACA GTAAGGGAAC CCTGCCTCCT 
GGTTTAGCAA AGCCACAAGT CCCAAGGGTA TCAGCAGCCA TGGGAAGCCA GAATCCCTCA 
TGGCAACATC AGGGGATGCC AAACCTGAGC AGCCAGACAC CTGGGAACAG CAGTGTGAGC 
CCCTTCACTG CGGCTTCCAG TTTCCACAGA CAGCAAGCCC ACCTGAAAAT GTCTGCTCAG 
CAGTTCTCCC AGGCCATGCC CACCAGGCCC ATGGCTCCTC TGAGTTCAGC AGCTGCAGCA 
GGGCCCATGC TGCCCTCAGT GAGCACACAG CAGAGGAACA GTGCCCCTGC CCCTGCCCCT 
CCCCAAGCAG CCTCACAGCA GGGCTTGCCT GGCTTAAGTC CTTCAGGGCC TGAGCTGGGG 
GCCTTCGGCC AGAGCCCCAC TTCCCAGATG AACAGCAGGC CTGGGCTGCA CTGTGCTCAG 
GCTTACCCTG TGAGGACCAT GGGCCAAGAG CTTCCCTTCG CTTACAGCGG GCAGCCAGGC 
AGCAGTGGTC TGTCCAGTGT GGCTGGACAC ACCGACCTGA TCGACTCGCT GCTGAAGAAC 
AGGACTTCCG AGGAGTGGAT CAATGAATTG GATGATCTTC TAGGGTCACA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate.
Neuroscience301276-88(2015 Aug)
Wang SY,Ren M,Jiang HZ,Wang J,Jiang HQ,Yin X,Qi Y,Wang XD,Dong GT,Wang TH,Yang YQ,Feng HL

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.
Nature neuroscience15(12)1627-35(2012 Dec)
Tiberi L,van den Ameele J,Dimidschstein J,Piccirilli J,Gall D,Herpoel A,Bilheu A,Bonnefont J,Iacovino M,Kyba M,Bouschet T,Vanderhaeghen P

Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways.
The Journal of clinical investigation121(2)525-33(2011 Feb)
Rentschler S,Harris BS,Kuznekoff L,Jain R,Manderfield L,Lu MM,Morley GE,Patel VV,Epstein JA

Cell and molecular biology of Notch.
The Journal of endocrinology194(3)459-74(2007 Sep)
Fi?za UM,Arias AM

The notch regulator MAML1 interacts with p53 and functions as a coactivator.
The Journal of biological chemistry282(16)11969-81(2007 Apr)
Zhao Y,Katzman RB,Delmolino LM,Bhat I,Zhang Y,Gurumurthy CB,Germaniuk-Kurowska A,Reddi HV,Solomon A,Zeng MS,Kung A,Ma H,Gao Q,Dimri G,Stanculescu A,Miele L,Wu L,Griffin JD,Wazer DE,Band H,Band V

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Maml1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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