Tnfrsf12a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tnfrsf12a
Entrez Gene ID	302965
Full Name	TNF receptor superfamily member 12A
Synonyms	Fn14
General protein information	Preferred Names TNF receptor superfamily member 12A Names tumor necrosis factor receptor superfamily member 12A tumor necrosis factor receptor superfamily, member 12a
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12
Summary	human homolog is a receptor that binds TWEAK, a member of the TNF family, and is involved in cell proliferation, adhesion and angiogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_181086.3	NP_851600.1	tumor necrosis factor receptor superfamily member 12A precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TNFRSF12A	XP_005621711.1
Bos taurus (cattle)	TNFRSF12A	NP_001193256.1
Homo sapiens (human)	TNFRSF12A	NP_057723.1
Mus musculus (house mouse)	Tnfrsf12a	NP_038777.2
Rattus norvegicus (Norway rat)	Tnfrsf12a	NP_851600.1
Pan troglodytes (chimpanzee)	TNFRSF12A	XP_001165479.1
	TNFRSF12A	XP_001089176.1

Gene Ontology
Bibliography

Related articles in PubMed

The role of the tumor necrosis factor (TNF)-related weak inducer of apoptosis (TWEAK) in offspring exposed to prenatal hypoxia.
Reyes LM, Shah A, Quon A, Morton JS, Davidge ST
Journal of developmental origins of health and disease1-9(2017 Dec)

A further TWEAK to multiple sclerosis pathophysiology.
Nazeri A, Heydarpour P, Sadaghiani S, Sahraian MA, Burkly LC, Bar-Or A
Molecular neurobiology49(1)78-87(2014 Feb)

TWEAK/Fn14 promotes the proliferation and collagen synthesis of rat cardiac fibroblasts via the NF-?B pathway.
Chen HN, Wang DJ, Ren MY, Wang QL, Sui SJ
Molecular biology reports39(8)8231-41(2012 Aug)

Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth.
Tanabe K, Bonilla I, Winkles JA, Strittmatter SM
The Journal of neuroscience : the official journal of the Society for Neuroscience23(29)9675-86(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings show that FGFR-1 can interact with the TNF receptor superfamily member fibroblast growth factor-inducible molecule 14 (Fn14) resulting in cardiomyocyte cell cycle reentry
Title: FGF1-mediated cardiomyocyte cell cycle reentry depends on the interaction of FGFR-1 and Fn14.

Studies carried out in animal models of multiple sclerosis (MS) and neuroinflammation suggest TWEAK/Fn14 signaling contribute to MS pathophysiology by enhancing neuroinflammation, demyelination, and cell infiltration to the central nervous system.
Title: A further TWEAK to multiple sclerosis pathophysiology.

TWEAK/Fn14 axis increased cell proliferation and collagen synthesis by activating the NF-small ka, CyrillicB pathway and increasing MMP-9 activity
Title: TWEAK/Fn14 promotes the proliferation and collagen synthesis of rat cardiac fibroblasts via the NF-?B pathway.

Results suggest that the cardiac TWEAK/Fn14 pathway is modified in response to myocardial injury, inflammation and pressure overload.
Title: Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats.

stress-induced regulation of the TWEAK/Fn14 axis in cardiomyocytes implies a role of the TWEAK/Fn14 pathway in cardiac remodeling
Title: FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK.

The following Tnfrsf12a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tnfrsf12a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04176	NM_181086.3 Latest version!	Rattus norvegicus TNF receptor superfamily member 12A (Tnfrsf12a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tnfrsf12a ( NM_181086.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_851600.1 Rattus norvegicus TNF receptor superfamily member 12A (Tnfrsf12a), mRNA.

Price & Availability↑

CloneID	ORa04176
Clone ID Related Accession (Same CDS sequence)	NM_181086.3
Accession Version	NM_181086.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Rattus norvegicus(Norway rat)
Product	tumor necrosis factor receptor superfamily member 12A precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC060537.1. On Aug 31, 2012 this sequence version replaced NM_181086.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC060537.1, DY471602.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCCGG GTTGGCCGCG GCCTCTGCCG CAGCTCCTCG TGTTGGGATT CGGGTTGGTG 
TTGATACGCG CCACGGCCGG GGAGCAAGCA CCAGGCAACG CCCCATGCTC AAGCGGCAGC 
TCCTGGAGCG CGGACCTCGA CAAGTGCATG GACTGCGCTT CTTGTCCAGC GCGACCACAC 
AGCGACTTCT GCCTGGGATG CGCAGCAGCA CCTCCTGCCC ACTTCAGGAT GCTATGGCCC 
ATTCTGGGAG GCGCTCTTAG TCTGGCCCTG GTTTTGGCGC TGGTTTCTGG TTTCCTGGTC 
TGGAGACGAT GCCGCCGGAG AGAAAAGTTT ACTACCCCCA TAGAGGAGAC TGGTGGAGAA 
GGCTGCCCAG GTGTGGCACT GATCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_851600.1
CDS	30..419
Translation	MAPGWPRPLPQLLVLGFGLVLIRATAGEQAPGNAPCSSGSSWSADLDKCMDCASCPARPHSDFCLGCAAAPPAHFRMLWPILGGALSLALVLALVSGFLVWRRCRRREKFTTPIEETGGEGCPGVALIQ

Target ORF information:

RefSeq Version	NM_181086.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TNF receptor superfamily member 12A (Tnfrsf12a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181086.3

ORF Insert Sequence:

ATGGCTCCGG GTTGGCCGCG GCCTCTGCCG CAGCTCCTCG TGTTGGGATT CGGGTTGGTG 
TTGATACGCG CCACGGCCGG GGAGCAAGCA CCAGGCAACG CCCCATGCTC AAGCGGCAGC 
TCCTGGAGCG CGGACCTCGA CAAGTGCATG GACTGCGCTT CTTGTCCAGC GCGACCACAC 
AGCGACTTCT GCCTGGGATG CGCAGCAGCA CCTCCTGCCC ACTTCAGGAT GCTATGGCCC 
ATTCTGGGAG GCGCTCTTAG TCTGGCCCTG GTTTTGGCGC TGGTTTCTGG TTTCCTGGTC 
TGGAGACGAT GCCGCCGGAG AGAAAAGTTT ACTACCCCCA TAGAGGAGAC TGGTGGAGAA 
GGCTGCCCAG GTGTGGCACT GATCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of the tumor necrosis factor (TNF)-related weak inducer of apoptosis (TWEAK) in offspring exposed to prenatal hypoxia.
Journal of developmental origins of health and disease1-9(2017 Dec)
Reyes LM,Shah A,Quon A,Morton JS,Davidge ST

A further TWEAK to multiple sclerosis pathophysiology.
Molecular neurobiology49(1)78-87(2014 Feb)
Nazeri A,Heydarpour P,Sadaghiani S,Sahraian MA,Burkly LC,Bar-Or A

TWEAK/Fn14 promotes the proliferation and collagen synthesis of rat cardiac fibroblasts via the NF-?B pathway.
Molecular biology reports39(8)8231-41(2012 Aug)
Chen HN,Wang DJ,Ren MY,Wang QL,Sui SJ

Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience23(29)9675-86(2003 Oct)
Tanabe K,Bonilla I,Winkles JA,Strittmatter SM

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Tnfrsf12a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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