Gpr143 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpr143
Entrez Gene ID	302619
Full Name	G protein-coupled receptor 143
Synonyms	RGD1565799
General protein information	Preferred Names G protein-coupled receptor 143 Names G-protein coupled receptor 143
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq13

mRNA and Protein(s)

mRNA	Protein	Name
NM_001106958.1	NP_001100428.1	G-protein coupled receptor 143

Pathways from BioSystems

Homologies

Homo sapiens (human)	GPR143	NP_000264.2
Gallus gallus (chicken)	GPR143	NP_001264668.1
Bos taurus (cattle)	GPR143	XP_002700505.1
Mus musculus (house mouse)	Gpr143	NP_035081.3
Xenopus tropicalis (tropical clawed frog)	gpr143	NP_001011018.1
	GPR143	XP_001090139.1
Canis lupus familiaris (dog)	GPR143	XP_005642124.1
Rattus norvegicus (Norway rat)	Gpr143	NP_001100428.1
Danio rerio (zebrafish)	gpr143	XP_005169192.1

Gene Ontology
Bibliography

Related articles in PubMed

Localization of ocular albinism-1 gene product GPR143 in the rat central nervous system.
Masukawa D, Nakamura F, Koga M, Kamiya M, Chen S, Yamashita N, Arai N, Goshima Y
Neuroscience research8849-57(2014 Nov)

The protein Ocular albinism 1 is the orphan GPCR GPR143 and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii.
Hiroshima Y, Miyamoto H, Nakamura F, Masukawa D, Yamamoto T, Muraoka H, Kamiya M, Yamashita N, Suzuki T, Matsuzaki S, Endo I, Goshima Y
British journal of pharmacology171(2)403-14(2014 Jan)

The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition.
Giordano F, Bonetti C, Surace EM, Marigo V, Raposo G
Human molecular genetics18(23)4530-45(2009 Dec)

The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells.
Palmisano I, Bagnato P, Palmigiano A, Innamorati G, Rotondo G, Altimare D, Venturi C, Sviderskaya EV, Piccirillo R, Coppola M, Marigo V, Incerti B, Ballabio A, Surace EM, Tacchetti C, Bennett DC, Schiaffino MV
Human molecular genetics17(22)3487-501(2008 Nov)

L-DOPA is an endogenous ligand for OA1.
Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS
PLoS biology6(9)e236(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the unique distribution pattern of gene OA1 product GPR143 in the rat central nervous system central nervous system
Title: Localization of ocular albinism-1 gene product GPR143 in the rat central nervous system.

gpr143 acted as a functional receptor for DOPA in the nucleus tractus solitarii
Title: The protein Ocular albinism 1 is the orphan GPCR GPR143 and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii.

The following Gpr143 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpr143 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02606	NM_001106958.1 Latest version!	Rattus norvegicus G protein-coupled receptor 143 (Gpr143), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpr143 ( NM_001106958.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100428.1 Rattus norvegicus G protein-coupled receptor 143 (Gpr143), mRNA.

Price & Availability↑

CloneID	ORa02606
Clone ID Related Accession (Same CDS sequence)	NM_001106958.1
Accession Version	NM_001106958.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	G-protein coupled receptor 143
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474014.2. On or before Oct 4, 2007 this sequence version replaced XM_001064908.1, XM_228848.4. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCCC CGCGCCTGGG AATCTTCTGC TGCCCTTCGT GGGATGCAGC CACACAGCTG 
GTGCTGACCT TCCAACCGCG GGTGTTCCAT GCGCTGTGTC TGGGCAGCGG CGCCCTCCGC 
CTGGTGCTTG GCCTCCTTCA GCTCCTAACA GGGCGCCGAT CTGTTGGTCA CAGGGCGCCT 
GCGACAACCC CAGCAGCCTC AGTCCACATC CTTCGTGCTG CCACCGCCTG TGATTTGCTT 
GGCTGCCTGG GAATCGTTAT CAGGTCCACA GTGTGGATAG CCTACCCAGA ATTCATTGAA 
AACATTTCCA ATATGAATGG AACAGACATT TGGCCTACTG CTTTCTGTGT CGGGAGTGCA 
ATGTGGATCC AGCTGTTGTA CAGTGCCTGC TTCTGGTGGC TCTTCTGCTA TGCAGTTGAT 
GTATACTTGG TGATCAGGAG ATCAGCAGGA CGGAGCACCA TCCTGCTGTA CCACATCATG 
GCCTGGGGCC TGCCTGTGCT GCTCTGTGTG GAAGGTGCAG TCATGCTTTA TTACCCTTCT 
GTGTCCAGGT GTGAGAGAGG CCTGGACCAT GCCATCCCCC ATTATGTCAC CACATACTTG 
CCACTTATGC TTGTCCTTGT GGCCAACCCG ATCCTGTTTC ACAAGACAGT GATTTCAGTG 
GCCTCTTTAC TGAAAGGACG AAAAGGTGTT TATACAGAGA ATGAGAGATT GATGGGGGCC 
GTGATCAAGA CCCGGTTTTT CAAAATAATG CTGGTGTTAA TTGCATGTTG GTTGTCCAAT 
ATCATCAATG AATGTCTTTT GTTCTACCTT GAAATGCAAC CAGATACCCA TGGAGGCTCT 
CTGAAACGCA TCCAGAATGC AGCCAGGACC ACATGGTTTA TTATGGGAAT ATTGAATCCA 
TCTCAAGGAC TTCTCTTGTC TCTGGCCTTC TATGGCTGGA CAGGATGCAG CCTGGATGTC 
CATGCTCCCA AGATGGTGAT TCAGTGGGAA ACAATGACTG CCTCGGCTGC TGAGGGCACA 
TATCAGACCC CTGAGGGTTC CTGTGTGCCC CATCAAAACC CCAGGAAGGT GGTGTGTGTT 
GGGGGGCACA CTTCTGATGA GGTGCTGAGT ATTTTGTCTG AAGGTTCGGA TGCTAGCACT 
GTTGAAATCC ATACTGCAAC TGGGTCCCAC AACATAAAGG AAGTTGACTC CATTTCCCAA 
GCCCAGGGGG ATCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100428.1
CDS	67..1284
Translation	MASPRLGIFCCPSWDAATQLVLTFQPRVFHALCLGSGALRLVLGLLQLLTGRRSVGHRAPATTPAASVHILRAATACDLLGCLGIVIRSTVWIAYPEFIENISNMNGTDIWPTAFCVGSAMWIQLLYSACFWWLFCYAVDVYLVIRRSAGRSTILLYHIMAWGLPVLLCVEGAVMLYYPSVSRCERGLDHAIPHYVTTYLPLMLVLVANPILFHKTVISVASLLKGRKGVYTENERLMGAVIKTRFFKIMLVLIACWLSNIINECLLFYLEMQPDTHGGSLKRIQNAARTTWFIMGILNPSQGLLLSLAFYGWTGCSLDVHAPKMVIQWETMTASAAEGTYQTPEGSCVPHQNPRKVVCVGGHTSDEVLSILSEGSDASTVEIHTATGSHNIKEVDSISQAQGDL

Target ORF information:

RefSeq Version	NM_001106958.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein-coupled receptor 143 (Gpr143), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106958.1

ORF Insert Sequence:

ATGGCCTCCC CGCGCCTGGG AATCTTCTGC TGCCCTTCGT GGGATGCAGC CACACAGCTG 
GTGCTGACCT TCCAACCGCG GGTGTTCCAT GCGCTGTGTC TGGGCAGCGG CGCCCTCCGC 
CTGGTGCTTG GCCTCCTTCA GCTCCTAACA GGGCGCCGAT CTGTTGGTCA CAGGGCGCCT 
GCGACAACCC CAGCAGCCTC AGTCCACATC CTTCGTGCTG CCACCGCCTG TGATTTGCTT 
GGCTGCCTGG GAATCGTTAT CAGGTCCACA GTGTGGATAG CCTACCCAGA ATTCATTGAA 
AACATTTCCA ATATGAATGG AACAGACATT TGGCCTACTG CTTTCTGTGT CGGGAGTGCA 
ATGTGGATCC AGCTGTTGTA CAGTGCCTGC TTCTGGTGGC TCTTCTGCTA TGCAGTTGAT 
GTATACTTGG TGATCAGGAG ATCAGCAGGA CGGAGCACCA TCCTGCTGTA CCACATCATG 
GCCTGGGGCC TGCCTGTGCT GCTCTGTGTG GAAGGTGCAG TCATGCTTTA TTACCCTTCT 
GTGTCCAGGT GTGAGAGAGG CCTGGACCAT GCCATCCCCC ATTATGTCAC CACATACTTG 
CCACTTATGC TTGTCCTTGT GGCCAACCCG ATCCTGTTTC ACAAGACAGT GATTTCAGTG 
GCCTCTTTAC TGAAAGGACG AAAAGGTGTT TATACAGAGA ATGAGAGATT GATGGGGGCC 
GTGATCAAGA CCCGGTTTTT CAAAATAATG CTGGTGTTAA TTGCATGTTG GTTGTCCAAT 
ATCATCAATG AATGTCTTTT GTTCTACCTT GAAATGCAAC CAGATACCCA TGGAGGCTCT 
CTGAAACGCA TCCAGAATGC AGCCAGGACC ACATGGTTTA TTATGGGAAT ATTGAATCCA 
TCTCAAGGAC TTCTCTTGTC TCTGGCCTTC TATGGCTGGA CAGGATGCAG CCTGGATGTC 
CATGCTCCCA AGATGGTGAT TCAGTGGGAA ACAATGACTG CCTCGGCTGC TGAGGGCACA 
TATCAGACCC CTGAGGGTTC CTGTGTGCCC CATCAAAACC CCAGGAAGGT GGTGTGTGTT 
GGGGGGCACA CTTCTGATGA GGTGCTGAGT ATTTTGTCTG AAGGTTCGGA TGCTAGCACT 
GTTGAAATCC ATACTGCAAC TGGGTCCCAC AACATAAAGG AAGTTGACTC CATTTCCCAA 
GCCCAGGGGG ATCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Localization of ocular albinism-1 gene product GPR143 in the rat central nervous system.
Neuroscience research8849-57(2014 Nov)
Masukawa D,Nakamura F,Koga M,Kamiya M,Chen S,Yamashita N,Arai N,Goshima Y

The protein Ocular albinism 1 is the orphan GPCR GPR143 and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii.
British journal of pharmacology171(2)403-14(2014 Jan)
Hiroshima Y,Miyamoto H,Nakamura F,Masukawa D,Yamamoto T,Muraoka H,Kamiya M,Yamashita N,Suzuki T,Matsuzaki S,Endo I,Goshima Y

The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition.
Human molecular genetics18(23)4530-45(2009 Dec)
Giordano F,Bonetti C,Surace EM,Marigo V,Raposo G

The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells.
Human molecular genetics17(22)3487-501(2008 Nov)
Palmisano I,Bagnato P,Palmigiano A,Innamorati G,Rotondo G,Altimare D,Venturi C,Sviderskaya EV,Piccirillo R,Coppola M,Marigo V,Incerti B,Ballabio A,Surace EM,Tacchetti C,Bennett DC,Schiaffino MV

L-DOPA is an endogenous ligand for OA1.
PLoS biology6(9)e236(2008 Sep)
Lopez VM,Decatur CL,Stamer WD,Lynch RM,McKay BS

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Gpr143 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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