Mmp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp1
Entrez Gene ID	300339
Full Name	matrix metallopeptidase 1
Synonyms	Clgn,MMP-1,Mmp1a
General protein information	Preferred Names matrix metallopeptidase 1 Names interstitial collagenase fibroblast collagenase matrix metallopeptidase 1a matrix metalloproteinase 1 matrix metalloproteinase 1a (interstitial collagenase) myocardial collagenase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001134530.1	NP_001128002.1	interstitial collagenase precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MMP1	XP_508722.2
	MMP1	XP_001098302.1
Gallus gallus (chicken)	MMP1	XP_417176.1
Homo sapiens (human)	MMP1	NP_002412.1
Bos taurus (cattle)	MMP1	NP_776537.1
Mus musculus (house mouse)	Mmp1a	NP_114395.1
Bos taurus (cattle)	LOC100848085	XP_003586977.1
Rattus norvegicus (Norway rat)	Mmp1	NP_001128002.1
Canis lupus familiaris (dog)	LOC489428	XP_546546.3

Gene Ontology
Bibliography

Related articles in PubMed

Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-?.
Li W, Cui N, Mazzuca MQ, Mata KM, Khalil RA
American journal of physiology. Heart and circulatory physiology313(3)H491-H507(2017 Sep)

Renal damage following Alloxan-induced diabetes is associated with generation of reactive oxygen species, alterations of p53, TGF-?1, and extracellular matrix metalloproteinases in rats.
Abdel Aziz MA, Badary DM, Hussein MRA
Cell biology international41(5)525-533(2017 May)

Long-Term Selenium-Deficient Diet Induces Liver Damage by Altering Hepatocyte Ultrastructure and MMP1/3 and TIMP1/3 Expression in Growing Rats.
Han J, Liang H, Yi J, Tan W, He S, Wang S, Li F, Wu X, Ma J, Shi X, Guo X, Bai C
Biological trace element research175(2)396-404(2017 Feb)

Pentoxifylline Accelerates Wound Healing Process by Modulating Gene Expression of MMP-1, MMP-3, and TIMP-1 in Normoglycemic Rats.
Babaei S, Bayat M
Journal of investigative surgery : the official journal of the Academy of Surgical Research28(4)196-201(2015)

Budesonide ameliorates lung function of the cigarette smoke-exposed rats through reducing matrix metalloproteinase-1 content.
Sun J, Zhang P, Zhang B, Li K, Li Z, Li J, Zhang Y, Sun W
International journal of clinical and experimental pathology8(5)5137-44(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Placental ischemia, possibly through the release of TNF-alpha, causes increases in the levels of matrix metalloproteinase (MMP)-1 and MMP-7, which could alter collagen deposition and cause inadequate uteroplacental and vascular remodeling in hypertension in pregnancy.
Title: Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-?.

Alloxan-induced renal damage is associated with alterations of p53, TGF-beta1, and extracellular matrix metalloproteinases.
Title: Renal damage following Alloxan-induced diabetes is associated with generation of reactive oxygen species, alterations of p53, TGF-?1, and extracellular matrix metalloproteinases in rats.

upregulated expressions of MMP1/3 and downregulated expressions of TIMP1/3 at the messenger RNA (mRNA) and protein levels also appeared to be relevant to low Se intake. In conclusion, Se-deficient diet could cause low Se concentration in the liver, alterations of hepatocyte ultrastructure
Title: Long-Term Selenium-Deficient Diet Induces Liver Damage by Altering Hepatocyte Ultrastructure and MMP1/3 and TIMP1/3 Expression in Growing Rats.

In a normoglycemic rat model of wound healing, pentoxifylline significantly reduced gene expression of MMP-1.
Title: Pentoxifylline Accelerates Wound Healing Process by Modulating Gene Expression of MMP-1, MMP-3, and TIMP-1 in Normoglycemic Rats.

Inhaled budesonide mitigates the ongoing inflammatory process in the smoked lungs and ameliorates declining lung function through reducing MMP-1 content.
Title: Budesonide ameliorates lung function of the cigarette smoke-exposed rats through reducing matrix metalloproteinase-1 content.

The following Mmp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00035	NM_001134530.1 Latest version!	Rattus norvegicus matrix metallopeptidase 1 (Mmp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$272.30 $389.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp1 ( NM_001134530.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001128002.1 Rattus norvegicus matrix metallopeptidase 1 (Mmp1), mRNA.

Price & Availability↑

CloneID	ORa00035
Clone ID Related Accession (Same CDS sequence)	NM_001134530.1
Accession Version	NM_001134530.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1395bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Rattus norvegicus(Norway rat)
Product	interstitial collagenase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC169019.1. On or before Sep 4, 2008 this sequence version replaced XM_235794.3, XM_001072423.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC169019.1 [ECO:0000332] ##Evidence-Data-END##

ATGCTTAGCC TTCCTTTGCT GTTGCTTCTC TTGGCTACCA GCTCATACAG TTTCCCCGTG 
TTTCAGGACG GAGCCCGGCA GAATGTGGAA ACAGTCTGGA AATACCTGGA AAACTACTAC 
AACTTGGGTG AAGACGTCCA AGCTAAAAAC GTGGATGCCA AGGAGGTGAT GGCTGAAAAG 
CTGAGGCAAA TGCAGCAGTT ATTTGGGCTG AAAGTGACAG GAAATTCAAA TTCTGAAACC 
CTGAGTGCTA TGAGGAAACC TAGGTGTGGG GTGCCTGATG TGGCCCCATA TGCCATTACT 
CACAACAATC CTCGTTGGAC CAAAACACAT CTGACTTACA GCATTTTAAA CTACACACCA 
TATTTGCCAA AAGAAGTTAT AGAAAACGCC ATCGAGAGAG CCTTTAAAGT CTGGAGTGAT 
GTGACACCAC TAACATTCGA AAGGGTTTTT GAGGAGGAAG GTGATATTGT GTTCGCCTTC 
TACAGAGGAG ACCATAGTGA CAATAACCCA TTTGATGGAC CTGAATATGG ACTTGCTCAC 
ACATTCCCAC CAGGCCCACG TTTGGGGGGC GATGTTCATT ATGATCTGGA TGAGACGTGG 
ACCGACAACA GTGACAATTT CAATTTGTTC TATGTTACGG CTCATGAACT GGGCCACTCC 
CTTGGACTCA CTCATTCTAG AGATGTAGGA GCACTAATGT TCCCCAGCTA CACATGGTAC 
ACTGAAGACT TTGTGCTAAA CCAGGAGGAT ATTAATCGCA TCCAGGCTTT ATATGGGCCT 
TCCCCAAATC CCATCCAGCC AACAGGTGCA ACAACACCAC ATCCATGTGA TGGTGATCTA 
ACCTTCGACG CTATAACTAC GTTTAGGGGA GAGGTGATGT TCTTTAAAGG CAGGTTCTAC 
ATTCGTGTAA ATAAGTTCAT GCCAGAAGCT GAGCTCAATT TGATAGGTAT TATCTGGCCA 
AATCTGCCAG GTAAACTTGA TGCTGCTTAT GAAGTTAGTA TGATAGATCA AGTCCGCTAT 
TTCAAAGGCA ATAAAGTCTG GGTTGTTCGA GAGCATACTG TACTGAGAGG ATTCCCCACA 
GACATCCATA GCTTCTTTGG CTTCCCTAGC AGTGTGACAC ACATTGACGC TGCCGTTTGT 
GAGGAAGAGA CTGGAAAAAC ATACTTCTTC GTTGACAACA TGTACTGGAG GTATGATGAA 
AATACACAGT CCATGGATCC AGGTTATCCT AGATTAACAG CAGAAGATTT CCCTGGAATT 
GACGATAAAG TTGATGATGT TTTCCAAAAA GGCGAAAATT TCTACTTCTT TCACCAATCA 
GTTCAACGCA GATTTAGCCT CCGAATAAGA AGAGTTGATG ACTCCCGTGA TTCTAGTACC 
TGGTTCAACT GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128002.1
CDS	43..1437
Translation	MLSLPLLLLLLATSSYSFPVFQDGARQNVETVWKYLENYYNLGEDVQAKNVDAKEVMAEKLRQMQQLFGLKVTGNSNSETLSAMRKPRCGVPDVAPYAITHNNPRWTKTHLTYSILNYTPYLPKEVIENAIERAFKVWSDVTPLTFERVFEEEGDIVFAFYRGDHSDNNPFDGPEYGLAHTFPPGPRLGGDVHYDLDETWTDNSDNFNLFYVTAHELGHSLGLTHSRDVGALMFPSYTWYTEDFVLNQEDINRIQALYGPSPNPIQPTGATTPHPCDGDLTFDAITTFRGEVMFFKGRFYIRVNKFMPEAELNLIGIIWPNLPGKLDAAYEVSMIDQVRYFKGNKVWVVREHTVLRGFPTDIHSFFGFPSSVTHIDAAVCEEETGKTYFFVDNMYWRYDENTQSMDPGYPRLTAEDFPGIDDKVDDVFQKGENFYFFHQSVQRRFSLRIRRVDDSRDSSTWFNC

Target ORF information:

RefSeq Version	NM_001134530.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus matrix metallopeptidase 1 (Mmp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134530.1

ORF Insert Sequence:

ATGCTTAGCC TTCCTTTGCT GTTGCTTCTC TTGGCTACCA GCTCATACAG TTTCCCCGTG 
TTTCAGGACG GAGCCCGGCA GAATGTGGAA ACAGTCTGGA AATACCTGGA AAACTACTAC 
AACTTGGGTG AAGACGTCCA AGCTAAAAAC GTGGATGCCA AGGAGGTGAT GGCTGAAAAG 
CTGAGGCAAA TGCAGCAGTT ATTTGGGCTG AAAGTGACAG GAAATTCAAA TTCTGAAACC 
CTGAGTGCTA TGAGGAAACC TAGGTGTGGG GTGCCTGATG TGGCCCCATA TGCCATTACT 
CACAACAATC CTCGTTGGAC CAAAACACAT CTGACTTACA GCATTTTAAA CTACACACCA 
TATTTGCCAA AAGAAGTTAT AGAAAACGCC ATCGAGAGAG CCTTTAAAGT CTGGAGTGAT 
GTGACACCAC TAACATTCGA AAGGGTTTTT GAGGAGGAAG GTGATATTGT GTTCGCCTTC 
TACAGAGGAG ACCATAGTGA CAATAACCCA TTTGATGGAC CTGAATATGG ACTTGCTCAC 
ACATTCCCAC CAGGCCCACG TTTGGGGGGC GATGTTCATT ATGATCTGGA TGAGACGTGG 
ACCGACAACA GTGACAATTT CAATTTGTTC TATGTTACGG CTCATGAACT GGGCCACTCC 
CTTGGACTCA CTCATTCTAG AGATGTAGGA GCACTAATGT TCCCCAGCTA CACATGGTAC 
ACTGAAGACT TTGTGCTAAA CCAGGAGGAT ATTAATCGCA TCCAGGCTTT ATATGGGCCT 
TCCCCAAATC CCATCCAGCC AACAGGTGCA ACAACACCAC ATCCATGTGA TGGTGATCTA 
ACCTTCGACG CTATAACTAC GTTTAGGGGA GAGGTGATGT TCTTTAAAGG CAGGTTCTAC 
ATTCGTGTAA ATAAGTTCAT GCCAGAAGCT GAGCTCAATT TGATAGGTAT TATCTGGCCA 
AATCTGCCAG GTAAACTTGA TGCTGCTTAT GAAGTTAGTA TGATAGATCA AGTCCGCTAT 
TTCAAAGGCA ATAAAGTCTG GGTTGTTCGA GAGCATACTG TACTGAGAGG ATTCCCCACA 
GACATCCATA GCTTCTTTGG CTTCCCTAGC AGTGTGACAC ACATTGACGC TGCCGTTTGT 
GAGGAAGAGA CTGGAAAAAC ATACTTCTTC GTTGACAACA TGTACTGGAG GTATGATGAA 
AATACACAGT CCATGGATCC AGGTTATCCT AGATTAACAG CAGAAGATTT CCCTGGAATT 
GACGATAAAG TTGATGATGT TTTCCAAAAA GGCGAAAATT TCTACTTCTT TCACCAATCA 
GTTCAACGCA GATTTAGCCT CCGAATAAGA AGAGTTGATG ACTCCCGTGA TTCTAGTACC 
TGGTTCAACT GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-?.
American journal of physiology. Heart and circulatory physiology313(3)H491-H507(2017 Sep)
Li W,Cui N,Mazzuca MQ,Mata KM,Khalil RA

Renal damage following Alloxan-induced diabetes is associated with generation of reactive oxygen species, alterations of p53, TGF-?1, and extracellular matrix metalloproteinases in rats.
Cell biology international41(5)525-533(2017 May)
Abdel Aziz MA,Badary DM,Hussein MRA

Long-Term Selenium-Deficient Diet Induces Liver Damage by Altering Hepatocyte Ultrastructure and MMP1/3 and TIMP1/3 Expression in Growing Rats.
Biological trace element research175(2)396-404(2017 Feb)
Han J,Liang H,Yi J,Tan W,He S,Wang S,Li F,Wu X,Ma J,Shi X,Guo X,Bai C

Pentoxifylline Accelerates Wound Healing Process by Modulating Gene Expression of MMP-1, MMP-3, and TIMP-1 in Normoglycemic Rats.
Journal of investigative surgery : the official journal of the Academy of Surgical Research28(4)196-201(2015)
Babaei S,Bayat M

Budesonide ameliorates lung function of the cigarette smoke-exposed rats through reducing matrix metalloproteinase-1 content.
International journal of clinical and experimental pathology8(5)5137-44(2015)
Sun J,Zhang P,Zhang B,Li K,Li Z,Li J,Zhang Y,Sun W

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Mmp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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