Ntn4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ntn4
Entrez Gene ID	299737
Full Name	netrin 4
Synonyms	RGD1565947
General protein information	Preferred Names netrin 4 Names netrin-4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q13

mRNA and Protein(s)

mRNA	Protein	Name
NM_001106780.1	NP_001100250.1	netrin-4 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	NTN4	NP_001095673.1
Mus musculus (house mouse)	Ntn4	NP_067295.2
Danio rerio (zebrafish)	ntn4	NP_001032775.1
Homo sapiens (human)	NTN4	NP_067052.2
Gallus gallus (chicken)	NTN4	XP_004937705.1
Rattus norvegicus (Norway rat)	Ntn4	NP_001100250.1
Pan troglodytes (chimpanzee)	NTN4	XP_003313918.1
	NTN4	XP_001107505.1
Canis lupus familiaris (dog)	NTN4	XP_532655.2

Gene Ontology
Bibliography

Related articles in PubMed

Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B.
Hayano Y, Takasu K, Koyama Y, Yamada M, Ogawa K, Minami K, Asaki T, Kitada K, Kuwabara S, Yamashita T
The Journal of experimental medicine213(13)2949-2966(2016 Dec)

Transcriptome-based systematic identification of extracellular matrix proteins.
Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C, Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D, Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N, Kimata K, Hayashizaki Y, Sekiguchi K
Proceedings of the National Academy of Sciences of the United States of America105(35)12849-54(2008 Sep)

Binding of netrin-4 to laminin short arms regulates basement membrane assembly.
Schneiders FI, Maertens B, B?se K, Li Y, Brunken WJ, Paulsson M, Smyth N, Koch M
The Journal of biological chemistry282(33)23750-8(2007 Aug)

Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis.
Liu Y, Stein E, Oliver T, Li Y, Brunken WJ, Koch M, Tessier-Lavigne M, Hogan BL
Current biology : CB14(10)897-905(2004 May)

A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin: identification, expression, and functional characterization.
Koch M, Murrell JR, Hunter DD, Olson PF, Jin W, Keene DR, Brunken WJ, Burgeson RE
The Journal of cell biology151(2)221-34(2000 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the Unc5B receptor and subsequent activation of the tyrosine phosphatase SHP2 mediated Netrin-4-induced pain signaling in the spinal cord.
Title: Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B.

The following Ntn4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ntn4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02192	NM_001106780.1 Latest version!	Rattus norvegicus netrin 4 (Ntn4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ntn4 ( NM_001106780.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100250.1 Rattus norvegicus netrin 4 (Ntn4), mRNA.

Price & Availability↑

CloneID	ORa02192
Clone ID Related Accession (Same CDS sequence)	NM_001106780.1
Accession Version	NM_001106780.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1893bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	netrin-4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473960.2. On Oct 4, 2007 this sequence version replaced XM_001080341.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGAGCT GCGCACGGCT GCTGCTGCTC TGGGGCTGCT CCGCGGTGGC CGCAGGATTC 
AATGGAGTCT CTGGAGTGAA TTCCCGCTGC GAGAAGGCCT GCAACCCTCG AATGGGAAAC 
TTGGCTTTGG GAAGAAAACT CCAGGCGGAC ACTACCTGCG GGCAGAACGC CACCGAACTG 
TTCTGCTTCT ACAGCGAGAA TGCTGATCTC ACTTGCCGGC AGCCCAAGTG TGATAAGTGC 
AACGGGGCCC ATTCTCACCT GGCCCACCCA CCCTCTGCAA TGGCAGACTC GTCCTTCAGG 
TTTCCCCGGA CATGGTGGCA GTCGGCAGAG GATGTGCACA GGGAAAAGAT CCAGCTAGAC 
CTGGAAGCAG AATTCTATTT TACTCACCTA ATTATGGTGT TCAAGTCCCC CAGGCCTGCA 
GCCATGGTGC TGGACCGGTC CCAGGACTTT GGGAAGACTT GGAAACCTTA CAAGTACTTT 
GCAACAAACT GTTCTGCTAC GTTTGGCCTG GAAGATGATG TTGTCAAGAA GGGAGCTATT 
TGCACGTCGA GATACTCAAA TCCTTTCCCA TGTACTGGCG GAGAGGTTAT TTTCAGAGCC 
CTGTCACCAC CATATGACAT AGAAAACCCT TACAGTGCCA AAGTACAGGA GCAGCTGAAG 
ATCACCAACC TCCGCGTGCG GCTGCTCAAG CGACAGTCCT GCCCTTGTCA GAGAAACGAC 
TTGAATGCAA AGCCTCACCA TTTCACTCAC TACGCCATCT ACGACTTCAT CGTCAAGGGC 
AGCTGCTTCT GCAACGGCCA CGCTGACCAG TGTTTACCTG TGGAGGGCTT CAGACCCGTC 
AAGGCCCCAG GAGCGTTCCA TGTGGTCCAT GGGAAGTGCA TGTGTAAGCA CAACACGGCG 
GGCAGCCACT GCCAGCACTG TGCACCATTA TACAACGACC GGCCCTGGGA GGCAGCGGAT 
GGCAGAACAG GGGCTCCTAA CGAATGCAGA ACCTGCAAGT GCAATGGGCA CGCGGACACC 
TGTCACTTCG ACATCAACGT GTGGGAGGCA TCCGGGAATC GCAGCGGTGG TGTCTGCAAC 
AACTGTCAAC ACAACACCGA GGGTCAGCAT TGTCAGCGCT GTAAGCCGGG TTTCTACCGA 
GACCTCAGGA GGCCCTTCTC TGCCCCCGAT GCTTGTAAAG CATGTTCCTG CCACCCAGTT 
GGCTCGGCGA TCCTTCCTTT CAGCTCGGTG ACCTTCTGCG ACCCCAGCAA TGGTGACTGC 
CCTTGCAAGC CTGGGGTGGC AGGGCCACAT TGTGACAGGT GCATGGTGGG ATACTGGGGC 
TTTGGAGACT ACGGCTGCAG ACCTTGTGAC TGTGCGGGGA GCTGCGACCC GCTCACGGGA 
GACTGCATCA GCAGCAATGC TGACGTGGAC TGGTATCACG AAGTCCCCGC CTTTCACTCT 
CTGCACAATA AGAGTGAGCC AGGCTGGGAG TGGGAAGATG AGCAGGGATT TTCTGCACTT 
CGACACTCAG GTAAATGTGA ATGTAAGGAA CAAGTGTTAG GAAACCCCAA GGCCTTCTGT 
GGAATGAAGT ATTCATATGT GTTAAAAATC AAGATTTTAT CAGCTCATGA TAAAGGTTCC 
CACGCTGAGG TCAACGTGAA GATTAAGAAA GTCTTACAGG CTACCAAACT GAAGATCTTA 
CGAGGCAAGA GAACACTCTA TCCCGAGTCC TGGACTAACA GAGGCTGCAC CTGCCCGATC 
CTCAATCCAG GCTTGGAGTA CCTGGTAGCT GGCTATGAGG ACGTGAGAAC AGGCAGATTA 
ATTGTGAATA TGAAAAGCTT CGTCCAGCCC TGGAAACCAG CTCTTGGGAG AAGAGTCATG 
CACATCTTAA AAAGAGAATG CGTGGAGCAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100250.1
CDS	170..2062
Translation	MGSCARLLLLWGCSAVAAGFNGVSGVNSRCEKACNPRMGNLALGRKLQADTTCGQNATELFCFYSENADLTCRQPKCDKCNGAHSHLAHPPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIMVFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSRYSNPFPCTGGEVIFRALSPPYDIENPYSAKVQEQLKITNLRVRLLKRQSCPCQRNDLNAKPHHFTHYAIYDFIVKGSCFCNGHADQCLPVEGFRPVKAPGAFHVVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGRTGAPNECRTCKCNGHADTCHFDINVWEASGNRSGGVCNNCQHNTEGQHCQRCKPGFYRDLRRPFSAPDACKACSCHPVGSAILPFSSVTFCDPSNGDCPCKPGVAGPHCDRCMVGYWGFGDYGCRPCDCAGSCDPLTGDCISSNADVDWYHEVPAFHSLHNKSEPGWEWEDEQGFSALRHSGKCECKEQVLGNPKAFCGMKYSYVLKIKILSAHDKGSHAEVNVKIKKVLQATKLKILRGKRTLYPESWTNRGCTCPILNPGLEYLVAGYEDVRTGRLIVNMKSFVQPWKPALGRRVMHILKRECVEH

Target ORF information:

RefSeq Version	NM_001106780.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus netrin 4 (Ntn4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106780.1

ORF Insert Sequence:

ATGGGGAGCT GCGCACGGCT GCTGCTGCTC TGGGGCTGCT CCGCGGTGGC CGCAGGATTC 
AATGGAGTCT CTGGAGTGAA TTCCCGCTGC GAGAAGGCCT GCAACCCTCG AATGGGAAAC 
TTGGCTTTGG GAAGAAAACT CCAGGCGGAC ACTACCTGCG GGCAGAACGC CACCGAACTG 
TTCTGCTTCT ACAGCGAGAA TGCTGATCTC ACTTGCCGGC AGCCCAAGTG TGATAAGTGC 
AACGGGGCCC ATTCTCACCT GGCCCACCCA CCCTCTGCAA TGGCAGACTC GTCCTTCAGG 
TTTCCCCGGA CATGGTGGCA GTCGGCAGAG GATGTGCACA GGGAAAAGAT CCAGCTAGAC 
CTGGAAGCAG AATTCTATTT TACTCACCTA ATTATGGTGT TCAAGTCCCC CAGGCCTGCA 
GCCATGGTGC TGGACCGGTC CCAGGACTTT GGGAAGACTT GGAAACCTTA CAAGTACTTT 
GCAACAAACT GTTCTGCTAC GTTTGGCCTG GAAGATGATG TTGTCAAGAA GGGAGCTATT 
TGCACGTCGA GATACTCAAA TCCTTTCCCA TGTACTGGCG GAGAGGTTAT TTTCAGAGCC 
CTGTCACCAC CATATGACAT AGAAAACCCT TACAGTGCCA AAGTACAGGA GCAGCTGAAG 
ATCACCAACC TCCGCGTGCG GCTGCTCAAG CGACAGTCCT GCCCTTGTCA GAGAAACGAC 
TTGAATGCAA AGCCTCACCA TTTCACTCAC TACGCCATCT ACGACTTCAT CGTCAAGGGC 
AGCTGCTTCT GCAACGGCCA CGCTGACCAG TGTTTACCTG TGGAGGGCTT CAGACCCGTC 
AAGGCCCCAG GAGCGTTCCA TGTGGTCCAT GGGAAGTGCA TGTGTAAGCA CAACACGGCG 
GGCAGCCACT GCCAGCACTG TGCACCATTA TACAACGACC GGCCCTGGGA GGCAGCGGAT 
GGCAGAACAG GGGCTCCTAA CGAATGCAGA ACCTGCAAGT GCAATGGGCA CGCGGACACC 
TGTCACTTCG ACATCAACGT GTGGGAGGCA TCCGGGAATC GCAGCGGTGG TGTCTGCAAC 
AACTGTCAAC ACAACACCGA GGGTCAGCAT TGTCAGCGCT GTAAGCCGGG TTTCTACCGA 
GACCTCAGGA GGCCCTTCTC TGCCCCCGAT GCTTGTAAAG CATGTTCCTG CCACCCAGTT 
GGCTCGGCGA TCCTTCCTTT CAGCTCGGTG ACCTTCTGCG ACCCCAGCAA TGGTGACTGC 
CCTTGCAAGC CTGGGGTGGC AGGGCCACAT TGTGACAGGT GCATGGTGGG ATACTGGGGC 
TTTGGAGACT ACGGCTGCAG ACCTTGTGAC TGTGCGGGGA GCTGCGACCC GCTCACGGGA 
GACTGCATCA GCAGCAATGC TGACGTGGAC TGGTATCACG AAGTCCCCGC CTTTCACTCT 
CTGCACAATA AGAGTGAGCC AGGCTGGGAG TGGGAAGATG AGCAGGGATT TTCTGCACTT 
CGACACTCAG GTAAATGTGA ATGTAAGGAA CAAGTGTTAG GAAACCCCAA GGCCTTCTGT 
GGAATGAAGT ATTCATATGT GTTAAAAATC AAGATTTTAT CAGCTCATGA TAAAGGTTCC 
CACGCTGAGG TCAACGTGAA GATTAAGAAA GTCTTACAGG CTACCAAACT GAAGATCTTA 
CGAGGCAAGA GAACACTCTA TCCCGAGTCC TGGACTAACA GAGGCTGCAC CTGCCCGATC 
CTCAATCCAG GCTTGGAGTA CCTGGTAGCT GGCTATGAGG ACGTGAGAAC AGGCAGATTA 
ATTGTGAATA TGAAAAGCTT CGTCCAGCCC TGGAAACCAG CTCTTGGGAG AAGAGTCATG 
CACATCTTAA AAAGAGAATG CGTGGAGCAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B.
The Journal of experimental medicine213(13)2949-2966(2016 Dec)
Hayano Y,Takasu K,Koyama Y,Yamada M,Ogawa K,Minami K,Asaki T,Kitada K,Kuwabara S,Yamashita T

Transcriptome-based systematic identification of extracellular matrix proteins.
Proceedings of the National Academy of Sciences of the United States of America105(35)12849-54(2008 Sep)
Manabe R,Tsutsui K,Yamada T,Kimura M,Nakano I,Shimono C,Sanzen N,Furutani Y,Fukuda T,Oguri Y,Shimamoto K,Kiyozumi D,Sato Y,Sado Y,Senoo H,Yamashina S,Fukuda S,Kawai J,Sugiura N,Kimata K,Hayashizaki Y,Sekiguchi K

Binding of netrin-4 to laminin short arms regulates basement membrane assembly.
The Journal of biological chemistry282(33)23750-8(2007 Aug)
Schneiders FI,Maertens B,B?se K,Li Y,Brunken WJ,Paulsson M,Smyth N,Koch M

Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis.
Current biology : CB14(10)897-905(2004 May)
Liu Y,Stein E,Oliver T,Li Y,Brunken WJ,Koch M,Tessier-Lavigne M,Hogan BL

A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin: identification, expression, and functional characterization.
The Journal of cell biology151(2)221-34(2000 Oct)
Koch M,Murrell JR,Hunter DD,Olson PF,Jin W,Keene DR,Brunken WJ,Burgeson RE