Slc6a14 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc6a14
Entrez Gene ID	298340
Full Name	solute carrier family 6 member 14
Synonyms	Atb0+
General protein information	Preferred Names solute carrier family 6 member 14 Names sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) colonic system B0+ amino acid transporter neutral cationic amino acid transporter B0,+ solute carrier family 6 (amino acid transporter), member 14 solute carrier family 6 (neurotransmitter transporter), member 14
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq34

mRNA and Protein(s)

mRNA	Protein	Name
NM_001037544.1	NP_001032633.1	sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC6A14	NP_009162.1
Bos taurus (cattle)	SLC6A14	NP_001091931.1
Danio rerio (zebrafish)	slc6a14	XP_001923596.1
Rattus norvegicus (Norway rat)	Slc6a14	NP_001032633.1
Xenopus tropicalis (tropical clawed frog)	slc6a14.1	XP_002939712.2
Pan troglodytes (chimpanzee)	SLC6A14	XP_003317696.1
	SLC6A14	XP_001104391.1
Canis lupus familiaris (dog)	SLC6A14	XP_549207.2
Mus musculus (house mouse)	Slc6a14	NP_064433.3
Gallus gallus (chicken)	SLC6A14	XP_003641183.1

Gene Ontology
Bibliography

Related articles in PubMed

Protein kinase C restricts transport of carnitine by amino acid transporter ATB(0,+) apically localized in the blood-brain barrier.
Michalec K, Mysiorek C, Kuntz M, B?r?zowski V, Szczepankiewicz AA, Wilczy?ski GM, Cecchelli R, Na??cz KA
Archives of biochemistry and biophysics55428-35(2014 Jul)

Protein kinase C regulates amino acid transporter ATB(0,+).
Samluk L, Czeredys M, Skowronek K, Na??cz KA
Biochemical and biophysical research communications422(1)64-9(2012 May)

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Kesimer M, Scull M, Brighton B, DeMaria G, Burns K, O'Neal W, Pickles RJ, Sheehan JK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology23(6)1858-68(2009 Jun)

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal of proteome research8(3)1304-14(2009 Mar)

Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes.
Uchiyama T, Fujita T, Gukasyan HJ, Kim KJ, Borok Z, Crandall ED, Lee VH
Journal of cellular physiology214(3)645-54(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The analyses of brain slices demonstrated ATB(0,+) luminal localization in brain capillaries, confirmed by biotinylation experiments in an in vitro model of the blood-brain barrier.
Title: Protein kinase C restricts transport of carnitine by amino acid transporter ATB(0,+) apically localized in the blood-brain barrier.

The observed regulation of ATB(0,+) by PKC correlates with high activity of both proteins reported for cancer cells.
Title: Protein kinase C regulates amino acid transporter ATB(0,+).

Rat pneumocytes express ATB(0,+), which may partly contribute towards recovering cationic and neutral amino acids from alveolar luminal fluid.
Title: Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes.

The role of carnitine in inflammatory bowel disease (IBD)was evaluated using the expression of the carnitine transporters OCTN2 and ATB0+, and butyrate metabolism in colonocytes in a rat model of IBD.
Title: Experimental colitis: decreased Octn2 and Atb0+ expression in rat colonocytes induces carnitine depletion that is reversible by carnitine-loaded liposomes.

The following Slc6a14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc6a14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09429	NM_001037544.1 Latest version!	Rattus norvegicus solute carrier family 6 member 14 (Slc6a14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc6a14 ( NM_001037544.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001032633.1 Rattus norvegicus solute carrier family 6 member 14 (Slc6a14), mRNA.

Price & Availability↑

CloneID	ORa09429
Clone ID Related Accession (Same CDS sequence)	NM_001037544.1
Accession Version	NM_001037544.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1923bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ969954.1. On Dec 2, 2005 this sequence version replaced XM_233305.3. ##Evidence-Data-START## Transcript exon combination :: AJ969954.1, EF494736.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689599, SAMEA2689602 [ECO:0000348] ##Evidence-Data-END##

ATGGACAGAT TGAAGTGCCC GAGCTTCTTC AAGTGCAGAC AGAAGGAGAA AGTGACAGCT 
TCATCTGAGA ACTTCCATGT TGGTGAAAAT GATGAAAATC AGGAGCGTGG TAACTGGTCC 
AAAAAATCAG ATTATCTTCT TTCCATGGTT GGCTATGCAG TGGGATTGGG CAACGTGTGG 
CGATTCCCTT ACCTGACCTA CACCAATGGT GGAGGTGCTT TCTTGATACC CTATGCAATT 
ATGCTAGCAT TGGCTGGCTT GCCTTTGTTC TTCCTTGAAT GTTCACTGGG ACAATTTGCT 
AGCTTAGGTC CAGTTTCAGT TTGGAGGATT TTGCCACTGT TTCAAGGTGT GGGAATCACG 
ATGGTCCTGA TATCCATTTT TGTGACAATT TATTATAATG TCATCATTGC CTATAGTCTT 
TACTACTTAT TTGCTTCTTT TCAAAGTGTA CTGCCATGGG CTAATTGTTC TTCTTCTTGG 
GCAGACGATA ACTGTAGCAG ACAACCAATA GTAACTGGCT GTCGTGTGAG CACAGACACA 
GGAGGAGACA TGTTTATGAA TATAAGCTGG GTAAATAGCA ACAACTTCAC CTGCTTGAAT 
GGTAGTGAAG TTTTTCGGCC AGGACAACTT CCCAGTGAAC AGTATTGGGA TAAAGTGACG 
CTTCGGAGGT CAAGTGGAAT GGATGAAACT GGCGTAATTG TGTGGTACTT AGCACTTTGC 
CTTCTTCTAG CTTGGATCAT AGTTGGAGCA GCACTATTTA AAGGAATCAA ATCCTCTGGC 
AAGGTGGTAT ATTTTACAGC TCTTTTCCCG TATGTGGTCC TTCTCATTCT ACTAATACGA 
GGTGCAACTT TGGAGGGTGC ATCAAAAGGC ATTTCATATT ACATTGGAGC ACAGTCAAAT 
TTTACAAAAC TCAGAGAAGC TGAGGTTTGG AAGGATGCTG CCACTCAGAT ATTTTATTCC 
CTTTCTGTGG CTTGGGGTGG CCTAGTGGCT CTGTCATCTT ACAACAAGTT CAACAACAAC 
TGTTACTCTG ATGCCATTAT AGTTTGCTTG ACCAACTGCC TCACTAGTGT GTTTGCTGGA 
TTCGCCATTT TTTCTATTCT GGGACACATG GCTCATATAT CCGGAAAGGA AGTCTCTCAA 
GTTGTAAAAT CAGGATTTGA CTTGGCATTC ATTGCTTATC CGGAAGCACT AGCTCAACTC 
CCAGGTGGTC CATTCTGGTC CATATTATTT TTCTTCATGC TTTTAACATT GGGTCTGGAT 
TCTCAATTTG CTTCTATTGA AACAATCACA ACAACAATTC AAGATTTGTT TCCCAAAGCA 
ATGAAACGCA TGAGGGTTCC TATAACTTTG GGATGCTGCT TGATTTTGTT TCTCCTTGGT 
CTCGTCTGTG TGACTCAGGC TGGAATTTAC TGGGTTCATT TGATTGATCA CTTCTGTGCT 
GGATGGGGGA TCTTAATTGC TGCCATCTTG GAAATTGCAG GAATCATCTG GATTTATGGA 
GGAAATAGGT TCATTGAAGA TATAGAAATG ATGATTGGAG CAAAAAGATG GCTATTCTGG 
CTTTGGTGGA GAGCTTGTTG GTTTGTCATC ACTCCTATAC TGTTGTCTGC AATTCTAGTC 
TGGTCACTGG TGAAATTTCA CAGACCTAAT TATGCTGATA TTCCATATCC TGACTGGGGA 
GTCGCTCTCG GATGGTGTAT GATTATTTTC TGCATTATTT GGATACCAAT TATGGCGATC 
ATAAAAATAG TTCGGGCTGA AGGAAACATC CTTCAGCGTA TCATAAAATG CTGTAGACCA 
GCTTCAAACT GGGGTCCATA CCTGGAAAAA CATCGTGGAG AGAGATATAA AGACATGGCT 
GAACCTGCAA AGGAGACTGA CCACGAAATA CCTACTATTA GTGGCACTAG AAAACCAGAA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032633.1
CDS	118..2040
Translation	MDRLKCPSFFKCRQKEKVTASSENFHVGENDENQERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYLFASFQSVLPWANCSSSWADDNCSRQPIVTGCRVSTDTGGDMFMNISWVNSNNFTCLNGSEVFRPGQLPSEQYWDKVTLRRSSGMDETGVIVWYLALCLLLAWIIVGAALFKGIKSSGKVVYFTALFPYVVLLILLIRGATLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFNNNCYSDAIIVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKAMKRMRVPITLGCCLILFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWLFWLWWRACWFVITPILLSAILVWSLVKFHRPNYADIPYPDWGVALGWCMIIFCIIWIPIMAIIKIVRAEGNILQRIIKCCRPASNWGPYLEKHRGERYKDMAEPAKETDHEIPTISGTRKPE

Target ORF information:

RefSeq Version	NM_001037544.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 6 member 14 (Slc6a14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037544.1

ORF Insert Sequence:

ATGGACAGAT TGAAGTGCCC GAGCTTCTTC AAGTGCAGAC AGAAGGAGAA AGTGACAGCT 
TCATCTGAGA ACTTCCATGT TGGTGAAAAT GATGAAAATC AGGAGCGTGG TAACTGGTCC 
AAAAAATCAG ATTATCTTCT TTCCATGGTT GGCTATGCAG TGGGATTGGG CAACGTGTGG 
CGATTCCCTT ACCTGACCTA CACCAATGGT GGAGGTGCTT TCTTGATACC CTATGCAATT 
ATGCTAGCAT TGGCTGGCTT GCCTTTGTTC TTCCTTGAAT GTTCACTGGG ACAATTTGCT 
AGCTTAGGTC CAGTTTCAGT TTGGAGGATT TTGCCACTGT TTCAAGGTGT GGGAATCACG 
ATGGTCCTGA TATCCATTTT TGTGACAATT TATTATAATG TCATCATTGC CTATAGTCTT 
TACTACTTAT TTGCTTCTTT TCAAAGTGTA CTGCCATGGG CTAATTGTTC TTCTTCTTGG 
GCAGACGATA ACTGTAGCAG ACAACCAATA GTAACTGGCT GTCGTGTGAG CACAGACACA 
GGAGGAGACA TGTTTATGAA TATAAGCTGG GTAAATAGCA ACAACTTCAC CTGCTTGAAT 
GGTAGTGAAG TTTTTCGGCC AGGACAACTT CCCAGTGAAC AGTATTGGGA TAAAGTGACG 
CTTCGGAGGT CAAGTGGAAT GGATGAAACT GGCGTAATTG TGTGGTACTT AGCACTTTGC 
CTTCTTCTAG CTTGGATCAT AGTTGGAGCA GCACTATTTA AAGGAATCAA ATCCTCTGGC 
AAGGTGGTAT ATTTTACAGC TCTTTTCCCG TATGTGGTCC TTCTCATTCT ACTAATACGA 
GGTGCAACTT TGGAGGGTGC ATCAAAAGGC ATTTCATATT ACATTGGAGC ACAGTCAAAT 
TTTACAAAAC TCAGAGAAGC TGAGGTTTGG AAGGATGCTG CCACTCAGAT ATTTTATTCC 
CTTTCTGTGG CTTGGGGTGG CCTAGTGGCT CTGTCATCTT ACAACAAGTT CAACAACAAC 
TGTTACTCTG ATGCCATTAT AGTTTGCTTG ACCAACTGCC TCACTAGTGT GTTTGCTGGA 
TTCGCCATTT TTTCTATTCT GGGACACATG GCTCATATAT CCGGAAAGGA AGTCTCTCAA 
GTTGTAAAAT CAGGATTTGA CTTGGCATTC ATTGCTTATC CGGAAGCACT AGCTCAACTC 
CCAGGTGGTC CATTCTGGTC CATATTATTT TTCTTCATGC TTTTAACATT GGGTCTGGAT 
TCTCAATTTG CTTCTATTGA AACAATCACA ACAACAATTC AAGATTTGTT TCCCAAAGCA 
ATGAAACGCA TGAGGGTTCC TATAACTTTG GGATGCTGCT TGATTTTGTT TCTCCTTGGT 
CTCGTCTGTG TGACTCAGGC TGGAATTTAC TGGGTTCATT TGATTGATCA CTTCTGTGCT 
GGATGGGGGA TCTTAATTGC TGCCATCTTG GAAATTGCAG GAATCATCTG GATTTATGGA 
GGAAATAGGT TCATTGAAGA TATAGAAATG ATGATTGGAG CAAAAAGATG GCTATTCTGG 
CTTTGGTGGA GAGCTTGTTG GTTTGTCATC ACTCCTATAC TGTTGTCTGC AATTCTAGTC 
TGGTCACTGG TGAAATTTCA CAGACCTAAT TATGCTGATA TTCCATATCC TGACTGGGGA 
GTCGCTCTCG GATGGTGTAT GATTATTTTC TGCATTATTT GGATACCAAT TATGGCGATC 
ATAAAAATAG TTCGGGCTGA AGGAAACATC CTTCAGCGTA TCATAAAATG CTGTAGACCA 
GCTTCAAACT GGGGTCCATA CCTGGAAAAA CATCGTGGAG AGAGATATAA AGACATGGCT 
GAACCTGCAA AGGAGACTGA CCACGAAATA CCTACTATTA GTGGCACTAG AAAACCAGAA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protein kinase C restricts transport of carnitine by amino acid transporter ATB(0,+) apically localized in the blood-brain barrier.
Archives of biochemistry and biophysics55428-35(2014 Jul)
Michalec K,Mysiorek C,Kuntz M,B?r?zowski V,Szczepankiewicz AA,Wilczy?ski GM,Cecchelli R,Na??cz KA

Protein kinase C regulates amino acid transporter ATB(0,+).
Biochemical and biophysical research communications422(1)64-9(2012 May)
Samluk L,Czeredys M,Skowronek K,Na??cz KA

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology23(6)1858-68(2009 Jun)
Kesimer M,Scull M,Brighton B,DeMaria G,Burns K,O'Neal W,Pickles RJ,Sheehan JK

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Journal of proteome research8(3)1304-14(2009 Mar)
Gonzalez-Begne M,Lu B,Han X,Hagen FK,Hand AR,Melvin JE,Yates JR

Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes.
Journal of cellular physiology214(3)645-54(2008 Mar)
Uchiyama T,Fujita T,Gukasyan HJ,Kim KJ,Borok Z,Crandall ED,Lee VH

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Slc6a14 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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