Akirin2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Akirin2
Entrez Gene ID	297968
Full Name	akirin 2
Synonyms	FBI1,RGD1307791
General protein information	Preferred Names akirin 2 Names akirin-2 fourteen-three-three beta interactant 1 fourteen-three-three beta interacting-protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q21

mRNA and Protein(s)

mRNA	Protein	Name
NM_001039914.2	NP_001035003.1	akirin-2
XM_008763614.2	XP_008761836.1	akirin-2 isoform X1

Pathways from BioSystems

Homologies

	LOC700914	XP_001089230.1
Gallus gallus (chicken)	AKIRIN2	NP_001180524.1
Danio rerio (zebrafish)	akirin2	NP_998459.2
Canis lupus familiaris (dog)	AKIRIN2	XP_542340.3
Drosophila melanogaster (fruit fly)	akirin	NP_729249.1
Xenopus tropicalis (tropical clawed frog)	akirin2	NP_988914.1
Bos taurus (cattle)	AKIRIN2	NP_001103557.1
Mus musculus (house mouse)	Akirin2	NP_001007590.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006809	XP_308938.4
Homo sapiens (human)	AKIRIN2	NP_060534.1
Pan troglodytes (chimpanzee)	AKIRIN2	NP_001238836.1
Rattus norvegicus (Norway rat)	Akirin2	NP_001035003.1

Gene Ontology
Bibliography

Related articles in PubMed

FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cells.
Komiya Y, Akiyama H, Sakumoto R, Tashiro F
Biochemical and biophysical research communications444(3)382-6(2014 Feb)

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA
Molecular and cellular biology33(8)1487-502(2013 Apr)

The FBI1/Akirin2 target gene, BCAM, acts as a suppressive oncogene.
Akiyama H, Iwahana Y, Suda M, Yoshimura A, Kogai H, Nagashima A, Ohtsuka H, Komiya Y, Tashiro F
PloS one8(11)e78716(2013)

A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis.
Komiya Y, Kurabe N, Katagiri K, Ogawa M, Sugiyama A, Kawasaki Y, Tashiro F
The Journal of biological chemistry283(27)18753-64(2008 Jul)

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.
Goto A, Matsushita K, Gesellchen V, El Chamy L, Kuttenkeuler D, Takeuchi O, Hoffmann JA, Akira S, Boutros M, Reichhart JM
Nature immunology9(1)97-104(2008 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that FBI1/Akirin2 plays an important role in oncogenesis of LLC1 lung carcinoma cells, and this protein may also serve as an oncogene in other cancers
Title: FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cells.

Data indicate that the 14-3-3beta-FBI1/Akirin2 complex bound to the basal cell adhesion molecule (BCAM) promoter and repressed transcription.
Title: The FBI1/Akirin2 target gene, BCAM, acts as a suppressive oncogene.

The following Akirin2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Akirin2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13396	NM_001039914.2 Latest version!	Rattus norvegicus akirin 2 (Akirin2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
ORa45485	XM_008763614.2 Latest version!	Rattus norvegicus akirin 2 (Akirin2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Akirin2 ( NM_001039914.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001035003.1 Rattus norvegicus akirin 2 (Akirin2), mRNA.

Price & Availability↑

CloneID	ORa13396
Clone ID Related Accession (Same CDS sequence)	NM_001039914.2
Accession Version	NM_001039914.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Rattus norvegicus(Norway rat)
Product	akirin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB234867.1. On Feb 23, 2013 this sequence version replaced NM_001039914.1. ##Evidence-Data-START## Transcript exon combination :: AB234867.1, FM074314.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGTGCG GAGCCACTCT GAAAAGGACT CTGGATTTCG ACCCACTGCT TAGCCCGGCA 
TCTCCGAAGC GGAGGCGGTG CGCGCCTTTG TCGGCACCGG CTTCGGCTGC CGCCTCCCCT 
GCCGCCGCTA CCGCCGCCGC CGCTGCCTCT GCCGCGGCCG CTTCGCCGCA GAAGTATCTC 
CGGATGGAGC CTTCCCCCTT CGGCGACGTC TCCTCCCGTC TCACCACAGA ACAAATTCTG 
TACAACATAA AACAGGAATA TAAACGTATG CAGAAGAGGA GACATTTAGA AGCTAGTTTT 
CAGCAGACAG ACCCAGGTTG TAGTTCCGAT TCACAGCCAC ATGCATTTCT CATCAGTGGA 
CCAGCATCAC CAGGGACTTC ATCTGCAACA TCCTCACCAT TAAAAAAAGA ACAGCCCTTA 
TTTACTCTAA GGCAGGTTGG GATGATCTGT GAACGTTTGT TGAAAGAACG GGAAGAGAAG 
GTTCGAGAAG AATATGAAGA AATACTGAAC ACAAAACTTG CAGAACAATA CGATGCATTT 
GTGAAGTTTA CGCATGATCA GATAATGCGG CGATATGGAG AACAGCCTGC TAGTTATGTT 
TCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035003.1
CDS	199..804
Translation	MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAATAAAAASAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLEASFQQTDPGCSSDSQPHAFLISGPASPGTSSATSSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS

Target ORF information:

RefSeq Version	NM_001039914.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus akirin 2 (Akirin2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039914.2

ORF Insert Sequence:

ATGGCGTGCG GAGCCACTCT GAAAAGGACT CTGGATTTCG ACCCACTGCT TAGCCCGGCA 
TCTCCGAAGC GGAGGCGGTG CGCGCCTTTG TCGGCACCGG CTTCGGCTGC CGCCTCCCCT 
GCCGCCGCTA CCGCCGCCGC CGCTGCCTCT GCCGCGGCCG CTTCGCCGCA GAAGTATCTC 
CGGATGGAGC CTTCCCCCTT CGGCGACGTC TCCTCCCGTC TCACCACAGA ACAAATTCTG 
TACAACATAA AACAGGAATA TAAACGTATG CAGAAGAGGA GACATTTAGA AGCTAGTTTT 
CAGCAGACAG ACCCAGGTTG TAGTTCCGAT TCACAGCCAC ATGCATTTCT CATCAGTGGA 
CCAGCATCAC CAGGGACTTC ATCTGCAACA TCCTCACCAT TAAAAAAAGA ACAGCCCTTA 
TTTACTCTAA GGCAGGTTGG GATGATCTGT GAACGTTTGT TGAAAGAACG GGAAGAGAAG 
GTTCGAGAAG AATATGAAGA AATACTGAAC ACAAAACTTG CAGAACAATA CGATGCATTT 
GTGAAGTTTA CGCATGATCA GATAATGCGG CGATATGGAG AACAGCCTGC TAGTTATGTT 
TCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Akirin2 ( XM_008763614.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008761836.1 Rattus norvegicus akirin 2 (Akirin2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa45485
Clone ID Related Accession (Same CDS sequence)	XM_008763614.2
Accession Version	XM_008763614.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	akirin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008763614.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGTGCG GAGCCACTCT GAAAAGGACT CTGGATTTCG ACCCACTGCT TAGCCCGGCA 
TCTCCGAAGC GGAGGCGGTG CGCGCCTTTG TCGGCACCGG CTTCGGCTGC CGCCTCCCCT 
GCCGCCGCTA CCGCCGCCGC CGCTGCCTCT GCCGCGGCCG CTTCGCCGCA GAAGTATCTC 
CGGATGGAGC CTTCCCCCTT CGGCGACGTC TCCTCCCGTC TCACCACAGA ACAAATTCTG 
TACAACATAA AACAGGAATA TAAACGTATG CAGAAGAGGA GACATTTAGA AGCTAGTTTT 
CAGCAGACAG ACCCAGGTTG TAGTTCCGAT TCACAGCCAC ATGCATTTCT CATCAGTGGA 
CCAGCATCAC CAGGGACTTC ATCTGCAACA TCCTCACCAT TAAAAAAAGA ACAGCCCTTA 
TTTACTCTAA GGCAGGTTGG GATGATCTGT GAACGTTTGT TGAAAGAACG GGAAGAGAAG 
GTTCGAGAAG AATATGAAGA AATACTGAAC ACAAAACTTG CAGAACAATA CGATGCATTT 
GTGAAGTTTA CGCATGATCA GATAATGCGG CGATATGGAG AACAGCCTGC TAGTTGTAAG 
TATTTGACCT TTGAACTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008761836.1
CDS	449..1069
Translation	MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAATAAAAASAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLEASFQQTDPGCSSDSQPHAFLISGPASPGTSSATSSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASCKYLTFEL

Target ORF information:

RefSeq Version	XM_008763614.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus akirin 2 (Akirin2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008763614.2

ORF Insert Sequence:

ATGGCGTGCG GAGCCACTCT GAAAAGGACT CTGGATTTCG ACCCACTGCT TAGCCCGGCA 
TCTCCGAAGC GGAGGCGGTG CGCGCCTTTG TCGGCACCGG CTTCGGCTGC CGCCTCCCCT 
GCCGCCGCTA CCGCCGCCGC CGCTGCCTCT GCCGCGGCCG CTTCGCCGCA GAAGTATCTC 
CGGATGGAGC CTTCCCCCTT CGGCGACGTC TCCTCCCGTC TCACCACAGA ACAAATTCTG 
TACAACATAA AACAGGAATA TAAACGTATG CAGAAGAGGA GACATTTAGA AGCTAGTTTT 
CAGCAGACAG ACCCAGGTTG TAGTTCCGAT TCACAGCCAC ATGCATTTCT CATCAGTGGA 
CCAGCATCAC CAGGGACTTC ATCTGCAACA TCCTCACCAT TAAAAAAAGA ACAGCCCTTA 
TTTACTCTAA GGCAGGTTGG GATGATCTGT GAACGTTTGT TGAAAGAACG GGAAGAGAAG 
GTTCGAGAAG AATATGAAGA AATACTGAAC ACAAAACTTG CAGAACAATA CGATGCATTT 
GTGAAGTTTA CGCATGATCA GATAATGCGG CGATATGGAG AACAGCCTGC TAGTTGTAAG 
TATTTGACCT TTGAACTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cells.
Biochemical and biophysical research communications444(3)382-6(2014 Feb)
Komiya Y,Akiyama H,Sakumoto R,Tashiro F

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Molecular and cellular biology33(8)1487-502(2013 Apr)
Armour SM,Bennett EJ,Braun CR,Zhang XY,McMahon SB,Gygi SP,Harper JW,Sinclair DA

The FBI1/Akirin2 target gene, BCAM, acts as a suppressive oncogene.
PloS one8(11)e78716(2013)
Akiyama H,Iwahana Y,Suda M,Yoshimura A,Kogai H,Nagashima A,Ohtsuka H,Komiya Y,Tashiro F

A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis.
The Journal of biological chemistry283(27)18753-64(2008 Jul)
Komiya Y,Kurabe N,Katagiri K,Ogawa M,Sugiyama A,Kawasaki Y,Tashiro F

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.
Nature immunology9(1)97-104(2008 Jan)
Goto A,Matsushita K,Gesellchen V,El Chamy L,Kuttenkeuler D,Takeuchi O,Hoffmann JA,Akira S,Boutros M,Reichhart JM

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Akirin2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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