Pacsin1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pacsin1
Entrez Gene ID	29704
Full Name	protein kinase C and casein kinase substrate in neurons 1
General protein information	Preferred Names protein kinase C and casein kinase substrate in neurons 1 Names protein kinase C and casein kinase substrate in neurons protein 1 dynamin PRD-interacting protein dynamin proline-rich domain-interacting protein sdpI synaptic, dynamin-associated protein I syndapin-1 syndapin-I
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	may regulate cytoskeletal dynamics; may play a role in synaptic vesicle recycling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017294.1	NP_058990.1	protein kinase C and casein kinase substrate in neurons protein 1

Pathways from BioSystems

Homologies

	PACSIN1	XP_001116508.1
Bos taurus (cattle)	PACSIN1	NP_001094571.1
Rattus norvegicus (Norway rat)	Pacsin1	NP_058990.1
Pan troglodytes (chimpanzee)	PACSIN1	XP_518415.4
Canis lupus familiaris (dog)	PACSIN1	XP_850083.1
Gallus gallus (chicken)	PACSIN1	XP_418028.3
Homo sapiens (human)	PACSIN1	NP_001186512.1
Mus musculus (house mouse)	Pacsin1	NP_001273672.1
Danio rerio (zebrafish)	pacsin1b	NP_001028900.1
Xenopus tropicalis (tropical clawed frog)	pacsin1	XP_004910748.1

Gene Ontology
Bibliography

Related articles in PubMed

PACSIN1 regulates the dynamics of AMPA receptor trafficking.
Widagdo J, Fang H, Jang SE, Anggono V
Scientific reports631070(2016 Aug)

The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin.
Hou W, Izadi M, Nemitz S, Haag N, Kessels MM, Qualmann B
PLoS biology13(9)e1002233(2015)

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kr?hnert K, Sch?fer C, Rammner B, Koo SJ, Cla?en GA, Krauss M, Haucke V, Urlaub H, Rizzoli SO
Science (New York, N.Y.)344(6187)1023-8(2014 May)

Proteomic analysis of glycine receptor ? subunit (GlyR?)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors.
Del Pino I, Koch D, Schemm R, Qualmann B, Betz H, Paarmann I
The Journal of biological chemistry289(16)11396-409(2014 Apr)

PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression.
Anggono V, Ko?-Schmitz Y, Widagdo J, Kormann J, Quan A, Chen CM, Robinson PJ, Choi SY, Linden DJ, Plomann M, Huganir RL
Proceedings of the National Academy of Sciences of the United States of America110(34)13976-81(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The SdpI-binding site was mapped to a proline-rich sequence of 22 amino acids within the intracellular loop of GlyRbeta.
Title: Proteomic analysis of glycine receptor ? subunit (GlyR?)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors.

PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression.
Title: PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression.

Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation
Title: Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation.

Syndapin I was identified as the first non-kinase substrate for CaMKK.
Title: Identification of a novel CaMKK substrate.

syndapin 1 and novel protein kinase Cepsilon (nPKCepsilon) were identified as the TP-associated proteins
Title: Biochemical characterization of tau protein and its associated syndapin 1 and protein kinase Cepsilon for their functional regulation in rat brain.

The following Pacsin1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pacsin1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03564	NM_017294.1 Latest version!	Rattus norvegicus protein kinase C and casein kinase substrate in neurons 1 (Pacsin1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pacsin1 ( NM_017294.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058990.1 Rattus norvegicus protein kinase C and casein kinase substrate in neurons 1 (Pacsin1), mRNA.

Price & Availability↑

CloneID	ORa03564
Clone ID Related Accession (Same CDS sequence)	NM_017294.1
Accession Version	NM_017294.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1326bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	protein kinase C and casein kinase substrate in neurons protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF104402.1. On Jun 25, 2006 this sequence version replaced XM_001078122.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF104402.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCTGGCC CCTACGATGA GGCCTCGGAG GAGATCACAG ATAGCTTCTG GGAGGTGGGG 
AACTACAAGC GGACGGTGAA GCGCATCGAC GATGGGCACC GCTTGTGCAA CGACCTCATG 
AGCTGCGTGC AGGAGCGCGC CAAGATCGAG AAGGCATACG CGCAGCAGCT CACCGACTGG 
GCCAAGCGCT GGCGCCAGCT CATCGAGAAA GGTCCCCAGT ATGGCAGCCT GGAGCGGGCC 
TGGGGCGCCA TGATGACTGA GGCAGACAAA GTCAGCGAGC TGCACCAGGA GGTGAAGAAC 
AGCCTACTGA ACGAGGACCT GGAGAAAGTC AAGAACTGGC AGAAGGATGC CTACCACAAG 
CAGATCATGG GCGGCTTCAA GGAGACGAAG GAGGCGGAGG ATGGCTTCCG AAAGGCTCAG 
AAGCCCTGGG CTAAGAAGAT GAAGGAGCTG GAGGCAGCCA AGAAGGCCTA TCACTTGGCT 
TGCAAGGAGG AGAAGTTGGC CATGACCCGG GAGATGAACA GTAAGACGGA GCAGTCGGTC 
ACCCCTGAAC AGCAGAAGAA ACTTGTGGAT AAAGTGGACA AATGCAGGCA GGATGTACAA 
AAGACTCAGG AGAAGTATGA GAAGGTGCTG GAAGATGTGG GCAAGACCAC ACCGCAGTAC 
ATGGAGGGTA TGGAGCAGGT GTTCGAGCAG TGCCAGCAGT TTGAGGAGAA GCGGCTGGTC 
TTCCTGAAGG AAGTCCTGCT AGATATCAAA CGGCATCTCA ACCTAGCGGA GAACAGCAGC 
TACATTCACG TCTATCGAGA ACTGGAGCAG GCCATCCGAG GGGCCGATGC CCAGGAGGAC 
CTCAGGTGGT TCCGTAGCAC CAGTGGCCCC GGGATGCCCA TGAACTGGCC GCAGTTCGAG 
GAGTGGAACC CAGACCTCCC CCACACCGCT GCCAAGAAGG AGAAACAGCC TAAGAAGGCA 
GAGGGGGCCG CCCTGAGCAA TGCCACTGGG GCTGTAGAAT CTACATCCCA GGCTGGGGAC 
CGTGGCAGTG TCAGCAGCTA TGACCGAGGC CAAGCGTATG CCACCGAGTG GTCAGACGAT 
GAGAGCGGAA ACCCCTTTGG GGGGAACGAG GCCAATGGTG GCGCCAACCC CTTCGAGGAC 
GATGCCAAGG GAGTTCGTGT ACGGGCACTC TATGACTACG ACGGTCAGGA GCAGGATGAG 
CTCAGCTTCA AGGCCGGAGA CGAGCTCACC AAGCTCGGAG AGGAGGACGA ACAGGGTTGG 
TGCCGCGGGC GGCTGGACAG CGGGCAGCTG GGCCTCTATC CTGCCAACTA CGTTGAGGCT 
ATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058990.1
CDS	156..1481
Translation	MSGPYDEASEEITDSFWEVGNYKRTVKRIDDGHRLCNDLMSCVQERAKIEKAYAQQLTDWAKRWRQLIEKGPQYGSLERAWGAMMTEADKVSELHQEVKNSLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQKKLVDKVDKCRQDVQKTQEKYEKVLEDVGKTTPQYMEGMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTAAKKEKQPKKAEGAALSNATGAVESTSQAGDRGSVSSYDRGQAYATEWSDDESGNPFGGNEANGGANPFEDDAKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI

Target ORF information:

RefSeq Version	NM_017294.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein kinase C and casein kinase substrate in neurons 1 (Pacsin1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017294.1

ORF Insert Sequence:

ATGTCTGGCC CCTACGATGA GGCCTCGGAG GAGATCACAG ATAGCTTCTG GGAGGTGGGG 
AACTACAAGC GGACGGTGAA GCGCATCGAC GATGGGCACC GCTTGTGCAA CGACCTCATG 
AGCTGCGTGC AGGAGCGCGC CAAGATCGAG AAGGCATACG CGCAGCAGCT CACCGACTGG 
GCCAAGCGCT GGCGCCAGCT CATCGAGAAA GGTCCCCAGT ATGGCAGCCT GGAGCGGGCC 
TGGGGCGCCA TGATGACTGA GGCAGACAAA GTCAGCGAGC TGCACCAGGA GGTGAAGAAC 
AGCCTACTGA ACGAGGACCT GGAGAAAGTC AAGAACTGGC AGAAGGATGC CTACCACAAG 
CAGATCATGG GCGGCTTCAA GGAGACGAAG GAGGCGGAGG ATGGCTTCCG AAAGGCTCAG 
AAGCCCTGGG CTAAGAAGAT GAAGGAGCTG GAGGCAGCCA AGAAGGCCTA TCACTTGGCT 
TGCAAGGAGG AGAAGTTGGC CATGACCCGG GAGATGAACA GTAAGACGGA GCAGTCGGTC 
ACCCCTGAAC AGCAGAAGAA ACTTGTGGAT AAAGTGGACA AATGCAGGCA GGATGTACAA 
AAGACTCAGG AGAAGTATGA GAAGGTGCTG GAAGATGTGG GCAAGACCAC ACCGCAGTAC 
ATGGAGGGTA TGGAGCAGGT GTTCGAGCAG TGCCAGCAGT TTGAGGAGAA GCGGCTGGTC 
TTCCTGAAGG AAGTCCTGCT AGATATCAAA CGGCATCTCA ACCTAGCGGA GAACAGCAGC 
TACATTCACG TCTATCGAGA ACTGGAGCAG GCCATCCGAG GGGCCGATGC CCAGGAGGAC 
CTCAGGTGGT TCCGTAGCAC CAGTGGCCCC GGGATGCCCA TGAACTGGCC GCAGTTCGAG 
GAGTGGAACC CAGACCTCCC CCACACCGCT GCCAAGAAGG AGAAACAGCC TAAGAAGGCA 
GAGGGGGCCG CCCTGAGCAA TGCCACTGGG GCTGTAGAAT CTACATCCCA GGCTGGGGAC 
CGTGGCAGTG TCAGCAGCTA TGACCGAGGC CAAGCGTATG CCACCGAGTG GTCAGACGAT 
GAGAGCGGAA ACCCCTTTGG GGGGAACGAG GCCAATGGTG GCGCCAACCC CTTCGAGGAC 
GATGCCAAGG GAGTTCGTGT ACGGGCACTC TATGACTACG ACGGTCAGGA GCAGGATGAG 
CTCAGCTTCA AGGCCGGAGA CGAGCTCACC AAGCTCGGAG AGGAGGACGA ACAGGGTTGG 
TGCCGCGGGC GGCTGGACAG CGGGCAGCTG GGCCTCTATC CTGCCAACTA CGTTGAGGCT 
ATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PACSIN1 regulates the dynamics of AMPA receptor trafficking.
Scientific reports631070(2016 Aug)
Widagdo J,Fang H,Jang SE,Anggono V

The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin.
PLoS biology13(9)e1002233(2015)
Hou W,Izadi M,Nemitz S,Haag N,Kessels MM,Qualmann B

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Science (New York, N.Y.)344(6187)1023-8(2014 May)
Wilhelm BG,Mandad S,Truckenbrodt S,Kr?hnert K,Sch?fer C,Rammner B,Koo SJ,Cla?en GA,Krauss M,Haucke V,Urlaub H,Rizzoli SO

Proteomic analysis of glycine receptor ? subunit (GlyR?)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors.
The Journal of biological chemistry289(16)11396-409(2014 Apr)
Del Pino I,Koch D,Schemm R,Qualmann B,Betz H,Paarmann I

PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression.
Proceedings of the National Academy of Sciences of the United States of America110(34)13976-81(2013 Aug)
Anggono V,Ko?-Schmitz Y,Widagdo J,Kormann J,Quan A,Chen CM,Robinson PJ,Choi SY,Linden DJ,Plomann M,Huganir RL

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Pacsin1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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