Map2k5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Map2k5
Entrez Gene ID	29568
Full Name	mitogen activated protein kinase kinase 5
Synonyms	Mek5
General protein information	Preferred Names mitogen activated protein kinase kinase 5 Names dual specificity mitogen-activated protein kinase kinase 5 MAP kinase kinase 5 MAPK/ERK kinase 5 MAPKK 5 MEK 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24
Summary	kinase involved in signal transduction in the cell [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017595501.1	XP_017450990.1	dual specificity mitogen-activated protein kinase kinase 5 isoform X2
XM_017595502.1	XP_017450991.1	dual specificity mitogen-activated protein kinase kinase 5 isoform X3
XM_006243229.3	XP_006243291.1	dual specificity mitogen-activated protein kinase kinase 5 isoform X1
NM_001033987.1	NP_001029159.1	dual specificity mitogen-activated protein kinase kinase 5 isoform a
NM_017246.2	NP_058942.1	dual specificity mitogen-activated protein kinase kinase 5 isoform b

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MAP2K5	XP_001174814.1
Rattus norvegicus (Norway rat)	Map2k5	NP_001029159.1
Gallus gallus (chicken)	MAP2K5	NP_001073184.1
Homo sapiens (human)	MAP2K5	NP_660143.1
	MAP2K5	XP_001111645.1
Canis lupus familiaris (dog)	MAP2K5	XP_852868.3
Mus musculus (house mouse)	Map2k5	NP_035970.1
Xenopus tropicalis (tropical clawed frog)	map2k5	NP_001016288.1
Bos taurus (cattle)	MAP2K5	NP_001193699.1
Danio rerio (zebrafish)	map2k5	NP_001107789.1

Gene Ontology
Bibliography

Related articles in PubMed

Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades.
Stankiewicz TR, Ramaswami SA, Bouchard RJ, Aktories K, Linseman DA
The Journal of biological chemistry290(15)9363-76(2015 Apr)

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4).
Ohnesorge N, Viemann D, Schmidt N, Czymai T, Spiering D, Schmolke M, Ludwig S, Roth J, Goebeler M, Schmidt M
The Journal of biological chemistry285(34)26199-210(2010 Aug)

Mitogen-activated protein kinase activated protein kinase 2 (MK2) participates in p38 MAPK regulated control of oligodendrocyte differentiation.
Haines JD, Fang J, Mushynski WE, Almazan G
Glia58(11)1384-93(2010 Aug)

The ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats.
Wang RM, Zhang QG, Li J, Yang LC, Yang F, Brann DW
Brain research125532-41(2009 Feb)

The transcriptional regulation and cell-specific expression of the MAPK-activated protein kinase MK5.
Gerits N, Shiryaev A, Kostenko S, Klenow H, Shiryaeva O, Johannessen M, Moens U
Cellular & molecular biology letters14(4)548-74(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that NSC23766-mediated Rac inhibition induces cerebellar granule neurons (CGNs) apoptosis through deactivation of prosurvival MAP Kinase Kinase 5 MEK5/ERK5 kinase signaling.
Title: Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades.

The p38-mitogen-activated protein kinase activated protein kinase 2 (MK2) pathway is a component of the signaling cascade regulating oligodendrocyte differentiation.
Title: Mitogen-activated protein kinase activated protein kinase 2 (MK2) participates in p38 MAPK regulated control of oligodendrocyte differentiation.

Data show that the ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats.
Title: The ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats.

Several binding motifs for heat shock factor are dispersed in the mouse and rat promoter, and temperature shock transiently enhanced the MAP-kinase-activated kinase 5 transcript levels.
Title: The transcriptional regulation and cell-specific expression of the MAPK-activated protein kinase MK5.

a novel interaction between the PKA pathway and MAPK signaling cascades and suggest that MK5, but not MK2, is implicated in PKA-induced microfilament rearrangement.
Title: Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5.

The following Map2k5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Map2k5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa08815	NM_001033987.1 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa31279	XM_017595502.1 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa03379	NM_017246.2 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
ORa31276	XM_006243229.3 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa62342	XM_017595501.1 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Map2k5 ( NM_001033987.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029159.1 Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa08815
Clone ID Related Accession (Same CDS sequence)	NM_001033987.1
Accession Version	NM_001033987.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity mitogen-activated protein kinase kinase 5 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC078860.1. On Oct 9, 2005 this sequence version replaced XM_579403.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078860.1, U37462.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCTGTGGC TGGCCCTTGG CCCCTTTCGT GCCATGGAGA ACCAGGTGCT GGTGATTCGG 
ATCAAGATTC CAAATAGTGG CGCGGTGGAC TGGACCGTGC ACTCCGGGCC GCAGTTACTC 
TTCAGGGACG TGCTGGATGT GATAGGCCAG GTTCTGCCTG AAGCAACGAC GACAGCCTTT 
GAATATGAAG ATGAAGATGG TGATAGGATT ACAGTAAGAA GTGACGAAGA GATGAAGGCA 
ATGCTGTCCT ACTATTATTC CACAGTAATG GAACAGCAAG TAAATGGCCA GCTAATAGAG 
CCGCTGCAGA TCTTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 
AAGGTGAATA CACGGGCTGG ACCATCTCAG CACACCAGCC CTGTGGTCTC AGATTCACTT 
CCAAGCAATA GCTTGAAGAA GTCCTCGGCT GAACTGAGAA AGATACTGGC CAACGGCCAG 
ATGAATGAAC AAGACATACG GTATCGAGAC ACCCTTGGTC ATGGCAACGG AGGCACAGTC 
TACAAAGCAT ATCATGTCCC AAGTGGGAAA ATCTTAGCTG TAAAGGTTAT TCTGTTAGAC 
ATCACACTGG AGCTTCAGAA GCAGATCATG TCTGAGTTGG AAATTCTTTA TAAGTGTGAC 
TCATCGTATA TCATAGGATT TTACGGGGCA TTTTTTGTAG AAAACAGGAT TTCGATTTGT 
ACAGAATTCA TGGATGGGGG GTCTTTGGAT GTATATAGGA AAATTCCAGA GCACGTCCTC 
GGAAGAATTG CAGTAGCAGT TGTTAAAGGC CTTACCTATC TGTGGAGTTT AAAGATTTTA 
CACAGAGATG TGAAGCCTTC CAACATGCTT GTAAACACAA GCGGACAGGT CAAGCTGTGT 
GACTTCGGCG TGAGCACCCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 
GCTTATATGG CACCCGAAAG GATTTCAGGA GAGCAGTATG GGATCCATTC CGACGTGTGG 
AGCTTAGGGA TCTCTTTCAT GGAGCTTGCT CTTGGGAGGT TTCCATATCC TCAGATTCAG 
AAAAACCAGG GATCTTTAAT GCCTCTCCAG CTTCTGCAGT GCATTGTTGA TGAGGATTCG 
CCGGTCCTTC CGCTTGGAGA GTTCTCGGAG CCGTTTGTAC ATTTCATCAC TCAGTGCATG 
AGGAAGCAGC CCAAGGAAAG ACCAGCGCCC GAGGAGCTGA TGGGTCACCC ATTCATCGTG 
CAGTTCAATG ACGGAAACGC CACTGTGGTG TCCATGTGGG TTTGCCGAGC TCTGGAGGAG 
AGACGGAGCC AGCAGGGGCC CCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029159.1
CDS	600..1946
Translation	MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP

Target ORF information:

RefSeq Version	NM_001033987.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033987.1

ORF Insert Sequence:

ATGCTGTGGC TGGCCCTTGG CCCCTTTCGT GCCATGGAGA ACCAGGTGCT GGTGATTCGG 
ATCAAGATTC CAAATAGTGG CGCGGTGGAC TGGACCGTGC ACTCCGGGCC GCAGTTACTC 
TTCAGGGACG TGCTGGATGT GATAGGCCAG GTTCTGCCTG AAGCAACGAC GACAGCCTTT 
GAATATGAAG ATGAAGATGG TGATAGGATT ACAGTAAGAA GTGACGAAGA GATGAAGGCA 
ATGCTGTCCT ACTATTATTC CACAGTAATG GAACAGCAAG TAAATGGCCA GCTAATAGAG 
CCGCTGCAGA TCTTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 
AAGGTGAATA CACGGGCTGG ACCATCTCAG CACACCAGCC CTGTGGTCTC AGATTCACTT 
CCAAGCAATA GCTTGAAGAA GTCCTCGGCT GAACTGAGAA AGATACTGGC CAACGGCCAG 
ATGAATGAAC AAGACATACG GTATCGAGAC ACCCTTGGTC ATGGCAACGG AGGCACAGTC 
TACAAAGCAT ATCATGTCCC AAGTGGGAAA ATCTTAGCTG TAAAGGTTAT TCTGTTAGAC 
ATCACACTGG AGCTTCAGAA GCAGATCATG TCTGAGTTGG AAATTCTTTA TAAGTGTGAC 
TCATCGTATA TCATAGGATT TTACGGGGCA TTTTTTGTAG AAAACAGGAT TTCGATTTGT 
ACAGAATTCA TGGATGGGGG GTCTTTGGAT GTATATAGGA AAATTCCAGA GCACGTCCTC 
GGAAGAATTG CAGTAGCAGT TGTTAAAGGC CTTACCTATC TGTGGAGTTT AAAGATTTTA 
CACAGAGATG TGAAGCCTTC CAACATGCTT GTAAACACAA GCGGACAGGT CAAGCTGTGT 
GACTTCGGCG TGAGCACCCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 
GCTTATATGG CACCCGAAAG GATTTCAGGA GAGCAGTATG GGATCCATTC CGACGTGTGG 
AGCTTAGGGA TCTCTTTCAT GGAGCTTGCT CTTGGGAGGT TTCCATATCC TCAGATTCAG 
AAAAACCAGG GATCTTTAAT GCCTCTCCAG CTTCTGCAGT GCATTGTTGA TGAGGATTCG 
CCGGTCCTTC CGCTTGGAGA GTTCTCGGAG CCGTTTGTAC ATTTCATCAC TCAGTGCATG 
AGGAAGCAGC CCAAGGAAAG ACCAGCGCCC GAGGAGCTGA TGGGTCACCC ATTCATCGTG 
CAGTTCAATG ACGGAAACGC CACTGTGGTG TCCATGTGGG TTTGCCGAGC TCTGGAGGAG 
AGACGGAGCC AGCAGGGGCC CCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map2k5 ( XM_017595502.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017450991.1 Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa31279
Clone ID Related Accession (Same CDS sequence)	XM_017595502.1
Accession Version	XM_017595502.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity mitogen-activated protein kinase kinase 5 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAACAGC AAGTAAATGG CCAGCTAATA GAGCCGCTGC AGATCTTTCC AAGAGCCTGC 
AAGCCTCCTG GGGAACGGAA CATACATGGC CTGAAGGTGA ATACACGGGC TGGACCATCT 
CAGCACACCA GCCCTGTGGT CTCAGATTCA CTTCCAAGCA ATAGCTTGAA GAAGTCCTCG 
GCTGAACTGA GAAAGATACT GGCCAACGGC CAGATGAATG AACAAGACAT ACGGTATCGA 
GACACCCTTG GTCATGGCAA CGGAGGCACA GTCTACAAAG CATATCATGT CCCAAGTGGG 
AAAATCTTAG CTGTAAAGGT TATTCTGTTA GACATCACAC TGGAGCTTCA GAAGCAGATC 
ATGTCTGAGT TGGAAATTCT TTATAAGTGT GACTCATCGT ATATCATAGG ATTTTACGGG 
GCATTTTTTG TAGAAAACAG GATTTCGATT TGTACAGAAT TCATGGATGG GGGGTCTTTG 
GATGTATATA GGAAAATTCC AGAGCACGTC CTCGGAAGAA TTGCAGTAGC AGTTGTTAAA 
GGCCTTACCT ATCTGTGGAG TTTAAAGATT TTACACAGAG ATGTGAAGCC TTCCAACATG 
CTTGTAAACA CAAGCGGACA GGTCAAGCTG TGTGACTTCG GCGTGAGCAC CCAGCTGGTG 
AATTCTATAG CCAAGACGTA TGTTGGAACA AATGCTTATA TGGCACCCGA AAGGATTTCA 
GGAGAGCAGT ATGGGATCCA TTCCGACGTG TGGAGCTTAG GGATCTCTTT CATGGAGCTT 
GCTCTTGGGA GGTTTCCATA TCCTCAGATT CAGAAAAACC AGGGATCTTT AATGCCTCTC 
CAGCTTCTGC AGTGCATTGT TGATGAGGAT TCGCCGGTCC TTCCGCTTGG AGAGTTCTCG 
GAGCCGTTTG TACATTTCAT CACTCAGTGC ATGAGGAAGC AGCCCAAGGA AAGACCAGCG 
CCCGAGGAGC TGATGGGTCA CCCATTCATC GTGCAGTTCA ATGACGGAAA CGCCACTGTG 
GTGTCCATGT GGGTTTGCCG AGCTCTGGAG GAGAGACGGA GCCAGCAGGG GCCCCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017450991.1
CDS	92..1171
Translation	MEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP

Target ORF information:

RefSeq Version	XM_017595502.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017595502.1

ORF Insert Sequence:

ATGGAACAGC AAGTAAATGG CCAGCTAATA GAGCCGCTGC AGATCTTTCC AAGAGCCTGC 
AAGCCTCCTG GGGAACGGAA CATACATGGC CTGAAGGTGA ATACACGGGC TGGACCATCT 
CAGCACACCA GCCCTGTGGT CTCAGATTCA CTTCCAAGCA ATAGCTTGAA GAAGTCCTCG 
GCTGAACTGA GAAAGATACT GGCCAACGGC CAGATGAATG AACAAGACAT ACGGTATCGA 
GACACCCTTG GTCATGGCAA CGGAGGCACA GTCTACAAAG CATATCATGT CCCAAGTGGG 
AAAATCTTAG CTGTAAAGGT TATTCTGTTA GACATCACAC TGGAGCTTCA GAAGCAGATC 
ATGTCTGAGT TGGAAATTCT TTATAAGTGT GACTCATCGT ATATCATAGG ATTTTACGGG 
GCATTTTTTG TAGAAAACAG GATTTCGATT TGTACAGAAT TCATGGATGG GGGGTCTTTG 
GATGTATATA GGAAAATTCC AGAGCACGTC CTCGGAAGAA TTGCAGTAGC AGTTGTTAAA 
GGCCTTACCT ATCTGTGGAG TTTAAAGATT TTACACAGAG ATGTGAAGCC TTCCAACATG 
CTTGTAAACA CAAGCGGACA GGTCAAGCTG TGTGACTTCG GCGTGAGCAC CCAGCTGGTG 
AATTCTATAG CCAAGACGTA TGTTGGAACA AATGCTTATA TGGCACCCGA AAGGATTTCA 
GGAGAGCAGT ATGGGATCCA TTCCGACGTG TGGAGCTTAG GGATCTCTTT CATGGAGCTT 
GCTCTTGGGA GGTTTCCATA TCCTCAGATT CAGAAAAACC AGGGATCTTT AATGCCTCTC 
CAGCTTCTGC AGTGCATTGT TGATGAGGAT TCGCCGGTCC TTCCGCTTGG AGAGTTCTCG 
GAGCCGTTTG TACATTTCAT CACTCAGTGC ATGAGGAAGC AGCCCAAGGA AAGACCAGCG 
CCCGAGGAGC TGATGGGTCA CCCATTCATC GTGCAGTTCA ATGACGGAAA CGCCACTGTG 
GTGTCCATGT GGGTTTGCCG AGCTCTGGAG GAGAGACGGA GCCAGCAGGG GCCCCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map2k5 ( NM_017246.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058942.1 Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa03379
Clone ID Related Accession (Same CDS sequence)	NM_017246.2
Accession Version	NM_017246.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1317bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity mitogen-activated protein kinase kinase 5 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC078860.1 and U37464.1. On Oct 6, 2005 this sequence version replaced NM_017246.1. Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U37464.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCTGTGGC TGGCCCTTGG CCCCTTTCGT GCCATGGAGA ACCAGGTGCT GGTGATTCGG 
ATCAAGATTC CAAATAGTGG CGCGGTGGAC TGGACCGTGC ACTCCGGGCC GCAGTTACTC 
TTCAGGGACG TGCTGGATGT GATAGGCCAG GTTCTGCCTG AAGCAACGAC GACAGCCTTT 
GAATATGAAG ATGAAGATGG TGATAGGATT ACAGTAAGAA GTGACGAAGA GATGAAGGCA 
ATGCTGTCCT ACTATTATTC CACAGTAATG GAACAGCAAG TAAATGGCCA GCTAATAGAG 
CCGCTGCAGA TCTTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 
AAGGTGAATA CACGGGCTGG ACCATCTCAG CACACCAGCC CTGTGGTCTC AGATTCACTT 
CCAAGCAATA GCTTGAAGAA GTCCTCGGCT GAACTGAGAA AGATACTGGC CAACGGCCAG 
ATGAATGAAC AAGACATACG GTATCGAGAC ACCCTTGGTC ATGGCAACGG AGGCACAGTC 
TACAAAGCAT ATCATGTCCC AAGTGGGAAA ATCTTAGCTG TAAAGGTTAT TCTGTTAGAC 
ATCACACTGG AGCTTCAGAA GCAGATCATG TCTGAGTTGG AAATTCTTTA TAAGTGTGAC 
TCATCGTATA TCATAGGATT TTACGGGGCA TTTTTTGTAG AAAACAGGAT TTCGATTTGT 
ACAGAATTCA TGGATGGGGG GTCTTTGGAT GTATATAGGA AAATTCCAGA GCACGTCCTC 
GGAAGAATTG CAGTAGCAGT TGTTAAAGGC CTTACCTATC TGTGGAGTTT AAAGATTTTA 
CACAGAGATG TGAAGCCTTC CAACATGCTT GTAAACACAA GCGGACAGGT CAAGCTGTGT 
GACTTCGGCG TGAGCACCCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 
GCTTATATGG CACCCGAAAG GATTTCAGGA GAGCAGTATG GGATCCATTC CGACGTGTGG 
AGCTTAGGGA TCTCTTTCAT GGAGATTCAG AAAAACCAGG GATCTTTAAT GCCTCTCCAG 
CTTCTGCAGT GCATTGTTGA TGAGGATTCG CCGGTCCTTC CGCTTGGAGA GTTCTCGGAG 
CCGTTTGTAC ATTTCATCAC TCAGTGCATG AGGAAGCAGC CCAAGGAAAG ACCAGCGCCC 
GAGGAGCTGA TGGGTCACCC ATTCATCGTG CAGTTCAATG ACGGAAACGC CACTGTGGTG 
TCCATGTGGG TTTGCCGAGC TCTGGAGGAG AGACGGAGCC AGCAGGGGCC CCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058942.1
CDS	600..1916
Translation	MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP

Target ORF information:

RefSeq Version	NM_017246.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017246.2

ORF Insert Sequence:

ATGCTGTGGC TGGCCCTTGG CCCCTTTCGT GCCATGGAGA ACCAGGTGCT GGTGATTCGG 
ATCAAGATTC CAAATAGTGG CGCGGTGGAC TGGACCGTGC ACTCCGGGCC GCAGTTACTC 
TTCAGGGACG TGCTGGATGT GATAGGCCAG GTTCTGCCTG AAGCAACGAC GACAGCCTTT 
GAATATGAAG ATGAAGATGG TGATAGGATT ACAGTAAGAA GTGACGAAGA GATGAAGGCA 
ATGCTGTCCT ACTATTATTC CACAGTAATG GAACAGCAAG TAAATGGCCA GCTAATAGAG 
CCGCTGCAGA TCTTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 
AAGGTGAATA CACGGGCTGG ACCATCTCAG CACACCAGCC CTGTGGTCTC AGATTCACTT 
CCAAGCAATA GCTTGAAGAA GTCCTCGGCT GAACTGAGAA AGATACTGGC CAACGGCCAG 
ATGAATGAAC AAGACATACG GTATCGAGAC ACCCTTGGTC ATGGCAACGG AGGCACAGTC 
TACAAAGCAT ATCATGTCCC AAGTGGGAAA ATCTTAGCTG TAAAGGTTAT TCTGTTAGAC 
ATCACACTGG AGCTTCAGAA GCAGATCATG TCTGAGTTGG AAATTCTTTA TAAGTGTGAC 
TCATCGTATA TCATAGGATT TTACGGGGCA TTTTTTGTAG AAAACAGGAT TTCGATTTGT 
ACAGAATTCA TGGATGGGGG GTCTTTGGAT GTATATAGGA AAATTCCAGA GCACGTCCTC 
GGAAGAATTG CAGTAGCAGT TGTTAAAGGC CTTACCTATC TGTGGAGTTT AAAGATTTTA 
CACAGAGATG TGAAGCCTTC CAACATGCTT GTAAACACAA GCGGACAGGT CAAGCTGTGT 
GACTTCGGCG TGAGCACCCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 
GCTTATATGG CACCCGAAAG GATTTCAGGA GAGCAGTATG GGATCCATTC CGACGTGTGG 
AGCTTAGGGA TCTCTTTCAT GGAGATTCAG AAAAACCAGG GATCTTTAAT GCCTCTCCAG 
CTTCTGCAGT GCATTGTTGA TGAGGATTCG CCGGTCCTTC CGCTTGGAGA GTTCTCGGAG 
CCGTTTGTAC ATTTCATCAC TCAGTGCATG AGGAAGCAGC CCAAGGAAAG ACCAGCGCCC 
GAGGAGCTGA TGGGTCACCC ATTCATCGTG CAGTTCAATG ACGGAAACGC CACTGTGGTG 
TCCATGTGGG TTTGCCGAGC TCTGGAGGAG AGACGGAGCC AGCAGGGGCC CCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map2k5 ( XM_006243229.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243291.1 Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant X1, mRNA.

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CloneID	ORa31276
Clone ID Related Accession (Same CDS sequence)	XM_006243229.3
Accession Version	XM_006243229.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1320bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity mitogen-activated protein kinase kinase 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243229.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGTGGC TGGCCCTTGG CCCCTTTCGT GCCATGGAGA ACCAGGTGCT GGTGATTCGG 
ATCAAGATTC CAAATAGTGG CGCGGTGGAC TGGACCGTGC ACTCCGGGCC GCAGTTACTC 
TTCAGGGACG TGCTGGATGT GATAGGCCAG GTTCTGCCTG AAGCAACGAC GACAGCCTTT 
GAATATGAAG ATGAAGATGG TGATAGGATT ACAGTAAGAA GTGACGAAGA GATGAAGGCA 
ATGCTGTCCT ACTATTATTC CACAGTAATG GAACAGCAAG TAAATGGCCA GCTAATAGAG 
CCGCTGCAGA TCTTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 
AAGGTGAATA CACGGGCTGG ACCATCTCAG CACACCAGCC CTGTGGTCTC AGATTCACTT 
CCAAGCAATA GCTTGAAGAA GTCCTCGGCT GAACTGAGAA AGATACTGGC CAACGGCCAG 
ATGAATGAAC AAGACATACG GTATCGAGAC ACCCTTGGTC ATGGCAACGG AGGCACAGTC 
TACAAAGCAT ATCATGTCCC AAGTGGGAAA ATCTTAGCTG TAAAGGTTAT TCTGTTAGAC 
ATCACACTGG AGCTTCAGAA GCAGATCATG TCTGAGTTGG AAATTCTTTA TAAGTGTGAC 
TCATCGTATA TCATAGGATT TTACGGGGCA TTTTTTGTAG AAAACAGGAT TTCGATTTGT 
ACAGAATTCA TGGATGGGGG GTCTTTGGAT GTATATAGGA AAATTCCAGA GCACGTCCTC 
GGAAGAATTG CAGTAGCAGT TGTTAAAGGC CTTACCTATC TGTGGAGTTT AAAGATTTTA 
CACAGAGATG TGAAGCCTTC CAACATGCTT GTAAACACAA GCGGACAGGT CAAGCTGTGT 
GACTTCGGCG TGAGCACCCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 
GCTTATATGG CACCCGAAAG GATTTCAGGA GAGCAGTATG GGATCCATTC CGACGTGTGG 
AGCTTAGGGA TCTCTTTCAT GGAGCTTGCT CTTGGGAGGT TTCCATATCC TCAGCCTCTC 
CAGCTTCTGC AGTGCATTGT TGATGAGGAT TCGCCGGTCC TTCCGCTTGG AGAGTTCTCG 
GAGCCGTTTG TACATTTCAT CACTCAGTGC ATGAGGAAGC AGCCCAAGGA AAGACCAGCG 
CCCGAGGAGC TGATGGGTCA CCCATTCATC GTGCAGTTCA ATGACGGAAA CGCCACTGTG 
GTGTCCATGT GGGTTTGCCG AGCTCTGGAG GAGAGACGGA GCCAGCAGGG GCCCCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243291.1
CDS	674..1993
Translation	MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQPLQLLQCIVDEDSPVLPLGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP

Target ORF information:

RefSeq Version	XM_006243229.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243229.3

ORF Insert Sequence:

ATGCTGTGGC TGGCCCTTGG CCCCTTTCGT GCCATGGAGA ACCAGGTGCT GGTGATTCGG 
ATCAAGATTC CAAATAGTGG CGCGGTGGAC TGGACCGTGC ACTCCGGGCC GCAGTTACTC 
TTCAGGGACG TGCTGGATGT GATAGGCCAG GTTCTGCCTG AAGCAACGAC GACAGCCTTT 
GAATATGAAG ATGAAGATGG TGATAGGATT ACAGTAAGAA GTGACGAAGA GATGAAGGCA 
ATGCTGTCCT ACTATTATTC CACAGTAATG GAACAGCAAG TAAATGGCCA GCTAATAGAG 
CCGCTGCAGA TCTTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 
AAGGTGAATA CACGGGCTGG ACCATCTCAG CACACCAGCC CTGTGGTCTC AGATTCACTT 
CCAAGCAATA GCTTGAAGAA GTCCTCGGCT GAACTGAGAA AGATACTGGC CAACGGCCAG 
ATGAATGAAC AAGACATACG GTATCGAGAC ACCCTTGGTC ATGGCAACGG AGGCACAGTC 
TACAAAGCAT ATCATGTCCC AAGTGGGAAA ATCTTAGCTG TAAAGGTTAT TCTGTTAGAC 
ATCACACTGG AGCTTCAGAA GCAGATCATG TCTGAGTTGG AAATTCTTTA TAAGTGTGAC 
TCATCGTATA TCATAGGATT TTACGGGGCA TTTTTTGTAG AAAACAGGAT TTCGATTTGT 
ACAGAATTCA TGGATGGGGG GTCTTTGGAT GTATATAGGA AAATTCCAGA GCACGTCCTC 
GGAAGAATTG CAGTAGCAGT TGTTAAAGGC CTTACCTATC TGTGGAGTTT AAAGATTTTA 
CACAGAGATG TGAAGCCTTC CAACATGCTT GTAAACACAA GCGGACAGGT CAAGCTGTGT 
GACTTCGGCG TGAGCACCCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 
GCTTATATGG CACCCGAAAG GATTTCAGGA GAGCAGTATG GGATCCATTC CGACGTGTGG 
AGCTTAGGGA TCTCTTTCAT GGAGCTTGCT CTTGGGAGGT TTCCATATCC TCAGCCTCTC 
CAGCTTCTGC AGTGCATTGT TGATGAGGAT TCGCCGGTCC TTCCGCTTGG AGAGTTCTCG 
GAGCCGTTTG TACATTTCAT CACTCAGTGC ATGAGGAAGC AGCCCAAGGA AAGACCAGCG 
CCCGAGGAGC TGATGGGTCA CCCATTCATC GTGCAGTTCA ATGACGGAAA CGCCACTGTG 
GTGTCCATGT GGGTTTGCCG AGCTCTGGAG GAGAGACGGA GCCAGCAGGG GCCCCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map2k5 ( XM_017595501.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017450990.1 Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa62342
Clone ID Related Accession (Same CDS sequence)	XM_017595501.1
Accession Version	XM_017595501.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity mitogen-activated protein kinase kinase 5 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGTGGC TGGCCCTTGG CCCCTTTCGT GCCATGGAGA ACCAGGTGCT GGTGATTCGG 
ATCAAGATTC CAAATAGTGG CGCGGTGGAC TGGACCGTGC ACTCCGGGCC GCAGTTACTC 
TTCAGGGACG TGCTGGATGT GATAGGCCAG GTTCTGCCTG AAGCAACGAC GACAGCCTTT 
GAATATGAAG ATGAAGATGG TGATAGGATT ACAGTAAGAA GTGACGAAGA GATGAAGGCA 
ATGCTGTCCT ACTATTATTC CACAGTAATG GAACAGCAAG TAAATGGCCA GCTAATAGAG 
CCGCTGCAGA TCTTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 
AAGGTGAATA CACGGGCTGG ACCATCTCAG CACACCAGCC CTGTGGTCTC AGATTCACTT 
CCAAGCAATA GCTTGAAGAA GTCCTCGGCT GAACTGAGAA AGATACTGGC CAACGGCCAG 
ATGAATGAAC AAGACATACG GTATCGAGAC ACCCTTGGTC ATGGCAACGG AGGCACAGTC 
TACAAAGCAT ATCATGTCCC AAGTGGGAAA ATCTTAGCTG TAAAGGTTAT TCTGTTAGAC 
ATCACACTGG AGCTTCAGAA GCAGATCATG TCTGAGTTGG AAATTCTTTA TAAGTGTGAC 
TCATCGTATA TCATAGGATT TTACGGGGCA TTTTTTGTAG AAAACAGGAT TTCGATTTGT 
ACAGAATTCA TGGATGGGGG GTCTTTGGAT GTATATAGGA AAATTCCAGA GCACGTCCTC 
GGAAGAATTG CAGTAGCAGT TGTTAAAGGC CTTACCTATC TGTGGAGTTT AAAGATTTTA 
CACAGAGATG TGAAGCCTTC CAACATGCTT GTAAACACAA GCGGACAGGT CAAGCTGTGT 
GACTTCGGCG TGAGCACCCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 
GCTTATATGG CACCCGAAAG GATTTCAGGA GAGCAGTATG GGATCCATTC CGACGTGTGG 
AGCTTAGGGA TCTCTTTCAT GGAGCTTGCT CTTGGGAGGT TTCCATATCC TCAGGATTCG 
CCGGTCCTTC CGCTTGGAGA GTTCTCGGAG CCGTTTGTAC ATTTCATCAC TCAGTGCATG 
AGGAAGCAGC CCAAGGAAAG ACCAGCGCCC GAGGAGCTGA TGGGTCACCC ATTCATCGTG 
CAGTTCAATG ACGGAAACGC CACTGTGGTG TCCATGTGGG TTTGCCGAGC TCTGGAGGAG 
AGACGGAGCC AGCAGGGGCC CCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017450990.1
CDS	673..1959
Translation	MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQDSPVLPLGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP

Target ORF information:

RefSeq Version	XM_017595501.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase 5 (Map2k5), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017595501.1

ORF Insert Sequence:

ATGCTGTGGC TGGCCCTTGG CCCCTTTCGT GCCATGGAGA ACCAGGTGCT GGTGATTCGG 
ATCAAGATTC CAAATAGTGG CGCGGTGGAC TGGACCGTGC ACTCCGGGCC GCAGTTACTC 
TTCAGGGACG TGCTGGATGT GATAGGCCAG GTTCTGCCTG AAGCAACGAC GACAGCCTTT 
GAATATGAAG ATGAAGATGG TGATAGGATT ACAGTAAGAA GTGACGAAGA GATGAAGGCA 
ATGCTGTCCT ACTATTATTC CACAGTAATG GAACAGCAAG TAAATGGCCA GCTAATAGAG 
CCGCTGCAGA TCTTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 
AAGGTGAATA CACGGGCTGG ACCATCTCAG CACACCAGCC CTGTGGTCTC AGATTCACTT 
CCAAGCAATA GCTTGAAGAA GTCCTCGGCT GAACTGAGAA AGATACTGGC CAACGGCCAG 
ATGAATGAAC AAGACATACG GTATCGAGAC ACCCTTGGTC ATGGCAACGG AGGCACAGTC 
TACAAAGCAT ATCATGTCCC AAGTGGGAAA ATCTTAGCTG TAAAGGTTAT TCTGTTAGAC 
ATCACACTGG AGCTTCAGAA GCAGATCATG TCTGAGTTGG AAATTCTTTA TAAGTGTGAC 
TCATCGTATA TCATAGGATT TTACGGGGCA TTTTTTGTAG AAAACAGGAT TTCGATTTGT 
ACAGAATTCA TGGATGGGGG GTCTTTGGAT GTATATAGGA AAATTCCAGA GCACGTCCTC 
GGAAGAATTG CAGTAGCAGT TGTTAAAGGC CTTACCTATC TGTGGAGTTT AAAGATTTTA 
CACAGAGATG TGAAGCCTTC CAACATGCTT GTAAACACAA GCGGACAGGT CAAGCTGTGT 
GACTTCGGCG TGAGCACCCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 
GCTTATATGG CACCCGAAAG GATTTCAGGA GAGCAGTATG GGATCCATTC CGACGTGTGG 
AGCTTAGGGA TCTCTTTCAT GGAGCTTGCT CTTGGGAGGT TTCCATATCC TCAGGATTCG 
CCGGTCCTTC CGCTTGGAGA GTTCTCGGAG CCGTTTGTAC ATTTCATCAC TCAGTGCATG 
AGGAAGCAGC CCAAGGAAAG ACCAGCGCCC GAGGAGCTGA TGGGTCACCC ATTCATCGTG 
CAGTTCAATG ACGGAAACGC CACTGTGGTG TCCATGTGGG TTTGCCGAGC TCTGGAGGAG 
AGACGGAGCC AGCAGGGGCC CCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades.
The Journal of biological chemistry290(15)9363-76(2015 Apr)
Stankiewicz TR,Ramaswami SA,Bouchard RJ,Aktories K,Linseman DA

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4).
The Journal of biological chemistry285(34)26199-210(2010 Aug)
Ohnesorge N,Viemann D,Schmidt N,Czymai T,Spiering D,Schmolke M,Ludwig S,Roth J,Goebeler M,Schmidt M

Mitogen-activated protein kinase activated protein kinase 2 (MK2) participates in p38 MAPK regulated control of oligodendrocyte differentiation.
Glia58(11)1384-93(2010 Aug)
Haines JD,Fang J,Mushynski WE,Almazan G

The ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats.
Brain research125532-41(2009 Feb)
Wang RM,Zhang QG,Li J,Yang LC,Yang F,Brann DW

The transcriptional regulation and cell-specific expression of the MAPK-activated protein kinase MK5.
Cellular & molecular biology letters14(4)548-74(2009)
Gerits N,Shiryaev A,Kostenko S,Klenow H,Shiryaeva O,Johannessen M,Moens U

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Map2k5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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