Pebp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pebp1
Entrez Gene ID	29542
Full Name	phosphatidylethanolamine binding protein 1
Synonyms	HCNP,Pbp,Rkip
General protein information	Preferred Names phosphatidylethanolamine binding protein 1 Names phosphatidylethanolamine-binding protein 1 23 kDa morphine-binding protein HCNPpp P23K PEBP-1 Raf-1 kinase inhibitor protein hippocampal cholinergic neurostimulating peptide
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q16
Summary	lipid binding protein; enhances acetylcholine synthesis in medial septal regions; human homolog (RKIP) has been shown to inhibit MEK- and ERK- signalling pathways [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017236.1	NP_058932.1	phosphatidylethanolamine-binding protein 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PEBP1	NP_001028795.1
Mus musculus (house mouse)	Pebp1	NP_061346.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012962	XP_003436016.1
	PEBP1	XP_002798837.1
Rattus norvegicus (Norway rat)	Pebp1	NP_058932.1
Homo sapiens (human)	PEBP1	NP_002558.1
Pan troglodytes (chimpanzee)	PEBP1	XP_509413.2
Canis lupus familiaris (dog)	PEBP1	NP_001041557.1
Gallus gallus (chicken)	PEBP1	NP_001185571.1
Drosophila melanogaster (fruit fly)	CG10298	NP_649643.1
Danio rerio (zebrafish)	pebp1	NP_998488.1
Xenopus tropicalis (tropical clawed frog)	pebp1	NP_001016825.1

Gene Ontology
Bibliography

Related articles in PubMed

Raf Kinase Inhibitor Protein Attenuates Ischemic-Induced Microglia Cell Apoptosis and Activation Through NF-?B Pathway.
Su L, Zhang R, Chen Y, Zhu Z, Ma C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology41(3)1125-1134(2017)

GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity.
Brackley AD, Gomez R, Akopian AN, Henry MA, Jeske NA
Cell reports16(10)2686-2698(2016 09)

Loss of Raf kinase inhibitor protein is associated with malignant progression in hepatic fibrosis.
Huang Q, Wei L, Liang C, Nie J, Lu S, Lu C, Tan S, Lv S, Zhuo L, Lu Z, Lin X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie82669-76(2016 Aug)

Cardiac RKIP induces a beneficial ?-adrenoceptor-dependent positive inotropy.
Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Sch?fer F, Wagner N, Erg?n S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, M?ller OJ, Maier LS, Lohse MJ, Lorenz K
Nature medicine21(11)1298-306(2015 Nov)

Ibudilast reverses the decrease in the synaptic signaling protein phosphatidylethanolamine-binding protein 1 (PEBP1) produced by chronic methamphetamine intake in rats.
Charntikov S, Pittenger ST, Thapa I, Bastola DR, Bevins RA, Pendyala G
Drug and alcohol dependence15215-23(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RKIP attenuates ischemia-induced microglia cell apoptosis and activation through NF-kappaB pathway.
Title: Raf Kinase Inhibitor Protein Attenuates Ischemic-Induced Microglia Cell Apoptosis and Activation Through NF-?B Pathway.

Loss of RKIP may be associated with malignant progression in hepatic fibrosis.
Title: Loss of Raf kinase inhibitor protein is associated with malignant progression in hepatic fibrosis.

RKIP overexpression increases cardiac contractility mediated by the beta1-adrenoceptor. RKIP deficiency exaggerates pressure overload-induced cardiac failure.
Title: Cardiac RKIP induces a beneficial ?-adrenoceptor-dependent positive inotropy.

PEBP1, given its synaptic localization and its role as a signaling molecule acting via the ERK/MAPK pathway, could be a potential therapeutic target mediating drug-seeking behaviors associated with neuroinflammation.
Title: Ibudilast reverses the decrease in the synaptic signaling protein phosphatidylethanolamine-binding protein 1 (PEBP1) produced by chronic methamphetamine intake in rats.

LTD4 inhibits ASCT1 through PKC-mediated phosphorylation of RKIP, leading to the subsequent activation of PKA pathway, possibly through beta2-andrenergic receptor activation.
Title: Protein kinase C-mediated phosphorylation of RKIP regulates inhibition of Na-alanine cotransport by leukotriene D(4) in intestinal epithelial cells.

The following Pebp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pebp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12768	NM_017236.1 Latest version!	Rattus norvegicus phosphatidylethanolamine binding protein 1 (Pebp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pebp1 ( NM_017236.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058932.1 Rattus norvegicus phosphatidylethanolamine binding protein 1 (Pebp1), mRNA.

Price & Availability↑

CloneID	ORa12768
Clone ID Related Accession (Same CDS sequence)	NM_017236.1
Accession Version	NM_017236.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	phosphatidylethanolamine-binding protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X75253.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X75253.1, BC063171.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGCCG ACATCAGCCA GTGGGCCGGG CCGCTGTCAT TACAGGAGGT GGATGAGCCG 
CCCCAGCACG CCCTGAGGGT CGACTACGGC GGAGTAACGG TGGACGAGCT GGGCAAAGTG 
CTGACGCCCA CCCAGGTCAT GAATAGACCA AGCAGCATTT CATGGGATGG CCTTGATCCT 
GGGAAGCTCT ACACCCTGGT CCTCACAGAC CCCGATGCTC CCAGCAGGAA GGACCCCAAA 
TTCAGGGAGT GGCACCACTT CCTGGTGGTC AACATGAAGG GCAACGACAT TAGCAGTGGC 
ACTGTCCTCT CCGAATACGT GGGCTCCGGA CCTCCCAAAG ACACAGGTCT GCACCGCTAC 
GTCTGGCTGG TGTATGAGCA GGAGCAGCCT CTGAACTGTG ACGAGCCCAT CCTCAGCAAC 
AAGTCTGGAG ACAACCGCGG CAAGTTCAAG GTGGAGTCCT TCCGCAAGAA GTACCACCTG 
GGAGCCCCGG TGGCCGGCAC GTGCTTCCAG GCAGAGTGGG ATGACTCTGT GCCCAAGCTG 
CATGATCAGC TGGCTGGGAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058932.1
CDS	54..617
Translation	MAADISQWAGPLSLQEVDEPPQHALRVDYGGVTVDELGKVLTPTQVMNRPSSISWDGLDPGKLYTLVLTDPDAPSRKDPKFREWHHFLVVNMKGNDISSGTVLSEYVGSGPPKDTGLHRYVWLVYEQEQPLNCDEPILSNKSGDNRGKFKVESFRKKYHLGAPVAGTCFQAEWDDSVPKLHDQLAGK

Target ORF information:

RefSeq Version	NM_017236.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus phosphatidylethanolamine binding protein 1 (Pebp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017236.1

ORF Insert Sequence:

ATGGCCGCCG ACATCAGCCA GTGGGCCGGG CCGCTGTCAT TACAGGAGGT GGATGAGCCG 
CCCCAGCACG CCCTGAGGGT CGACTACGGC GGAGTAACGG TGGACGAGCT GGGCAAAGTG 
CTGACGCCCA CCCAGGTCAT GAATAGACCA AGCAGCATTT CATGGGATGG CCTTGATCCT 
GGGAAGCTCT ACACCCTGGT CCTCACAGAC CCCGATGCTC CCAGCAGGAA GGACCCCAAA 
TTCAGGGAGT GGCACCACTT CCTGGTGGTC AACATGAAGG GCAACGACAT TAGCAGTGGC 
ACTGTCCTCT CCGAATACGT GGGCTCCGGA CCTCCCAAAG ACACAGGTCT GCACCGCTAC 
GTCTGGCTGG TGTATGAGCA GGAGCAGCCT CTGAACTGTG ACGAGCCCAT CCTCAGCAAC 
AAGTCTGGAG ACAACCGCGG CAAGTTCAAG GTGGAGTCCT TCCGCAAGAA GTACCACCTG 
GGAGCCCCGG TGGCCGGCAC GTGCTTCCAG GCAGAGTGGG ATGACTCTGT GCCCAAGCTG 
CATGATCAGC TGGCTGGGAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Raf Kinase Inhibitor Protein Attenuates Ischemic-Induced Microglia Cell Apoptosis and Activation Through NF-?B Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology41(3)1125-1134(2017)
Su L,Zhang R,Chen Y,Zhu Z,Ma C

GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity.
Cell reports16(10)2686-2698(2016 09)
Brackley AD,Gomez R,Akopian AN,Henry MA,Jeske NA

Loss of Raf kinase inhibitor protein is associated with malignant progression in hepatic fibrosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie82669-76(2016 Aug)
Huang Q,Wei L,Liang C,Nie J,Lu S,Lu C,Tan S,Lv S,Zhuo L,Lu Z,Lin X

Cardiac RKIP induces a beneficial ?-adrenoceptor-dependent positive inotropy.
Nature medicine21(11)1298-306(2015 Nov)
Schmid E,Neef S,Berlin C,Tomasovic A,Kahlert K,Nordbeck P,Deiss K,Denzinger S,Herrmann S,Wettwer E,Weidendorfer M,Becker D,Sch?fer F,Wagner N,Erg?n S,Schmitt JP,Katus HA,Weidemann F,Ravens U,Maack C,Hein L,Ertl G,M?ller OJ,Maier LS,Lohse MJ,Lorenz K

Ibudilast reverses the decrease in the synaptic signaling protein phosphatidylethanolamine-binding protein 1 (PEBP1) produced by chronic methamphetamine intake in rats.
Drug and alcohol dependence15215-23(2015 Jul)
Charntikov S,Pittenger ST,Thapa I,Bastola DR,Bevins RA,Pendyala G

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Pebp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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