Mmp21 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp21
Entrez Gene ID	293573
Full Name	matrix metallopeptidase 21
General protein information	Preferred Names matrix metallopeptidase 21 Names matrix metalloproteinase-21 matrix metalloproteinase 21
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q41

mRNA and Protein(s)

mRNA	Protein	Name
NM_001106308.1	NP_001099778.1	matrix metalloproteinase-21 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MMP21	XP_003312866.1
	MMP21	XP_001085506.1
Danio rerio (zebrafish)	LOC100003089	XP_001342721.4
Rattus norvegicus (Norway rat)	Mmp21	NP_001099778.1
Xenopus tropicalis (tropical clawed frog)	mmp21	XP_002932698.2
Homo sapiens (human)	MMP21	NP_671724.1
Mus musculus (house mouse)	Mmp21	NP_694423.1
Canis lupus familiaris (dog)	MMP21	XP_003640036.1

Gene Ontology
Bibliography

Related articles in PubMed

A human laterality disorder caused by a homozygous deleterious mutation in MMP21.
Perles Z, Moon S, Ta-Shma A, Yaacov B, Francescatto L, Edvardson S, Rein AJ, Elpeleg O, Katsanis N
Journal of medical genetics52(12)840-7(2015 Dec)

MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates.
Guimier A, Gabriel GC, Bajolle F, Tsang M, Liu H, Noll A, Schwartz M, El Malti R, Smith LD, Klena NT, Jimenez G, Miller NA, Oufadem M, Moreau de Bellaing A, Yagi H, Saunders CJ, Baker CN, Di Filippo S, Peterson KA, Thiffault I, Bole-Feysot C, Cooley LD, Farrow EG, Masson C, Schoen P, Deleuze JF, Nitschk? P, Lyonnet S, de Pontual L, Murray SA, Bonnet D, Kingsmore SF, Amiel J, Bouvagnet P, Lo CW, Gordon CT
Nature genetics47(11)1260-3(2015 Nov)

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y, Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J, Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury L, Ganapathiraju MK, Tobita K, Pazour GJ, Lo CW
Nature521(7553)520-4(2015 May)

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K, Suda T, Nakamura T, Wolff L, Honda H, Inaba T
Cancer cell24(3)305-17(2013 Sep)

Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT cells.
Skoog T, Elomaa O, Pasonen-Sepp?nen SM, Forsberg S, Ahokas K, Jeskanen L, P?rssinen J, Tiala I, Rollman O, Lohi J, Saarialho-Kere U
The Journal of investigative dermatology129(1)119-30(2009 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MMP-21 may be an important protease in the terminal differentiation of keratinocytes
Title: Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT cells.

The following Mmp21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00839	NM_001106308.1 Latest version!	Rattus norvegicus matrix metallopeptidase 21 (Mmp21), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$335.30 $479.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp21 ( NM_001106308.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099778.1 Rattus norvegicus matrix metallopeptidase 21 (Mmp21), mRNA.

Price & Availability↑

CloneID	ORa00839
Clone ID Related Accession (Same CDS sequence)	NM_001106308.1
Accession Version	NM_001106308.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	matrix metalloproteinase-21 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473953.1. On or before Oct 4, 2007 this sequence version replaced XM_001054903.1, XM_219415.4. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052297, SAMEA2689602 [ECO:0000350] ##Evidence-Data-END##

ATGCTTGCTG TCTCTGACTT GCGTCTGACA ATGCTGCTCT GCTGGCTAGT TACACCCCAG 
CCAGCCCAGC CTGAGAGGCT CTTCCACAGC CGGGACCGTT CGGACCTGGA GCCATCCCCC 
CTGAGTCGGG CCAAGCCCAT TGCCGACCTC CATGCTGCTC AGAACTTCCT ATTGAAATAT 
GGCTGGTCAG AGGTGTCCAG CCCAAAGGAG TCAGCCGGAG TCCCTGTGGG CTTCACCTTG 
GCTCAAGCTG TGCGTAGATT CCAGAAGGCA AACAGACTGC CAGCCAGCGG GAAACTAGAC 
TCACCTACAC TGGCAGCTAT GAATAAGCCA CGCTGTGGCG TCCCTGACAC ACGACTACCC 
CTTCAGGATG CCCTGCCAAC TCCACCAGCC CTGCCAACCC CTCTAGGTCT CCAGCCCAGG 
GCCCGACAAA AGCGCTTTCT TCAAATGCTG CTGCCCAAGC CAGGTGGGAA ACAGGAGGGC 
CGGTCAGACA CGGGGGCCAG CAGGGTCTTC TCCAAGAAGA CACTGACCTG GAGACTAGTG 
GGAGATGCCT ACAGCAGCCA ACTCTCTGGG GATGAGCAGA GATACATCTT TAGACTGGCC 
TTCAGGATGT GGAGCGAGGT GACGCCACTG GACTTCCGGG AGGACCTCAC TGCCCCTGGT 
ACCATGGTGG ACATAAAGCT GGGTTTTGGG AGAGGCCGGC ACCTGGGCTG TCCACGGGTG 
TTTGACGGGA GTGGACAGGA GTTTGCACAT GCCTGGCACC TGGGTGAGAT CCACTTTGAT 
GACGATGAGC ACTTTACTCC TCTCTCCAGT GACACGGGCA TCAGCCTTCT CAAAGTAGCT 
GTCCATGAAA TTGGTCACGT CCTTGGATTG CCTCACACCT ACAGGGTGGG ATCCATAATG 
CAACCAAACT ACATTCCCCA GGAGCCTGCA TTTGAGTTGG ACTGGTCAGA CAGAAAAGCA 
ATTCAAAGAC TATATGGGTC ATGTGAGGGA TCATTTGATA TAGTGTTTGA CTGGATTCGC 
AAGGAGAGGA ACCAATATGG TGAGGTGAGG GTGAGGTTCA ACACCTACTT CTTCCGCAAC 
AGCTGGTACT GGCTCTACGA AAACCGCAAC AACAGGACTC GCTACGGGGA CCCCCTCCAA 
ATCCTCACCG GCTGGCGTGG AATTCCCATG CAAAGAATAG ATGCTTTCGT CCATGTCTGG 
TCATGGGGTA GAGATGAGCG GTATTTTTTC AAAGGAAACC AATACTGGAG ATATGACAGT 
GAGAATGACC AGGCACACAC ACAAGATGAA CAAGGAAGGA GCTACCCCAA ACTGATTTCA 
GAAGGCTTCC CTGGCATCCC CAGTCCCTTG GACACGGCCT TCTATGAGCG GAGGCAGCAG 
CTAATTTACT TCTTCAAGGA GTCTCTAGTA TATGCATTTG ATGTCAACCG AAACCAAGCA 
CTTTCTTCTT ATCCAAAGAA GATGAGCCAA GTGTTCCCAG CAATAATGCC TCAAAACCAC 
CCATTCAGAA ACCTCGATTC CGCGTACTAC TCCTATGCAC ACAATGCCAT CTTCTTTTTC 
AAAGGCAACT CGTTTTGGAA AGTAGTTAGT GACAAGGACA AACAGCAGGA CTCTCGGCTC 
CCTCTGAATG GCTTATTTCC AAAACAATCT GTTTCAGGGA AGTGGTTTGA TGTTTGTGAC 
GTTCATACCT CTACACTGAA CATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099778.1
CDS	16..1722
Translation	MLAVSDLRLTMLLCWLVTPQPAQPERLFHSRDRSDLEPSPLSRAKPIADLHAAQNFLLKYGWSEVSSPKESAGVPVGFTLAQAVRRFQKANRLPASGKLDSPTLAAMNKPRCGVPDTRLPLQDALPTPPALPTPLGLQPRARQKRFLQMLLPKPGGKQEGRSDTGASRVFSKKTLTWRLVGDAYSSQLSGDEQRYIFRLAFRMWSEVTPLDFREDLTAPGTMVDIKLGFGRGRHLGCPRVFDGSGQEFAHAWHLGEIHFDDDEHFTPLSSDTGISLLKVAVHEIGHVLGLPHTYRVGSIMQPNYIPQEPAFELDWSDRKAIQRLYGSCEGSFDIVFDWIRKERNQYGEVRVRFNTYFFRNSWYWLYENRNNRTRYGDPLQILTGWRGIPMQRIDAFVHVWSWGRDERYFFKGNQYWRYDSENDQAHTQDEQGRSYPKLISEGFPGIPSPLDTAFYERRQQLIYFFKESLVYAFDVNRNQALSSYPKKMSQVFPAIMPQNHPFRNLDSAYYSYAHNAIFFFKGNSFWKVVSDKDKQQDSRLPLNGLFPKQSVSGKWFDVCDVHTSTLNM

Target ORF information:

RefSeq Version	NM_001106308.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus matrix metallopeptidase 21 (Mmp21), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106308.1

ORF Insert Sequence:

ATGCTTGCTG TCTCTGACTT GCGTCTGACA ATGCTGCTCT GCTGGCTAGT TACACCCCAG 
CCAGCCCAGC CTGAGAGGCT CTTCCACAGC CGGGACCGTT CGGACCTGGA GCCATCCCCC 
CTGAGTCGGG CCAAGCCCAT TGCCGACCTC CATGCTGCTC AGAACTTCCT ATTGAAATAT 
GGCTGGTCAG AGGTGTCCAG CCCAAAGGAG TCAGCCGGAG TCCCTGTGGG CTTCACCTTG 
GCTCAAGCTG TGCGTAGATT CCAGAAGGCA AACAGACTGC CAGCCAGCGG GAAACTAGAC 
TCACCTACAC TGGCAGCTAT GAATAAGCCA CGCTGTGGCG TCCCTGACAC ACGACTACCC 
CTTCAGGATG CCCTGCCAAC TCCACCAGCC CTGCCAACCC CTCTAGGTCT CCAGCCCAGG 
GCCCGACAAA AGCGCTTTCT TCAAATGCTG CTGCCCAAGC CAGGTGGGAA ACAGGAGGGC 
CGGTCAGACA CGGGGGCCAG CAGGGTCTTC TCCAAGAAGA CACTGACCTG GAGACTAGTG 
GGAGATGCCT ACAGCAGCCA ACTCTCTGGG GATGAGCAGA GATACATCTT TAGACTGGCC 
TTCAGGATGT GGAGCGAGGT GACGCCACTG GACTTCCGGG AGGACCTCAC TGCCCCTGGT 
ACCATGGTGG ACATAAAGCT GGGTTTTGGG AGAGGCCGGC ACCTGGGCTG TCCACGGGTG 
TTTGACGGGA GTGGACAGGA GTTTGCACAT GCCTGGCACC TGGGTGAGAT CCACTTTGAT 
GACGATGAGC ACTTTACTCC TCTCTCCAGT GACACGGGCA TCAGCCTTCT CAAAGTAGCT 
GTCCATGAAA TTGGTCACGT CCTTGGATTG CCTCACACCT ACAGGGTGGG ATCCATAATG 
CAACCAAACT ACATTCCCCA GGAGCCTGCA TTTGAGTTGG ACTGGTCAGA CAGAAAAGCA 
ATTCAAAGAC TATATGGGTC ATGTGAGGGA TCATTTGATA TAGTGTTTGA CTGGATTCGC 
AAGGAGAGGA ACCAATATGG TGAGGTGAGG GTGAGGTTCA ACACCTACTT CTTCCGCAAC 
AGCTGGTACT GGCTCTACGA AAACCGCAAC AACAGGACTC GCTACGGGGA CCCCCTCCAA 
ATCCTCACCG GCTGGCGTGG AATTCCCATG CAAAGAATAG ATGCTTTCGT CCATGTCTGG 
TCATGGGGTA GAGATGAGCG GTATTTTTTC AAAGGAAACC AATACTGGAG ATATGACAGT 
GAGAATGACC AGGCACACAC ACAAGATGAA CAAGGAAGGA GCTACCCCAA ACTGATTTCA 
GAAGGCTTCC CTGGCATCCC CAGTCCCTTG GACACGGCCT TCTATGAGCG GAGGCAGCAG 
CTAATTTACT TCTTCAAGGA GTCTCTAGTA TATGCATTTG ATGTCAACCG AAACCAAGCA 
CTTTCTTCTT ATCCAAAGAA GATGAGCCAA GTGTTCCCAG CAATAATGCC TCAAAACCAC 
CCATTCAGAA ACCTCGATTC CGCGTACTAC TCCTATGCAC ACAATGCCAT CTTCTTTTTC 
AAAGGCAACT CGTTTTGGAA AGTAGTTAGT GACAAGGACA AACAGCAGGA CTCTCGGCTC 
CCTCTGAATG GCTTATTTCC AAAACAATCT GTTTCAGGGA AGTGGTTTGA TGTTTGTGAC 
GTTCATACCT CTACACTGAA CATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A human laterality disorder caused by a homozygous deleterious mutation in MMP21.
Journal of medical genetics52(12)840-7(2015 Dec)
Perles Z,Moon S,Ta-Shma A,Yaacov B,Francescatto L,Edvardson S,Rein AJ,Elpeleg O,Katsanis N

MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates.
Nature genetics47(11)1260-3(2015 Nov)
Guimier A,Gabriel GC,Bajolle F,Tsang M,Liu H,Noll A,Schwartz M,El Malti R,Smith LD,Klena NT,Jimenez G,Miller NA,Oufadem M,Moreau de Bellaing A,Yagi H,Saunders CJ,Baker CN,Di Filippo S,Peterson KA,Thiffault I,Bole-Feysot C,Cooley LD,Farrow EG,Masson C,Schoen P,Deleuze JF,Nitschk? P,Lyonnet S,de Pontual L,Murray SA,Bonnet D,Kingsmore SF,Amiel J,Bouvagnet P,Lo CW,Gordon CT

Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Nature521(7553)520-4(2015 May)
Li Y,Klena NT,Gabriel GC,Liu X,Kim AJ,Lemke K,Chen Y,Chatterjee B,Devine W,Damerla RR,Chang C,Yagi H,San Agustin JT,Thahir M,Anderton S,Lawhead C,Vescovi A,Pratt H,Morgan J,Haynes L,Smith CL,Eppig JT,Reinholdt L,Francis R,Leatherbury L,Ganapathiraju MK,Tobita K,Pazour GJ,Lo CW

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Cancer cell24(3)305-17(2013 Sep)
Nagamachi A,Matsui H,Asou H,Ozaki Y,Aki D,Kanai A,Takubo K,Suda T,Nakamura T,Wolff L,Honda H,Inaba T

Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT cells.
The Journal of investigative dermatology129(1)119-30(2009 Jan)
Skoog T,Elomaa O,Pasonen-Sepp?nen SM,Forsberg S,Ahokas K,Jeskanen L,P?rssinen J,Tiala I,Rollman O,Lohi J,Saarialho-Kere U

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Mmp21 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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