The following Pkn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pkn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa13174 | |
| Clone ID Related Accession (Same CDS sequence) | NM_017175.2 | |
| Accession Version | NM_017175.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2841bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-19 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | serine/threonine-protein kinase N1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB608722.1, D26180.1, BC061836.1 and EV774518.1. On Jan 24, 2008 this sequence version replaced NM_017175.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ222217.1, D26180.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGGCCGGCG ACGCCGTGCA GAGTGAACCT CGCAGCTGGT CACTGCTGGA GCAGCTGGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_058871.2 |
| CDS | 175..3015 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_017175.2 |
1 | ATGGCCGGCG ACGCCGTGCA GAGTGAACCT CGCAGCTGGT CACTGCTGGA GCAGCTGGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa38696 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006255245.2 | |
| Accession Version | XM_006255245.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2856bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | serine/threonine-protein kinase N1 isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006255245.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGCAGCTG ATCCCCCTTT GGATTTGGAG CTGGAGAGTG AACCTCGCAG CTGGTCACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006255307.1 |
| CDS | 1200..4055 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006255245.2 |
1 | ATGGCAGCTG ATCCCCCTTT GGATTTGGAG CTGGAGAGTG AACCTCGCAG CTGGTCACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa59419 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017601249.1 | |
| Accession Version | XM_017601249.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3351bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | serine/threonine-protein kinase N1 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGATGCCT CTATGCAGCT AGGCGGTGTG TGTAGGGAGG TGGATCGTGA CTTTTGCTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_017456738.1 |
| CDS | 535..3885 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017601249.1 |
1 | ATGGATGCCT CTATGCAGCT AGGCGGTGTG TGTAGGGAGG TGGATCGTGA CTTTTGCTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury. |
Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation. |
Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling. |
Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration. |
Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. |
