Arg1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Arg1
Entrez Gene ID	29221
Full Name	arginase 1
General protein information	Preferred Names arginase 1 Names arginase-1 AI type I arginase arginase, liver liver-type arginase type I arginase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p12
Summary	catalyzes the hydrolysis of arginine to ornithine and urea in arginine metabolism; regulates nitric oxide production [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017134.3	NP_058830.2	arginase-1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ARG1	NP_001231367.1
Pan troglodytes (chimpanzee)	ARG1	XP_003311537.1
	ARG1	XP_001103609.2
Danio rerio (zebrafish)	LOC100148378	XP_001922598.1
Schizosaccharomyces pombe (fission yeast)	aru1	NP_593549.1
Canis lupus familiaris (dog)	ARG1	XP_003639475.1
Saccharomyces cerevisiae (baker's yeast)	CAR1	NP_015214.1
Eremothecium gossypii	AGOS_AGR225C	NP_986891.1
Rattus norvegicus (Norway rat)	Arg1	NP_058830.2
Xenopus tropicalis (tropical clawed frog)	arg1	NP_001006714.1
Mus musculus (house mouse)	Arg1	NP_031508.1
Kluyveromyces lactis	KLLA0F00704g	XP_455111.1
Schizosaccharomyces pombe (fission yeast)	car1	NP_595133.1
Magnaporthe oryzae (rice blast fungus)	MGG_10854	XP_003713240.1
Bos taurus (cattle)	ARG1	NP_001039619.1
Danio rerio (zebrafish)	arg1	NP_001038662.1
Neurospora crassa	NCU02333	XP_959759.2

Gene Ontology
Bibliography

Related articles in PubMed

Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus.
Pernow J, Kiss A, Tratsiakovich Y, Climent B
British journal of pharmacology172(19)4684-98(2015 Oct)

Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.
Nara A, Nagai H, Shintani-Ishida K, Ogura S, Shimosawa T, Kuwahira I, Shirai M, Yoshida K
American journal of respiratory cell and molecular biology53(2)184-92(2015 Aug)

Genotype-Associated Arginase 1 Expression in Rat Peritoneal Macrophages Induced by Toxoplasma gondii.
Zhang Q, He L, Kong L, Zhang Y, Chen H, An R, Wang L, Wang W, Xu X, Zhang A, Cai Y, Li M, Wen H, Luo Q, Shen J
The Journal of parasitology101(4)418-23(2015 Aug)

Arginase promotes endothelial dysfunction and hypertension in obese rats.
Johnson FK, Peyton KJ, Liu XM, Azam MA, Shebib AR, Johnson RA, Durante W
Obesity (Silver Spring, Md.)23(2)383-90(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus
Title: Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus.

Intermittent hypoxia increases expression levels of arginase I and II proteins in adult rats.
Title: Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.

Arg1 expression, which is abundant in polarized M2 cells, is associated with strain/genotype differences from different pathways.
Title: Genotype-Associated Arginase 1 Expression in Rat Peritoneal Macrophages Induced by Toxoplasma gondii.

Arginase promotes endothelial dysfunction and hypertension in obesity by reducing arginine bioavailability.
Title: Arginase promotes endothelial dysfunction and hypertension in obese rats.

Lower activity and expression levels of iNOS and higher activity and expression levels of arginase-1 in rat alveolar macrophages were found to be linked to the susceptibility of T. gondii infection in these cells
Title: Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection.

The following Arg1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Arg1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12202	NM_017134.3 Latest version!	Rattus norvegicus arginase 1 (Arg1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Arg1 ( NM_017134.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058830.2 Rattus norvegicus arginase 1 (Arg1), mRNA.

Price & Availability↑

CloneID	ORa12202
Clone ID Related Accession (Same CDS sequence)	NM_017134.3
Accession Version	NM_017134.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Rattus norvegicus(Norway rat)
Product	arginase-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC139610.2, FM100195.1 and FM120421.1. On Aug 30, 2012 this sequence version replaced NM_017134.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ218591.1, J02720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: experimental evidence (PMID:3571256) ##RefSeq-Attributes-END##

ATGAGCTCCA AGCCAAAGCC CATAGAGATT ATCGGAGCGC CTTTCTCTAA GGGACAGCCT 
CGAGGAGGGG TAGAGAAAGG TCCCGCAGCA TTAAGGAAAG CTGGCCTGGT GGAGAAGCTT 
AAAGAAACAG AGTACAATGT GAGAGACCAC GGGGATCTGG CCTTTGTGGA TGTCCCCAAT 
GACAGCCCCT TTCAAATTGT GAAGAACCCA CGGTCTGTGG GAAAAGCCAA TGAACAGCTG 
GCTGCTGTGG TAGCAGAGAC CCAGAAGAAT GGAACAATCA GTGTGGTGCT GGGTGGAGAC 
CACAGTATGG CAATTGGAAG CATCTCTGGC CACGCCAGGG TCCACCCTGA CCTATGCGTC 
ATTTGGGTGG ATGCTCACAC TGACATCAAC ACTCCGCTGA CAACCAGCTC TGGGAATCTG 
CACGGGCAAC CGGTGGCCTT TCTCCTGAAG GAACTGAAAG GAAAGTTCCC AGATGTACCA 
GGATTCTCCT GGGTGACCCC CTGCATATCT GCCAAGGACA TCGTGTACAT CGGCTTGCGA 
GATGTGGACC CTGGGGAACA CTATATAATA AAAACTCTGG GCATTAAGTA TTTCTCAATG 
ACTGAAGTGG ACAAGCTGGG AATTGGCAAA GTGATGGAAG AGACCTTCAG CTACCTGCTG 
GGAAGGAAGA AAAGGCCCAT TCACCTGAGT TTTGATGTTG ATGGACTGGA CCCAGTATTC 
ACCCCGGCTA CGGGCACACC CGTTGTGGGA GGCCTATCTT ACAGAGAAGG TCTCTACATC 
ACAGAAGAAA TTTACAAGAC AGGGCTACTT TCAGGACTAG ATATCATGGA AGTGAACCCA 
ACTCTTGGGA AGACACCAGA GGAGGTGACT CGTACTGTGA ACACGGCAGT GGCGTTGACC 
TTGTCTTGTT TTGGAACGAA ACGGGAAGGT AATCATAAGC CAGAGACTGA CTACCTTAAA 
CCACCGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058830.2
CDS	146..1117
Translation	MSSKPKPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYLKPPK

Target ORF information:

RefSeq Version	NM_017134.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus arginase 1 (Arg1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017134.3

ORF Insert Sequence:

ATGAGCTCCA AGCCAAAGCC CATAGAGATT ATCGGAGCGC CTTTCTCTAA GGGACAGCCT 
CGAGGAGGGG TAGAGAAAGG TCCCGCAGCA TTAAGGAAAG CTGGCCTGGT GGAGAAGCTT 
AAAGAAACAG AGTACAATGT GAGAGACCAC GGGGATCTGG CCTTTGTGGA TGTCCCCAAT 
GACAGCCCCT TTCAAATTGT GAAGAACCCA CGGTCTGTGG GAAAAGCCAA TGAACAGCTG 
GCTGCTGTGG TAGCAGAGAC CCAGAAGAAT GGAACAATCA GTGTGGTGCT GGGTGGAGAC 
CACAGTATGG CAATTGGAAG CATCTCTGGC CACGCCAGGG TCCACCCTGA CCTATGCGTC 
ATTTGGGTGG ATGCTCACAC TGACATCAAC ACTCCGCTGA CAACCAGCTC TGGGAATCTG 
CACGGGCAAC CGGTGGCCTT TCTCCTGAAG GAACTGAAAG GAAAGTTCCC AGATGTACCA 
GGATTCTCCT GGGTGACCCC CTGCATATCT GCCAAGGACA TCGTGTACAT CGGCTTGCGA 
GATGTGGACC CTGGGGAACA CTATATAATA AAAACTCTGG GCATTAAGTA TTTCTCAATG 
ACTGAAGTGG ACAAGCTGGG AATTGGCAAA GTGATGGAAG AGACCTTCAG CTACCTGCTG 
GGAAGGAAGA AAAGGCCCAT TCACCTGAGT TTTGATGTTG ATGGACTGGA CCCAGTATTC 
ACCCCGGCTA CGGGCACACC CGTTGTGGGA GGCCTATCTT ACAGAGAAGG TCTCTACATC 
ACAGAAGAAA TTTACAAGAC AGGGCTACTT TCAGGACTAG ATATCATGGA AGTGAACCCA 
ACTCTTGGGA AGACACCAGA GGAGGTGACT CGTACTGTGA ACACGGCAGT GGCGTTGACC 
TTGTCTTGTT TTGGAACGAA ACGGGAAGGT AATCATAAGC CAGAGACTGA CTACCTTAAA 
CCACCGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus.
British journal of pharmacology172(19)4684-98(2015 Oct)
Pernow J,Kiss A,Tratsiakovich Y,Climent B

Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.
American journal of respiratory cell and molecular biology53(2)184-92(2015 Aug)
Nara A,Nagai H,Shintani-Ishida K,Ogura S,Shimosawa T,Kuwahira I,Shirai M,Yoshida K

Genotype-Associated Arginase 1 Expression in Rat Peritoneal Macrophages Induced by Toxoplasma gondii.
The Journal of parasitology101(4)418-23(2015 Aug)
Zhang Q,He L,Kong L,Zhang Y,Chen H,An R,Wang L,Wang W,Xu X,Zhang A,Cai Y,Li M,Wen H,Luo Q,Shen J

Arginase promotes endothelial dysfunction and hypertension in obese rats.
Obesity (Silver Spring, Md.)23(2)383-90(2015 Feb)
Johnson FK,Peyton KJ,Liu XM,Azam MA,Shebib AR,Johnson RA,Durante W

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Arg1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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